| scholarly article | Q13442814 |
| P50 | author | Ernesto Miquel | Q59677287 |
| P2093 | author name string | Adriana Cassina | |
| Carmen Bolatto | |||
| Emiliano Trías | |||
| Laura Martínez-Palma | |||
| Luis Barbeito | |||
| Mandi Gandelman | |||
| Patricia Cassina | |||
| Rafael Radi | |||
| P2860 | cites work | Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND) | Q24246517 |
| Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands | Q24300555 | ||
| Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model | Q24631645 | ||
| Akt1 intramitochondrial cycling is a crucial step in the redox modulation of cell cycle progression | Q27339328 | ||
| Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children | Q28237609 | ||
| A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth | Q28283339 | ||
| Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons | Q28298056 | ||
| Lead exposure stimulates VEGF expression in the spinal cord and extends survival in a mouse model of ALS | Q28393678 | ||
| 1H-NMR-based metabolomic profiling of CSF in early amyotrophic lateral sclerosis | Q28475721 | ||
| Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation | Q29547561 | ||
| THE METABOLISM OF TUMORS IN THE BODY | Q29616202 | ||
| ALS: a disease of motor neurons and their nonneuronal neighbors | Q29618000 | ||
| Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis | Q29619430 | ||
| E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation | Q33640253 | ||
| Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis | Q33837133 | ||
| Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). | Q34010341 | ||
| Mitochondrial dysfunction and intracellular calcium dysregulation in ALS | Q34103782 | ||
| Dichloroacetate- and Trichloroacetate-Induced Modulation of Superoxide Dismutase, Catalase, and Glutathione Peroxidase Activities and Glutathione Level in the livers of Mice after Subacute and Subchronic exposure | Q34407860 | ||
| On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate. | Q34498003 | ||
| Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo | Q34961411 | ||
| Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis | Q35518293 | ||
| Gender-Specific Mechanism of Synaptic Impairment and Its Prevention by GCSF in a Mouse Model of ALS. | Q35613992 | ||
| Mitochondria in amyotrophic lateral sclerosis: a trigger and a target | Q36565597 | ||
| Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice. | Q51714635 | ||
| Natural history of amyotrophic lateral sclerosis in a database population Validation of a scoring system and a model for survival prediction | Q52340479 | ||
| Pyruvate slows disease progression in a G93A SOD1 mutant transgenic mouse model. | Q53582566 | ||
| Antioxidant strategies based on tomato-enriched food or pyruvate do not affect disease onset and survival in an animal model of amyotrophic lateral sclerosis | Q63410203 | ||
| Effects of dichloroacetate on brain pyruvate dehydrogenase | Q71249395 | ||
| Astrocytes interact intimately with degenerating motor neurons in mouse amyotrophic lateral sclerosis (ALS) | Q73177446 | ||
| Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration | Q73348009 | ||
| Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants | Q37352307 | ||
| Neuromuscular junction destruction during amyotrophic lateral sclerosis: insights from transgenic models | Q37455509 | ||
| The cell cycle is a redox cycle: linking phase-specific targets to cell fate | Q37504064 | ||
| Mitochondrial kinases in cell signaling: Facts and perspectives | Q37592646 | ||
| Effect of genetic background on phenotype variability in transgenic mouse models of amyotrophic lateral sclerosis: a window of opportunity in the search for genetic modifiers | Q37829424 | ||
| Estrogen and the regulation of mitochondrial structure and function in the brain | Q37983332 | ||
| The pharmacology of dichloroacetate | Q38300732 | ||
| Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells | Q39910905 | ||
| Sexual dimorphism in disease onset and progression of a rat model of ALS. | Q40233416 | ||
| Stabilization of the pyruvate dehydrogenase E1alpha subunit by dichloroacetate | Q40994489 | ||
| Metabolomic analysis of serum by (1) H NMR spectroscopy in amyotrophic lateral sclerosis | Q43185595 | ||
| Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease | Q43676817 | ||
| Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis | Q43831275 | ||
| Survival in transgenic ALS mice does not vary with CNS glutathione peroxidase activity. | Q44131398 | ||
| Dichloroacetate increases skeletal muscle pyruvate dehydrogenase activity during acute limb ischemia | Q44473827 | ||
| Effects of high-intensity endurance exercise training in the G93A mouse model of amyotrophic lateral sclerosis | Q44873404 | ||
| Ovariectomy and 17beta-estradiol modulate disease progression of a mouse model of ALS. | Q45029482 | ||
| Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice | Q46254778 | ||
| Fibroblast growth factor-1 induces heme oxygenase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: consequences for motor neuron survival. | Q46471196 | ||
| Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis | Q46980730 | ||
| Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis | Q47865118 | ||
| Genistein is neuroprotective in murine models of familial amyotrophic lateral sclerosis and stroke | Q48209689 | ||
| Early motor and electrophysiological changes in transgenic mouse model of amyotrophic lateral sclerosis and gender differences on clinical outcome. | Q50265503 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P4510 | describes a project that uses | ImageJ | Q1659584 |
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | amyotrophic lateral sclerosis | Q206901 |
| dichloroacetate | Q27077050 | ||
| P304 | page(s) | e34776 | |
| P577 | publication date | 2012-01-01 | |
| P1433 | published in | PLOS One | Q564954 |
| P1476 | title | Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis | |
| P478 | volume | 7 |
| Q35822554 | A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis |
| Q38174451 | A mitochondrial basis for Huntington's disease: therapeutic prospects |
| Q38160415 | Advances in cellular models to explore the pathophysiology of amyotrophic lateral sclerosis. |
| Q39014987 | Alternative Fuels in Epilepsy and Amyotrophic Lateral Sclerosis. |
| Q37635458 | Astrocyte-like cells derived from human oral mucosa stem cells provide neuroprotection in vitro and in vivo. |
| Q35878096 | Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation |
| Q36902164 | Electrophilic nitro-fatty acids prevent astrocyte-mediated toxicity to motor neurons in a cell model of familial amyotrophic lateral sclerosis via nuclear factor erythroid 2-related factor activation |
| Q52651163 | Energy metabolism in ALS: an underappreciated opportunity? |
| Q42658376 | Implications of white matter damage in amyotrophic lateral sclerosis (Review). |
| Q33848626 | Long-term dietary exposure to low concentration of dichloroacetic acid promoted longevity and attenuated cellular and functional declines in aged Drosophila melanogaster |
| Q61796248 | Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis |
| Q38958585 | Management and therapeutic perspectives in amyotrophic lateral sclerosis |
| Q39101800 | Metabolic Dysfunctions in Amyotrophic Lateral Sclerosis Pathogenesis and Potential Metabolic Treatments |
| Q42749841 | Metabolic therapy with Deanna Protocol supplementation delays disease progression and extends survival in amyotrophic lateral sclerosis (ALS) mouse model |
| Q36772984 | Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis. |
| Q33752927 | Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock |
| Q39386582 | Morphological changes and altered expression of antioxidant proteins in a heterozygous dynein mutant; a mouse model of spinal muscular atrophy |
| Q49334640 | Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease. |
| Q62785679 | Neuronal glucose metabolism is impaired while astrocytic TCA cycling is unaffected at symptomatic stages in the hSOD1G93A mouse model of amyotrophic lateral sclerosis |
| Q90341507 | Overview of Lipid Biomarkers in Amyotrophic Lateral Sclerosis (ALS) |
| Q54972559 | Profile of Arachidonic Acid-Derived Inflammatory Markers and Its Modulation by Nitro-Oleic Acid in an Inherited Model of Amyotrophic Lateral Sclerosis. |
| Q24613709 | Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS) |
| Q48228453 | Role and Therapeutic Potential of Astrocytes in Amyotrophic Lateral Sclerosis |
| Q35802837 | Seeking homeostasis: temporal trends in respiration, oxidation, and calcium in SOD1 G93A Amyotrophic Lateral Sclerosis mice |
| Q50041901 | Small Molecules: Therapeutic Application in Neuropsychiatric and Neurodegenerative Disorders. |
| Q28079891 | Targeting Glial Mitochondrial Function for Protection from Cerebral Ischemia: Relevance, Mechanisms, and the Role of MicroRNAs |
| Q38126396 | The multifaceted role of glial cells in amyotrophic lateral sclerosis |
| Q38988403 | Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1. |
| Q52343842 | Thermodynamics in Neurodegenerative Diseases: Interplay Between Canonical WNT/Beta-Catenin Pathway-PPAR Gamma, Energy Metabolism and Circadian Rhythms. |
| Q38542939 | Transcriptional analysis reveals distinct subtypes in amyotrophic lateral sclerosis: implications for personalized therapy |
| Q36114275 | Triheptanoin Protects Motor Neurons and Delays the Onset of Motor Symptoms in a Mouse Model of Amyotrophic Lateral Sclerosis |
| Q36332951 | Type I Vs. Type II Cytokine Levels as a Function of SOD1 G93A Mouse Amyotrophic Lateral Sclerosis Disease Progression |
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