Bruton's tyrosine kinase mediates the synergistic signalling between TLR9 and the B cell receptor by regulating calcium and calmodulin

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Bruton's tyrosine kinase mediates the synergistic signalling between TLR9 and the B cell receptor by regulating calcium and calmodulin is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...874103K
P356DOI10.1371/JOURNAL.PONE.0074103
P932PMC publication ID3743783
P698PubMed publication ID23967355
P5875ResearchGate publication ID256073004

P50authorLuke A. J. O'NeillQ24209151
Sarah L DoyleQ55948328
P2093author name stringHans van Eenennaam
Elaine F Kenny
Susan R Quinn
Paul M Vink
P2860cites workThe Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancyQ24633214
Structural Basis for Calmodulin as a Dynamic Calcium SensorQ27679043
Calmodulin: a prototypical calcium sensorQ28111969
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Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in mice.Q45877580
Up-regulation of the endoplasmic reticulum transmembrane protein UNC93B in the B cells of patients with active systemic lupus erythematosus.Q51721411
Ca²+ signaling in B cells.Q55427972
Mutation detection in the X-linked agammaglobulinemia gene, BTK, using single strand conformation polymorphism analysisQ58161464
The effect of IL-4 on antigen expression: a comparison of fluorescence intensity and antigen densityQ72349613
Bridging B cell and T cell recognition of antigenQ79912591
Bruton's tyrosine kinase separately regulates NFkappaB p65RelA activation and cytokine interleukin (IL)-10/IL-12 production in TLR9-stimulated B CellsQ80705820
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signalingQ28590478
Store-operated calcium channelsQ29617459
Essential role of Ca2+/calmodulin in Early Endosome Antigen-1 localization.Q30478337
Plasticity of B cell receptor internalization upon conditional depletion of clathrinQ33768505
Calcium signaling in immune cells.Q33878792
Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignanciesQ33893704
TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupusQ33902262
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognitionQ33930537
It's all about change: the antigen-driven initiation of B-cell receptor signalingQ33931940
Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765.Q34026194
Initiation and processing of signals from the B cell antigen receptorQ34425416
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.Q34566135
Bruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signalling?Q35744665
B cell antigen receptor signaling 101.Q35818846
Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese populationQ35954523
The tipping points in the initiation of B cell signalling: how small changes make big differences.Q36121790
Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptorsQ36349536
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupusQ36403146
Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus.Q36423215
Peripheral B cell subsetsQ36867717
Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupusQ36907698
The role of calcium and other ions in sorting and delivery in the late endocytic pathwayQ36979614
Calcium, troponin, calmodulin, S100 proteins: from myocardial basics to new therapeutic strategiesQ36983008
The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigensQ37012927
Endocytosed BCRs sequentially regulate MAPK and Akt signaling pathways from intracellular compartmentsQ37103676
TLR9 is localized in the endoplasmic reticulum prior to stimulationQ37377551
Impact of Ca2+ signaling on B cell functionQ37945974
Integration of B cell responses through Toll-like receptors and antigen receptorsQ37994060
TLR7 and TLR9 in SLE: when sensing self goes wrongQ37995556
Tyrosine kinase inhibitors as potential drugs for B-cell lymphoid malignancies and autoimmune disordersQ38011765
B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin.Q39827413
Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinaseQ40068866
MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transductionQ40324640
Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharideQ40431320
TLR9 signals after translocating from the ER to CpG DNA in the lysosomeQ40600429
Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.Q40651159
Relationships between EEA1 binding partners and their role in endosome fusion.Q40809294
Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID miceQ41541610
Inhibition of IgE-mediated secretion from human basophils with a highly selective Bruton's tyrosine kinase, Btk, inhibitorQ41852151
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue8
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
P304page(s)e74103
P577publication date2013-08-14
P1433published inPLOS OneQ564954
P1476titleBruton's tyrosine kinase mediates the synergistic signalling between TLR9 and the B cell receptor by regulating calcium and calmodulin
P478volume8