From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme

scientific article published on 29 February 2020

From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/CELLS9030579
P932PMC publication ID7140478
P698PubMed publication ID32121449

P2093author name stringOleh Khalimonchuk
Amit R Reddi
Courtney M Moore
Amy E Medlock
Jason R Marcero
Samantha A Swenson
P2860cites workIterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidaseQ21184006
SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndromeQ22008476
Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is disrupted in sideroblastic anemiaQ22253368
A mutation in the human heme A:farnesyltransferase gene (COX10 ) causes cytochrome c oxidase deficiencyQ22253915
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Measurement of heme concentrationQ42856098
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Intravenous heme-albumin in acute intermittent porphyria: evidence for repletion of hepatic hemoproteins and regulatory heme poolsQ43898909
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Identification of novel hemes generated by heme A synthase: evidence for two successive monooxygenase reactionsQ44121782
Why heme needs to be degraded to iron, biliverdin IXalpha, and carbon monoxide?Q45042106
Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alphaQ46669140
Mitochondrial cytochrome c oxidase biogenesis: Recent developments.Q47783506
Mutation in human CLPX elevates levels of δ-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyriaQ47851870
Spatial distribution of heme species in erythrocytes infected with Plasmodium falciparum by use of resonance Raman imaging and multivariate analysisQ47879703
Measurement of heme efflux and heme content in isolated developing chloroplastsQ47920900
Molecular analysis of cytochrome c oxidase deficiency in Leigh's syndromeQ48054632
Endocytosis of Red Blood Cell Microparticles by Pulmonary Endothelial Cells is Mediated By Rab5.Q50042263
Identification of the receptor scavenging hemopexin-heme complexes.Q50337480
The Fowler syndrome-associated protein FLVCR2 is an importer of hemeQ24298998
The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpinQ24299093
Mitochondrial Atpif1 regulates haem synthesis in developing erythroblastsQ24302493
Identification of a human heme exporter that is essential for erythropoiesisQ24304121
Identification of a mammalian mitochondrial porphyrin transporterQ24305008
The mitochondrial heme exporter FLVCR1b mediates erythroid differentiationQ24305046
Site-directed mutagenesis and spectroscopic characterization of human ferrochelatase: identification of residues coordinating the [2Fe-2S] clusterQ24308804
HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosisQ24315610
Mutations in COX10 result in a defect in mitochondrial heme A biosynthesis and account for multiple, early-onset clinical phenotypes associated with isolated COX deficiencyQ24317097
Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemiaQ24321734
Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathyQ24328756
Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexinQ24338112
Erythroid-specific 5-aminolevulinate synthase protein is stabilized by low oxygen and proteasomal inhibitionQ24338581
Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans.Q24531335
C-terminal deletions in the ALAS2 gene lead to gain of function and cause X-linked dominant protoporphyria without anemia or iron overloadQ24642289
Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1pQ24645476
Noninvasive molecular imaging of small living subjects using Raman spectroscopyQ24653843
Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbetaQ24655134
Measurement of the heme affinity for yeast dap1p, and its importance in cellular functionQ24658256
Functional and genetic studies demonstrate that mutation in the COX15 gene can cause Leigh syndromeQ24675204
The role of mitochondria in cellular iron-sulfur protein biogenesis: mechanisms, connected processes, and diseasesQ26865882
The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesisQ27629543
Architecture of succinate dehydrogenase and reactive oxygen species generationQ27640410
Structural Insights into Ubiquinone Biosynthesis in MembranesQ27681854
Solution structure of apocytochrome b562Q27729836
Redox-coupled crystal structural changes in bovine heart cytochrome c oxidaseQ27758647
Heme dynamics and trafficking factors revealed by genetically encoded fluorescent heme sensors.Q27929826
Sequence and chromosomal localization of two PET genes required for cytochrome c oxidase assembly in Saccharomyces cerevisiaeQ27930995
Analysis of Oligomerization Properties of Heme a Synthase Provides Insights into Its Function in Eukaryotes.Q27931313
Identification of rate-limiting steps in yeast heme biosynthesisQ27931650
Overlapping Specificities of the Mitochondrial Cytochrome c and c1 Heme LyasesQ27931671
Yeast flavohemoglobin, a nitric oxide oxidoreductase, is located in both the cytosol and the mitochondrial matrix: effects of respiration, anoxia, and the mitochondrial genome on its intracellular level and distributionQ27932410
Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51.Q27933369
Analysis of Leigh syndrome mutations in the yeast SURF1 homolog reveals a new member of the cytochrome oxidase assembly factor familyQ27933372
Adenine nucleotide translocator transports haem precursors into mitochondriaQ27933402
Structure, expression and regulation of a nuclear gene encoding a mitochondrial protein: the yeast L(+)-lactate cytochrome c oxidoreductase (cytochrome b2)Q27933413
Mitochondrial ferredoxin is required for heme A synthesis in Saccharomyces cerevisiaeQ27935174
Yeast mutants deficient in heme biosynthesis and a heme mutant additionally blocked in cyclization of 2,3-oxidosqualeneQ27936429
Glycine and Folate Ameliorate Models of Congenital Sideroblastic AnemiaQ27936634
Involvement of mitochondrial ferredoxin and Cox15p in hydroxylation of heme O.Q27937032
Role of PUG1 in inducible porphyrin and heme transport in Saccharomyces cerevisiaeQ27937165
Cyc2p, a membrane-bound flavoprotein involved in the maturation of mitochondrial c-type cytochromesQ27937225
Coa2 is an assembly factor for yeast cytochrome c oxidase biogenesis that facilitates the maturation of Cox1.Q27937418
Plasma membrane microdomains regulate turnover of transport proteins in yeastQ27939761
Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in diseaseQ28087521
Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteinsQ28115078
A Novel Role for Progesterone Receptor Membrane Component 1 (PGRMC1): A Partner and Regulator of FerrochelataseQ28118692
Human delta-aminolevulinate synthase: assignment of the housekeeping gene to 3p21 and the erythroid-specific gene to the X chromosomeQ28119035
Missense mutations in SURF1 associated with deficient cytochrome c oxidase assembly in Leigh syndrome patientsQ28140418
Two novel mutations of SURF1 in Leigh syndrome with cytochrome c oxidase deficiencyQ28143304
Cytochrome c oxidase deficiencyQ28189586
Conserved residues of the human mitochondrial holocytochrome c synthase mediate interactions with hemeQ28244549
Mechanisms of mitochondrial holocytochrome c synthase and the key roles played by cysteines and histidine of the heme attachment site, Cys-XX-Cys-HisQ28246920
The role of succinyl-CoA synthetase in the control of heme biosynthesisQ28256911
ABCB6 is dispensable for erythropoiesis and specifies the new blood group system LangereisQ28257493
Sequential regulation of ferroportin expression after erythrophagocytosis in murine macrophages: early mRNA induction by haem, followed by iron-dependent protein expressionQ28260693
Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancyQ28265885
Heme is involved in microRNA processingQ28278198
TMEM14C is required for erythroid mitochondrial heme metabolismQ28505553
Role of the heme regulatory motif in the heme-mediated inhibition of mitochondrial import of 5-aminolevulinate synthaseQ28572054
Heme Assimilation in Schizosaccharomyces pombe Requires Cell-surface-anchored Protein Shu1 and Vacuolar Transporter Abc3.Q51139086
A missing metabolic pathway in the cattle tick Boophilus microplus.Q52571343
Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic Enzyme.Q52650168
Label-Free Imaging of Heme Dynamics in Living Organisms by Transient Absorption Microscopy.Q52699580
Transfer of heme from ferrihemoglobin and ferrihemoglobin isolated chains to hemopexin.Q52913136
Lessons from bloodless worms: heme homeostasis in C. elegans.Q53232578
Pro-oxidant and cytotoxic effects of circulating heme.Q53854957
Human ferrochelatase is an iron-sulfur protein.Q54642721
Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes.Q55043047
Infantile cardioencephalopathy due to a COX15 gene defect: report and review.Q55054069
Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.Q55333337
Glyceraldehyde-3-phosphate dehydrogenase is a chaperone that allocates labile heme in cellsQ57255599
Crystal structure of heme A synthase fromQ58612169
Glutamine via α-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesisQ58761708
Epitope mapping of anti-PGRMC1 antibodies reveals the non-conventional membrane topology of PGRMC1 on the cell surfaceQ61444636
A scavenger receptor B (CD36)-like protein is a potential mediator of intestinal heme absorption in the hematophagous ectoparasite Lepeophtheirus salmonisQ64105702
Heme regulates hepatic 5-aminolevulinate synthase mRNA expression by decreasing mRNA half-life and not by altering its rate of transcriptionQ67981471
Assignment of the histidine axial ligands to the cytochrome bH and cytochrome bL components of the bcl complex from Rhodobacter sphaeroides by site-directed mutagenesisQ68243533
Induction of hepatic delta-amino-levulinic acid synthetase by oral contraceptive steroidsQ70127385
Analysis of the affinity of each haptoglobin polymer for hemoglobin by two-dimensional affinity electrophoresisQ73165134
Phylogenetic analysis of the 5-aminolevulinate synthase geneQ73924669
The mechanism of porphyrin formation; the formation of a succinyl intermediate from succinateQ74049700
Photothermal imaging of nanometer-sized metal particles among scatterersQ74620784
ACETONE EXTRACTION OF HEME FROM MYOGLOBIN AND HEMOGLOBIN AT ACID PHQ76639066
Evaluating the roles of the heme a side chains in cytochrome c oxidase using designed heme proteinsQ79212543
PorphyriasQ83185413
The flavoprotein Cyc2p, a mitochondrial cytochrome c assembly factor, is a NAD(P)H-dependent haem reductaseQ83274084
HPLC methods for analysis of porphyrins in biological mediaQ87417881
Recurrent attacks of acute hepatic porphyria: major role of the chronic inflammatory response in the liverQ87937480
The major facilitator transporter Str3 is required for low-affinity heme acquisition in Schizosaccharomyces pombeQ88084786
Heme bioavailability and signaling in response to stress in yeast cellsQ89157346
Handling heme: The mechanisms underlying the movement of heme within and between cellsQ90854530
PGRMC2 is an intracellular haem chaperone critical for adipocyte functionQ91362753
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesisQ91594557
Heme biosynthesis and the porphyriasQ92046226
Enasidenib drives human erythroid differentiation independently of isocitrate dehydrogenase 2Q92374458
Heme acquisition by Shu1 requires Nbr1 and proteins of the ESCRT complex in Schizosaccharomyces pombeQ92816966
Mechanistic study of PpIX accumulation using the JFCR39 cell panel revealed a role for dynamin 2-mediated exocytosisQ92826130
The Molar Light Absorption of Pyridine Ferroprotoporphrin (Pyridine Haemochromogen)Q100807771
ABCG2 transports and transfers heme to albumin through its large extracellular loopQ34236666
GAPDH regulates cellular heme insertion into inducible nitric oxide synthaseQ34241252
Structure, function, and assembly of heme centers in mitochondrial respiratory complexesQ34272542
Heme protein assembliesQ34296929
Cytochrome c oxidase biogenesis in a patient with a mutation in COX10 gene.Q34354144
The heme a synthase Cox15 associates with cytochrome c oxidase assembly intermediates during Cox1 maturationQ34366873
Heme deficiency may be a factor in the mitochondrial and neuronal decay of agingQ34379668
Mutations of SURF-1 in Leigh disease associated with cytochrome c oxidase deficiencyQ34388122
The human COX10 gene is disrupted during homologous recombination between the 24 kb proximal and distal CMT1A-REPs.Q34438070
Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and functionQ34449959
Biogenesis of cytochrome c oxidaseQ34455978
Molecular identification of adrenal inner zone antigen as a heme-binding proteinQ34466405
Identification of the Mitochondrial Heme Metabolism ComplexQ34490149
Iron-sulfur protein biogenesis in eukaryotes: components and mechanismsQ34545190
Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposalQ34555359
Novel mutations in COX15 in a long surviving Leigh syndrome patient with cytochrome c oxidase deficiencyQ34650518
Regulation of the heme A biosynthetic pathway: differential regulation of heme A synthase and heme O synthase in Saccharomyces cerevisiaeQ34866183
Molecular enzymology of 5-aminolevulinate synthase, the gatekeeper of heme biosynthesisQ34958839
An intercellular heme-trafficking protein delivers maternal heme to the embryo during development in C. elegansQ35014184
ABCG2: a perspective.Q35016817
ApoHRP-based assay to measure intracellular regulatory hemeQ35079585
Lon peptidase 1 (LONP1)-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cellsQ35128157
Heme oxygenase-1 in inflammation and cardiovascular diseaseQ35660128
Selective Oma1 protease-mediated proteolysis of Cox1 subunit of cytochrome oxidase in assembly mutantsQ35801928
Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell diseaseQ35813199
Mitochondrial cytochrome c biogenesis: no longer an enigma.Q35875522
In situ Spectroscopy on Intact Leptospirillum ferrooxidans Reveals that Reduced Cytochrome 579 is an Obligatory Intermediate in the Aerobic Iron Respiratory ChainQ35884542
ATP-dependent mitochondrial porphyrin importer ABCB6 protects against phenylhydrazine toxicity.Q35921685
Cellular and mitochondrial iron homeostasis in vertebratesQ35954736
Human Erythroid 5-Aminolevulinate Synthase Mutations Associated with X-Linked Protoporphyria Disrupt the Conformational Equilibrium and Enhance Product Release.Q36068952
Oligomerization of heme o synthase in cytochrome oxidase biogenesis is mediated by cytochrome oxidase assembly factor Coa2.Q36137383
Free heme toxicity and its detoxification systems in humanQ36139710
One ring to rule them all: trafficking of heme and heme synthesis intermediates in the metazoansQ36143730
CO as a cellular signaling moleculeQ36364694
The heme-Bach1 pathway in the regulation of oxidative stress response and erythroid differentiationQ36399771
Heme as key regulator of major mammalian cellular functions: molecular, cellular, and pharmacological aspects.Q36411963
Biosynthesis of heme in mammalsQ36535259
Heme: a versatile signaling molecule controlling the activities of diverse regulators ranging from transcription factors to MAP kinasesQ36559262
The impairment of HCCS leads to MLS syndrome by activating a non-canonical cell death pathway in the brain and eyesQ36602142
Heme and FLVCR-related transporter families SLC48 and SLC49.Q36700191
Interdomain lateral gene transfer of an essential ferrochelatase gene in human parasitic nematodesQ36835654
Null alleles of ABCG2 encoding the breast cancer resistance protein define the new blood group system JuniorQ36843054
Heme as a magnificent molecule with multiple missions: heme determines its own fate and governs cellular homeostasisQ36929292
Mitochondrial and cellular heme-dependent proteins as targets for the bioactive function of the heme oxygenase/carbon monoxide systemQ36940024
The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6.Q37181184
Regulation of intracellular heme trafficking revealed by subcellular reportersQ37258637
A role for heme in Alzheimer's disease: heme binds amyloid beta and has altered metabolismQ37285877
Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis.Q37350017
Surf1, associated with Leigh syndrome in humans, is a heme-binding protein in bacterial oxidase biogenesisQ37377668
Trafficking of heme and porphyrins in metazoa.Q37403265
Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagementQ37490200
The heme groups of cytochrome o from Escherichia coliQ37546856
Cytochrome c biogenesis: mechanisms for covalent modifications and trafficking of heme and for heme-iron redox control.Q37590030
Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyriaQ37635844
Quantification of labile heme in live malaria parasites using a genetically encoded biosensorQ37711617
Inventory control: cytochrome c oxidase assembly regulates mitochondrial translationQ37823208
Role of Surf1 in heme recruitment for bacterial COX biogenesisQ37938429
Heme A biosynthesisQ38000881
MAM (mitochondria-associated membranes) in mammalian cells: lipids and beyondQ38169449
Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranesQ38208296
Heme on innate immunity and inflammationQ38218093
Human mitochondrial COX1 assembly into cytochrome c oxidase at a glanceQ38348706
Proteomic analysis of lipid raft-enriched membranes isolated from internal organellesQ38500174
Regulation of heme biosynthesis and transport in metazoaQ38534629
Compartmentalization of iron between mitochondria and the cytosol and its regulationQ38538795
Porphyrias: A 2015 updateQ38542777
Heme Mobilization in Animals: A Metallolipid's Journey.Q38559870
Direct measurement of metal ion chelation in the active site of human ferrochelataseQ38621097
Heme Gazing: Illuminating Eukaryotic Heme Trafficking, Dynamics, and Signaling with Fluorescent Heme Sensors.Q38711615
A Genetically Encoded FRET Sensor for Intracellular HemeQ38888959
Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product.Q39103477
Trans-regulation of RNA-binding protein motifs by microRNA.Q39105795
Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteinsQ39469494
There is blood in the water: hemolysis, hemoglobin, and heme in acute lung injuryQ39472367
Rapid and sensitive quantitation of heme in hemoglobinized cellsQ39487515
Shu1 is a cell-surface protein involved in iron acquisition from heme in Schizosaccharomyces pombe.Q39715525
Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking.Q39781832
Identification of enzymically inactive apocytochrome c peroxidase in anaerobically grown Saccharomyces cerevisiaeQ40152375
Mutated PET117 causes complex IV deficiency and is associated with neurodevelopmental regression and medulla oblongata lesions.Q40261041
Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2.Q40394197
Molecular regulation of heme biosynthesis in higher vertebrates.Q40473960
Biosynthesis and functional role of haem O and haem A.Q40609423
Absorbance and redox based approaches for measuring free heme and free hemoglobin in biological matricesQ40990649
The Plasma Membrane Protein Nce102 Implicated in Eisosome Formation Rescues a Heme Defect in MitochondriaQ41045936
Transient absorption imaging of hemes with 2-color, independently tunable visible-wavelength ultrafast sourceQ41069821
The free heme concentration in healthy human erythrocytesQ41140605
Spectroscopic and mutagenesis studies of human PGRMC1.Q41445077
Special delivery from mitochondria to peroxisomesQ41452491
Identification of a novel erythroid-specific enhancer for the ALAS2 gene and its loss-of-function mutation which is associated with congenital sideroblastic anemiaQ41813591
Measurement of cytochrome P450 and NADPH-cytochrome P450 reductaseQ41840629
Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging.Q41927329
Correction for Khalimonchuk et al., "Formation of the Redox Cofactor Centers during Cox1 Maturation in Yeast Cytochrome Oxidase".Q42251082
Translational inhibition by heme of the synthesis of hepatic delta-aminolevulinate synthase in a cell-free systemQ42253065
Evidence for the transcriptional inhibition by heme of the synthesis of delta-aminolevulinate synthase in rat liverQ42264149
Ascorbate peroxidase proximity labeling coupled with biochemical fractionation identifies promoters of endoplasmic reticulum-mitochondrial contactsQ42285856
A heme-sensing mechanism in the translational regulation of mitochondrial cytochrome c oxidase biogenesisQ42412712
The Assembly Factor Pet117 Couples Heme a Synthase Activity to Cytochrome Oxidase AssemblyQ42427959
Pyridine Hemochromagen Assay for Determining the Concentration of Heme in Purified Protein Solutions.Q42432474
SURF1 missense mutations promote a mild Leigh phenotype.Q42460422
Storage lesion: role of red blood cell breakdownQ42720111
Hemopexin prevents endothelial damage and liver congestion in a mouse model of heme overloadQ28585150
Mitoferrin is essential for erythroid iron assimilationQ28587125
Examination of mitochondrial protein targeting of haem synthetic enzymes: in vivo identification of three functional haem-responsive motifs in 5-aminolaevulinate synthaseQ28589533
A heme export protein is required for red blood cell differentiation and iron homeostasisQ28592039
Characterization of Human and Yeast Mitochondrial Glycine Carriers with Implications for Heme Biosynthesis and Anemia.Q29568201
Regulation by heme of mitochondrial protein transport through a conserved amino acid motifQ30467462
Topologically conserved residues direct heme transport in HRG-1-related proteins.Q30505390
Drugs mediate the transcriptional activation of the 5-aminolevulinic acid synthase (ALAS1) gene via the chicken xenobiotic-sensing nuclear receptor (CXR).Q30711956
Heme A synthase does not incorporate molecular oxygen into the formyl group of heme A.Q30941319
Imaging chromophores with undetectable fluorescence by stimulated emission microscopyQ33511745
The role of Coa2 in hemylation of yeast Cox1 revealed by its genetic interaction with Cox10Q33558128
Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophagesQ33570011
Investigations of heme distortion, low-frequency vibrational excitations, and electron transfer in cytochrome cQ33607085
Formation of the redox cofactor centers during Cox1 maturation in yeast cytochrome oxidase.Q33627236
Assembly factors monitor sequential hemylation of cytochrome b to regulate mitochondrial translation.Q33663212
Induction of -aminolevulinic acid synthetase in chick embryo liver cells in clutureQ33704586
Like iron in the blood of the people: the requirement for heme trafficking in iron metabolism.Q33709768
Control of metazoan heme homeostasis by a conserved multidrug resistance proteinQ33737434
Progesterone inhibits apoptosis in part by PGRMC1-regulated gene expression.Q33749200
Cell biology of hemeQ33752149
5-aminolevulinate synthase: catalysis of the first step of heme biosynthesisQ33830495
Mutation of the heme axial ligand of Escherichia coli succinate-quinone reductase: implications for heme ligation in mitochondrial complex II from yeastQ33926010
Lack of heme synthesis in a free-living eukaryoteQ33934583
Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesionQ33957600
Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesisQ33977876
Structure--function relationships of rat hepatic tryptophan 2,3-dioxygenase: identification of the putative heme-ligating histidine residuesQ34084855
Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesisQ34112735
CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasmaQ34114924
Molecular mechanism of heme signaling in yeast: the transcriptional activator Hap1 serves as the key mediator.Q34158451
Involvement of ABC7 in the biosynthesis of heme in erythroid cells: interaction of ABC7 with ferrochelataseQ34164494
Pump-probe optical microscopy for imaging nonfluorescent chromophoresQ34192555
Biogenesis and assembly of eukaryotic cytochrome c oxidase catalytic coreQ34220248
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P577publication date2020-02-29
P1433published inCellsQ27724621
P1476titleFrom Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme
P478volume9

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