Anticancer effects of valproic acid on oral squamous cell carcinoma via SUMOylation in vivo and in vitro

scientific article

Anticancer effects of valproic acid on oral squamous cell carcinoma via SUMOylation in vivo and in vitro is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/ETM.2016.3907
P932PMC publication ID5228083
P698PubMed publication ID28101176

P2093author name stringYong Cheng
Xiaojun Ding
Yang Sun
Hong Ruan
Youcheng Yu
Zhijian Sang
P2860cites workTrends in incidence and prognosis for head and neck cancer in the United States: a site-specific analysis of the SEER databaseQ44849577
Valproic acid in normal therapeutic concentration has no neuroprotective or differentiation influencing effects on long term expanded murine neural stem cellsQ45205029
Valproic acid induces differentiation of a supratentorial primitive neuroectodermal tumorQ45288673
Impact of combined HDAC and mTOR inhibition on adhesion, migration and invasion of prostate cancer cellsQ47589926
Microinjection of valproic acid into the ventrolateral orbital cortex exerts an antidepressant-like effect in the rat forced swim testQ48888799
Effect of trichostatin A on cell growth and expression of cell cycle- and apoptosis-related molecules in human gastric and oral carcinoma cell linesQ54028710
Decreased histone deacetylase activity in chronic obstructive pulmonary diseaseQ54664094
Proliferative activity in periapical lesionsQ73448632
Important role of SUMOylation of Spliceosome factors in prostate cancer cellsQ87401469
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Structural and functional characterization of the phosphorylation-dependent interaction between PML and SUMO1Q27696842
Mechanisms, regulation and consequences of protein SUMOylationQ27865251
Resistance after chronic application of the HDAC-inhibitor valproic acid is associated with elevated Akt activation in renal cell carcinoma in vivoQ28485252
Neuropilin-1 promotes epithelial-to-mesenchymal transition by stimulating nuclear factor-kappa B and is associated with poor prognosis in human oral squamous cell carcinomaQ33856474
Valproic acid induces differentiation and transient tumor regression, but spares leukemia-initiating activity in mouse models of APL.Q34254302
Control of cardiac growth by histone acetylation/deacetylationQ34482206
Microinjection of Valproic Acid into the Ventrolateral Orbital Cortex Enhances Stress-Related Memory FormationQ34542172
Expression of FACT in mammalian tissues suggests its role in maintaining of undifferentiated state of cellsQ35640168
Valproate Inhibits Methamphetamine Induced Hyperactivity via Glycogen Synthase Kinase 3β Signaling in the Nucleus Accumbens CoreQ35647946
Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancerQ35694399
NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cellsQ35850681
Enhanced Cytotoxic Effects of Combined Valproic Acid and the Aurora Kinase Inhibitor VE465 on Gynecologic Cancer CellsQ36700778
Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiationQ36858606
Histone deacetylase inhibitors: molecular mechanisms of actionQ36908440
Histone deacetylase inhibitor potentiated the ability of MTOR inhibitor to induce autophagic cell death in Burkitt leukemia/lymphomaQ37042173
Chromatin-remodelling mechanisms in cancer.Q37134923
Senp1 is essential for desumoylating Sumo1-modified proteins but dispensable for Sumo2 and Sumo3 deconjugation in the mouse embryoQ37178230
DeSUMOylating enzymes--SENPsQ37230112
Identification and Characterization of a New Chemotype of Noncovalent SENP InhibitorsQ37341772
SUMO playing tag with ubiquitinQ37948388
Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stressQ39366270
An acetylation switch regulates SUMO-dependent protein interaction networks.Q39502343
Valproic acid: growth inhibition of head and neck cancer by induction of terminal differentiation and senescence.Q39570650
Overexpression of small ubiquitin-related modifier-1 and sumoylated Mdm2 in oral squamous cell carcinoma: possible involvement in tumor proliferation and prognosis.Q40098999
Targeting AML1/ETO-histone deacetylase repressor complex: a novel mechanism for valproic acid-mediated gene expression and cellular differentiation in AML1/ETO-positive acute myeloid leukemia cellsQ40153779
Long-term efficacy of valproate versus lamotrigine in treatment of idiopathic generalized epilepsies in children and adolescentsQ43157409
Overexpression of SENP5 in oral squamous cell carcinoma and its association with differentiationQ43725106
Valproate recovers the inhibitory effect of dexamethasone on the proliferation of the adult dentate gyrus-derived neural precursor cells via GSK-3β and β-catenin pathwayQ44495925
P433issue6
P921main subjectprotein sumoylationQ3503705
oral squamous cell carcinomaQ18553522
P304page(s)3979-3987
P577publication date2016-11-15
P1433published inExperimental and Therapeutic MedicineQ23979083
P1476titleAnticancer effects of valproic acid on oral squamous cell carcinoma via SUMOylation in vivo and in vitro
P478volume12

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cites work (P2860)
Q92598876DynOVis: a web tool to study dynamic perturbations for capturing dose-over-time effects in biological networks
Q89701153GANT61 and Valproic Acid Synergistically Inhibited Multiple Myeloma Cell Proliferation via Hedgehog Signaling Pathway
Q47100939HDAC inhibition as a treatment concept to combat temsirolimus-resistant bladder cancer cells
Q47136713The role and possible molecular mechanism of valproic acid in the growth of MCF-7 breast cancer cells.

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