Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles

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Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...870991C
P356DOI10.1371/JOURNAL.PONE.0070991
P932PMC publication ID3737232
P698PubMed publication ID23951061
P5875ResearchGate publication ID255959463

P2093author name stringDomenico Praticò
Jin Chu
Jin-Guo Li
P2860cites work5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer diseaseQ36299503
5-Lipoxygenase: regulation of expression and enzyme activityQ36852065
Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer's disease.Q36974939
5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's diseaseQ37232572
Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's diseaseQ37441782
Post-translational modifications of tau protein: implications for Alzheimer's disease.Q37826875
Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenaseQ39689586
5-Lipoxygenase (5-LOX) promoter polymorphism in patients with early-onset and late-onset Alzheimer's diseaseQ43670979
Altered expression of synaptic proteins occurs early during progression of Alzheimer's diseaseQ45172855
A randomized, comparative, multicentric clinical trial to assess the efficacy and safety of zileuton extended-release tablets with montelukast sodium tablets in patients suffering from chronic persistent asthmaQ46190704
The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old.Q48438144
Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severityQ48983820
Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer diseaseQ24657243
p39 activates cdk5 in neurons, and is associated with the actin cytoskeletonQ28145210
Gene knockout of 5-lipoxygenase rescues synaptic dysfunction and improves memory in the triple-transgenic model of Alzheimer's diseaseQ30540833
5-lipoxygenase as an endogenous modulator of amyloid β formation in vivoQ34636148
Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretaseQ34805615
Cdk5: One of the links between senile plaques and neurofibrillary tangles?Q35116571
Advances in therapy with antileukotriene drugsQ36008377
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectpathologyQ7208
Alzheimer's diseaseQ11081
P304page(s)e70991
P577publication date2013-08-07
P1433published inPLOS OneQ564954
P1476titleZileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles
P478volume8

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cites work (P2860)
Q38980572A COX/5-LOX Inhibitor Licofelone Revealed Anticonvulsant Properties Through iNOS Diminution in Mice
Q51731158Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice.
Q37739453Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.
Q37184747GATA1-mediated transcriptional regulation of the γ-secretase activating protein increases Aβ formation in Down syndrome
Q35185115Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles
Q37678192Homocysteine modulates 5-lipoxygenase expression level via DNA methylation.
Q54976720Learning Impairments, Memory Deficits, and Neuropathology in Aged Tau Transgenic Mice Are Dependent on Leukotrienes Biosynthesis: Role of the cdk5 Kinase Pathway.
Q48127496Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice
Q37576743Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses
Q64121987New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties
Q54979137Novel Key Players in the Development of Tau Neuropathology: Focus on the 5-Lipoxygenase.
Q37678676Novel lipid signaling pathways in Alzheimer's disease pathogenesis
Q35929097Pharmacologic inhibition of 5-lipoxygenase improves memory, rescues synaptic dysfunction, and ameliorates tau pathology in a transgenic model of tauopathy
Q35745694Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence
Q33949740Syntheses, neural protective activities, and inhibition of glycogen synthase kinase-3β of substituted quinolines.
Q35691073The Intracellular Localisation and Phosphorylation Profile of the Human 5-Lipoxygenase Δ13 Isoform Differs from That of Its Full Length Counterpart
Q89771694The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies
Q26795652The role of lipoxygenases in pathophysiology; new insights and future perspectives
Q34225004Zileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer's disease mice

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