Leptin excites proopiomelanocortin neurons via activation of TRPC channels

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Leptin excites proopiomelanocortin neurons via activation of TRPC channels is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.4816-09.2010
P932PMC publication ID3095824
P698PubMed publication ID20107083

P2093author name stringYuan Fang
Jian Qiu
Oline K Rønnekleiv
Martin J Kelly
P2860cites workDirect activation of human TRPC6 and TRPC3 channels by diacylglycerolQ22001504
Subunit composition of mammalian transient receptor potential channels in living cellsQ24530559
Recent advances in understanding leptin signaling and leptin resistanceQ24658188
International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channelsQ28289146
Formation of novel TRPC channels by complex subunit interactions in embryonic brainQ28568573
Intracellular signalling. Key enzyme in leptin-induced anorexiaQ28573472
A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feedingQ28582133
Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphateQ28616287
TRP channels as cellular sensorsQ29615917
TRP channelsQ29616673
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleusQ29619635
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in miceQ30481572
Phospholipase C-gamma: diverse roles in receptor-mediated calcium signalingQ36301886
Leptin depolarizes rat hypothalamic paraventricular nucleus neurons.Q38336060
Distributions of leptin receptor mRNA isoforms in the rat brainQ38336839
Rapid vesicular translocation and insertion of TRP channelsQ40534350
TRPC1 and TRPC5 form a novel cation channel in mammalian brain.Q40812989
Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5.Q40876055
Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.Q41063499
Intracellular calcium strongly potentiates agonist-activated TRPC5 channels.Q42548715
Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.Q43595875
TRPC5 as a candidate for the nonselective cation channel activated by muscarinic stimulation in murine stomachQ44358911
Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channelsQ44363939
Involvement of transient receptor potential-like channels in responses to mGluR-I activation in midbrain dopamine neurons.Q44658168
Kisspeptin depolarizes gonadotropin-releasing hormone neurons through activation of TRPC-like cationic channels.Q46628485
Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to cholecystokinin are mediated by a transient receptor potential-like currentQ48177727
Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signalingQ77195331
Leptin signalling and leptin-mediated activation of human platelets: importance of JAK2 and the phospholipases Cgamma2 and A2Q79828482
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1560-1565
P577publication date2010-01-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleLeptin excites proopiomelanocortin neurons via activation of TRPC channels
P478volume30

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cites work (P2860)
Q573004863-Iodothyronamine Activates a Set of Membrane Proteins in Murine Hypothalamic Cell Lines
Q904010323-Iodothyronamine and Derivatives: New Allies Against Metabolic Syndrome?
Q39164871A short history of the 5-HT2C receptor: from the choroid plexus to depression, obesity and addiction treatment
Q37278826Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons
Q42318122AgRP to Kiss1 neuron signaling links nutritional state and fertility
Q35187963Apelin-13 enhances arcuate POMC neuron activity via inhibiting M-current
Q26865811Brain regulation of energy balance and body weight
Q37808730CNS leptin and insulin action in the control of energy homeostasis
Q57288000Calcium Channel Ca2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons
Q35974329Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse
Q35690260Canonical transient receptor potential 4 and its small molecule modulators
Q36128810Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss
Q35172234Cell-type-specific CCK2 receptor signaling underlies the cholecystokinin-mediated selective excitation of hippocampal parvalbumin-positive fast-spiking basket cells
Q35217667Cholecystokinin facilitates neuronal excitability in the entorhinal cortex via activation of TRPC-like channels
Q37122845Cross-talk between reproduction and energy homeostasis: central impact of estrogens, leptin and kisspeptin signaling
Q39028402Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity
Q38249879Delineating the regulation of energy homeostasis using hypothalamic cell models
Q36906393Dependence of spontaneous electrical activity and basal prolactin release on nonselective cation channels in pituitary lactotrophs.
Q35675203Developmental changes in synaptic distribution in arcuate nucleus neurons
Q33936028Developmental switch of leptin signaling in arcuate nucleus neurons
Q52721019Diverse actions of estradiol on anorexigenic and orexigenic hypothalamic arcuate neurons.
Q48607961Down-regulation of the epithelial Na⁺ channel ENaC by Janus kinase 2.
Q37700082Dual depolarization responses generated within the same lateral septal neurons by TRPC4-containing channels
Q40171362Eat and Death: Chronic Over-Eating
Q37983786Electrophysiological analysis of circuits controlling energy homeostasis
Q55408788Endocannabinoid Signaling at Hypothalamic Steroidogenic Factor-1/Proopiomelanocortin Synapses Is Sex- and Diet-Sensitive.
Q26849318Environment, leptin sensitivity, and hypothalamic plasticity
Q46303091Estradiol Protects Proopiomelanocortin Neurons against Insulin Resistance.
Q36392903Estradiol signaling in the regulation of reproduction and energy balance
Q34757712Estrogen signaling in hypothalamic circuits controling reproduction
Q56530264Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females
Q37378053Expression of transient receptor potential (TRP) channel mRNAs in the mouse olfactory bulb
Q35626745Fasting and 17β-estradiol differentially modulate the M-current in neuropeptide Y neurons
Q26828589From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior
Q37127727Functional heterogeneity of arcuate nucleus pro-opiomelanocortin neurons: implications for diverging melanocortin pathways
Q30354371GLP-1R Signaling Directly Activates Arcuate Nucleus Kisspeptin Action in Brain Slices but Does not Rescue Luteinizing Hormone Inhibition in Ovariectomized Mice During Negative Energy Balance.
Q44689881Gastric vagal afferent modulation by leptin is influenced by food intake status.
Q27320926Glucose level determines excitatory or inhibitory effects of adiponectin on arcuate POMC neuron activity and feeding
Q35225763Glucose rapidly induces different forms of excitatory synaptic plasticity in hypothalamic POMC neurons
Q34807661Guinea pig kisspeptin neurons are depolarized by leptin via activation of TRPC channels
Q38297012High dietary protein decreases fat deposition induced by high-fat and high-sucrose diet in rats
Q37876093Hypothalamic control of lipid metabolism: focus on leptin, ghrelin and melanocortins
Q38380733Hypothalamic neurones governing glucose homeostasis
Q35114807Impact of hypothalamic reactive oxygen species in the regulation of energy metabolism and food intake
Q39413501Insulin and Leptin Excite Anorexigenic Proopiomelanocortin Neurons via Activation of TRPC5 Channels
Q30588792Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels
Q58715405Insulin regulates POMC neuronal plasticity to control glucose metabolism
Q35222301Interplay between glucose and leptin signalling determines the strength of GABAergic synapses at POMC neurons
Q38111760Ion channels in the central regulation of energy and glucose homeostasis
Q39038541Is the Carotid Body a Metabolic Monitor?
Q28288184Kisspeptin excitation of GnRH neurons
Q50420247Leptin alters somatosensory thalamic networks by decreasing gaba release from reticular thalamic nucleus and action potential frequency at ventrobasal neurons.
Q35676283Leptin and insulin act on POMC neurons to promote the browning of white fat.
Q37253457Leptin and insulin engage specific PI3K subunits in hypothalamic SF1 neurons
Q34048680Leptin potentiates GABAergic synaptic transmission in the developing rodent hippocampus
Q37590281Leptin signaling defects in a mouse model of Prader-Willi syndrome: An orphan genetic obesity syndrome no more?
Q36249000Leptin-Induced Endothelium-Independent Vasoconstriction in Thoracic Aorta and Pulmonary Artery of Spontaneously Hypertensive Rats: Role of Calcium Channels and Stores.
Q33935914Leptin-induced spine formation requires TrpC channels and the CaM kinase cascade in the hippocampus.
Q37112040Leptin-mediated ion channel regulation: PI3K pathways, physiological role, and therapeutic potential
Q38161388Leptin-stimulated KATP channel trafficking: a new paradigm for β-cell stimulus-secretion coupling?
Q28485151Magel2 is required for leptin-mediated depolarization of POMC neurons in the hypothalamic arcuate nucleus in mice
Q92306300Mechanisms for Sex Differences in Energy Homeostasis
Q36745212Membrane-initiated actions of estradiol that regulate reproduction, energy balance and body temperature
Q35087316Membrane-initiated non-genomic signaling by estrogens in the hypothalamus: cross-talk with glucocorticoids with implications for behavior.
Q34898915Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network
Q36520628Modulatory influences of estradiol and other anorexigenic hormones on metabotropic, Gi/o-coupled receptor function in the hypothalamic control of energy homeostasis
Q35417113Molecular properties of Kiss1 neurons in the arcuate nucleus of the mouse
Q90286752Neurochemical Characterization of Brainstem Pro-Opiomelanocortin Cells
Q36786510Neurochemical characterization of neurons expressing melanin-concentrating hormone receptor 1 in the mouse hypothalamus
Q37161389Neuronal circuits that regulate feeding behavior and metabolism
Q46014779Neuropeptide RFRP inhibits the pacemaker activity of terminal nerve GnRH neurons.
Q36945206Optogenetic Stimulation of Arcuate Nucleus Kiss1 Neurons Reveals a Steroid-Dependent Glutamatergic Input to POMC and AgRP Neurons in Male Mice
Q50026417Organophosphate flame-retardants alter adult mouse homeostasis and gene expression in a sex-dependent manner potentially through interactions with ERα.
Q36460622Oxidative Stress in the Hypothalamus: the Importance of Calcium Signaling and Mitochondrial ROS in Body Weight Regulation
Q36928732PI3K p110β subunit in leptin receptor expressing cells is required for the acute hypophagia induced by endotoxemia.
Q26991910Pacemaking kisspeptin neurons
Q34452212Persistent histamine excitation of glutamatergic preoptic neurons
Q27025466Prolactin receptor in regulation of neuronal excitability and channels
Q43843076Prolactin regulates tuberoinfundibular dopamine neuron discharge pattern: novel feedback control mechanisms in the lactotrophic axis
Q46252382Recent Advances in the Cellular and Molecular Mechanisms of Hypothalamic Neuronal Glucose Detection.
Q33977447Research resource: Gene profiling of G protein-coupled receptors in the arcuate nucleus of the female
Q90045362Role of POMC and AgRP neuronal activities on glycaemia in mice
Q35159377Role of nonselective cation channels in spontaneous and protein kinase A-stimulated calcium signaling in pituitary cells
Q28585910Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels
Q36041859Serotonin 5-HT2C receptor-mediated inhibition of the M-current in hypothalamic POMC neurons
Q36128202Single-Cell Gene Expression Analysis of Cholinergic Neurons in the Arcuate Nucleus of the Hypothalamus.
Q38046072Synaptic plasticity in neuronal circuits regulating energy balance
Q38190342TIDAL WAVES: Network mechanisms in the neuroendocrine control of prolactin release
Q38222956TRP channels in reproductive (neuro)endocrinology.
Q39309086TRPC Channel Downstream Signaling Cascades.
Q88959363TRPCing around the hypothalamus
Q34201215The CNS glucagon-like peptide-2 receptor in the control of energy balance and glucose homeostasis
Q28081316The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels
Q47137727The TRPC1 Ca2+-permeable channel inhibits exercise-induced protection against high-fat diet-induced obesity and type II diabetes
Q35870445The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus
Q36914498The beneficial effects of leptin on REM sleep deprivation-induced cognitive deficits in mice
Q36933315Thyrotropin-releasing hormone (TRH) inhibits melanin-concentrating hormone neurons: implications for TRH-mediated anorexic and arousal actions
Q36219440Transient receptor potential canonical 3 (TRPC3) is required for IgG immune complex-induced excitation of the rat dorsal root ganglion neurons
Q26849317Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
Q48351470TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons
Q38084559Unraveling the central proopiomelanocortin neural circuits.
Q34508419Wired on sugar: the role of the CNS in the regulation of glucose homeostasis
Q36605423mRNA expression of ion channels in GnRH neurons: subtype-specific regulation by 17β-estradiol

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