GATA1-mediated transcriptional regulation of the γ-secretase activating protein increases Aβ formation in Down syndrome

scientific article published on 08 October 2015

GATA1-mediated transcriptional regulation of the γ-secretase activating protein increases Aβ formation in Down syndrome is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/ANA.24540
P932PMC publication ID4989126
P698PubMed publication ID26448035

P50authorThomas WisniewskiQ41043812
P2093author name stringDomenico Praticò
Jin Chu
P2860cites workGamma-secretase activating protein is a therapeutic target for Alzheimer's diseaseQ24298408
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activityQ24321405
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeuticsQ27860914
Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndromeQ28217381
Decreased expression of synapse-related genes and loss of synapses in major depressive disorderQ28580177
GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndromeQ34177171
Gamma secretase-activating protein is a substrate for caspase-3: implications for Alzheimer's diseaseQ34714810
Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tanglesQ34948311
Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degenerationQ35683326
National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approachQ35706615
Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP miceQ35750756
5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer diseaseQ36299503
100 years and counting: prospects for defeating Alzheimer's diseaseQ36643419
Regulation of gamma-secretase activity in Alzheimer's diseaseQ36734828
Mental retardation and associated neurological dysfunctions in Down syndrome: a consequence of dysregulation in critical chromosome 21 genes and associated molecular pathwaysQ36969504
Inhibition and modulation of gamma-secretase for Alzheimer's diseaseQ37215842
Amyloid precursor protein processing and Alzheimer's diseaseQ37860317
Development and mechanism of γ-secretase modulators for Alzheimer's diseaseQ38101383
A fast growing spectrum of biological functions of γ-secretase in development and diseaseQ38149886
Pharmacological modulation of GSAP reduces amyloid-β levels and tau phosphorylation in a mouse model of Alzheimer's disease with plaques and tanglesQ39012382
Immunohistochemical characterization of γ-secretase activating protein expression in Alzheimer's disease brains.Q49108254
Lifelong management of amyloid-beta metabolism to prevent Alzheimer's disease.Q53441656
Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesisQ78863050
P433issue1
P304page(s)138-143
P577publication date2015-10-08
P1433published inAnnals of NeurologyQ564414
P1476titleGATA1-mediated transcriptional regulation of the γ-secretase activating protein increases Aβ formation in Down syndrome
P478volume79

Reverse relations

cites work (P2860)
Q37730984Alzheimer's disease in people with Down's syndrome: the prospects for and the challenges of developing preventative treatments
Q38661982Frontal Cortex and Hippocampal γ-Secretase Activating Protein Levels in Prodromal Alzheimer Disease
Q60197707GSAP modulates γ-secretase specificity by inducing conformational change in PS1
Q64118047GSAP modulates γ-secretase specificity by inducing conformational change in PS1

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