What has traditional Chinese medicine delivered for modern medicine?

scientific article published on 11 May 2018

What has traditional Chinese medicine delivered for modern medicine? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1017/ERM.2018.3
P698PubMed publication ID29747718

P2093author name stringJigang Wang
Yin-Kwan Wong
Fulong Liao
P2860cites workThe Plasmodium falciparum Ca 2+ -ATPase PfATP6: insensitive to artemisinin, but a potential drug targetQ22061857
Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparumQ22061870
Artemisinins target the SERCA of Plasmodium falciparumQ22061877
A Randomised, Double Blind, Placebo-Controlled Pilot Study of Oral Artesunate Therapy for Colorectal CancerQ22061945
Randomized Phase III Trial of Retinoic Acid and Arsenic Trioxide Versus Retinoic Acid and Chemotherapy in Patients With Acute Promyelocytic Leukemia: Health-Related Quality-of-Life OutcomesQ23671265
A drug from poison: how the therapeutic effect of arsenic trioxide on acute promyelocytic leukemia was discoveredQ23671266
The antihyperglycaemic activity of berberine arises from a decrease of glucose absorptionQ44536650
Artesunate combinations for malariaQ44786739
Protective effects of Danshensu from the aqueous extract of Salvia miltiorrhiza (Danshen) against homocysteine-induced endothelial dysfunctionQ45110363
A randomized safety and tolerability trial of artesunate plus sulfadoxine--pyrimethamine versus sulfadoxine-pyrimethamine alone for the treatment of uncomplicated malaria in Gambian children.Q46365105
Effects of purified herbal extract of Salvia miltiorrhiza on ischemic rat myocardium after acute myocardial infarction.Q46420845
Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channelsQ46444472
Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobinQ46448577
Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberineQ46656835
Therapeutic wisdom in traditional Chinese medicine: a perspective from modern scienceQ47248621
Clinical observation of Danhong Injection (herbal TCM product from Radix Salviae miltiorrhizae and Flos Carthami tinctorii) in the treatment of traumatic intracranial hematomaQ47597154
Western-medicine-validated anti-tumor agents and traditional Chinese medicineQ47732460
The Fe2+-mediated decomposition, PfATP6 binding, and antimalarial activities of artemisone and other artemisinins: the unlikelihood of C-centered radicals as bioactive intermediatesQ47842376
Treatment of African children with uncomplicated falciparum malaria with a new antimalarial drug, CGP 56697.Q48037496
Characterization of the Artemisinin Binding Site for Translationally Controlled Tumor Protein (TCTP) by Bioorthogonal Click ChemistryQ48133209
Status and thoughts of Chinese patent medicines seeking approval in the US marketQ48540411
Excess hemoglobin digestion and the osmotic stability of Plasmodium falciparum-infected red blood cells.Q52024420
Study of the protective mechanisms of Compound Danshen Tablet (Fufang Danshen Pian) against myocardial ischemia/reperfusion injury via the Akt-eNOS signaling pathway in rats.Q54325734
Alkylation of proteins by artemisinin. Effects of heme, pH, and drug structureQ72145515
Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin: the importance of a carbon-centered radical for antimalarial activityQ72405730
Differential SMN2 expression associated with SMA severityQ77525869
Arsenite induces apoptosis via a direct effect on the mitochondrial permeability transition poreQ77874093
Traditional Chinese medicineQ79637865
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trialQ24630683
Efficacy of berberine in patients with type 2 diabetes mellitusQ24645248
Chinese Herbal Medicine for Symptom Management in Cancer Palliative Care: Systematic Review And Meta-analysisQ26765134
Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data.Q26783902
Danhong Injection (a Traditional Chinese Patent Medicine) for Acute Myocardial Infarction: A Systematic Review and Meta-AnalysisQ26785588
The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locusQ28241824
Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxidesQ28266857
Profiling of Multiple Targets of Artemisinin Activated by Hemin in Cancer Cell ProteomeQ28273065
The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisininQ28274190
Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical useQ28282171
The quest for modernisation of traditional Chinese medicineQ28292682
Cardiovascular effects of DanshenQ28293119
Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradationQ28367104
Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemiaQ28370464
Efficacy and safety of traditional chinese medicine for diabetes: a double-blind, randomised, controlled trialQ28487001
Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor b expression in diabetic rat liverQ28564768
Natural products as sources of new drugs over the 30 years from 1981 to 2010Q29616640
A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoproteinQ29620737
Artemisinin-A Gift from Traditional Chinese Medicine to the World (Nobel Lecture).Q30248633
Artemisinins Target GABAA Receptor Signaling and Impair α Cell IdentityQ30365127
Drug discovery and natural products: end of an era or an endless frontier?Q30866998
Retinoic acid and arsenic trioxide for acute promyelocytic leukemiaQ33409020
Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML.Q33551142
Biphasic effects of sodium danshensu on vessel function in isolated rat aortaQ33557238
Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medicationQ33650571
First-in-human phase II trial of the botanical formulation PHY906 with capecitabine as second-line therapy in patients with advanced pancreatic cancerQ34008520
The antimalarial drug artemisinin alkylates heme in infected miceQ34015782
Arsenic trioxide - An old drug rediscoveredQ34054167
Heme as trigger and target for trioxane-containing antimalarial drugs.Q34134820
Qinghaosu (artemisinin): an antimalarial drug from ChinaQ34193570
The discovery of artemisinin (qinghaosu) and gifts from Chinese medicineQ34223139
Old formula, new Rx: the journey of PHY906 as cancer adjuvant therapyQ34253726
Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysisQ34309558
Natural products: a continuing source of novel drug leadsQ34328933
The efficacy of Chinese herbal medicine as an adjunctive therapy for advanced non-small cell lung cancer: a systematic review and meta-analysis.Q34331575
Arsenic trioxide, a therapeutic agent for APL.Q34435492
Pathways of retinoic acid- or arsenic trioxide-induced PML/RARalpha catabolism, role of oncogene degradation in disease remissionQ34435558
Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxideQ34478428
Involvement of CD95-independent caspase 8 activation in arsenic trioxide-induced apoptosisQ34511210
All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemiaQ34546653
Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemiaQ34563645
Target identification for small bioactive molecules: finding the needle in the haystackQ34589404
Arsenic trioxide: mechanisms of actionQ34638579
New developments in the chemistry and biology of the bioactive constituents of TanshenQ34652663
Traditional Chinese medicine in cancer care: a review of controlled clinical studies published in chinese.Q34656398
Acute promyelocytic leukemia: from highly fatal to highly curableQ34755208
Artemisinin: mechanisms of action, resistance and toxicityQ34999485
Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protectionQ35041476
Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestionQ35105092
Application of berberine on treating type 2 diabetes mellitusQ35226998
Effects of danshensu on platelet aggregation and thrombosis: in vivo arteriovenous shunt and venous thrombosis models in ratsQ35398540
Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertensionQ35512345
Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitusQ35751965
Chinese herb and formulas for promoting blood circulation and removing blood stasis and antiplatelet therapiesQ35796683
Chinese Herbal Medicine Treatment Improves the Overall Survival Rate of Individuals with Hypertension among Type 2 Diabetes Patients and Modulates In Vitro Smooth Muscle Cell ContractilityQ35877249
Target identification of natural and traditional medicines with quantitative chemical proteomics approachesQ35903397
Toward a scientific understanding of the effectiveness, material basis and prescription compatibility of a Chinese herbal formula Dan-hong injectionQ36341859
Modulating gut microbiota as an anti-diabetic mechanism of berberine.Q36516516
The antimalarial trioxaquine DU1301 alkylates heme in malaria-infected mice.Q36803908
Molecular understanding and modern application of traditional medicines: triumphs and trials.Q36828585
From traditional Chinese medicine to rational cancer therapy.Q36888420
Recent advances in understanding the mechanism of hemozoin (malaria pigment) formationQ37069799
The Relationship between Traditional Chinese Medicine and Modern MedicineQ37101065
Traditional Chinese medicines (TCMs) for molecular targeted therapies of tumours.Q37692436
Toxicity of the antimalarial artemisinin and its dervatives.Q37693152
The molecular mechanism of action of artemisinin--the debate continues.Q37718570
Berberine: a potential phytochemical with multispectrum therapeutic activitiesQ37788220
Acute promyelocytic leukaemia: novel insights into the mechanisms of cureQ37802188
Arsenic trioxide for management of acute promyelocytic leukemia: current evidence on its role in front-line therapy and recurrent diseaseQ37999067
Artemisinins: pharmacological actions beyond anti-malarialQ38169463
Berberine as a promising anti-diabetic nephropathy drug: An analysis of its effects and mechanismsQ38442501
Effectiveness of Chinese herbal medicine for cancer palliative care: overview of systematic reviews with meta-analyses.Q38669935
Open randomized trial of oral artemether alone and a sequential combination with mefloquine for acute uncomplicated falciparum malariaQ39188532
Randomised trial of artesunate and mefloquine alone and in sequence for acute uncomplicated falciparum malariaQ39188623
Danshensu is the major marker for the antioxidant and vasorelaxation effects of Danshen (Salvia miltiorrhiza) water-extracts produced by different heat water-extractionsQ39268306
Alteration in miRNA gene expression pattern in acute promyelocytic leukemia cell induced by arsenic trioxide: a possible mechanism to explain arsenic multi-target action.Q39445570
Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs.Q39491810
Treatment of diabetes using traditional Chinese medicine: past, present and futureQ39562298
Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expressionQ39908313
Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant statesQ40250572
Progress in traditional Chinese medicineQ40469875
Effects of berberine on glucose metabolism in vitroQ40693802
Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinaseQ40857729
Randomised comparative study of mefloquine, qinghaosu, and pyrimethamine-sulfadoxine in patients with falciparum malariaQ41918058
Trioxaquines and heme-artemisinin adducts inhibit the in vitro formation of hemozoin better than chloroquine.Q41942403
Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cellsQ42545311
Blood's 70th anniversary: arsenic--from poison pill to magic bullet.Q42910730
PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3.Q42978007
Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437.Q43830969
Phase I/IIA randomized study of PHY906, a novel herbal agent, as a modulator of chemotherapy in patients with advanced colorectal cancerQ44348824
Molecular modes of action of artesunate in tumor cell lines.Q44517624
P921main subjecttraditional Chinese medicineQ200253
P304page(s)e4
P577publication date2018-05-11
P1433published inExpert Reviews in Molecular MedicineQ15755244
P1476titleWhat has traditional Chinese medicine delivered for modern medicine?
P478volume20

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cites work (P2860)
Q92945448A Discovery of Clinically Approved Formula FBRP for Repositioning to Treat HCC by Inhibiting PI3K/AKT/NF-κB Activation
Q57814810Quantitative and systems pharmacology 4. Network-based analysis of drug pleiotropy on coronary artery disease

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