review article | Q7318358 |
scholarly article | Q13442814 |
P356 | DOI | 10.1016/S0020-7519(02)00194-7 |
P698 | PubMed publication ID | 12435450 |
P50 | author | Steven R. Meshnick | Q62070963 |
P2860 | cites work | Artemisinin, an Endoperoxide Antimalarial, Disrupts the Hemoglobin Catabolism and Heme Detoxification Systems in Malarial Parasite | Q22061847 |
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Ataxia and slurred speech after artesunate treatment for falciparum malaria | Q48036625 | ||
Induction and isolation of artemisinine-resistant mutants of Plasmodium falciparum. | Q54450901 | ||
Ring opening of artemisinin (qinghaosu) and dihydroartemisinin and interception of the open hydroperoxides with Formation of N-oxides — a chemical model for antimalarial mode of action | Q59870606 | ||
The behaviour of qinghaosu (artemisinin) in the presence of heme iron(II) and (III) | Q59870621 | ||
Hemin-catalyzed decomposition of artemisinin (qinghaosu) | Q68109840 | ||
The antimalarial action on Plasmodium falciparum of qinghaosu and artesunate in combination with agents which modulate oxidant stress | Q68236209 | ||
Stage specific actions of antimalarial drugs on Plasmodium falciparum in culture | Q69491793 | ||
Atovaquone in the treatment of Babesia microti infections in hamsters | Q71466000 | ||
Reaction between ferriprotoporphyrin IX and the antimalarial endoperoxide artesunate gives an intermediate species with enhanced redox catalytic activity | Q71815492 | ||
Further Evidence Supporting the Importance of and the Restrictions on a Carbon-Centered Radical for High Antimalarial Activity of 1,2,4-Trioxanes Like Artemisinin | Q71871177 | ||
Alkylation of proteins by artemisinin. Effects of heme, pH, and drug structure | Q72145515 | ||
The toxicity of artemisinin and related compounds on neuronal and glial cells in culture | Q72236509 | ||
Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin: the importance of a carbon-centered radical for antimalarial activity | Q72405730 | ||
Morphologic effects of artemisinin in Plasmodium falciparum | Q72542894 | ||
Alkylation of human albumin by the antimalarial artemisinin | Q72870627 | ||
Correlation of antimalarial activity of artemisinin derivatives with binding affinity with ferroprotoporphyrin IX | Q73126615 | ||
Artemisinin enhances heme-catalysed oxidation of lipid membranes | Q73212284 | ||
Ferryl-oxo heme intermediate in the antimalarial mode of action of artemisinin | Q73851164 | ||
Comparison of 3D quantitative structure-activity relationship methods: analysis of the in vitro antimalarial activity of 154 artemisinin analogues by hypothetical active-site lattice and comparative molecular field analysis | Q74835547 | ||
EPR evidence for the involvement of free radicals in the iron-catalysed decomposition of qinghaosu (artemisinin) and some derivatives; antimalarial action of some polycyclic endoperoxides | Q77083696 | ||
Assessment of the pharmacodynamic properties of antimalarial drugs in vivo | Q24670346 | ||
Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum | Q27861931 | ||
The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin | Q28274190 | ||
The Plasmodium falciparum translationally controlled tumor protein: subcellular localization and calcium binding | Q30039014 | ||
Adverse effects in patients with acute falciparum malaria treated with artemisinin derivatives | Q33646966 | ||
Reaction of antimalarial endoperoxides with specific parasite proteins | Q33757165 | ||
Artemisinin derivatives for treating uncomplicated malaria | Q33908651 | ||
Artemether-lumefantrine for the treatment of multidrug-resistant falciparum malaria | Q33929311 | ||
Mechanisms of artemisinin resistance in the rodent malaria pathogen Plasmodium yoelii | Q33978709 | ||
In vitro and in vivo potentiation of artemisinin and synthetic endoperoxide antimalarial drugs by metalloporphyrins | Q33980800 | ||
Hemoglobin catabolism and iron utilization by malaria parasites | Q34415972 | ||
The potential of artemether for the control of schistosomiasis | Q34455017 | ||
Antimalarial drug resistance and combination chemotherapy | Q35212414 | ||
The mechanisms of parasite clearance after antimalarial treatment of Plasmodium falciparum malaria | Q38945844 | ||
Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum | Q38980049 | ||
Studies of the neurotoxicity of oral artemisinin derivatives in mice. | Q39308519 | ||
Assessment of the neurotoxicity of parenteral artemisinin derivatives in mice | Q39308526 | ||
Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study | Q39309831 | ||
The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand. | Q39472395 | ||
Immunoprecipitation of [(3)H]dihydroartemisinin translationally controlled tumor protein (TCTP) adducts from Plasmodium falciparum-infected erythrocytes by using anti-TCTP antibodies | Q39478101 | ||
Artesunate reduces but does not prevent posttreatment transmission of Plasmodium falciparum to Anopheles gambiae. | Q39511728 | ||
Plasmodium falciparum: in vitro studies of the pharmacodynamic properties of drugs used for the treatment of severe malaria | Q39517554 | ||
Neurotoxic mode of action of artemisinin | Q39653002 | ||
Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu). | Q39866015 | ||
The chemotherapy of rodent malaria, XL. The action of artemisinin and related sesquiterpenes | Q41914989 | ||
Qinghaosu-induced changes in the morphology of Plasmodium inui. | Q41917102 | ||
Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum | Q41918212 | ||
In vitro susceptibility of Plasmodium falciparum isolates in Vietnam to artemisinin derivatives and other antimalarials | Q41929149 | ||
In vitro stage-specific sensitivity of Plasmodium falciparum to quinine and artemisinin drugs | Q41930870 | ||
Effects of antimalarials and protease inhibitors on plasmodial hemozoin production | Q41934587 | ||
Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu on Plasmodium falciparum | Q41944750 | ||
Enhancement of hemin-induced membrane damage by artemisinin | Q42497034 | ||
Apparent drug failure following artesunate treatment of Plasmodium falciparum malaria in Freetown, Sierra Leone: four case reports | Q43697040 | ||
Structure-activity relationships of the antimalarial agent artemisinin. 6. The development of predictive in vitro potency models using CoMFA and HQSAR methodologies | Q43849708 | ||
Artemisinin (qinghaosu)--a new gametocytocidal drug for malaria | Q44147893 | ||
Artemisinin derivatives in the treatment of falciparum malaria in pregnancy | Q44514584 | ||
Alkylating capacity and reaction products of antimalarial trioxanes after activation by a heme model | Q45713615 | ||
Artemisinin (qinghaosu): the role of intracellular hemin in its mechanism of antimalarial action | Q47308607 | ||
Thalassaemia trait, red blood cell age and oxidant stress: effects on Plasmodium falciparum growth and sensitivity to artemisinin. | Q47826078 | ||
Two patients with falciparum malaria and poor in vivo responses to artesunate | Q47847492 | ||
Qinghaosu, dietary vitamin E, selenium, and cod-liver oil: effect on the susceptibility of mice to the malarial parasite Plasmodium yoelii | Q47898085 | ||
Arteether, a new antimalarial drug: synthesis and antimalarial properties | Q47910630 | ||
The interaction of artemisinin with malarial hemozoin | Q48016192 | ||
P433 | issue | 13 | |
P921 | main subject | artemisinin | Q426921 |
P304 | page(s) | 1655-1660 | |
P577 | publication date | 2002-12-01 | |
P1433 | published in | International Journal for Parasitology | Q6051284 |
P1476 | title | Artemisinin: mechanisms of action, resistance and toxicity | |
P478 | volume | 32 |
Q34602021 | 21st century natural product research and drug development and traditional medicines |
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Q38998772 | A randomised trial to assess the efficacy and safety of chlorproguanil/dapsone + artesunate for the treatment of uncomplicated Plasmodium falciparum malaria |
Q38194450 | A review of dihydroartemisinin as another gift from traditional Chinese medicine not only for malaria control but also for schistosomiasis control |
Q46925199 | A study on antimalarial artemisinin derivatives using MEP maps and multivariate QSAR. |
Q37138144 | Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent |
Q38089167 | Advances in the discovery and development of trematocidal drugs |
Q30632070 | Agglomerated oral dosage forms of artemisinin/β-cyclodextrin spray-dried primary microparticles showing increased dissolution rate and bioavailability |
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Q36222756 | Anti-malarial effect of semi-synthetic drug amitozyn |
Q37626137 | Anticancer activities of artemisinin and its bioactive derivatives |
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Q47972484 | Antimalarial activity of artemisinins: identification of a novel target? |
Q38967366 | Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice |
Q35840382 | Antimalarial combinations |
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Q35105092 | Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion |
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Q22061805 | Artemisinin and a Series of Novel Endoperoxide Antimalarials Exert Early Effects on Digestive Vacuole Morphology |
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Q39138866 | Artemisinin as a Chinese medicine, selectively induces apoptosis in pancreatic tumor cell line |
Q38042732 | Artemisinin derivatives: a patent review (2006 - present). |
Q46184684 | Artemisinin induces hormonal imbalance and oxidative damage in the erythrocytes and uterus but not in the ovary of rats. |
Q38725091 | Artemisinin inhibits inflammatory response via regulating NF-κB and MAPK signaling pathways |
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Q38772717 | Artemisinins as potential anticancer agents: uptake detection in erythrocytes using Fourier transform infrared spectroscopy and cytotoxicity against bladder cancer cells. |
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Q38855577 | Artesunate induces ROS- and p38 MAPK-mediated apoptosis and counteracts tumor growth in vivo in embryonal rhabdomyosarcoma cells |
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Q46758736 | Clinical pharmacokinetics of the diastereomers of arteether in healthy volunteers |
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Q41970025 | Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers). |
Q30497710 | Cryo transmission X-ray imaging of the malaria parasite, P. falciparum. |
Q37735182 | Current knowledge and challenges of antimalarial drugs for treatment and prevention in pregnancy |
Q38774777 | Current status of synthetic hemozoin adjuvant: A preliminary safety evaluation. |
Q34611440 | De Novo transcriptome assembly (NGS) of Curcuma longa L. rhizome reveals novel transcripts related to anticancer and antimalarial terpenoids |
Q27973107 | Deconvoluting heme biosynthesis to target blood-stage malaria parasites |
Q28478307 | Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells |
Q39675027 | Dihydroartemisinin Induces Apoptosis by a Bak-Dependent Intrinsic Pathway |
Q34292461 | Dihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5 |
Q36811863 | Dihydroartemisinin induces autophagy and inhibits the growth of iron-loaded human myeloid leukemia K562 cells via ROS toxicity |
Q39594720 | Dihydroartemisinin induces caspase-8-dependent apoptosis in murine GT1-7 hypothalamic neurons. |
Q50145429 | Dihydroartemisinin inhibits colon cancer cell viability by inducing apoptosis through up-regulation of PPARγ expression |
Q39921071 | Dihydroartemisinin is a Hypoxia-Active Anti-Cancer Drug in Colorectal Carcinoma Cells |
Q34740860 | Dihydroartemisinin promotes angiogenesis during the early embryonic development of zebrafish |
Q38949261 | Dihydroartemisinin suppresses glioma proliferation and invasion via inhibition of the ADAM17 pathway |
Q50053462 | Dihydroartemisinin treatment of multiple myeloma cells causes activation of c-Jun leading to cell apoptosis |
Q35006418 | Discovery, mechanisms of action and combination therapy of artemisinin |
Q28484494 | Dried whole plant Artemisia annua as an antimalarial therapy |
Q36248426 | Drug-resistant malaria |
Q39744038 | Effect of artemisinin derivatives on apoptosis and cell cycle in prostate cancer cells |
Q50596355 | Effect of oral coadministration of artesunate with ferrous sulfate on rat liver mitochondrial membrane permeability transition. |
Q40197611 | Effects of artemisinin and its derivatives on growth inhibition and apoptosis of oral cancer cells. |
Q37962462 | Effects of artemisinins on reticulocyte count and relationship to possible embryotoxicity in confirmed and unconfirmed malarial patients |
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Q37326475 | Embryotoxicity and toxicokinetics of the antimalarial artesunate in rats |
Q38710983 | Emerging Anti-Mitotic Activities and Other Bioactivities of Sesquiterpene Compounds upon Human Cells. |
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Q36118255 | Emerging issues in traditional Chinese medicine |
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Q43654854 | Engineering dynamic pathway regulation using stress-response promoters. |
Q90150657 | Enhancement Effect of Shark Cartilage Extract on Treatment of Leishmania infantum with Artemisinin and Glucantime and Evaluation of killing Factors and Apoptosis in-vitro Condition |
Q33743694 | Ergosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria. |
Q64235017 | Evaluation of synergistic therapeutic effect of shark cartilage extract with artemisinin and glucantime on visceral leishmaniasis in BALB/c mice |
Q28748825 | Evaluation of the effect of pyrimethamine, an anti-malarial drug, on HIV-1 replication |
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Q30362459 | Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites |
Q37857748 | Genetic analysis in mice identifies cysteamine as a novel partner for artemisinin in the treatment of malaria |
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