Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo

scholarly article

Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2003PNAS..100.4879I
P356DOI10.1073/PNAS.0831078100
P932PMC publication ID153649
P698PubMed publication ID12668764
P5875ResearchGate publication ID10827683

P2093author name stringYoshiaki Itoh
Louis Sokoloff
Kazuaki Shimoji
Michelle Cook
Takanori Esaki
Elaine Kaufman
Mona J Law
P2860cites workLactate rise detected by 1H NMR in human visual cortex during physiologic stimulationQ24564399
Measurement of protein using bicinchoninic acidQ26778491
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilizationQ29620724
Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging.Q30580992
The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat.Q34062645
Role of sodium and potassium ions in regulation of glucose metabolism in cultured astroglia.Q34350893
Do active cerebral neurons really use lactate rather than glucose?Q34384249
Synopsis of the workshop entitled "Is lactate a nutrient for neurons" held at the Brain Energy Meeting in Trondheim, NorwayQ34464749
Glucose and lactate metabolism during brain activationQ34464755
Treatment of congenital lactic acidosis with dichloroacetateQ35257790
Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activityQ35677747
The regulation of pyruvate oxidation during membrane depolarization of rat brain synaptosomesQ41833053
Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acidsQ41945381
Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate (Short Communication).Q42923931
Interconversion and kinetic properties of pyruvate dehydrogenase from brain.Q43742261
Energy on demandQ48283930
Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttleQ48371514
Acetoacetate and glucose as lipid precursors and energy substrates in primary cultures of astrocytes and neurons from mouse cerebral cortexQ48373256
Regulation of energy metabolism in synaptic terminals and cultured rat brain astrocytes: differences revealed using aminooxyacetateQ48390156
Effects of antimycin, glucose deprivation, and serum on cultures of neurons, astrocytes, and neuroblastoma cellsQ48558981
Diisopropylammonium dichloroacetate (DIPA) and sodium dichloracetate (DCA): effect on glucose and fat metabolism in normal and diabetic tissue.Q54148351
Hypoglycaemic action of DIISOpropylammonium salts in experimental diabetesQ56141988
Energy metabolism in glutamatergic neurons, GABAergic neurons and astrocytes in primary culturesQ69923269
Lactate release from cultured astrocytes and neurons: a comparisonQ70069775
Effects of dichloroacetate on brain pyruvate dehydrogenaseQ71249395
Excitatory amino acids stimulate aerobic glycolysis in astrocytes via an activation of the Na+/K+ ATPaseQ71826798
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectglucoseQ37525
astrocyteQ502961
dichloroacetateQ27077050
P304page(s)4879-4884
P577publication date2003-03-31
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleDichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo
P478volume100

Reverse relations

cites work (P2860)
Q46183247'SNO'-Storms Compromise Protein Activity and Mitochondrial Metabolism in Neurodegenerative Disorders
Q5013670413 reasons why the brain is susceptible to oxidative stress
Q58777975A Comparison of Oxidative Lactate Metabolism in Traumatically Injured Brain and Control Brain
Q34656867Activity-dependent regulation of energy metabolism by astrocytes: an update
Q35646715Age-related metabolic fatigue during low glucose conditions in rat hippocampus
Q45230322Ampakine CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators
Q33889224Amyloid beta resistance in nerve cell lines is mediated by the Warburg effect
Q34123789An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex.
Q31034673Astrocyte-neuron lactate shuttle may boost more ATP supply to the neuron under hypoxic conditions--in silico study supported by in vitro expression data
Q36104665Astrocytic contributions to bioenergetics of cerebral ischemia
Q102220193Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes
Q36109558BACE1 activity impairs neuronal glucose oxidation: rescue by beta-hydroxybutyrate and lipoic acid.
Q39447083Bioenergetic Impairment in Animal and Cellular Models of Alzheimer's Disease: PARP-1 Inhibition Rescues Metabolic Dysfunctions.
Q36688433Brain Glucose Metabolism Controls Hepatic Glucose and Lipid Production.
Q34160702Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation
Q39259780Brain metabolism in health, aging, and neurodegeneration
Q37512891CNS regulation of glucose homeostasis
Q92512924CYP1B1: A key regulator of redox homeostasis
Q37188619Cell type-specific transcriptome profiling in mammalian brains
Q31119994Cellular pathways of energy metabolism in the brain: is glucose used by neurons or astrocytes?
Q30452509Cerebral Developmental Abnormalities in a Mouse with Systemic Pyruvate Dehydrogenase Deficiency
Q39375372Chronic treatment of mitochondrial disease patients with dichloroacetate
Q53076712Combined Treatment With Dichloroacetic Acid and Pyruvate Reduces Hippocampal Neuronal Death After Transient Cerebral Ischemia.
Q92043375Computational singular perturbation analysis of brain lactate metabolism
Q37980380Control of brain capillary blood flow
Q83405289Copper accelerates glycolytic flux in cultured astrocytes
Q40078756Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes
Q28483736Determinants of brain cell metabolic phenotypes and energy substrate utilization unraveled with a modeling approach
Q37459046Direct measurement of oxidative metabolism in the living brain by microdialysis: a review
Q44969014Dual-gene, dual-cell type therapy against an excitotoxic insult by bolstering neuroenergetics.
Q48474002Effectiveness of extracellular lactate/pyruvate for sustaining synaptic vesicle proton gradient generation and vesicular accumulation of GABA.
Q35578830Effects of L-glutamate/D-aspartate and monensin on lactic acid production in retina and cultured retinal Müller cells
Q48128879Effects of chlorinated acetates on the glutathione metabolism and on glycolysis of cultured astrocytes
Q42268953Endogenous Two-Photon Excited Fluorescence Imaging Characterizes Neuron and Astrocyte Metabolic Responses to Manganese Toxicity
Q35576702Energy Substrates for Neurons during Neural Activity: A Critical Review of the Astrocyte-Neuron Lactate Shuttle Hypothesis
Q31048542Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis
Q38300423Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice.
Q33359525Evidence for the mitochondrial lactate oxidation complex in rat neurons: demonstration of an essential component of brain lactate shuttles
Q36907068Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals.
Q26752408Exercise Counteracts Aging-Related Memory Impairment: A Potential Role for the Astrocytic Metabolic Shuttle
Q37984474Exploiting metabolic differences in glioma therapy
Q47869148Expression Changes in Lactate and Glucose Metabolism and Associated Transporters in Basal Ganglia following Hypoxic-Ischemic Reperfusion Injury in Piglets.
Q59138043Fatty Acid Increases cAMP-dependent Lactate and MAO-B-dependent GABA Production in Mouse Astrocytes by Activating a G Protein-coupled Receptor
Q33634475Fatty acids in energy metabolism of the central nervous system
Q45050947Fluorometric determination of glucose utilization in neurons in vitro and in vivo
Q28182087Food for thought: challenging the dogmas
Q44580287Formaldehyde metabolism and formaldehyde-induced stimulation of lactate production and glutathione export in cultured neurons.
Q35268977Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase
Q48199262Glutamatergic and GABAergic neurotransmitter cycling and energy metabolism in rat cerebral cortex during postnatal development
Q36217316How astrocytes feed hungry neurons.
Q33731300Hyperglycaemia and diabetes impair gap junctional communication among astrocytes
Q91361908Identification of novel common variants associated with chronic pain using conditional false discovery rate analysis with major depressive disorder and assessment of pleiotropic effects of LRFN5
Q46523634Interaction between astrocytes and neurons studied using a mathematical model of compartmentalized energy metabolism
Q57167668Interaction of the cryptic fragment of myelin basic protein with mitochondrial voltage-dependent anion-selective channel-1 affects cell energy metabolism
Q48411071Kinetic parameters and lactate dehydrogenase isozyme activities support possible lactate utilization by neurons
Q36596141L-Lactate protects neurons against excitotoxicity: implication of an ATP-mediated signaling cascade.
Q37620008Lactate Shuttles in Neuroenergetics-Homeostasis, Allostasis and Beyond.
Q36147046Lactate as a biomarker for sleep
Q50532023Lactate in the brain: from metabolic end-product to signalling molecule.
Q44644241Lactate is a preferential oxidative energy substrate over glucose for neurons in culture
Q40202940Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia
Q42120061Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices
Q36171853Lactate: the ultimate cerebral oxidative energy substrate?
Q47673925Lanthanum damages learning and memory and suppresses astrocyte-neuron lactate shuttle in rat hippocampus
Q39101800Metabolic Dysfunctions in Amyotrophic Lateral Sclerosis Pathogenesis and Potential Metabolic Treatments
Q38777732Metabolic and Inflammatory Adaptation of Reactive Astrocytes: Role of PPARs
Q24655314Metabolic and hemodynamic events after changes in neuronal activity: current hypotheses, theoretical predictions and in vivo NMR experimental findings
Q89617431Metabolic compartmentalization between astroglia and neurons in physiological and pathophysiological conditions of the neurovascular unit
Q42749841Metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in amyotrophic lateral sclerosis (ALS) mouse model
Q38874849Metabolism of Mannose in Cultured Primary Rat Neurons
Q36772984Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis.
Q38688703Metformin Accelerates Glycolytic Lactate Production in Cultured Primary Cerebellar Granule Neurons
Q37340252Methodological limitations in determining astrocytic gene expression
Q35063131Methylglyoxal, the dark side of glycolysis
Q64093260Methylglyoxal-Derived Advanced Glycation Endproducts Accumulate in Multiple Sclerosis Lesions
Q37690997Methylglyoxal-Derived Advanced Glycation Endproducts in Multiple Sclerosis.
Q58577433Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cell function and postnatal cerebellar development
Q46668726Modulation of astrocytic metabolic phenotype by proinflammatory cytokines
Q28482111Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis
Q35772794Neural Stem Cells in the Adult Subventricular Zone Oxidize Fatty Acids to Produce Energy and Support Neurogenic Activity
Q35677227Neuroenergetics: calling upon astrocytes to satisfy hungry neurons
Q35619717Neurometabolic coupling between neural activity, glucose, and lactate in activated visual cortex
Q49334640Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease.
Q36366441Neuronal-glial glucose oxidation and glutamatergic-GABAergic function.
Q43616402Nitric oxide induces the expression of the monocarboxylate transporter MCT4 in cultured astrocytes by a cGMP-independent transcriptional activation
Q46815054Nitric oxide reduces astrocytic lactate production and induces neuronal vulnerability in stroke-prone spontaneously hypertensive rats
Q48224588Noradrenaline enhances the expression of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of PI3K/Akt and the mTOR/S6K pathway
Q92683975Obesity-associated, but not obesity-independent, tumors respond to insulin by increasing mitochondrial glucose oxidation
Q91825235Oxidation and alkylation stresses activate ribosome-quality control
Q46562383Oxidative metabolism in cultured rat astroglia: effects of reducing the glucose concentration in the culture medium and of D-aspartate or potassium stimulation.
Q54388530Oxygen tension controls the expression of the monocarboxylate transporter MCT4 in cultured mouse cortical astrocytes via a hypoxia-inducible factor-1α-mediated transcriptional regulation.
Q34230877PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism
Q34043021Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons.
Q36533462Primary cultures of astrocytes: their value in understanding astrocytes in health and disease.
Q38252513Purinergic receptor stimulation decreases ischemic brain damage by energizing astrocyte mitochondria.
Q24320179Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells
Q39375963Pyruvate incubation enhances glycogen stores and sustains neuronal function during subsequent glucose deprivation
Q26864926Reevaluating Metabolism in Alzheimer's Disease from the Perspective of the Astrocyte-Neuron Lactate Shuttle Model
Q33764544Regulation of pyruvate metabolism and human disease
Q38896993Respiration-Deficient Astrocytes Survive As Glycolytic Cells In Vivo.
Q33854710Role of monocarboxylate transporters in drug delivery to the brain
Q45050950Selective uptake of [14C]2-deoxyglucose by neurons and astrocytes: high-resolution microautoradiographic imaging by cellular 14C-trajectography combined with immunohistochemistry
Q36079324Sweet sixteen for ANLS.
Q37562669TLR4-dependent metabolic changes are associated with cognitive impairment in an animal model of type 1 diabetes
Q28076125The Warburg effect: 80 years on
Q24654727The astrocyte odyssey
Q45152014The astrocyte-neuron lactate shuttle: a challenge of a challenge
Q36530685The physiological and biochemical bases of functional brain imaging
Q62485478The potential contribution of impaired brain glucose metabolism to congenital Zika syndrome
Q40499078The potential of metabolomic analysis techniques for the characterisation of α1-adrenergic receptors in cultured N1E-115 mouse neuroblastoma cells
Q35752267The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
Q37639384The significance of neuroglobin in the brain.
Q81567207The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex
Q33641532Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation
Q26866532Unraveling the complex metabolic nature of astrocytes