Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress (scientific article)

Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo

Q24312156

Acetylation is indispensable for p53 activation

Q24313477

Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2

Q24337403

Performing in vitro sumoylation reactions using recombinant enzymes.

Q27865224

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

Q27865256

SUMO: a history of modification

Q28243325

Concepts in sumoylation: a decade on

Q28257220

Blinded by the Light: The Growing Complexity of p53

Q29547590

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

Q29547667

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

Q29619117

p53 ubiquitination: Mdm2 and beyond

Q29619502

Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis

Q33390343

Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).

Q34520098

Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).

Q34550257

Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage

Q35071254

Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate.

Q36117542

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

Q36601373

How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?

Q36879036

How many mutant p53 molecules are needed to inactivate a tetramer?

Q37278142

HDAC expression and clinical prognosis in human malignancies

Q37356662

Emerging roles of desumoylating enzymes

Q37375239

Histone deacetylases: salesmen and customers in the post-translational modification market.

Q37389553

STAT6 and STAT1 are essential antagonistic regulators of cell survival in classical Hodgkin lymphoma cell line

Q38354113

SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress

Q38828331

Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2.

Q39455093

Histone deacetylase inhibitors enhance the anticancer activity of nutlin-3 and induce p53 hyperacetylation and downregulation of MDM2 and MDM4 gene expression

Q39672349

Coordination of PAD4 and HDAC2 in the regulation of p53-target gene expression

Q39733989

Immunohistochemical detection of histone deacetylases in endometrial carcinoma: involvement of histone deacetylase 2 in the proliferation of endometrial carcinoma cells

Q39736131

HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA.

Q39837701

PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia.

Q39968880

Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2.

Q39996230

Transforming pathways unleashed by a HDAC2 mutation in human cancer.

Q40014673

Histone deacetylase 2 modulates p53 transcriptional activities through regulation of p53-DNA binding activity

Q40149346

Histone deacetylase inhibitors differentially stabilize acetylated p53 and induce cell cycle arrest or apoptosis in prostate cancer cells.

Q40450785

p21 does not protect cancer cells from apoptosis induced by nongenotoxic p53 activation

Q54647670

P433

issue

P921

main subject

apoptotic process

genotoxicity

protein sumoylation

page(s)

284-293

P577

publication date

2012-04-05

P1433

published in

Journal of Molecular Cell Biology

Q2456339

P1476

title

Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress

P478

volume

Reverse relations

cites work (P2860)

Q42482212	Aberrant expression and activity of histone deacetylases in sporadic idiopathic pulmonary fibrosis
Q41390061	Acetylation and sumoylation control STAT5 activation antagonistically
Q46475017	Analysis of Histone Deacetylases Sumoylation by Immunoprecipitation Techniques
Q37581632	Anticancer effects of valproic acid on oral squamous cell carcinoma via SUMOylation in vivo and in vitro
Q64095044	Carbocisteine Improves Histone Deacetylase 2 Deacetylation Activity via Regulating Sumoylation of Histone Deacetylase 2 in Human Tracheobronchial Epithelial Cells
Q38459546	Computational genomic analysis of PARK7 interactome reveals high BBS1 gene expression as a prognostic factor favoring survival in malignant pleural mesothelioma.
Q37622604	Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration
Q51727713	Detection of Sumo Modification of Endogenous Histone Deacetylase 2 (HDAC2) in Mammalian Cells.
Q64083246	Epigenetically Down-Regulated Acetyltransferase PCAF Increases the Resistance of Colorectal Cancer to 5-Fluorouracil
Q58760407	Establishment, functional and genetic characterization of a colon derived large cell neuroendocrine carcinoma cell line
Q36325670	Exposure to atheroma-relevant 7-oxysterols causes proteomic alterations in cell death, cellular longevity, and lipid metabolism in THP-1 macrophages
Q54979438	Expressional analysis of disease-relevant signalling-pathways in primary tumours and metastasis of head and neck cancers.
Q34480741	Functional characterization of novel mutations affecting survivin (BIRC5)-mediated therapy resistance in head and neck cancer patients
Q48233598	HDAC2 selectively regulates FOXO3a-mediated gene transcription during oxidative stress-induced neuronal cell death
Q40566982	HIV-1 Vpr reactivates latent HIV-1 provirus by inducing depletion of class I HDACs on chromatin.
Q34100931	Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1
Q64233937	Histone deacetylase 2 is involved in DNA damage-mediated cell death of human osteosarcoma cells through stimulation of the ATM/p53 pathway
Q92612020	Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes
Q36727468	Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH
Q91755494	Is small smarter? Nanomaterial-based detection and elimination of circulating tumor cells: current knowledge and perspectives
Q89880110	Nano Meets Micro-Translational Nanotechnology in Medicine: Nano-Based Applications for Early Tumor Detection and Therapy
Q92433730	Nanosized food additives impact beneficial and pathogenic bacteria in the human gut: a simulated gastrointestinal study
Q98778842	Protein acetylation and deacetylation: An important regulatory modification in gene transcription (Review)
Q53416230	Quantitative phosphoproteomic analysis reveals γ-bisabolene inducing p53-mediated apoptosis of human oral squamous cell carcinoma via HDAC2 inhibition and ERK1/2 activation.
Q35676378	Role of histone deacetylase 2 and its posttranslational modifications in cardiac hypertrophy
Q52655031	Role of novel histone modifications in cancer.
Q46262918	SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease
Q38177821	STAT5 acetylation: Mechanisms and consequences for immunological control and leukemogenesis
Q35275798	SUMOylation occurs in acute kidney injury and plays a cytoprotective role
Q50296468	SUMOylation of HDAC2 with SUMO1
Q34628002	Small-molecular modulators of cancer-associated epigenetic mechanisms
Q39107046	Sub-cellular localization specific SUMOylation in the heart
Q38907048	Sumoylation of HDAC2 promotes NF-κB-dependent gene expression.
Q47677143	TFIIA transcriptional activity is controlled by a 'cleave-and-run' Exportin-1/Taspase 1-switch.
Q43638817	The Hydra small ubiquitin-like modifier.
Q58803114	Tricho-rhino-phalangeal syndrome 1 protein functions as a scaffold required for ubiquitin-specific protease 4-directed histone deacetylase 2 de-ubiquitination and tumor growth
Q92083193	p53 at the Crossroads between Different Types of HDAC Inhibitor-Mediated Cancer Cell Death
Q37558978	p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors.