Artemisinin: mechanisms of action, resistance and toxicity

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Artemisinin: mechanisms of action, resistance and toxicity is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0020-7519(02)00194-7
P698PubMed publication ID12435450

P50authorSteven R. MeshnickQ62070963
P2860cites workArtemisinin, an Endoperoxide Antimalarial, Disrupts the Hemoglobin Catabolism and Heme Detoxification Systems in Malarial ParasiteQ22061847
Molecular modeling studies of the artemisinin (qinghaosu)-hemin interaction: docking between the antimalarial agent and its putative receptorQ48024666
Effects of artemisinin derivatives on malaria transmissibilityQ48027455
Ataxia and slurred speech after artesunate treatment for falciparum malariaQ48036625
Induction and isolation of artemisinine-resistant mutants of Plasmodium falciparum.Q54450901
Ring opening of artemisinin (qinghaosu) and dihydroartemisinin and interception of the open hydroperoxides with Formation of N-oxides — a chemical model for antimalarial mode of actionQ59870606
The behaviour of qinghaosu (artemisinin) in the presence of heme iron(II) and (III)Q59870621
Hemin-catalyzed decomposition of artemisinin (qinghaosu)Q68109840
The antimalarial action on Plasmodium falciparum of qinghaosu and artesunate in combination with agents which modulate oxidant stressQ68236209
Stage specific actions of antimalarial drugs on Plasmodium falciparum in cultureQ69491793
Atovaquone in the treatment of Babesia microti infections in hamstersQ71466000
Reaction between ferriprotoporphyrin IX and the antimalarial endoperoxide artesunate gives an intermediate species with enhanced redox catalytic activityQ71815492
Further Evidence Supporting the Importance of and the Restrictions on a Carbon-Centered Radical for High Antimalarial Activity of 1,2,4-Trioxanes Like ArtemisininQ71871177
Alkylation of proteins by artemisinin. Effects of heme, pH, and drug structureQ72145515
The toxicity of artemisinin and related compounds on neuronal and glial cells in cultureQ72236509
Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin: the importance of a carbon-centered radical for antimalarial activityQ72405730
Morphologic effects of artemisinin in Plasmodium falciparumQ72542894
Alkylation of human albumin by the antimalarial artemisininQ72870627
Correlation of antimalarial activity of artemisinin derivatives with binding affinity with ferroprotoporphyrin IXQ73126615
Artemisinin enhances heme-catalysed oxidation of lipid membranesQ73212284
Ferryl-oxo heme intermediate in the antimalarial mode of action of artemisininQ73851164
Comparison of 3D quantitative structure-activity relationship methods: analysis of the in vitro antimalarial activity of 154 artemisinin analogues by hypothetical active-site lattice and comparative molecular field analysisQ74835547
EPR evidence for the involvement of free radicals in the iron-catalysed decomposition of qinghaosu (artemisinin) and some derivatives; antimalarial action of some polycyclic endoperoxidesQ77083696
Assessment of the pharmacodynamic properties of antimalarial drugs in vivoQ24670346
Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparumQ27861931
The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisininQ28274190
The Plasmodium falciparum translationally controlled tumor protein: subcellular localization and calcium bindingQ30039014
Adverse effects in patients with acute falciparum malaria treated with artemisinin derivativesQ33646966
Reaction of antimalarial endoperoxides with specific parasite proteinsQ33757165
Artemisinin derivatives for treating uncomplicated malariaQ33908651
Artemether-lumefantrine for the treatment of multidrug-resistant falciparum malariaQ33929311
Mechanisms of artemisinin resistance in the rodent malaria pathogen Plasmodium yoeliiQ33978709
In vitro and in vivo potentiation of artemisinin and synthetic endoperoxide antimalarial drugs by metalloporphyrinsQ33980800
Hemoglobin catabolism and iron utilization by malaria parasitesQ34415972
The potential of artemether for the control of schistosomiasisQ34455017
Antimalarial drug resistance and combination chemotherapyQ35212414
The mechanisms of parasite clearance after antimalarial treatment of Plasmodium falciparum malariaQ38945844
Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparumQ38980049
Studies of the neurotoxicity of oral artemisinin derivatives in mice.Q39308519
Assessment of the neurotoxicity of parenteral artemisinin derivatives in miceQ39308526
Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective studyQ39309831
The pfmdr1 gene is associated with a multidrug-resistant phenotype in Plasmodium falciparum from the western border of Thailand.Q39472395
Immunoprecipitation of [(3)H]dihydroartemisinin translationally controlled tumor protein (TCTP) adducts from Plasmodium falciparum-infected erythrocytes by using anti-TCTP antibodiesQ39478101
Artesunate reduces but does not prevent posttreatment transmission of Plasmodium falciparum to Anopheles gambiae.Q39511728
Plasmodium falciparum: in vitro studies of the pharmacodynamic properties of drugs used for the treatment of severe malariaQ39517554
Neurotoxic mode of action of artemisininQ39653002
Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu).Q39866015
The chemotherapy of rodent malaria, XL. The action of artemisinin and related sesquiterpenesQ41914989
Qinghaosu-induced changes in the morphology of Plasmodium inui.Q41917102
Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparumQ41918212
In vitro susceptibility of Plasmodium falciparum isolates in Vietnam to artemisinin derivatives and other antimalarialsQ41929149
In vitro stage-specific sensitivity of Plasmodium falciparum to quinine and artemisinin drugsQ41930870
Effects of antimalarials and protease inhibitors on plasmodial hemozoin productionQ41934587
Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu on Plasmodium falciparumQ41944750
Enhancement of hemin-induced membrane damage by artemisininQ42497034
Apparent drug failure following artesunate treatment of Plasmodium falciparum malaria in Freetown, Sierra Leone: four case reportsQ43697040
Structure-activity relationships of the antimalarial agent artemisinin. 6. The development of predictive in vitro potency models using CoMFA and HQSAR methodologiesQ43849708
Artemisinin (qinghaosu)--a new gametocytocidal drug for malariaQ44147893
Artemisinin derivatives in the treatment of falciparum malaria in pregnancyQ44514584
Alkylating capacity and reaction products of antimalarial trioxanes after activation by a heme modelQ45713615
Artemisinin (qinghaosu): the role of intracellular hemin in its mechanism of antimalarial actionQ47308607
Thalassaemia trait, red blood cell age and oxidant stress: effects on Plasmodium falciparum growth and sensitivity to artemisinin.Q47826078
Two patients with falciparum malaria and poor in vivo responses to artesunateQ47847492
Qinghaosu, dietary vitamin E, selenium, and cod-liver oil: effect on the susceptibility of mice to the malarial parasite Plasmodium yoeliiQ47898085
Arteether, a new antimalarial drug: synthesis and antimalarial propertiesQ47910630
The interaction of artemisinin with malarial hemozoinQ48016192
P433issue13
P921main subjectartemisininQ426921
P304page(s)1655-1660
P577publication date2002-12-01
P1433published inInternational Journal for ParasitologyQ6051284
P1476titleArtemisinin: mechanisms of action, resistance and toxicity
P478volume32

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