Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice

scientific article published on 5 January 2012

Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1047300519
P356DOI10.1186/1750-1326-7-1
P8608Fatcat IDrelease_2tadq2yyizemliwuotim6adbt4
P932PMC publication ID3277480
P698PubMed publication ID22222029
P5875ResearchGate publication ID221726440

P2093author name stringTodd E Golde
Domenico Pratico
Phillip F Giannopoulos
Jin Chu
Carolina Ceballos-Diaz
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BRI2 (ITM2b) inhibits Abeta deposition in vivoQ24319041
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Diet-induced hyperhomocysteinemia increases amyloid-beta formation and deposition in a mouse model of Alzheimer's diseaseQ30444790
Normalization of hyperhomocysteinemia improves cognitive deficits and ameliorates brain amyloidosis of a transgenic mouse model of Alzheimer's diseaseQ30497574
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.Q34169736
Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREBQ34353695
Aging-associated up-regulation of neuronal 5-lipoxygenase expression: putative role in neuronal vulnerabilityQ34463247
5-lipoxygenase as an endogenous modulator of amyloid β formation in vivoQ34636148
Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretaseQ34805615
5-Lipoxygenase: regulation of expression and enzyme activityQ36852065
Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer's disease.Q36974939
5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's diseaseQ37232572
Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenaseQ39689586
A role for 12/15 lipoxygenase in the amyloid beta precursor protein metabolismQ40079113
Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brainQ40329324
Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Abeta levels.Q42247303
5-Lipoxygenase (5-LOX) promoter polymorphism in patients with early-onset and late-onset Alzheimer's diseaseQ43670979
Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice.Q43913392
Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic miceQ46964616
The 5-lipoxygenase enzymatic pathway in the mouse brain: young versus old.Q48438144
Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months.Q52012764
Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.Q52173404
Arachidonate 5-lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signalingQ70790631
P433issue1
P921main subjectphenotypeQ104053
P304page(s)1
P577publication date2012-01-05
P1433published inMolecular NeurodegenerationQ15817329
P1476titleAdeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice
P478volume7

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cites work (P2860)
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