Dimerization of MLH1 and PMS2 Limits Nuclear Localization of MutLα

scientific article published on May 1, 2003

Dimerization of MLH1 and PMS2 Limits Nuclear Localization of MutLα is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.23.9.3320-3328.2003
P953full work available at URLhttps://doi.org/10.1128/mcb.23.9.3320-3328.2003
https://europepmc.org/articles/PMC153201
https://europepmc.org/articles/pmc153201?pdf=render
https://europepmc.org/articles/PMC153201?pdf=render
https://journals.asm.org/doi/pdf/10.1128/MCB.23.9.3320-3328.2003
https://www.tandfonline.com/doi/pdf/10.1128/MCB.23.9.3320-3328.2003
P932PMC publication ID153201
P698PubMed publication ID12697830

P50authorMarilia CascalhoQ56858816
Jeffrey L PlattQ87911589
P2093author name stringXiaosheng Wu
P2860cites workCancer ResearchQ326097
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damageQ22010200
HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexesQ24291378
Nuclear and nucleolar targeting of human ribosomal protein S6Q24321240
CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicityQ24554535
A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylationQ40800224
Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpointQ41303489
Mismatch repair co-opted by hypermutation.Q43917262
The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factorsQ49486533
Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal CancerQ61946741
Mutations and loss of expression of a mismatch repair gene, hMLH1, in leukemia and lymphoma cell linesQ73126110
Signaling mismatch repair in cancerQ73143600
Identification of a second MutL DNA mismatch repair complex (hPMS1 and hMLH1) in human epithelial cellsQ73626700
Tight control of gene expression in mammalian cells by tetracycline-responsive promotersQ24564850
The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2Q24596494
Disruption of the FG nucleoporin NUP98 causes selective changes in nuclear pore complex stoichiometry and functionQ24632994
Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesisQ27766073
Functional studies on the candidate ATPase domains of Saccharomyces cerevisiae MutLalpha.Q27929951
Eukaryotic DNA mismatch repairQ27939116
Mutation of a mutL homolog in hereditary colon cancerQ28114939
Nucleocytoplasmic transport: the soluble phaseQ28131723
The interaction of the human MutL homologues in hereditary nonpolyposis colon cancerQ28137782
hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNAQ28138775
Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targetingQ28506440
Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation processQ28507129
Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution patternQ28510640
Meiotic pachytene arrest in MLH1-deficient miceQ28510650
Severe attenuation of the B cell immune response in Msh2-deficient miceQ28585021
Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modificationsQ28586687
Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2Q28910215
Identification of a signal for rapid export of proteins from the nucleusQ29547742
Mismatch repair in replication fidelity, genetic recombination, and cancer biologyQ29616483
Steady-state regulation of the human DNA mismatch repair system.Q33896699
Nuclear targeting signal recognition: a key control point in nuclear transport?Q33936678
Mutations within the hMLH1 and hPMS2 subunits of the human MutLalpha mismatch repair factor affect its ATPase activity, but not its ability to interact with hMutSalphaQ34123282
DNA mismatch repair and cancerQ34164892
Regulation of p53 localizationQ34254613
Functional interactions and signaling properties of mammalian DNA mismatch repair proteinsQ34425450
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologsQ34554581
The contribution of nuclear compartmentalization to gene regulationQ34574321
The Escherichia coli MutL protein stimulates binding of Vsr and MutS to heteroduplex DNA.Q34657088
The role of DNA repair in somatic hypermutation of immunoglobulin genesQ36400909
Expression of the DNA mismatch repair proteins hMLH1 and hPMS2 in normal human tissuesQ36431145
Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutationsQ36570003
Reconstitution of HIV-1 rev nuclear export: independent requirements for nuclear import and exportQ37477637
Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adductQ37522716
Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosisQ38293261
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
P304page(s)3320-3328
P577publication date2003-05-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleDimerization of MLH1 and PMS2 limits nuclear localization of MutLalpha
Dimerization of MLH1 and PMS2 Limits Nuclear Localization of MutLα
P478volume23

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cites work (P2860)
Q53290249A CRM1‐dependent nuclear export pathway is involved in the regulation of MutLα subcellular localization
Q24564010ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage
Q37001985Alternative splicing regulates activation-induced cytidine deaminase (AID): implications for suppression of AID mutagenic activity in normal and malignant B cells
Q36614680An intact Pms2 ATPase domain is not essential for male fertility
Q48233207Analysis of clinically relevant somatic mutations in high-risk head and neck cutaneous squamous cell carcinoma.
Q34820495Apoptotic function of human PMS2 compromised by the nonsynonymous single-nucleotide polymorphic variant R20Q
Q34163755C-terminal fluorescent labeling impairs functionality of DNA mismatch repair proteins
Q55423138CRABS CLAW Acts as a Bifunctional Transcription Factor in Flower Development.
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Q83227500Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome
Q24647002DNA mismatch repair: molecular mechanism, cancer, and ageing
Q62817582DNA repair processes are critical mediators of p53-dependent tumor suppression
Q36946520Human PMS2 deficiency is associated with impaired immunoglobulin class switch recombination
Q39695410Identification of Lynch syndrome mutations in the MLH1-PMS2 interface that disturb dimerization and mismatch repair
Q40084513MLH1- and ATM-dependent MAPK signaling is activated through c-Abl in response to the alkylator N-methyl-N'-nitro-N'-nitrosoguanidine
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Q48332104The Changing Landscape of Lynch Syndrome due to PMS2 Mutations.
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Q37694831Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome

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