ABCG2: a perspective.

scientific article

ABCG2: a perspective. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.ADDR.2008.11.003
P8608Fatcat IDrelease_q2oa3gf6hvamhp7ljfumc2454u
P932PMC publication ID3105088
P698PubMed publication ID19135109
P5875ResearchGate publication ID23769394

P50authorKenneth Kin Wah ToQ55458847
Rob RobeyQ58798575
Susan E BatesQ88874526
Michael DeanQ37841464
P2093author name stringPatricia Fetsch
Orsolya Polgar
Marius Dohse
P2860cites workA human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistanceQ22008526
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell lineQ24338329
Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surfaceQ24553151
ABC Transporters: From Microorganisms to ManQ28181688
The human ATP-binding cassette (ABC) transporter superfamilyQ28204495
Multidrug resistance in cancer: role of ATP-dependent transportersQ28208049
The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitorsQ28214940
Expression and transport activity of breast cancer resistance protein (Bcrp/Abcg2) in dually perfused rat placenta and HRP-1 cell lineQ28567948
Functional expression of rat ABCG2 on the luminal side of brain capillaries and its enhancement by astrocyte-derived soluble factor(s)Q28569107
Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the ratQ28572818
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotypeQ29615563
Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivoQ29619355
Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) geneQ30724183
The GxxxG motif: a framework for transmembrane helix-helix associationQ30839523
The expression and functional characterization of ABCG2 in brain endothelial cells and vesselsQ30980421
Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genesQ31932176
An ATP-binding cassette gene (ABCG3) closely related to the multidrug transporter ABCG2 (MXR/ABCP) has an unusual ATP-binding domainQ31936637
Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cellsQ42053730
The distribution of drug-efflux pumps, P-gp, BCRP, MRP1 and MRP2, in the normal blood-testis barrier and in primary testicular tumours.Q42466925
N-Linked glycosylation of the human ABC transporter ABCG2 on asparagine 596 is not essential for expression, transport activity, or trafficking to the plasma membraneQ42476415
The nature of amino acid 482 of human ABCG2 affects substrate transport and ATP hydrolysis but not substrate bindingQ42497704
Involvement of breast cancer resistance protein (BCRP/ABCG2) in the biliary excretion and intestinal efflux of troglitazone sulfate, the major metabolite of troglitazone with a cholestatic effectQ42503887
Reduced drug accumulation and multidrug resistance in human breast cancer cells without associated P-glycoprotein or MRP overexpressionQ42814970
The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with hemeQ42830333
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.Q43579744
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.Q43739398
Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.Q44245530
C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance.Q44246870
Polymorphism C3435T of the MDR-1 gene predicts response to preoperative chemotherapy in locally advanced breast cancerQ44396425
Characterisation of the brain multidrug resistance protein (BMDP/ABCG2/BCRP) expressed at the blood–brain barrierQ44410490
Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cellsQ44490307
Overexpression of P-glycoprotein in K562 cells does not confer resistance to the growth inhibitory effects of imatinib (STI571) in vitroQ44525894
Single nucleotide polymorphisms result in impaired membrane localization and reduced atpase activity in multidrug transporter ABCG2.Q44747134
Pheophorbide a is a specific probe for ABCG2 function and inhibition.Q44769964
Identification of a novel estrogen response element in the breast cancer resistance protein (ABCG2) geneQ44769966
Functional C3435T polymorphism of MDR1 gene: an impact on genetic susceptibility and clinical outcome of childhood acute lymphoblastic leukemia.Q44826211
Isolation and genetic characterization of human KB cell lines resistant to multiple drugsQ44844584
Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier.Q44883138
Subcellular localization of the ABCG2 transporter in normal and malignant human gallbladder epitheliumQ44898058
Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotypeQ44960521
Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studiesQ44991784
Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) sulfate in breast cancer resistance protein (BCRP1/ABCG2) knockout miceQ45023481
Breast cancer resistance protein and P-glycoprotein in 149 adult acute myeloid leukemiasQ45178457
The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.Q45246954
Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronides.Q45305094
Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type miceQ46413821
Regulation of the cell surface expression of human BCRP/ABCG2 by the phosphorylation state of Akt in polarized cellsQ46448053
Effect of ABCG2 genotype on the oral bioavailability of topotecanQ46503033
The role of placental breast cancer resistance protein in the efflux of glyburide across the human placentaQ46536640
Distribution of breast cancer resistance protein (BCRP/ABCG2) mRNA expression along the human GI tractQ46584750
Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milkQ46586540
The effect of P-gp (Mdr1a/1b), BCRP (Bcrp1) and P-gp/BCRP inhibitors on the in vivo absorption, distribution, metabolism and excretion of imatinibQ46617229
Identification of intra- and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2.Q46656254
Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicityQ46726161
P-glycoprotein and breast cancer resistance protein: two dominant transporters working together in limiting the brain penetration of topotecanQ46920680
Breast cancer resistance protein: mediating the trans-placental transfer of glyburide across the human placentaQ46960810
Disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in relation to ABC transporter genotypesQ46967012
Evolution of the vertebrate ABC gene family: analysis of gene birth and deathQ48090918
Modulation of the brain distribution of imatinib and its metabolites in mice by valspodar, zosuquidar and elacridarQ48230991
Isolation and characterization of an anthracycline-resistant human leukemic cell line.Q48543772
Short communication: a polymorphism in ABCG2 in Bos indicus and Bos taurus cattle breeds.Q50474210
Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR.Q52171281
Expression of breast cancer resistance protein in blast cells from patients with acute leukemia.Q53408008
Influence of breast cancer resistance protein (Abcg2) and p-glycoprotein (Abcb1a) on the transport of imatinib mesylate (Gleevec® ) across the mouse blood-brain barrierQ57374265
Interaction of enrofloxacin with breast cancer resistance protein (BCRP/ABCG2): influence of flavonoids and role in milk secretion in sheepQ61736943
Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase 2 trial.Q64911638
Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell LinesQ72561176
Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecanQ73088375
Pharmacogenetics of ABCG2 and adverse reactions to gefitinibQ79407999
Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemiaQ79455910
Independent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids, and growth factorsQ79608737
The important role of Bcrp (Abcg2) in the biliary excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in miceQ80229300
Evidence for the interaction of imatinib at the transport-substrate site(s) of the multidrug-resistance-linked ABC drug transporters ABCB1 (P-glycoprotein) and ABCG2Q80777899
ABCG2: structure, function and role in drug responseQ80968077
Breast cancer resistance protein 1 limits fetal distribution of nitrofurantoin in the pregnant mouseQ81038641
MDR1 single nucleotide polymorphisms predict response to vinorelbine-based chemotherapy in patients with non-small cell lung cancerQ81240787
The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinibQ81604961
Estrogen-mediated post transcriptional down-regulation of breast cancer resistance protein/ABCG2Q95800148
Regulation of ABCG2 expression at the 3' untranslated region of its mRNA through modulation of transcript stability and protein translation by a putative microRNA in the S1 colon cancer cell line.Q36846027
Part II: management of resistance to imatinib in chronic myeloid leukaemiaQ37022464
Effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of phytoestrogensQ38299812
Localization of the ABCG2 mitoxantrone resistance-associated protein in normal tissues.Q38442081
Amplification of 4q21-q22 and the MXR gene in independently derived mitoxantrone-resistant cell linesQ38498733
ABCG2/BCRP decreases the transfer of a food-born chemical carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in perfused term human placenta.Q39953815
Quantitative investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) in limiting brain and testis penetration of xenobiotic compoundsQ40005555
ABCG2 expression and side population abundance regulated by a transforming growth factor beta-directed epithelial-mesenchymal transitionQ40017306
In vitro evaluation of photosensitivity risk related to genetic polymorphisms of human ABC transporter ABCG2 and inhibition by drugsQ40030959
The breast cancer resistance protein (Bcrp1/Abcg2) limits fetal distribution of glyburide in the pregnant mouse: an Obstetric-Fetal Pharmacology Research Unit Network and University of Washington Specialized Center of Research StudyQ40035590
Progesterone receptor (PR) isoforms PRA and PRB differentially regulate expression of the breast cancer resistance protein in human placental choriocarcinoma BeWo cellsQ40043860
Evaluation of the role of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated protein 4 (MRP4/ABCC4) in the urinary excretion of sulfate and glucuronide metabolites of edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5Q40097205
Involvement of breast cancer resistance protein (ABCG2) in the biliary excretion mechanism of fluoroquinolones.Q40105359
Oligomerization domain of the multidrug resistance-associated transporter ABCG2 and its dominant inhibitory activityQ40136502
The tyrosine kinase inhibitor imatinib mesylate enhances the efficacy of photodynamic therapy by inhibiting ABCG2.Q40145054
Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitorQ40220295
Effects of sex hormones on regulation of ABCG2 expression in the placental cell line BeWoQ40254328
Novel 5' untranslated region variants of BCRP mRNA are differentially expressed in drug-selected cancer cells and in normal human tissues: implications for drug resistance, tissue-specific expression, and alternative promoter usageQ40278791
Breast cancer resistance protein (Bcrp/abcg2) is a major determinant of sulfasalazine absorption and elimination in the mouseQ40281717
Functional ABCG2 is overexpressed on primary CML CD34+ cells and is inhibited by imatinib mesylateQ40289723
Functional validation of the genetic polymorphisms of human ATP-binding cassette (ABC) transporter ABCG2: identification of alleles that are defective in porphyrin transport.Q40293727
Breast cancer resistance protein (BCRP/ABCG2) is expressed by progenitor cells/reactive ductules and hepatocytes and its expression pattern is influenced by disease etiology and species type: possible functional consequencesQ40324109
Breast cancer resistance protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretionQ40325508
Regulation of BCRP/ABCG2 expression by progesterone and 17beta-estradiol in human placental BeWo cellsQ40340314
Characterization of ABCG2 gene amplification manifesting as extrachromosomal DNA in mitoxantrone-selected SF295 human glioblastoma cells.Q40402929
Involvement of BCRP (ABCG2) in the biliary excretion of pitavastatinQ40409926
Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonistsQ40417118
Lack of improvement of oral absorption of ME3277 by prodrug formation is ascribed to the intestinal efflux mediated by breast cancer resistant protein (BCRP/ABCG2).Q40431648
Cyclosporin A is a broad-spectrum multidrug resistance modulatorQ40443016
Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2.Q40446340
The breast cancer resistance protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion, and milk secretion of the antibiotic nitrofurantoin.Q40458879
Mutational analysis of ABCG2: role of the GXXXG motifQ40534113
High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporterQ40553425
Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitroQ40571040
Single amino acid substitutions in the transmembrane domains of breast cancer resistance protein (BCRP) alter cross resistance patterns in transfectants.Q40624976
The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.Q40626046
Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded materialQ40633176
MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line modelsQ40667580
Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerizationQ40755310
Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein.Q40904151
Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C.Q40985808
Cross-resistance to camptothecin analogues in a mitoxantrone-resistant human breast carcinoma cell line is not due to DNA topoisomerase I alterationsQ41295118
Reduced intracellular drug accumulation in the absence of P-glycoprotein (mdr1) overexpression in mitoxantrone-resistant human MCF-7 breast cancer cellsQ41594260
Membrane vesicle formation due to acquired mitoxantrone resistance in human gastric carcinoma cell line EPG85-257.Q41721659
Characterization of adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane proteinQ41730997
Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2.Q41792411
Akt signaling regulates side population cell phenotype via Bcrp1 translocation.Q33187686
Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity.Q33194953
Single nucleotide polymorphisms modify the transporter activity of ABCG2.Q33214177
Mutational studies of G553 in TM5 of ABCG2: a residue potentially involved in dimerizationQ33240063
Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cellsQ33247258
Subcellular distribution of daunorubicin in P-glycoprotein-positive and -negative drug-resistant cell lines using laser-assisted confocal microscopyQ33247937
Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells.Q33285468
Genetic support for a quantitative trait nucleotide in the ABCG2 gene affecting milk composition of dairy cattleQ33288487
The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane.Q33304788
Localisation of breast cancer resistance protein in microvessel endothelium of human brainQ33962609
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugsQ34059522
Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivoQ34156054
The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoproteinQ34235311
VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance proteinQ34304819
ATP-binding cassette transporters in bacteriaQ34326023
Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters.Q34369690
The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.Q34388548
Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebratesQ34446056
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutantsQ34488592
Transport of glyburide by placental ABC transporters: implications in fetal drug exposure.Q34491784
The blood-brain barrier and cancer: transporters, treatment, and Trojan horsesQ34577796
ABC transporters and inhibitors: new targets, new agents.Q35023165
Aberrant promoter methylation of the ABCG2 gene in renal carcinomaQ35131563
Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cellsQ35612557
Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milkQ35641888
Histone modifications at the ABCG2 promoter following treatment with histone deacetylase inhibitor mirror those in multidrug-resistant cellsQ35837565
ABCG2 expression, function, and promoter methylation in human multiple myelomaQ35848835
Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome predictionQ35848938
Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defenseQ36104162
Mechanisms of resistance to anticancer drugs: the role of the polymorphic ABC transporters ABCB1 and ABCG2.Q36120816
Effect of calcium antagonists on the chemosensitivity of two multidrug-resistant human tumour cell lines which do not overexpress P-glycoproteinQ36466963
Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1).Q36691571
ABCG2: determining its relevance in clinical drug resistanceQ36745478
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)3-13
P577publication date2008-12-16
P1433published inAdvanced Drug Delivery ReviewsQ2825362
P1476titleABCG2: a perspective
P478volume61

Reverse relations

cites work (P2860)
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Q38883165Natural Polyphenols in Cancer Chemoresistance.
Q37193073Overlapping substrate and inhibitor specificity of human and murine ABCG2.
Q36953090PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo
Q26777643Pathobiology of tobacco smoking and neurovascular disorders: untied strings and alternative products
Q46018199PharmGKB summary: very important pharmacogene information for ABCG2.
Q38242601Pharmacogenetics of membrane transporters: a review of current approaches.
Q37875115Pharmacogenomics and adverse drug reactions: the case of statins
Q36734138Pharmacokinetics of drugs in pregnancy
Q35585820Photochemical internalisation, a minimally invasive strategy for light-controlled endosomal escape of cancer stem cell-targeting therapeutics.
Q37082646Placental expression of the heme transporter, feline leukemia virus subgroup C receptor, is related to maternal iron status in pregnant adolescents.
Q37686521Population-specific association between ABCG2 variants and tophaceous disease in people with gout
Q42676608Positive regulation of the Candida albicans multidrug efflux pump Cdr1p function by phosphorylation of its N-terminal extension.
Q38282100Potency of non-steroidal anti-inflammatory drugs in chemotherapy.
Q84007319Preoperative taxane-based chemotherapy and celecoxib for carcinoma of the esophagus and gastroesophageal junction: results of a phase 2 trial
Q38166961Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier.
Q51749326Rare Variants in the ABCG2 Promoter Modulate In Vivo Activity.
Q37604385Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines
Q32181276Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling
Q38514267Regulation of the function of the human ABCG2 multidrug transporter by cholesterol and bile acids: effects of mutations in potential substrate and steroid binding sites
Q36027132Reversing multidrug resistance in breast cancer cells by silencing ABC transporter genes with nanoparticle-facilitated delivery of target siRNAs
Q50642121Role of STAT5 and epigenetics in lactation-associated upregulation of multidrug transporter ABCG2 in the mammary gland.
Q33890952Role of basic residues within or near the predicted transmembrane helix 2 of the human breast cancer resistance protein in drug transport
Q26865927Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance
Q34211113Role of breast cancer resistance protein in the adaptive response to cholestasis
Q28548494SALL4 as an Epithelial-Mesenchymal Transition and Drug Resistance Inducer through the Regulation of c-Myc in Endometrial Cancer
Q37311636Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver.
Q89642081Simvastatin intolerance genetic determinants: some features in ethnic Uzbek patients with coronary artery disease
Q38068912Species differences in drug transporters and implications for translating preclinical findings to humans
Q28482973StarD7 knockdown modulates ABCG2 expression, cell migration, proliferation, and differentiation of human choriocarcinoma JEG-3 cells
Q36413366Stemness and chemotherapeutic drug resistance induced by EIF5A2 overexpression in esophageal squamous cell carcinoma
Q88249559Structural basis of small-molecule inhibition of human multidrug transporter ABCG2
Q34176588Structure and Function of the Human Breast Cancer Resistance Protein (BCRP/ABCG2)
Q41597764Structure of the human multidrug transporter ABCG2.
Q48344291Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers.
Q37560771Structure-activity relationships and quantitative structure-activity relationships for breast cancer resistance protein (ABCG2).
Q35855634Targeting blood-brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery
Q37317194Targeting the chromatin remodeling enzyme BRG1 increases the efficacy of chemotherapy drugs in breast cancer cells
Q28088708Targeting transporters: promoting blood-brain barrier repair in response to oxidative stress injury
Q37059699The ABC membrane transporter ABCG2 prevents access of FAAH inhibitor URB937 to the central nervous system
Q91525910The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid
Q37810986The ABCG2 transporter and its relations with the pharmacokinetics, drug interaction and lipid-lowering effects of statins
Q36790321The Lipid Transfer Protein StarD7: Structure, Function, and Regulation
Q28395237The blood-testis barrier and its implications for male contraception
Q38089090The controversy of a wider statin utilization: why?
Q40147815The human breast cancer resistance protein (BCRP/ABCG2) shows conformational changes with mitoxantrone
Q34631971The role of OATP1B1 and BCRP in pharmacokinetics and DDI of novel statins
Q36332448The sensitivity of glioma cells to pyropheophorbide-αmethyl ester-mediated photodynamic therapy is enhanced by inhibiting ABCG2.
Q35927508Three-dimensional structure of the human breast cancer resistance protein (BCRP/ABCG2) in an inward-facing conformation
Q37963498Translocation of nucleoside analogs across the plasma membrane in hematologic malignancies
Q33672739Transmembrane helices 1 and 6 of the human breast cancer resistance protein (BCRP/ABCG2): identification of polar residues important for drug transport
Q37627544Transporter pharmacogenetics and statin toxicity
Q37735146Transporter pharmacogenetics: transporter polymorphisms affect normal physiology, diseases, and pharmacotherapy
Q57684264Transporters in Drug Discovery
Q84437444Transverse and tangential orientation of predicted transmembrane fragments 4 and 10 from the human multidrug resistance protein (hMRP1/ABCC1) in membrane mimics
Q37190973Tumorigenic lung tumorospheres exhibit stem-like features with significantly increased expression of CD133 and ABCG2.
Q37151581Unconjugated bilirubin elevation impairs the function and expression of breast cancer resistance protein (BCRP) at the blood-brain barrier in bile duct-ligated rats
Q39584939Upregulation of ABCG2 by romidepsin via the aryl hydrocarbon receptor pathway.
Q52721223Validation of membrane vesicle-based breast cancer resistance protein and multidrug resistance protein 2 assays to assess drug transport and the potential for drug-drug interaction to support regulatory submissions.
Q35776784Xanthines down-regulate the drug transporter ABCG2 and reverse multidrug resistance

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