Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).

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Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). is …
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scholarly articleQ13442814

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P819ADS bibcode2011PNAS..108.1925L
P356DOI10.1073/PNAS.1019619108
P932PMC publication ID3033317
P698PubMed publication ID21245319
P5875ResearchGate publication ID49765297

P50authorWei-Guo ZhuQ42962893
P2093author name stringLina Wang
Robert G Roeder
Wei Gu
Ying Zhao
Haiying Wang
Bo Tu
Zhixing Zheng
Xiangyu Liu
Donglai Wang
P2860cites workHistone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors.Q46668186
Negative control of p53 by Sir2alpha promotes cell survival under stressQ24291828
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylaseQ24291829
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responsesQ24293580
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activityQ24298755
DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1Q24300074
DBC1 is a negative regulator of SIRT1Q24309055
Negative regulation of the deacetylase SIRT1 by DBC1Q24309090
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylaseQ24310456
Regulation of p53 activity through lysine methylationQ24311514
Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2Q24314290
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activityQ24320035
CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damageQ24328995
Gene-specific modulation of TAF10 function by SET9-mediated methylationQ24337399
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formationQ24672514
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domainQ27860534
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylaseQ27860668
Mammalian SIRT1 represses forkhead transcription factorsQ28246430
The Sir2 family of protein deacetylasesQ28266179
The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylationQ28304726
Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genesQ30437467
Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcriptionQ30437951
Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase.Q34108153
Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cellsQ37126117
SET7/9 mediated methylation of non-histone proteins in mammalian cellsQ37580675
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stressQ38828331
Lysine methylation regulates the pRb tumour suppressor proteinQ39742282
JNK2-dependent regulation of SIRT1 protein stabilityQ39931968
Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivoQ40012428
Methylation-acetylation interplay activates p53 in response to DNA damageQ40103473
SIRT1 is significantly elevated in mouse and human prostate cancer.Q40105577
Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival.Q40351435
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1925-1930
P577publication date2011-01-18
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleMethyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).
P478volume108

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cites work (P2860)
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Q34777068Upregulation of Unc-51-like kinase 1 by nitric oxide stabilizes SIRT1, independent of autophagy.
Q36739079p53 and metabolism: old player in a new game

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