Insulin and Leptin Excite Anorexigenic Proopiomelanocortin Neurons via Activation of TRPC5 Channels

scientific article published on 4 July 2017

Insulin and Leptin Excite Anorexigenic Proopiomelanocortin Neurons via Activation of TRPC5 Channels is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/JNE.12501
P932PMC publication ID5957276
P698PubMed publication ID28675783

P50authorJian QiuQ88177063
P2093author name stringM J Kelly
O K Rønnekleiv
E J Wagner
P2860cites workInternational Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channelsQ28289146
Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphateQ28616287
Central nervous system control of food intakeQ29547439
TRP channels as cellular sensorsQ29615917
Central nervous system control of food intake and body weightQ29619020
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleusQ29619635
PI3K integrates the action of insulin and leptin on hypothalamic neuronsQ30475788
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in miceQ30481572
Rapid, reversible activation of AgRP neurons drives feeding behavior in miceQ30499305
Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channelsQ30588792
Hypothalamic pathways linking energy balance and reproductionQ33345231
From lesions to leptin: hypothalamic control of food intake and body weight.Q33539460
Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neuronsQ33720343
Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area.Q33873670
AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without trainingQ34157730
Consumption of a high-fat diet induces central insulin resistance independent of adiposityQ34669531
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesityQ34691534
Brain insulin controls adipose tissue lipolysis and lipogenesisQ34701526
Guinea pig kisspeptin neurons are depolarized by leptin via activation of TRPC channelsQ34807661
Leptin excites proopiomelanocortin neurons via activation of TRPC channelsQ34985093
The hardship of obesity: a soft-wired hypothalamusQ36108709
Neurobiology of feeding and energy expenditureQ36824059
Kisspeptin activation of TRPC4 channels in female GnRH neurons requires PIP2 depletion and cSrc kinase activationQ37018544
The membrane estrogen receptor ligand STX rapidly enhances GABAergic signaling in NPY/AgRP neurons: role in mediating the anorexigenic effects of 17β-estradiolQ37142394
Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulinQ37474320
CNS leptin and insulin action in the control of energy homeostasisQ37808730
Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectinQ39207848
Rapid vesicular translocation and insertion of TRP channelsQ40534350
TRPC1 and TRPC5 form a novel cation channel in mammalian brain.Q40812989
Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.Q41063499
Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker ratsQ41182816
Dual Regulation of Voltage-Sensitive Ion Channels by PIP(2).Q42705251
Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neuronsQ42937219
Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channelsQ44363939
Rapid Signaling of Estrogen in Hypothalamic Neurons Involves a Novel G-Protein-Coupled Estrogen Receptor that Activates Protein Kinase CQ44628437
Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J miceQ47321396
TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc NeuronsQ48351470
The catabolic action of insulin in the brain is mediated by melanocortins.Q48464594
Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signalingQ77195331
Differential accessibility of circulating leptin to individual hypothalamic sitesQ80775967
P433issue2
P577publication date2017-07-04
P1433published inJournal of NeuroendocrinologyQ3186929
P1476titleInsulin and Leptin Excite Anorexigenic Proopiomelanocortin Neurons via Activation of TRPC5 Channels
P478volume30

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cites work (P2860)
Q90307809Acute effects of zinc and insulin on arcuate anorexigenic proopiomelanocortin neurons
Q58715405Insulin regulates POMC neuronal plasticity to control glucose metabolism
Q46252382Recent Advances in the Cellular and Molecular Mechanisms of Hypothalamic Neuronal Glucose Detection.
Q89468002TRPC channels: Structure, function, regulation and recent advances in small molecular probes
Q88959363TRPCing around the hypothalamus
Q91968695The melanocortin pathway and control of appetite-progress and therapeutic implications
Q91721563Trpc5 deficiency causes hypoprolactinemia and altered function of oscillatory dopamine neurons in the arcuate nucleus

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