Imbalance between HAT and HDAC activities in the PBMCs of patients with ankylosing spondylitis or rheumatoid arthritis and influence of HDAC inhibitors on TNF alpha production

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Imbalance between HAT and HDAC activities in the PBMCs of patients with ankylosing spondylitis or rheumatoid arthritis and influence of HDAC inhibitors on TNF alpha production is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...870939T
P356DOI10.1371/JOURNAL.PONE.0070939
P932PMC publication ID3748901
P698PubMed publication ID24039666
P5875ResearchGate publication ID256614032

P50authorKashif Aziz KhanQ58380487
Daniel WendlingQ66753972
Wasim AbbasQ96013741
Georges HerbeinQ47015111
P2093author name stringEric Toussirot
Georges Herbein
Lucile Baud
Ewa Bertolini
Marion Tissot
Alicia Jeudy
P2860cites workExpression and function of histone deacetylases in rheumatoid arthritis synovial fibroblasts.Q53389033
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Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patientsQ54806462
Bcl-3-Regulated Transcription from Major Immediate-Early Promoter of Human Cytomegalovirus in Monocyte-Derived MacrophagesQ60595400
Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritisQ61633704
Histone hyperacetylation is associated with amelioration of experimental colitis in miceQ83059529
SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistanceQ84531194
The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expressionQ24548310
Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expressionQ28281070
Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell linesQ28568728
Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infectionQ33476165
Distinct mechanisms trigger apoptosis in human immunodeficiency virus type 1-infected and in uninfected bystander T lymphocytesQ33782118
Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosisQ33828002
The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokinesQ34015778
Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritisQ34152949
Histone deacetylase inhibitors: new drugs for the treatment of inflammatory diseases?Q34393807
The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivoQ34504770
Histone deacetylase inhibitors in clinical developmentQ35609717
Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents.Q36052572
Epigenetics in inflammatory rheumatic diseasesQ36985127
Epigenetic modifications in rheumatoid arthritisQ37306838
Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on?Q37317209
HDAC inhibition in rheumatoid arthritis and juvenile idiopathic arthritisQ37838731
Function of histone deacetylase inhibitors in inflammation.Q37899219
Sirt1: def-eating senescence?Q38043910
Histone deacetylase/acetylase activity in total synovial tissue derived from rheumatoid arthritis and osteoarthritis patientsQ40229057
Exogenous Nef protein activates NF-kappa B, AP-1, and c-Jun N-terminal kinase and stimulates HIV transcription in promonocytic cells. Role in AIDS pathogenesisQ40691772
Similarities and differences between human and murine TNF promoters in their response to lipopolysaccharideQ40960914
Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse modelQ41183432
Histone deacetylase inhibitors: a new and promising drug class for the treatment of arthritis?Q42182612
Histone deacetylase inhibitors: new treatment options for inflammatory joint disease?Q42930146
Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS.Q43143715
Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissueQ43184367
Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infectionQ44166565
Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse modelQ46786924
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectankylosing spondylitisQ52849
rheumatoid arthritisQ187255
TNFQ18032037
P304page(s)e70939
P577publication date2013-08-15
P1433published inPLOS OneQ564954
P1476titleImbalance between HAT and HDAC activities in the PBMCs of patients with ankylosing spondylitis or rheumatoid arthritis and influence of HDAC inhibitors on TNF alpha production
P478volume8

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