Impact of elevated plasma serotonin on global gene expression of murine megakaryocytes

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Impact of elevated plasma serotonin on global gene expression of murine megakaryocytes is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...872580M
P356DOI10.1371/JOURNAL.PONE.0072580
P932PMC publication ID3754925
P698PubMed publication ID24013211
P5875ResearchGate publication ID256468996

P2093author name stringCharles P Mercado
Marjorie L Beggs
Fusun Kilic
Endrit Ziu
Preeti Singh
Randy S Haun
Stephanie Byrum
Vinay R Raj
P2860cites workSerotonin and morphogenesis. I. Sites of serotonin uptake and -binding protein immunoreactivity in the midgestation mouse embryo.Q48094137
S-100 beta and insulin-like growth factor-II differentially regulate growth of developing serotonin and dopamine neurons in vitroQ48427378
Purification of native bone marrow megakaryocytes for studies of gene expression.Q54336167
Gene expression profiling of normal and malignant CD34-derived megakaryocytic cellsQ57001073
The irreversibility of platelet aggregation is regulated by myosin IIA, but is not compromised in MYH9-related diseaseQ57589437
Proplatelet formation is regulated by the Rho/ROCK pathwayQ58125582
Isolation of rat megakaryocytes by immunomagnetic beadsQ68391419
Isolation of human megakaryocytes by immunomagnetic beadsQ69107842
Measurement of secretion of serotoninQ69500607
Transcardiac serotonin concentration is increased in selected patients with limiting angina and complex coronary lesion morphologyQ69936131
The cytoplasmic domain of P-selectin is phosphorylated on serine and threonine residuesQ72096643
Small GTPase Rab4 regulates Ca2+-induced alpha-granule secretion in plateletsQ74153372
Serotonin is associated with coronary artery disease and cardiac eventsQ78077693
The RIN: an RNA integrity number for assigning integrity values to RNA measurementsQ21263010
Plasma serotonin levels and the platelet serotonin transporterQ24306106
Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporterQ24307915
Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac functionQ24655830
Linear models and empirical bayes methods for assessing differential expression in microarray experimentsQ27860758
CalDAG-GEFI deficiency protects mice in a novel model of Fcγ RIIA-mediated thrombosis and thrombocytopeniaQ33395687
Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and functionQ33399439
Molecular Mechanisms of SERT in Platelets: Regulation of Plasma Serotonin LevelsQ34248836
Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule releaseQ34286484
The medical benefit of 5-HT researchQ34558808
The serotonin signaling system: from basic understanding to drug development for functional GI disordersQ34604868
Communication between 5-HT and small GTPasesQ34777833
The expanded biology of serotoninQ34993925
Down-regulation of the serotonin transporter in hyperreactive platelets counteracts the pro-thrombotic effect of serotoninQ35892630
Megakaryocyte apoptosis: sorting out the signalsQ36075300
Serotonin is a sword and a shield of the bowel: serotonin plays offense and defenseQ36519716
CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in plateletsQ36843696
Cell isolation and expansion using DynabeadsQ36902886
The platelet release reaction: just when you thought platelet secretion was simpleQ37150648
Developmental determinants of the independence and complexity of the enteric nervous systemQ37773058
Neurotransmitter synthetic enzymesQ39873609
Neurotransmitters as growth regulatory signals: role of receptors and second messengersQ40488729
Serotonin stimulates megakaryocytopoiesis via the 5-HT2 receptorQ41221521
The platelet actin cytoskeleton associates with SNAREs and participates in alpha-granule secretionQ41490092
Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis.Q42574744
Blood serotonergic mechanisms in type 2 (non-insulin-dependent) diabetes mellitusQ44662979
CalDAG-GEFI is at the nexus of calcium-dependent platelet activation.Q45921416
Inhibition of 5-hydroxytryptamine receptor prevents occlusive thrombus formation on neointima of the rabbit femoral arteryQ46892256
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)e72580
P577publication date2013-08-27
P1433published inPLOS OneQ564954
P1476titleImpact of elevated plasma serotonin on global gene expression of murine megakaryocytes
P478volume8

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cites work (P2860)
Q37205659A serotonin-induced N-glycan switch regulates platelet aggregation
Q35615132A study of blood serotonin and serotonin transporter promoter variant (5-HTTLPR) polymorphism in Egyptian autistic children.
Q96811813Gut microbial metabolism of dietary fiber protects against high-energy feeding induced ovarian follicular atresia in a pig model
Q36293723Resilience to orthostasis and haemorrhage: A pilot study of common genetic and conditioning mechanisms
Q48327416Serotonin transporter protects the placental cells against apoptosis in caspase 3-independent pathway.