scholarly article | Q13442814 |
P819 | ADS bibcode | 2011PNAS..108.8668C |
P356 | DOI | 10.1073/PNAS.1015022108 |
P932 | PMC publication ID | 3102347 |
P698 | PubMed publication ID | 21555587 |
P5875 | ResearchGate publication ID | 51110787 |
P2093 | author name string | James Graham | |
David Danielpour | |||
Mark W Jackson | |||
Martha Stampfer | |||
Rocky Cipriano | |||
Charlene E Kan | |||
P2860 | cites work | The Hallmarks of Cancer | Q221226 |
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Stepwise DNA methylation changes are linked to escape from defined proliferation barriers and mammary epithelial cell immortalization. | Q37229718 | ||
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Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a). | Q39605512 | ||
C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells | Q39954044 | ||
Inactivation of p53 function in cultured human mammary epithelial cells turns the telomere-length dependent senescence barrier from agonescence into crisis. | Q40099043 | ||
High-resolution mapping of molecular events associated with immortalization, transformation, and progression to breast cancer in the MCF10 model. | Q40345520 | ||
Aberrant function of the Ras signal transduction pathway in human breast cancer | Q40445366 | ||
Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. | Q40845331 | ||
Defects in TGF-beta signaling overcome senescence of mouse keratinocytes expressing v-Ha-ras | Q40887247 | ||
Chromosome 9p allelic loss and p16/CDKN2 in breast cancer and evidence of p16 inactivation in immortal breast epithelial cells | Q41328336 | ||
Senescent Human Diploid Cells in Culture: Survival, DNA Synthesis and Morphology | Q41502456 | ||
The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence. | Q42123048 | ||
A negative feedback signaling network underlies oncogene-induced senescence | Q43116108 | ||
Effects of transforming growth factor beta on growth of human mammary epithelial cells in culture | Q44185366 | ||
Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion | Q46230264 | ||
P433 | issue | 21 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 8668-8673 | |
P577 | publication date | 2011-05-09 | |
P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
P1476 | title | TGF-beta signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells | |
P478 | volume | 108 |
Q90134538 | A FAM83A Positive Feed-back Loop Drives Survival and Tumorigenicity of Pancreatic Ductal Adenocarcinomas |
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Q34688159 | Are there roles for brain cell senescence in aging and neurodegenerative disorders? |
Q35891245 | Attenuation of TGF-β signaling suppresses premature senescence in a p21-dependent manner and promotes oncogenic Ras-mediated metastatic transformation in human mammary epithelial cells |
Q38051156 | Basic consideration of research strategies for head and neck cancer. |
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Q34579889 | Constitutive CCND1/CDK2 activity substitutes for p53 loss, or MYC or oncogenic RAS expression in the transformation of human mammary epithelial cells |
Q38055308 | Controversial aspects of oncogene-induced senescence |
Q37525854 | Coordinated regulation of p31(Comet) and Mad2 expression is required for cellular proliferation |
Q46897923 | Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence |
Q33739319 | Epigenome remodelling in breast cancer: insights from an early in vitro model of carcinogenesis |
Q34606469 | Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells |
Q27005909 | Extracellular matrix as a contextual determinant of transforming growth factor-β signaling in epithelial-mesenchymal transition and in cancer |
Q24296283 | FAM83B mediates EGFR- and RAS-driven oncogenic transformation |
Q24292888 | FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies |
Q28295550 | Growth arrest and DNA damage 45G down-regulation contributes to Janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma |
Q37066459 | HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis |
Q41627509 | Haplodeficiency of Ataxia Telangiectasia Mutated Accelerates Heart Failure After Myocardial Infarction |
Q54969736 | Human cytomegalovirus glycoprotein B inhibits migration of breast cancer MDA-MB-231 cells and impairs TGF-β/Smad2/3 expression. |
Q36941497 | Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations |
Q36185771 | Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations. |
Q90197696 | Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors |
Q36019718 | Low dose IR-induced IGF-1-sCLU expression: a p53-repressed expression cascade that interferes with TGFβ1 signaling to confer a pro-survival bystander effect |
Q37299696 | Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis. |
Q40837123 | Multidrug resistance protein 3 loss promotes tumor formation by inducing senescence escape. |
Q36208555 | Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response in immortalized cells. |
Q52797980 | Oncostatin M activation of Stat3:Smad3 complexes drives senescence. |
Q33902576 | Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling |
Q34482997 | Phosphorylation of ΔNp63α via a novel TGFβ/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFβ. |
Q42720346 | Protein O-glucosyltransferase 1 overexpression downregulates p16 in BT474 human breast cancer cells |
Q61805780 | RAC1B: A Rho GTPase with Versatile Functions in Malignant Transformation and Tumor Progression |
Q33847432 | Rapamycin enhances the antiproliferative effect of transforming growth factor-β on MCF-7 human breast cancer cells |
Q41838045 | Regulation of p53 during senescence in normal human keratinocytes. |
Q36545237 | SIP1 is a downstream effector of GADD45G in senescence induction and growth inhibition of liver tumor cells |
Q38790057 | STAT3-mediated SMAD3 activation underlies Oncostatin M-induced Senescence |
Q63916359 | Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2 |
Q33722545 | Suppression of Transforming Growth Factor-β Signaling Delays Cellular Senescence and Preserves the Function of Endothelial Cells Derived from Human Pluripotent Stem Cells |
Q39029986 | TGF-β Family Signaling in the Control of Cell Proliferation and Survival |
Q38670666 | TGF-β-Dependent Growth Arrest and Cell Migration in Benign and Malignant Breast Epithelial Cells Are Antagonistically Controlled by Rac1 and Rac1b |
Q58568282 | Targeting 17q23 amplicon to overcome the resistance to anti-HER2 therapy in HER2+ breast cancer |
Q89835065 | The Histone Code of Senescence |
Q42380380 | The Immortal Senescence |
Q49988025 | The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway. |
Q37916975 | Transforming growth factor-β in the gastrointestinal and hepatic tumor microenvironment. |
Q37162410 | Tumor microenvironmental signaling elicits epithelial-mesenchymal plasticity through cooperation with transforming genetic events |
Q33975103 | c-MYC functions as a molecular switch to alter the response of human mammary epithelial cells to oncostatin M. |
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