Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9.

scientific article published on 8 February 2013

Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/NAR/GKT078
P932PMC publication ID3616729
P698PubMed publication ID23396449
P5875ResearchGate publication ID235441880

P2093author name stringLakshmi Bhagat
Dong Yu
Ekambar R Kandimalla
Nicola La Monica
Daqing Wang
Sudhir Agrawal
Tim Sullivan
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A Suppressive Oligodeoxynucleotide Enhances the Efficacy of Myelin Cocktail/IL-4-Tolerizing DNA Vaccination and Treats Autoimmune DiseaseQ61853102
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Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptomsQ79946741
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Modifications incorporated in CpG motifs of oligodeoxynucleotides lead to antagonist activity of toll-like receptors 7 and 9Q84339569
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Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient miceQ84960461
Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifsQ24644853
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Oligodeoxyribonucleotide-based antagonists for Toll-like receptors 7 and 9.Q33395050
TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupusQ33902262
TLR recognition of self nucleic acids hampers glucocorticoid activity in lupusQ34241004
Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosisQ34312767
'Immunomers'--novel 3'-3'-linked CpG oligodeoxyribonucleotides as potent immunomodulatory agentsQ34368468
Anti-malarial drugs: possible mechanisms of action in autoimmune disease and prospects for drug development.Q34396739
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.Q34566135
Optimal oligonucleotide sequences for TLR9 inhibitory activity in human cells: lack of correlation with TLR9 bindingQ34647633
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Interferon alpha as a primary pathogenic factor in human lupusQ35603587
The discovery and development of belimumab: the anti-BLyS-lupus connectionQ35691272
Stabilized immune modulatory RNA compounds as agonists of Toll-like receptors 7 and 8.Q35963017
Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: in vitro and in vivo studiesQ36052460
Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosusQ36246166
Interferon pathway activation in systemic lupus erythematosusQ36319618
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosusQ36403653
DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivoQ37270799
Classification, mechanisms of action, and therapeutic applications of inhibitory oligonucleotides for Toll-like receptors (TLR) 7 and 9.Q37758263
Hydroxychloroquine: from malaria to autoimmunityQ37827403
The role of antimalarial agents in the treatment of SLE and lupus nephritisQ37947108
TLR7 and TLR9 in SLE: when sensing self goes wrongQ37995556
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
P304page(s)3947-3961
P577publication date2013-02-08
P1433published inNucleic Acids ResearchQ135122
P1476titleDesign, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9.
P478volume41

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