EV02: a Phase I trial to compare the safety and immunogenicity of HIV DNA-C prime-NYVAC-C boost to NYVAC-C alone

scientific article published on 6 May 2008

EV02: a Phase I trial to compare the safety and immunogenicity of HIV DNA-C prime-NYVAC-C boost to NYVAC-C alone is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.VACCINE.2008.02.072
P698PubMed publication ID18502003

P50authorAlexandre HarariQ43779462
Wolfgang StöhrQ86907024
Giuseppe PantaleoQ88061163
Jonathan L. HeeneyQ39066258
P2093author name stringJonathan Weber
Ralf Wagner
Cristina Cellerai
Christiane Moog
Abdel Babiker
Elizabeth Brodnicki
Sheena McCormack
Tristan Barber
Jim Tartaglia
Donatella Ciuffreda
Pierre-Alexandre Bart
Hans Wolf
Ken Legg
Séverine Burnet
Marie-Joëlle Frachette
Miranda Cowen
Romilda Gamboni
P2860cites workEV01: a phase I trial in healthy HIV negative volunteers to evaluate a clade C HIV vaccine, NYVAC-C undertaken by the EuroVacc Consortium.Q54454033
Estimating the benefit of an HIV-1 vaccine that reduces viral load set pointQ79580562
Involvement of Fc gamma RI (CD64) in the mechanism of HIV-1 inhibition by polyclonal IgG purified from infected patients in cultured monocyte-derived macrophagesQ80967901
Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: the ANRS 1265 TrialQ21144715
Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodiesQ29619015
Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trialQ29619176
Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trialQ29619179
Immunoglobulin G (IgG) and IgA, but also nonantibody factors, account for in vitro neutralization of human immunodeficiency virus (HIV) type 1 primary isolates by serum and plasma of HIV-infected patientsQ33852361
An HIV vaccine--evolving conceptsQ34629012
Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responsesQ36229406
An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responsesQ36446900
P433issue25
P407language of work or nameEnglishQ1860
P921main subjectphase I clinical trialQ5452194
P304page(s)3162-3174
P577publication date2008-05-06
P1433published inVaccineQ7907941
P1476titleEV02: a Phase I trial to compare the safety and immunogenicity of HIV DNA-C prime-NYVAC-C boost to NYVAC-C alone
P478volume26

Reverse relations

cites work (P2860)
Q37656908A Comparative Phase I Study of Combination, Homologous Subtype-C DNA, MVA, and Env gp140 Protein/Adjuvant HIV Vaccines in Two Immunization Regimes
Q26851165A brief history of the global effort to develop a preventive HIV vaccine
Q21135240A candidate HIV/AIDS vaccine (MVA-B) lacking vaccinia virus gene C6L enhances memory HIV-1-specific T-cell responses
Q35628697A comparative analysis of HIV-specific mucosal/systemic T cell immunity and avidity following rDNA/rFPV and poxvirus-poxvirus prime boost immunisations
Q34593969A phase I trial of preventive HIV vaccination with heterologous poxviral-vectors containing matching HIV-1 inserts in healthy HIV-uninfected subjects
Q36391900A vaccinia virus renaissance: new vaccine and immunotherapeutic uses after smallpox eradication
Q28482252Altering an artificial Gagpolnef polyprotein and mode of ENV co-administration affects the immunogenicity of a clade C HIV DNA vaccine
Q37277825Assessment of the Safety and Immunogenicity of 2 Novel Vaccine Platforms for HIV-1 Prevention: A Randomized Trial
Q37221660Broad HIV-1 inhibition in vitro by vaccine-elicited CD8(+) T cells in African adults
Q36697992Broad and potent immune responses to a low dose intradermal HIV-1 DNA boosted with HIV-1 recombinant MVA among healthy adults in Tanzania
Q37799412Comparison of T cell immune responses induced by vectored HIV vaccines in non-human primates and humans
Q39992443Comparison of human and rhesus macaque T-cell responses elicited by boosting with NYVAC encoding human immunodeficiency virus type 1 clade C immunogens
Q38184579Conserved immunogens in prime-boost strategies for the next-generation HIV-1 vaccines
Q30364312Developments in HIV-1 immunotherapy and therapeutic vaccination.
Q59360867Efficient Delivery of Human Cytomegalovirus T Cell Antigens by Attenuated Sendai Virus Vectors
Q33489847Enhancement of the priming efficacy of DNA vaccines encoding dendritic cell-targeted antigens by synergistic toll-like receptor ligands.
Q36978452Enhancing poxvirus vectors vaccine immunogenicity.
Q37590335Genetic heterologous prime-boost vaccination strategies for improved systemic and mucosal immunity
Q34342558HIV vaccines: lessons learned and the way forward
Q35140001HIV-specific humoral responses benefit from stronger prime in phase Ib clinical trial
Q40339467HIV/AIDS Vaccine Candidates Based on Replication-Competent Recombinant Poxvirus NYVAC-C-KC Expressing Trimeric gp140 and Gag-Derived Virus-Like Particles or Lacking the Viral Molecule B19 That Inhibits Type I Interferon Activate Relevant HIV-1-Speci
Q35914311Head-to-Head Comparison of Poxvirus NYVAC and ALVAC Vectors Expressing Identical HIV-1 Clade C Immunogens in Prime-Boost Combination with Env Protein in Nonhuman Primates
Q36302688Heterologous prime-boost vaccination with DNA and MVA vaccines, expressing HIV-1 subtype C mosaic Gag virus-like particles, is highly immunogenic in mice
Q47252143Immune Modulation of NYVAC-Based HIV Vaccines by Combined Deletion of Viral Genes that Act on Several Signalling Pathways
Q27320923Immunogenic profiling in mice of a HIV/AIDS vaccine candidate (MVA-B) expressing four HIV-1 antigens and potentiation by specific gene deletions
Q50043326Immunogenicity of NYVAC prime-protein boost HIV-1 envelope vaccination and SHIV challenge of nonhuman primates
Q45031334Immunogenicity, safety, biodistribution and persistence of ADVAX, a prophylactic DNA vaccine for HIV-1, delivered by in vivo electroporation
Q27489413Improved Efficacy of a Gene Optimised Adenovirus-based Vaccine for Venezuelan Equine Encephalitis Virus
Q28742751Improved innate and adaptive immunostimulation by genetically modified HIV-1 protein expressing NYVAC vectors
Q38009870Improved outlook on HIV-1 prevention and vaccine development
Q28744555In vivo electroporation enhances the immunogenicity of an HIV-1 DNA vaccine candidate in healthy volunteers
Q34309830Intranasal DNA Vaccine for Protection against Respiratory Infectious Diseases: The Delivery Perspectives.
Q34816639Lessons drawn from recent HIV vaccine efficacy trials
Q104486611Mucosal IL-4R antagonist HIV vaccination with SOSIP-gp140 booster can induce high-quality cytotoxic CD4+/CD8+ T cells and humoral responses in macaques
Q64074435Mucosal and systemic SIV-specific cytotoxic CD4+ T cell hierarchy in protection following intranasal/intramuscular recombinant pox-viral vaccination of pigtail macaques
Q26861148Nonhuman primate models for HIV/AIDS vaccine development
Q33693891Nonreplicating vectors in HIV vaccines
Q33645528Novel directions in HIV-1 vaccines revealed from clinical trials
Q30378897Obstacles to the successful development of an efficacious T cell-inducing HIV-1 vaccine.
Q34487151Optimizing cellular immunity against HIV-1 Gag and preventing suppression by HIV-1 gp120.
Q30977303Phase 1 safety and immunogenicity evaluation of ADMVA, a multigenic, modified vaccinia Ankara-HIV-1 B'/C candidate vaccine
Q33527383Phase 1 safety and immunogenicity evaluation of ADVAX, a multigenic, DNA-based clade C/B' HIV-1 candidate vaccine
Q34772727Phase 1 safety and immunogenicity testing of DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particles
Q33749950Phase I safety and immunogenicity evaluation of MVA-CMDR, a multigenic, recombinant modified vaccinia Ankara-HIV-1 vaccine candidate
Q36736400Potential To Streamline Heterologous DNA Prime and NYVAC/Protein Boost HIV Vaccine Regimens in Rhesus Macaques by Employing Improved Antigens
Q26995078Poxvirus vectors as HIV/AIDS vaccines in humans
Q59351003Priming with a potent HIV-1 DNA vaccine frames the quality of immune responses prior to a poxvirus and protein boost
Q28485174Prospective surveillance for cardiac adverse events in healthy adults receiving modified vaccinia Ankara vaccines: a systematic review
Q35943846Removal of vaccinia virus genes that block interferon type I and II pathways improves adaptive and memory responses of the HIV/AIDS vaccine candidate NYVAC-C in mice
Q59351008Replication-competent NYVAC-KC yields improved immunogenicity to HIV-1 antigens in rhesus macaques, compared to non-replicating NYVAC
Q34589611Safety and immunogenicity of DNA and MVA HIV-1 subtype C vaccine prime-boost regimens: a phase I randomised Trial in HIV-uninfected Indian volunteers
Q36668517Safety and immunogenicity of DNA prime and modified vaccinia ankara virus-HIV subtype C vaccine boost in healthy adults.
Q38484762Safety and immunogenicity of a modified pox vector-based HIV/AIDS vaccine candidate expressing Env, Gag, Pol and Nef proteins of HIV-1 subtype B (MVA-B) in healthy HIV-1-uninfected volunteers: A phase I clinical trial (RISVAC02).
Q90637089Safety and immunogenicity of a multivalent HIV vaccine comprising envelope protein with either DNA or NYVAC vectors (HVTN 096): a phase 1b, double-blind, placebo-controlled trial
Q33875160Safety and tolerability of conserved region vaccines vectored by plasmid DNA, simian adenovirus and modified vaccinia virus ankara administered to human immunodeficiency virus type 1-uninfected adults in a randomized, single-blind phase I trial.
Q26770839Scientific and regulatory challenges in evaluating clinical trial protocols for HIV-1/AIDS vaccines - A review from a regulatory perspective
Q36119504Sequential Immunization with gp140 Boosts Immune Responses Primed by Modified Vaccinia Ankara or DNA in HIV-Uninfected South African Participants
Q35868091Superior induction of T cell responses to conserved HIV-1 regions by electroporated alphavirus replicon DNA compared to that with conventional plasmid DNA vaccine
Q34247289Systems analysis of MVA-C induced immune response reveals its significance as a vaccine candidate against HIV/AIDS of clade C.
Q38725610The HIV/AIDS vaccine candidate MVA-B administered as a single immunogen in humans triggers robust, polyfunctional, and selective effector memory T cell responses to HIV-1 antigens.
Q26995905The evolution of poxvirus vaccines
Q34077543The influence of delivery vectors on HIV vaccine efficacy
Q37548329Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1.
Q24602593Vaccine-induced HIV seropositivity/reactivity in noninfected HIV vaccine recipients
Q41039943Vaccinia virus strain NYVAC induces substantially lower and qualitatively different human antibody responses compared with strains Lister and Dryvax
Q35571248Vaccinia viruses: vaccines against smallpox and vectors against infectious diseases and tumors.
Q34991112Virological and immunological characterization of novel NYVAC-based HIV/AIDS vaccine candidates expressing clade C trimeric soluble gp140(ZM96) and Gag(ZM96)-Pol-Nef(CN54) as virus-like particles.

Search more.