TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus

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TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus is …
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scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.0902592
P932PMC publication ID4098568
P698PubMed publication ID20089701
P5875ResearchGate publication ID41102074

P50authorMark ShlomchikQ29887913
P2093author name stringMichael Kashgarian
Daniel Kim
Sean R Christensen
Jonathan Shupe
Keith Elkon
Kevin M Nickerson
P2860cites workAIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASCQ24319706
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNAQ24319765
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasomeQ24319799
Trex1 prevents cell-intrinsic initiation of autoimmunityQ24648757
Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammationQ24676343
Novel packages of viral and self-antigens are generated during apoptosisQ27485110
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responsesQ27860685
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNAQ28585347
Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNAQ28587147
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirusQ29615029
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptorsQ29615065
Recognition of cytosolic DNA activates an IRF3-dependent innate immune responseQ29616156
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosisQ30080034
Oligoclonality of rheumatoid factors arising spontaneously in lpr/lpr miceQ68256179
Phenotypes of immunocompetent cells and Ia antigen expression in oral mucosa and skin of autoimmune mouse strainsQ69855378
Dermatopathological studies on skin lesions of MRL miceQ70379621
Murine lupus in the absence of alpha beta T cellsQ71059502
Propagation and regulation of systemic autoimmunity by gammadelta T cellsQ71860211
The structure of mammalian small nuclear ribonucleoproteins. Identification of multiple protein components reactive with anti-(U1)ribonucleoprotein and anti-Sm autoantibodiesQ72812865
Genetic dissection of vasculitis in MRL/lpr lupus mice: a novel susceptibility locus involving the CD72c alleleQ74165048
Pathogenesis of autoimmunity in alphabeta T cell-deficient lupus-prone miceQ74211567
Blebs and apoptotic bodies are B cell autoantigensQ74334880
Perforin protects against autoimmunity in lupus-prone miceQ74463426
Toll-like receptor 9-independent aggravation of glomerulonephritis in a novel model of SLEQ79785802
Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupusQ79834758
Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptomsQ79946741
Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupusQ80219157
Protection against autoimmune nephritis in MyD88-deficient MRL/lpr miceQ80238431
Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 productionQ80358480
Interaction of mutant lpr gene with background strain influences renal diseaseQ93612765
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.Q34566135
Toll-like receptors in systemic autoimmune diseaseQ34576448
Host modifier genes affect mouse autoimmunity induced by the lpr geneQ35764934
TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE.Q36228411
Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying lociQ36232118
Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytesQ36363024
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupusQ36403146
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.Q36403678
Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing moleculesQ36535512
Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptorsQ36726933
Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptorsQ36727307
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunityQ36811126
Innate and adaptive immune response to apoptotic cellsQ36948827
Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunityQ36990647
Nucleic acid recognition receptors in autoimmunity.Q37028836
Turning NF-kappaB and IRFs on and off in DC.Q37183815
IL-1, IL-18, and IL-33 families of cytokinesQ37211243
Development of TLR inhibitors for the treatment of autoimmune diseasesQ37211279
When signaling pathways collide: positive and negative regulation of toll-like receptor signal transductionQ37217884
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupusQ37274484
Toll-like receptors in autoimmunityQ37348426
Innate immunity to virus infection.Q37361448
Loci predisposing to autoimmunity in MRL-Fas lpr and C57BL/6-Faslpr miceQ37378097
The innate immune response to DNA.Q37508443
The functional effects of physical interactions among Toll-like receptors 7, 8, and 9.Q38308562
Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensingQ39849800
Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin miceQ40231922
Etiology and pathogenesis of a spontaneous lupus-like syndrome in miceQ40682091
A rheumatoid factor transgenic mouse model of autoantibody regulationQ41523682
Frequency and epitope recognition of anti-ribosome P antibodies from humans with systemic lupus erythematosus and MRL/lpr mice are similarQ41808133
T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cellsQ41831629
The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activationQ42525772
Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradationQ42972278
Analysis of antibodies to RNA in patients with systemic lupus erythematosus and other autoimmune rheumatic diseasesQ44154557
Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG.Q47368420
Nucleosomes are exposed at the cell surface in apoptosis.Q47579101
Specificities and genetic characteristics of nucleosome-reactive antibodies from autoimmune miceQ48067825
V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr miceQ48132884
Plasma cells for a lifetime?Q52013650
B cells are required for lupus nephritis in the polygenic, Fas-intact MRL model of systemic autoimmunity.Q52032016
P4510describes a project that usesImageJQ1659584
P433issue4
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
autoantibodyQ785022
murine modelQ122890741
P304page(s)1840-1848
P577publication date2010-01-20
P1433published inJournal of ImmunologyQ3521441
P1476titleTLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus
P478volume184

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cites work (P2860)
Q9300262017β-Estradiol and 17α-Ethinyl Estradiol Exhibit Immunologic and Epigenetic Regulatory Effects in NZB/WF1 Female Mice
Q42290162A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens
Q38318048A Toll-like receptor 7, 8, and 9 antagonist inhibits Th1 and Th17 responses and inflammasome activation in a model of IL-23-induced psoriasis
Q44175614A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice
Q39579822A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding
Q37394553A role for IRF8 in B cell anergy
Q35735423A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells
Q51067865Abnormal thymic maturation and lymphoproliferation in MRL-Fas lpr/lpr mice can be partially reversed by synthetic oligonucleotides: implications for systemic lupus erythematosus and autoimmune lymphoproliferative syndrome.
Q55402266Accelerated model of lupus autoimmunity and vasculopathy driven by toll-like receptor 7/9 imbalance.
Q38673417Age-associated B cells: key mediators of both protective and autoreactive humoral responses
Q45835397Aliskiren attenuates proteinuria in mice with lupus nephritis by a blood pressure-independent mechanism
Q90468943Alpha 1 Antitrypsin Gene Therapy Extends the Lifespan of Lupus-Prone Mice
Q33924642Altered B cell signalling in autoimmunity
Q36080732Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome
Q89266529Apoptosis-derived membrane vesicles drive the cGAS-STING pathway and enhance type I IFN production in systemic lupus erythematosus
Q45212505Are autoantibodies the targets of B-cell-directed therapy?
Q34420799Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9.
Q42321000Autoreactive helper T cells alleviate the need for intrinsic TLR signaling in autoreactive B cell activation
Q91964435B Cell Abnormalities in Systemic Lupus Erythematosus and Lupus Nephritis-Role in Pathogenesis and Effect of Immunosuppressive Treatments
Q64094881B Cell Dysfunction Associated With Aging and Autoimmune Diseases
Q36031630B Cell-Specific MHC Class II Deletion Reveals Multiple Nonredundant Roles for B Cell Antigen Presentation in Murine Lupus.
Q36532226B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice
Q35658606B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) mice
Q34364711B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers.
Q90458171B cell-intrinsic TLR9 expression is protective in murine lupus
Q37509056B cell-specific loss of Lyn kinase leads to autoimmunity
Q52331790B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex.
Q39241954B-cell tolerance and autoimmunity.
Q36030578BANK1 Regulates IgG Production in a Lupus Model by Controlling TLR7-Dependent STAT1 Activation
Q33606019Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9
Q92549917Below the surface: The inner lives of TLR4 and TLR9
Q37983058Beyond transitional selection: New roles for BLyS in peripheral tolerance
Q47371480Bim suppresses the development of SLE by limiting myeloid inflammatory responses.
Q34965726Bruton's tyrosine kinase mediates the synergistic signalling between TLR9 and the B cell receptor by regulating calcium and calmodulin
Q42234851Bruton's tyrosine kinase regulates TLR9 but not TLR7 signaling in human plasmacytoid dendritic cells
Q37415233CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP.
Q43213271Cell-intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses
Q47221189Co-Stimulation of BCR and Toll-Like Receptor 7 Increases Somatic Hypermutation, Memory B Cell Formation, and Secondary Antibody Response to Protein Antigen
Q36181690Commensal Microbe-specific Activation of B2 Cell Subsets Contributes to Atherosclerosis Development Independently of Lipid Metabolism
Q38170793Contributions of B cells to lupus pathogenesis
Q40608991Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells.
Q35617573Cytokine disturbances in systemic lupus erythematosus
Q27022855Cytosolic DNA sensing via the stimulator of interferon genes adaptor: Yin and Yang of immune responses to DNA
Q34443260Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage
Q36740874Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9.
Q36684831Differences in codon bias and GC content contribute to the balanced expression of TLR7 and TLR9
Q33637487Dosage of X-linked Toll-like receptor 8 determines gender differences in the development of systemic lupus erythematosus
Q36389926Endosomal Toll-like receptors in clinically overt and silent autoimmunity
Q51516999Engagement of the B cell receptor for antigen differentially affects B cell responses to Toll-like receptor-7 agonists and antagonists in BXSB mice.
Q42668884Enhanced IFN-α production is associated with increased TLR7 retention in the lysosomes of palasmacytoid dendritic cells in systemic lupus erythematosus
Q36637528Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus
Q28583551Estrogen receptor alpha modulates Toll-like receptor signaling in murine lupus
Q36754420Exacerbated autoimmunity in the absence of TLR9 in MRL.Fas(lpr) mice depends on Ifnar1
Q85267997Expression and function of dectin-1 is defective in monocytes from patients with systemic lupus erythematosus and rheumatoid arthritis
Q36527339Expression of TLR-7, MyD88, NF-kB, and INF-α in B Lymphocytes of Mayan Women with Systemic Lupus Erythematosus in Mexico
Q92382940Extrafollicular responses in humans and SLE
Q89060748Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation
Q38063202Fungal pathogens-a sweet and sour treat for toll-like receptors
Q51062941Gender bias in lupus: does immune response initiated in the gut mucosa have a role?
Q50332623Graft-versus-host disease is independent of innate signaling pathways triggered by pathogens in host hematopoietic cells
Q89531004Gut microbiota differently contributes to intestinal immune phenotype and systemic autoimmune progression in female and male lupus-prone mice
Q30424263HLA-DR3 restricted T cell epitope mimicry in induction of autoimmune response to lupus-associated antigen SmD
Q36098032Heterozygous carriage of a dysfunctional Toll-like receptor 9 allele affects CpG oligonucleotide responses in B cells.
Q60046064Human Chorionic Gonadotropin Influences Systemic Autoimmune Responses
Q34208023Humanized TLR7/8 expression drives proliferative multisystemic histiocytosis in C57BL/6 mice
Q52364003Impaired TLR9 responses in B cells from patients with systemic lupus erythematosus.
Q41168768Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo
Q38557048Inhibition of Toll-Like Receptor Signaling as a Promising Therapy for Inflammatory Diseases: A Journey from Molecular to Nano Therapeutics
Q37994060Integration of B cell responses through Toll-like receptors and antigen receptors
Q43538775Interferon regulatory factor 5 is critical for the development of lupus in MRL/lpr mice.
Q33975488Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2.
Q26997316Intracellular nucleic acid sensors and autoimmunity
Q33715465Leaky Gut As a Danger Signal for Autoimmune Diseases
Q38177270Licensing Adaptive Immunity by NOD-Like Receptors
Q41813048Love triangle between Unc93B1, TLR7, and TLR9 prevents fatal attraction
Q91595484Low-dose 17α-ethinyl estradiol (EE) exposure exacerbates lupus renal disease and modulates immune responses to TLR7/9 agonists in genetically autoimmune-prone mice
Q36456019MS2 VLP-based delivery of microRNA-146a inhibits autoantibody production in lupus-prone mice
Q37734746Microbial TLR Agonists and Humoral Immunopathogenesis in HIV Disease
Q84199414Microparticles as autoadjuvants in the pathogenesis of SLE
Q37956536Modulating toll-like receptor 7 and 9 responses as therapy for allergy and autoimmunity
Q58788272Modulation of Apoptosis by Cytotoxic Mediators and Cell-Survival Molecules in Sjögren's Syndrome
Q37805517Modulation of toll-like receptor function has therapeutic potential in autoimmune disease
Q59136338Monogenic Lupus: A Developing Paradigm of Disease
Q35935783Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity
Q47739264Myd88 is required for disease development in a primary Sjögren's syndrome mouse model.
Q36991699NADPH oxidase inhibits the pathogenesis of systemic lupus erythematosus.
Q50101560Negative regulation of B cell responses and self-tolerance to RNA-related lupus self-antigen
Q38099772Neutrophil extracellular chromatin traps connect innate immune response to autoimmunity
Q55493201New application of anti-TLR monoclonal antibodies: detection, inhibition and protection.
Q28081728Nucleic Acid-Sensing Receptors: Rheostats of Autoimmunity and Autoinflammation
Q28534779Nucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responses
Q37819256Nucleic acid sensing Toll-like receptors in autoimmunity
Q39025992Nucleic acid-sensing TLRs: trafficking and regulation.
Q52691361Our Environment Shapes Us: The Importance of Environment and Sex Differences in Regulation of Autoantibody Production.
Q33620555Pathways leading to an immunological disease: systemic lupus erythematosus
Q91596386Patrolling monocytes promote the pathogenesis of early lupus-like glomerulonephritis
Q37991471Pattern recognition receptors in immune disorders affecting the skin.
Q51039778Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients.
Q90288795Pharmacological modulation of nucleic acid sensors - therapeutic potential and persisting obstacles
Q36583115Phenotypic and functional alterations of pDCs in lupus-prone mice.
Q55266542Plasma Cell Differentiation Pathways in Systemic Lupus Erythematosus.
Q40407608Plasmacytoid Dendritic Cells Respond Directly to Apoptotic Cells by Secreting Immune Regulatory IL-10 or IFN-α.
Q91868543Pneumococcal Polysaccharide Vaccine Ameliorates Murine Lupus
Q33790424RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events
Q37397807RNA recognition by human TLR8 can lead to autoimmune inflammation
Q36300273RNA sensing by conventional dendritic cells is central to the development of lupus nephritis
Q93204275Recent clinical trends in Toll-like receptor targeting therapeutics
Q21131298Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination
Q37925064Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity
Q38078138Recognition of pathogen-associated nucleic acids by endosomal nucleic acid-sensing toll-like receptors
Q90221618Release from UNC93B1 reinforces the compartmentalized activation of select TLRs
Q38649480Relevant genetic polymorphisms and kidney expression of Toll-like receptor (TLR)-5 and TLR-9 in lupus nephritis.
Q33911256Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice
Q34655526Requirements for innate immune pathways in environmentally induced autoimmunity
Q36625438Rheumatoid factor B cell memory leads to rapid, switched antibody-forming cell responses
Q37059648Role of nucleic acid-sensing TLRs in diverse autoantibody specificities and anti-nuclear antibody-producing B cells
Q38293111STING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy?
Q37258447Scavenging nucleic acid debris to combat autoimmunity and infectious disease
Q92239589Self-DNA at the Epicenter of SLE: Immunogenic Forms, Regulation, and Effects
Q47912211Self-dsDNA in the pathogenesis of systemic lupus erythematosus.
Q61816755Sex and Pubertal Differences in the Type 1 Interferon Pathway Associate With Both X Chromosome Number and Serum Sex Hormone Concentration
Q28080459Sexual dimorphism in autoimmunity
Q36800112Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus
Q42210935Single nucleotide polymorphisms in genes encoding toll-like receptors 7, 8 and 9 in Danish patients with systemic lupus erythematosus
Q62067346Smaller CpG-Conjugated Gold Nanoconstructs Achieve Higher Targeting Specificity of Immune Activation
Q33909504Spontaneous activation of RNA-sensing pathways in autoimmune disease
Q40343247Spontaneous germinal centers and autoimmunity
Q90307219Stimulator of interferon genes agonists attenuate type I diabetes progression in NOD mice
Q93052232TLR7 Agonism Accelerates Disease and Causes a Fatal Myeloproliferative Disorder in NZM 2410 Lupus Mice
Q92239398TLR7 Protein Expression in Mild and Severe Lupus-Prone Models Is Regulated in a Leukocyte, Genetic, and IRAK4 Dependent Manner
Q37995556TLR7 and TLR9 in SLE: when sensing self goes wrong
Q35168231TLR7 and TLR9 trigger distinct neuroinflammatory responses in the CNS
Q35205325TLR7- and TLR9-responsive human B cells share phenotypic and genetic characteristics
Q38656329TLR7/TLR9- and B Cell Receptor-Signaling Crosstalk: Promotion of Potentially Dangerous B Cells
Q37543854TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice
Q39647280TLR9 Deficiency Leads to Accelerated Renal Disease and Myeloid Lineage Abnormalities in Pristane-Induced Murine Lupus.
Q36585700TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation
Q92412704TLR9 signaling in fibroblastic reticular cells regulates peritoneal immunity
Q27023982TLRs and interferons: a central paradigm in autoimmunity
Q38929407Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent?
Q33420162Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases
Q47399059The Activation of Human Dermal Microvascular Cells by Poly(I:C), Lipopolysaccharide, Imiquimod, and ODN2395 Is Mediated by the Fli1/FOXO3A Pathway
Q38117377The TLR family protein RP105/MD-1 complex: A new player in obesity and adipose tissue inflammation
Q26745929The germinal center antibody response in health and disease
Q28260075The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity
Q38095861The role of B lymphocyte stimulator in B cell biology: implications for the treatment of lupus
Q38158240The role of TLR4 in pathophysiology of antiphospholipid syndrome-associated thrombosis and pregnancy morbidity
Q36295343Therapeutic effects of DZ2002, a reversible SAHH inhibitor, on lupus-prone NZB×NZW F1 mice via interference with TLR-mediated APC response
Q59127682Toll-Like Receptor 9 Deficiency Breaks Tolerance to RNA-Associated Antigens and Up-Regulates Toll-Like Receptor 7 Protein in Sle1 Mice
Q61805992Toll-Like Receptor Signaling Drives Btk-Mediated Autoimmune Disease
Q93080297Toll-Like Receptors and Relevant Emerging Therapeutics with Reference to Delivery Methods
Q36302763Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice
Q37838577Toll-like receptor driven B cell activation in the induction of systemic autoimmunity
Q34015433Toll-like receptor signaling: a potential link among rheumatoid arthritis, systemic lupus, and atherosclerosis
Q97536785Toll-like receptor-9 (TLR-9) deficiency alleviates optic nerve injury (ONI) by inhibiting inflammatory response in vivo and in vitro
Q38832613Toll-like receptors and chronic inflammation in rheumatic diseases: new developments
Q52323268Toll-like receptors in lupus nephritis.
Q34650870Toll-like receptors in systemic lupus erythematosus: potential for personalized treatment.
Q28067211Toll-like receptors in the pathogenesis of autoimmune diseases: recent and emerging translational developments
Q35848152Toll-like receptors: potential targets for lupus treatment
Q38925152Toll-like receptors: promising therapeutic targets for inflammatory diseases
Q42268267Toxoplasma gondii: bystander or cofactor in rheumatoid arthritis
Q38179688Trafficking of endosomal Toll-like receptors
Q38570333Translating nucleic acid-sensing pathways into therapies
Q57801953Triaryl Pyrazole Toll-Like Receptor Signaling Inhibitors: Structure-Activity Relationships Governing Pan- and Selective Signaling Inhibitors
Q35854962Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production
Q35498054Using Poly I:C as an adjuvant does not induce or exacerbate models of systemic lupus erythematosus
Q38150849Waldenström macroglobulinemia: clinical and immunological aspects, natural history, cell of origin, and emerging mouse models

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