| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Giuseppe Maulucci | Q30505365 |
| P2093 | author name string | Giovambattista Pani | |
| Salvatore Fusco | |||
| P2860 | cites work | Negative control of p53 by Sir2alpha promotes cell survival under stress | Q24291828 |
| hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase | Q24291829 | ||
| JNK1 phosphorylates SIRT1 and promotes its enzymatic activity | Q24293117 | ||
| Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses | Q24293580 | ||
| Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase | Q24293656 | ||
| Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma | Q24294948 | ||
| Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase | Q24297207 | ||
| SIRT1 deacetylates and positively regulates the nuclear receptor LXR | Q24297669 | ||
| Phosphorylation of HuR by Chk2 regulates SIRT1 expression | Q24297993 | ||
| Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity | Q24298755 | ||
| A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction | Q35673630 | ||
| SIRT1 protects against α-synuclein aggregation by activating molecular chaperones | Q35686386 | ||
| The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop | Q35709058 | ||
| Using PDE inhibitors to harness the benefits of calorie restriction: lessons from resveratrol | Q35947368 | ||
| The journey of resveratrol from yeast to human | Q35947372 | ||
| SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase | Q35990346 | ||
| Sirtuins as regulators of mammalian aging | Q36288634 | ||
| Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway | Q36431185 | ||
| Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways | Q36510743 | ||
| Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt | Q36728127 | ||
| Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. | Q36751440 | ||
| Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. | Q36809695 | ||
| The interrelations among feeding, circadian rhythms and ageing | Q36812281 | ||
| A c-Myc-SIRT1 feedback loop regulates cell growth and transformation. | Q37237606 | ||
| The role of transcriptional regulators in central control of appetite and body weight | Q37396803 | ||
| STAT3 inhibition of gluconeogenesis is downregulated by SirT1 | Q37466250 | ||
| Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation | Q37580452 | ||
| Caloric restriction, SIRT1 and longevity | Q37588274 | ||
| p53, ROS and senescence in the control of aging | Q37781655 | ||
| Crosstalk between components of circadian and metabolic cycles in mammals | Q37834110 | ||
| Franklin H. Epstein Lecture: Sirtuins, aging, and medicine | Q37886170 | ||
| SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress | Q38828331 | ||
| Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization. | Q39765588 | ||
| Sirt1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX. | Q39778173 | ||
| Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. | Q39842472 | ||
| Regulation of SIRT1 protein levels by nutrient availability | Q39973475 | ||
| Regulation of glycolytic enzyme phosphoglycerate mutase-1 by Sirt1 protein-mediated deacetylation | Q41228873 | ||
| Tissue-specific regulation of SIRT1 by calorie restriction | Q41298631 | ||
| SIRT1 is a circadian deacetylase for core clock components | Q41492709 | ||
| Controlling SIRT1 expression by microRNAs in health and metabolic disease | Q41773152 | ||
| Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection | Q42811651 | ||
| Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress | Q42811705 | ||
| SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons | Q42914852 | ||
| Dual regulation of TERT activity through transcription and splicing by DeltaNP63alpha | Q42924344 | ||
| Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans. | Q43099242 | ||
| Can resveratrol extend your life? | Q43269865 | ||
| Molecular links between aging and adipose tissue | Q43527162 | ||
| Ageing: a toast to long life | Q44580938 | ||
| Sirt1 regulates aging and resistance to oxidative stress in the heart | Q44830459 | ||
| Diabetes, obesity, and the brain | Q45232063 | ||
| Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. | Q46752037 | ||
| Ageing and the mystery at Arles | Q47609609 | ||
| Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. | Q51565792 | ||
| Sirt1 contributes critically to the redox-dependent fate of neural progenitors. | Q51961854 | ||
| Increase in activity during calorie restriction requires Sirt1 | Q81598148 | ||
| SIRT1 promotes DNA repair activity and deacetylation of Ku70 | Q24298814 | ||
| Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1 | Q24299057 | ||
| Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage | Q24299098 | ||
| DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1 | Q24300074 | ||
| SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation | Q24300487 | ||
| Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin | Q24306469 | ||
| DBC1 is a negative regulator of SIRT1 | Q24309055 | ||
| Negative regulation of the deacetylase SIRT1 by DBC1 | Q24309090 | ||
| Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase | Q24310456 | ||
| Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state | Q24312132 | ||
| A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy | Q24316492 | ||
| SIRT1 regulates the function of the Nijmegen breakage syndrome protein | Q24317230 | ||
| SIRT1 deacetylates APE1 and regulates cellular base excision repair | Q24320136 | ||
| CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage | Q24328995 | ||
| SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1 | Q24337470 | ||
| Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha | Q24338422 | ||
| FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1) | Q24338668 | ||
| The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis | Q24540613 | ||
| Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases | Q24548362 | ||
| AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity | Q24595845 | ||
| Extending healthy life span--from yeast to humans | Q24599191 | ||
| SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. | Q24601406 | ||
| Cellular adaptation contributes to calorie restriction-induced preservation of skeletal muscle in aged rhesus monkeys | Q24601896 | ||
| Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases | Q24608197 | ||
| SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production | Q24611702 | ||
| A novel pathway regulates memory and plasticity via SIRT1 and miR-134 | Q24624906 | ||
| Hypoxia-Inducible Factors and the Response to Hypoxic Stress | Q24629323 | ||
| Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes | Q24645537 | ||
| A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange | Q24648525 | ||
| miR-34a repression of SIRT1 regulates apoptosis | Q24652720 | ||
| Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol | Q24654272 | ||
| Histone H4 lysine 16 acetylation regulates cellular lifespan | Q24657553 | ||
| Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis | Q24658408 | ||
| A local mechanism mediates NAD-dependent protection of axon degeneration | Q24679199 | ||
| Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age | Q27324536 | ||
| Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase | Q27860668 | ||
| Inflammation and metabolic disorders | Q27860923 | ||
| Resveratrol improves health and survival of mice on a high-calorie diet | Q27860950 | ||
| RETRACTED: Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex | Q28117469 | ||
| Genetic pathways that regulate ageing in model organisms | Q28138437 | ||
| SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha} | Q28235481 | ||
| Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1 | Q28237795 | ||
| CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability | Q28245419 | ||
| Mammalian SIRT1 represses forkhead transcription factors | Q28246430 | ||
| SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B | Q28251461 | ||
| The sirtuin SIRT6 regulates lifespan in male mice | Q28260687 | ||
| Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha | Q28274682 | ||
| Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation | Q28507185 | ||
| Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha | Q28513388 | ||
| SIRT1 transgenic mice show phenotypes resembling calorie restriction | Q29301793 | ||
| A brief introduction to FOXOlogy | Q29392646 | ||
| Autophagy: renovation of cells and tissues | Q29547206 | ||
| Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration | Q29616075 | ||
| Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators | Q29617353 | ||
| Recent progress in the biology and physiology of sirtuins | Q29617573 | ||
| Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts | Q29618748 | ||
| Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1 | Q29619241 | ||
| Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice | Q29619786 | ||
| Phosphorylation regulates SIRT1 function. | Q30440595 | ||
| Proteasomal regulation of the hypoxic response modulates aging in C. elegans | Q30489976 | ||
| Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans | Q32774312 | ||
| The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth | Q33328513 | ||
| Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction | Q33565848 | ||
| SIRT1 performs a balancing act on the tight-rope toward longevity | Q33588790 | ||
| Acetylation of tau inhibits its degradation and contributes to tauopathy | Q33703231 | ||
| CREB couples neurotrophin signals to survival messages | Q33857179 | ||
| Shear stress, SIRT1, and vascular homeostasis | Q33933093 | ||
| Four faces of cellular senescence. | Q34025754 | ||
| Impact of Sirt1 on mammalian aging. | Q34056444 | ||
| CREB and the CRTC co-activators: sensors for hormonal and metabolic signals | Q34166530 | ||
| Telomeres and longevity | Q34169219 | ||
| A single-nucleotide variation in a p53-binding site affects nutrient-sensitive human SIRT1 expression | Q34184772 | ||
| Hormesis, cell death and aging | Q34217654 | ||
| Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction | Q34222778 | ||
| The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+). | Q34242709 | ||
| SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function | Q34272924 | ||
| Calorie restriction--the SIR2 connection | Q34398200 | ||
| Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons. | Q34406809 | ||
| Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). | Q34550257 | ||
| Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila | Q34632518 | ||
| Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner | Q34799862 | ||
| SirT1 brings stemness closer to cancer and aging | Q34852306 | ||
| Does hypothalamic SIRT1 regulate aging? | Q34966735 | ||
| Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity | Q35063067 | ||
| SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2. | Q35188243 | ||
| P275 | copyright license | Creative Commons Attribution-NonCommercial 3.0 Unported | Q18810331 |
| P433 | issue | 22 | |
| P921 | main subject | enzyme | Q8047 |
| P1104 | number of pages | 12 | |
| P304 | page(s) | 4135-4146 | |
| P577 | publication date | 2012-09-14 | |
| 2012-11-15 | |||
| P1433 | published in | Cell Cycle | Q1254166 |
| P1476 | title | Sirt1: def-eating senescence? | |
| P478 | volume | 11 |
| Q45055593 | Alcohol Induces Cellular Senescence and Impairs Osteogenic Potential in Bone Marrow-Derived Mesenchymal Stem Cells |
| Q39223241 | Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene |
| Q52878562 | Are you certain about SIRT? |
| Q92649188 | Brain Insulin Resistance and Hippocampal Plasticity: Mechanisms and Biomarkers of Cognitive Decline |
| Q38069942 | Brain response to calorie restriction |
| Q35208102 | Dysregulated serum IL-23 and SIRT1 activity in peripheral blood mononuclear cells of patients with rheumatoid arthritis |
| Q39420265 | Experimental models for aging and their potential for novel drug discovery. |
| Q99712200 | Glucose Overload Inhibits Glutamatergic Synaptic Transmission: A Novel Role for CREB-Mediated Regulation of Synaptotagmins 2 and 4 |
| Q34988095 | Imbalance between HAT and HDAC activities in the PBMCs of patients with ankylosing spondylitis or rheumatoid arthritis and influence of HDAC inhibitors on TNF alpha production |
| Q35568177 | Modulation of hippocampal neural plasticity by glucose-related signaling |
| Q92721152 | Non-phagocytic Activation of NOX2 is Implicated in Progressive Non-alcoholic Steatohepatitis During Aging |
| Q38133938 | Oxidative stress in aging--matters of the heart and mind. |
| Q30579284 | Rapid changes in histone deacetylases and inflammatory gene expression in expert meditators |
| Q39078249 | Regulation of histone H2A.Z expression is mediated by sirtuin 1 in prostate cancer. |
| Q39188912 | Resveratrol activates SIRT1 in a Lamin A-dependent manner. |
| Q37549574 | Resveratrol restores sirtuin 1 (SIRT1) activity and pyruvate dehydrogenase kinase 1 (PDK1) expression after hemorrhagic injury in a rat model |
| Q43084482 | Resveratrol, a sirtuin 1 activator, increases IL-6 production by peripheral blood mononuclear cells of patients with knee osteoarthritis |
| Q46772238 | SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models |
| Q47280053 | SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients. |
| Q38409974 | SIRT1 and Neural Cell Fate Determination |
| Q35041187 | SIRT1 expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC. |
| Q51727683 | Sirtuin1 (SIRT1) in the Acetylation of Downstream Target Proteins. |
| Q48362779 | The Effects of Resveratrol on Inflammation and Oxidative Stress in a Rat Model of Chronic Obstructive Pulmonary Disease. |
| Q38196656 | The fine line between lifespan extension and shortening in response to caloric restriction. |
| Q33713171 | The metal nanoparticle-induced inflammatory response is regulated by SIRT1 through NF-κB deacetylation in aseptic loosening |
| Q87159811 | The yeast product Milmed enhances the effect of physical exercise on motor performance and dopamine neurochemistry recovery in MPTP-lesioned mice |
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