Virological and immunological characterization of novel NYVAC-based HIV/AIDS vaccine candidates expressing clade C trimeric soluble gp140(ZM96) and Gag(ZM96)-Pol-Nef(CN54) as virus-like particles.

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Virological and immunological characterization of novel NYVAC-based HIV/AIDS vaccine candidates expressing clade C trimeric soluble gp140(ZM96) and Gag(ZM96)-Pol-Nef(CN54) as virus-like particles. is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.02469-14
P8608Fatcat IDrelease_6x7x6epj7bckhbiskntjcze55q
P932PMC publication ID4300665
P698PubMed publication ID25355891

P50authorMariano EstebanQ30004051
Giuseppe PantaleoQ88061163
Beatriz PerdigueroQ112248161
Victoria CepedaQ114406489
Lucas Sánchez-SampedroQ114406490
Ernesto Mejías-PérezQ114406491
Benedikt AsbachQ114406492
Karen V KiblerQ114406493
Thierry RogerQ40228404
Carmen E GómezQ42100464
Carlos Oscar Sanchez SorzanoQ56027899
Thierry CalandraQ56616768
Ralf WagnerQ57979852
Juan Carlos OliverosQ59464072
Juan García-ArriazaQ79782431
P2093author name stringBertram L Jacobs
Julie Delaloye
Cristina Sánchez
Victoria Jiménez
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Highly attenuated vaccinia virus mutants for the generation of safe recombinant virusesQ33838030
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Improving Adaptive and Memory Immune Responses of an HIV/AIDS Vaccine Candidate MVA-B by Deletion of Vaccinia Virus Genes (C6L and K7R) Blocking Interferon Signaling PathwaysQ34796206
Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates.Q34880294
Removal of vaccinia virus genes that block interferon type I and II pathways improves adaptive and memory responses of the HIV/AIDS vaccine candidate NYVAC-C in miceQ35943846
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An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responsesQ36446900
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The canarypox virus vector ALVAC induces distinct cytokine responses compared to the vaccinia virus-based vectors MVA and NYVAC in rhesus monkeysQ37547241
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Biology of attenuated modified vaccinia virus Ankara recombinant vector in mice: virus fate and activation of B- and T-cell immune responses in comparison with the Western Reserve strain and advantages as a vaccineQ39589039
Preclinical evaluation of the immunogenicity of C-type HIV-1-based DNA and NYVAC vaccines in the Balb/C mouse modelQ39790409
Poxvirus-based vaccine candidates for cancer, AIDS, and other infectious diseases.Q40447904
Detection of a protein encoded by the vaccinia virus C7L open reading frame and study of its effect on virus multiplication in different cell linesQ41544688
NYVAC: a highly attenuated strain of vaccinia virusQ41626050
HIV-1 gag proteins: diverse functions in the virus life cycleQ43783202
NYVAC immunization induces polyfunctional HIV-specific T-cell responses in chronically-infected, ART-treated HIV patientsQ44766920
Virus-like particles: a novel tool for the induction and monitoring of both T-helper and cytotoxic T-lymphocyte activity.Q45676992
EV02: a Phase I trial to compare the safety and immunogenicity of HIV DNA-C prime-NYVAC-C boost to NYVAC-C aloneQ46576663
Mouse neurotoxicity test for vaccinia-based smallpox vaccines.Q47823151
A comparative study of the pathogenesis of western equine and eastern equine encephalomyelitis viral infections in mice by intracerebral and subcutaneous inoculations.Q48910022
EV01: a phase I trial in healthy HIV negative volunteers to evaluate a clade C HIV vaccine, NYVAC-C undertaken by the EuroVacc Consortium.Q54454033
HIV-1 p24 Gag-specific cytotoxic T-lymphocyte responses in miceQ71528382
Generation and immunogenicity of novel HIV/AIDS vaccine candidates targeting HIV-1 Env/Gag-Pol-Nef antigens of clade CQ79561534
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectvirologyQ7215
HIV/AIDSQ12199
P304page(s)970-988
P577publication date2014-10-29
P1433published inJournal of VirologyQ1251128
P1476titleVirological and immunological characterization of novel NYVAC-based HIV/AIDS vaccine candidates expressing clade C trimeric soluble gp140(ZM96) and Gag(ZM96)-Pol-Nef(CN54) as virus-like particles
P478volume89