5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5.

scientific article published on 16 January 2013

5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.NEUROBIOLAGING.2012.12.009
P932PMC publication ID3596429
P698PubMed publication ID23332172

P2093author name stringDomenico Praticò
Jin Chu
P2860cites workAdeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP miceQ35750756
5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer diseaseQ36299503
Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway diseaseQ36774177
5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's diseaseQ37232572
Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's diseaseQ37441782
The role of tau in Alzheimer's disease and related disordersQ37765632
Inhibition of cyclin-dependent kinase 5 but not of glycogen synthase kinase 3-β prevents neurite retraction and tau hyperphosphorylation caused by secretable products of human T-cell leukemia virus type I-infected lymphocytes.Q39207637
Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenaseQ39689586
Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory.Q44720653
Blocking Abeta42 accumulation delays the onset and progression of tau pathology via the C terminus of heat shock protein70-interacting protein: a mechanistic link between Abeta and tau pathology.Q46081295
Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.Q46303283
Alzheimer's DiseaseQ22248111
TauopathiesQ22252803
p39 activates cdk5 in neurons, and is associated with the actin cytoskeletonQ28145210
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunctionQ29547778
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse modelQ29617937
5-lipoxygenase as an endogenous modulator of amyloid β formation in vivoQ34636148
Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretaseQ34805615
Tau in Alzheimer disease and related tauopathiesQ34953869
Cdk5: One of the links between senile plaques and neurofibrillary tangles?Q35116571
Tau phosphorylation, tangles, and neurodegeneration: the chicken or the egg?Q35594823
P433issue6
P921main subjectphosphorylationQ242736
P304page(s)1549-1554
P577publication date2013-01-16
P1433published inNeurobiology of AgingQ7002141
P1476title5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5.
P478volume34

Reverse relations

cites work (P2860)
Q510305575-LOX in Alzheimer's Disease: Potential Serum Marker and In Vitro Evidences for Rescue of Neurotoxicity by Its Inhibitor YWCS.
Q369161585-lipoxygenase-activating protein as a modulator of olanzapine-induced lipid accumulation in adipocyte
Q38587949Cdk5 at crossroads of protein oligomerization in neurodegenerative diseases: facts and hypotheses
Q47280362Dissecting the Role of 5-Lipoxygenase in the Homocysteine-Induced Alzheimer's Disease Pathology
Q54979717Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy.
Q33647503FLAP pharmacological blockade modulates metabolism of endogenous tau in vivo .
Q37627877Modulation of lipopolysaccharide-induced memory insult, γ-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase
Q37678676Novel lipid signaling pathways in Alzheimer's disease pathogenesis
Q26999358The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimer's disease phenotype
Q38557958The Role of Cdk5 in Alzheimer's Disease
Q28119005The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy