Aryl hydrocarbon receptor promotes RORγt⁺ group 3 ILCs and controls intestinal immunity and inflammation

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Aryl hydrocarbon receptor promotes RORγt⁺ group 3 ILCs and controls intestinal immunity and inflammation is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1021352382
P356DOI10.1007/S00281-013-0393-5
P932PMC publication ID3797199
P698PubMed publication ID23975386

P2093author name stringLiang Zhou
Ju Qiu
P2860cites workEssential role of IL-7 receptor alpha in the formation of Peyer's patch anlageQ74261728
CD4+CD3- cells induce Peyer's patch development: role of alpha4beta1 integrin activation by CXCR5Q78298267
Role of gamma delta T cells in the inflammatory response of experimental colitis miceQ79274267
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitisQ79755041
Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype statusQ79902968
Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblastsQ81163296
Effects of aryl hydrocarbon receptor signaling on the modulation of TH1/TH2 balanceQ81512254
IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migrationQ82829186
CCR6 identifies lymphoid tissue inducer cells within cryptopatchesQ82866177
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161Q84933191
An accessory role of TCRgammadelta (+) cells in the exacerbation of inflammatory bowel disease in TCRalpha mutant miceQ95721125
Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cellsQ24293709
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptidesQ24303817
Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host diseaseQ24626202
Transcription factor RORα is critical for nuocyte developmentQ24629126
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunityQ24630261
Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22Q24648620
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestineQ24648636
Development of all CD4 T lineages requires nuclear factor TOXQ24652128
RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cellsQ24657337
Communicable ulcerative colitis induced by T-bet deficiency in the innate immune systemQ24680733
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsQ27860620
A chemokine-driven positive feedback loop organizes lymphoid folliclesQ28142202
The role of the nuclear hormone receptor RORγt in the development of lymph nodes and Peyer's patchesQ28206376
An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cellsQ28235728
Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tractQ28238242
Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activationQ28250446
Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid folliclesQ28251675
AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesisQ28273478
Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptorQ28273769
IL-22 increases the innate immunity of tissuesQ28276850
Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanismQ28297392
A human natural killer cell subset provides an innate source of IL-22 for mucosal immunityQ28299539
Activation of aryl hydrocarbon receptor (AhR) leads to reciprocal epigenetic regulation of FoxP3 and IL-17 expression and amelioration of experimental colitisQ28476563
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gammaQ28506783
Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophagesQ28507476
Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activityQ28512981
A validated regulatory network for Th17 cell specificationQ28586624
The Ikaros gene is required for the development of all lymphoid lineagesQ28594316
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteriaQ28594441
Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in miceQ43128638
CD8+ cells protect mice against reinfection with the intestinal parasite Eimeria falciformisQ43535141
The fetal liver counterpart of adult common lymphoid progenitors gives rise to all lymphoid lineages, CD45+CD4+CD3- cells, as well as macrophagesQ43612834
IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's diseaseQ43964285
Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cellsQ43991749
Mucosal T cells bearing TCRgammadelta play a protective role in intestinal inflammationQ44681379
Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells.Q45918490
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.Q45939390
RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiotaQ46167903
Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defenseQ46197286
Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cellsQ46231038
Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursorsQ46553571
Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.Q48075133
IL-22 defines a novel immune pathway of antifungal resistance.Q51054891
Notch signaling is necessary for adult, but not fetal, development of RORγt(+) innate lymphoid cells.Q51854388
Runx1/Cbfβ2 complexes are required for lymphoid tissue inducer cell differentiation at two developmental stages.Q51892856
Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells.Q51985115
The aryl hydrocarbon receptor: studies using the AHR-null mice.Q52181333
The lymphotoxin-beta receptor is critical for control of murine Citrobacter rodentium-induced colitis.Q52560971
Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone.Q52586488
Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis.Q52590127
Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease.Q52602187
IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease.Q52926495
Impact of dioxin-type induction of drug-metabolizing enzymes on the metabolism of endo- and xenobiotics.Q53431512
Lineage Relationship Analysis of RORγt+Innate Lymphoid CellsQ57520258
Regulation of Cytokine Secretion in Human CD127+ LTi-like Innate Lymphoid Cells by Toll-like Receptor 2Q58478673
Expression of the γ-δ T-cell receptor on intestinal CD8+ intraepithelial lymphocytesQ59067450
Seeding of neonatal lymph nodes by T cells and identification of a novel population of CD3-CD4+ cellsQ67513963
Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cellsQ73838320
Functional role of AhR in the expression of toxic effects by TCDDQ28609386
The canonical Notch signaling pathway: unfolding the activation mechanismQ29547725
Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cellsQ29614271
Genetics and pathogenesis of inflammatory bowel diseaseQ29616350
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogensQ29617432
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxinsQ29620097
The PAS superfamily: sensors of environmental and developmental signalsQ29622907
Development and maturation of secondary lymphoid tissues.Q33652498
IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursorsQ33656197
Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesisQ33778033
Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2.Q33854381
Notch signaling in T cell developmentQ33860554
Lymphotoxin beta receptor signaling in intestinal epithelial cells orchestrates innate immune responses against mucosal bacterial infectionQ33883606
The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27.Q34131656
Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue–inducer cell and NK cell lineagesQ34146031
The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling.Q34152180
The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestineQ34224134
Innate lymphoid cells: emerging insights in development, lineage relationships, and functionQ34245256
Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria.Q34279451
AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesisQ34299077
Retinoic-acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation.Q34299874
Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutationQ34412659
RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cellsQ34441341
Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cellsQ34501407
CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut.Q34562235
Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytesQ34591589
Aryl hydrocarbon receptor activation by TCDD reduces inflammation associated with Crohn's diseaseQ34601368
Gammadelta T cells: functional plasticity and heterogeneityQ34659133
TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosaQ34694834
The aryl hydrocarbon receptor ligand ITE inhibits TGFβ1-induced human myofibroblast differentiationQ34805707
Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathologyQ34973693
Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel diseaseQ35001872
Identity, regulation and in vivo function of gut NKp46+RORγt+ and NKp46+RORγt- lymphoid cellsQ35177247
The Th17 immune response is controlled by the Rel-RORγ-RORγ T transcriptional axisQ35441559
The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cellsQ35713322
Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestineQ35760849
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense.Q35784100
Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cellsQ35894203
Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge.Q36031510
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of NotchQ36309139
Cytolytic and IFN-gamma-producing activities of gamma delta T cells in the mouse intestinal epithelium are T cell receptor-beta-chain dependentQ36396886
CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentiumQ36499693
The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells.Q36518480
Innate lymphoid cells: balancing immunity, inflammation, and tissue repair in the intestine.Q36645149
Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axisQ36667276
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growthQ36696555
gammadelta T cells: firefighters or fire boosters in the front lines of inflammatory responsesQ36732670
The search for endogenous activators of the aryl hydrocarbon receptorQ36946755
A protective function for interleukin 17A in T cell-mediated intestinal inflammationQ37260173
Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responsesQ37331544
Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain lociQ37377456
Ikaros regulates Notch target gene expression in developing thymocytesQ37424241
Dietary influences on intestinal immunityQ38046108
Identification of a novel domain in the aryl hydrocarbon receptor required for DNA bindingQ38361500
IL-23-responsive innate lymphoid cells are increased in inflammatory bowel diseaseQ38423061
Regulation of TCF ETS-domain transcription factors by helix-loop-helix motifs.Q39391769
IL-22 mediates host defense against an intestinal intracellular parasite in the absence of IFN-γ at the cost of Th17-driven immunopathologyQ39408398
A role of the aryl hydrocarbon receptor in attenuation of colitisQ39581558
Innate and adaptive interleukin-22 protects mice from inflammatory bowel diseaseQ39902875
The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells.Q40990833
RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medullaQ41868543
Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue.Q41893697
Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.Q41904687
STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healingQ41953828
Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteriaQ42148408
IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cellsQ42321500
Striking similarity: GATA-3 regulates ILC2 and Th2 cellsQ42564456
Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skinQ42604162
Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β.Q42702492
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)657-670
P577publication date2013-08-23
P1433published inSeminars in ImmunopathologyQ15724576
P1476titleAryl hydrocarbon receptor promotes RORγt⁺ group 3 ILCs and controls intestinal immunity and inflammation
P478volume35

Reverse relations

cites work (P2860)
Q36447796AHR Function in Lymphocytes: Emerging Concepts
Q57194204AhR modulates the IL-22-producing cell proliferation/recruitment in imiquimod-induced psoriasis mouse model
Q64963771An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease.
Q38233854An overview of the role of innate lymphoid cells in gut infections and inflammation
Q39367508Aryl hydrocarbon receptor (AHR): "pioneer member" of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of "sensors" of foreign and endogenous signals
Q42317622Aryl hydrocarbon receptor signaling involves in the human intestinal ILC3/ILC1 conversion in the inflamed terminal ileum of Crohn's disease patients
Q38872148Development of innate lymphoid cells
Q28078180Gut microbiota and immune crosstalk in metabolic disease
Q61444266Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells
Q92668462Indole-3-carbinol prevents colitis and associated microbial dysbiosis in an IL-22-dependent manner
Q42683314Innate Lymphoid Cells in Intestinal Inflammation
Q38605374Innate lymphoid cells in intestinal immunity and inflammation
Q26765223Intestinal inflammation and the diet: Is food friend or foe?
Q38694409Lactobacillus delivery of bioactive interleukin-22.
Q58575504Old Friends, immunoregulation, and stress resilience
Q89927095Plasticity of innate lymphoid cell subsets
Q34289345Restriction of IL-22-producing T cell responses and differential regulation of regulatory T cell compartments by zinc finger transcription factor Ikaros
Q38927415Role of AhR in positive regulation of cell proliferation and survival
Q51519172Sinomenine induces the generation of intestinal Treg cells and attenuates arthritis via activation of aryl hydrocarbon receptor.
Q46420621The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells.
Q64924530The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface.
Q30248903The Microbiota, Immunoregulation, and Mental Health: Implications for Public Health
Q60920837The Role of the Aryl Hydrocarbon Receptor (AHR) in Immune and Inflammatory Diseases
Q37549732The aryl hydrocarbon receptor controls cell-fate decisions in B cells.
Q48146269The role of innate lymphoid cells in health and disease
Q36299851Type 3 innate lymphoid cell depletion is mediated by TLRs in lymphoid tissues of simian immunodeficiency virus-infected macaques
Q53533655Type 3 innate lymphoid cells producing IL-17 and IL-22 are expanded in the gut, in the peripheral blood, synovial fluid and bone marrow of patients with ankylosing spondylitis.

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