| review article | Q7318358 |
| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1045961553 |
| P356 | DOI | 10.1080/13550280290100978 |
| P698 | PubMed publication ID | 12476348 |
| P5875 | ResearchGate publication ID | 10996508 |
| P2093 | author name string | Mark P Mattson | |
| P2860 | cites work | Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons | Q73675821 |
| Education and other measures of socioeconomic status and risk of incident Alzheimer disease in a defined population of older persons | Q73859381 | ||
| Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis | Q74516844 | ||
| Intrahippocampal LPS injections reduce Abeta load in APP+PS1 transgenic mice | Q77384367 | ||
| Ca2+ signaling in T-lymphocytes | Q77452470 | ||
| A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein | Q22009982 | ||
| Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE | Q22010705 | ||
| Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor | Q22253449 | ||
| Calsenilin reverses presenilin-mediated enhancement of calcium signaling | Q22254629 | ||
| Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila | Q24546116 | ||
| Shattuck lecture--neurodegenerative diseases and prions | Q28189500 | ||
| Skeletal and CNS defects in Presenilin-1-deficient mice | Q28238795 | ||
| Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux | Q28270468 | ||
| Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment | Q28285327 | ||
| Notch1 is required for the coordinate segmentation of somites | Q28513676 | ||
| Ultrastructural localization of sorcin, a 22 kDa calcium binding protein, in the rat caudate-putamen nucleus: association with ryanodine receptors and intracellular calcium release | Q28570694 | ||
| Presenilin-1 regulates neuronal differentiation during neurogenesis | Q28590604 | ||
| The versatility and universality of calcium signalling | Q29547402 | ||
| Notch signaling | Q29618190 | ||
| Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse | Q29619237 | ||
| Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function. | Q31832269 | ||
| Calcium signaling mechanisms in T lymphocytes | Q32186061 | ||
| A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease | Q33292093 | ||
| Ca2+ and synaptic plasticity. | Q33544685 | ||
| Brain inflammation in Alzheimer disease and the therapeutic implications | Q33753927 | ||
| Notch and the immune system. | Q33812251 | ||
| Pathobiology of human immunodeficiency virus dementia | Q33863784 | ||
| Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation. | Q33900383 | ||
| Traumatic brain injury as a risk factor for Alzheimer's disease: a review. | Q33999686 | ||
| Neuroinflammatory signaling upregulation in Alzheimer's disease | Q34074190 | ||
| Apoptosis in neurodegenerative disorders | Q34186312 | ||
| Prion-induced neuronal damage--the mechanisms of neuronal destruction in the subacute spongiform encephalopathies | Q34288218 | ||
| Programmed cell death in virus infections of the nervous system | Q34288243 | ||
| HIV in the CNS: pathogenic relationships to systemic HIV disease and other CNS diseases | Q34343628 | ||
| Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide | Q34456855 | ||
| Interleukin-1, neuroinflammation, and Alzheimer's disease | Q34469514 | ||
| Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function | Q35984381 | ||
| Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice | Q36327027 | ||
| Identification of the ankyrin-binding domain of the mouse T-lymphoma cell inositol 1,4,5-trisphosphate (IP3) receptor and its role in the regulation of IP3-mediated internal Ca2+ release | Q36698977 | ||
| Complement activation by beta-amyloid in Alzheimer disease | Q37262889 | ||
| The calmodulin-binding domain in the mouse type 1 inositol 1,4,5-trisphosphate receptor | Q38295298 | ||
| Neuropathology of unconventional virus infections: molecular pathology of spongiform change and amyloid plaque deposition | Q39518214 | ||
| Neuronal injury associated with HIV-1: approaches to treatment | Q40858582 | ||
| Lymphocytes and neutrophils as peripheral models to study the effect of beta-amyloid on cellular calcium signalling in Alzheimer's disease | Q41077286 | ||
| Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor | Q41182990 | ||
| Functional cloning of genes involved in T-cell receptor-induced programmed cell death | Q41433505 | ||
| Amyloid, the presenilins and Alzheimer's disease | Q41433661 | ||
| Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein | Q41467443 | ||
| Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives | Q41630805 | ||
| Altered Ca2+ homeostasis in lymphoblasts from patients with late-onset Alzheimer disease | Q41686195 | ||
| Abeta25-35 induces rapid lysis of red blood cells: contrast with Abeta1-42 and examination of underlying mechanisms | Q42447543 | ||
| Oxidative damage to DNA in lymphocytes from AD patients. | Q42462719 | ||
| Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death. | Q42482357 | ||
| Elevated levels of oxidative DNA damage in lymphocytes from patients with Alzheimer's disease | Q42514779 | ||
| A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. | Q43560472 | ||
| Clinical-neuropathological correlations in Alzheimer's disease and related dementias | Q46927555 | ||
| A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease | Q47583762 | ||
| Distinct pH homeostatic features in lymphoblasts from Alzheimer's disease patients. | Q47671707 | ||
| Increased natural killer cell cytotoxicity in Alzheimer's disease may involve protein kinase C dysregulation | Q47854572 | ||
| Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: evidence for a preconditioning mechanism | Q48124285 | ||
| Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease | Q48169104 | ||
| Induction of beta (A4)-amyloid in primates by injection of Alzheimer's disease brain homogenate. Comparison with transmission of spongiform encephalopathy | Q48184210 | ||
| Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1. | Q48263427 | ||
| Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice | Q48275838 | ||
| Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults | Q48302939 | ||
| Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice | Q48308608 | ||
| HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress | Q48313745 | ||
| Intracellular calcium response is reduced in CD4+ lymphocytes in Alzheimer's disease and in older persons with Down's syndrome. | Q48327987 | ||
| Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein | Q48342880 | ||
| Potentiation of N-methyl-D-aspartate-mediated neurotoxicity by immunostimulated murine microglia | Q48373300 | ||
| Longitudinal study of inflammatory factors in serum, cerebrospinal fluid, and brain tissue in Alzheimer disease: interleukin-1beta, interleukin-6, interleukin-1 receptor antagonist, tumor necrosis factor-alpha, the soluble tumor necrosis factor rece | Q48376805 | ||
| 4-hydroxynonenal, a lipid peroxidation product, impairs glutamate transport in cortical astrocytes. | Q48490623 | ||
| Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration | Q48615547 | ||
| Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice | Q48655243 | ||
| Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats. | Q48685833 | ||
| Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals. | Q48703300 | ||
| Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice. | Q48920415 | ||
| Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer's disease. | Q49124233 | ||
| T-lymphocyte interleukin 6 receptor binding in patients with dementia of Alzheimer type. | Q50861797 | ||
| T-cell interferon gamma binding in patients with dementia of the Alzheimer type. | Q50961198 | ||
| Factors associated with mortality in patients with early-onset Alzheimer's disease: a five-year longitudinal study. | Q51963833 | ||
| Alterations in immune functions during normal aging and Alzheimer's disease. | Q51985858 | ||
| The calcium response of human T lymphocytes is decreased in aging but increased in Alzheimer's dementia. | Q51985966 | ||
| Complementary and combinatorial patterns of Notch gene family expression during early mouse development. | Q52204884 | ||
| Functional phenotype in transgenic mice expressing mutant human presenilin-1. | Q52538989 | ||
| T lymphocyte subpopulations and activation markers correlate with severity of Alzheimer's disease. | Q53202624 | ||
| Multivalent binding of complement protein C1Q to the amyloid beta-peptide (A beta) promotes the nucleation phase of A beta aggregation. | Q53210579 | ||
| Increased proteolytic activity in lymphocytes from patients with early onset Alzheimer's disease. | Q53211402 | ||
| Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide. | Q53216314 | ||
| Impaired proteolytic processing of presenilin-1 in chromosome 14-linked familial Alzheimer's disease patient lymphocytes. | Q53226425 | ||
| A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease. | Q53228560 | ||
| Characterization of cytokine production, screening of lymphocyte subset patterns and in vitro apoptosis in healthy and Alzheimer's Disease (AD) individuals. | Q53229484 | ||
| Gluthatione level is altered in lymphoblasts from patients with familial Alzheimer's disease. | Q53231519 | ||
| Increased plasma levels of interleukin-1, interleukin-6 and alpha-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain? | Q53233114 | ||
| Copper catalyzed oxidation of Alzheimer Abeta. | Q53236205 | ||
| A High Plasma Concentration of TNF- Is Associated With Dementia in Centenarians | Q59326375 | ||
| Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons | Q67654986 | ||
| [Topographic analysis of neuropathologic findings in 16 cases of Creutzfeldt-Jacob disease] | Q70228558 | ||
| Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation | Q71971013 | ||
| Longitudinal exposure of human T lymphocytes to weak oxidative stress suppresses transmembrane and nuclear signal transduction | Q72812945 | ||
| Presenilin-mediated modulation of capacitative calcium entry | Q73133100 | ||
| Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain | Q73454988 | ||
| P433 | issue | 6 | |
| P921 | main subject | Alzheimer's disease | Q11081 |
| P304 | page(s) | 539-550 | |
| P577 | publication date | 2002-12-01 | |
| P1433 | published in | Journal of NeuroVirology | Q6295640 |
| P1476 | title | Oxidative stress, perturbed calcium homeostasis, and immune dysfunction in Alzheimer's disease | |
| P478 | volume | 8 |
| Q24297339 | AATF protects neural cells against oxidative damage induced by amyloid beta-peptide |
| Q57155493 | Alzheimer Disease - Future Therapy Based on Dendrimers |
| Q37172823 | Amelioration of the haloperidol-induced memory impairment and brain oxidative stress by cinnarizine |
| Q42210986 | Antiaging effect of dietary chitosan supplementation on glutathione-dependent antioxidant system in young and aged rats |
| Q35624697 | Autophagy in dementias |
| Q53288284 | Biochemical properties of endogenous presenilin 1 and presenilin 2 in cultured human B-lymphocytes. |
| Q46541808 | Blocking the phosphatidylinositol 3-kinase pathway inhibits neuregulin-1-mediated rescue of neurotoxicity induced by Aβ1-42. |
| Q36358055 | Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression |
| Q34616660 | Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated fibroblasts |
| Q35570834 | Cycles of aberrant synaptic sprouting and neurodegeneration in Alzheimer's and dementia with Lewy bodies |
| Q38304771 | Dantrolene, a treatment for Alzheimer disease? |
| Q51963735 | Decreased phospholipase A2 activity in cerebrospinal fluid of patients with dementia. |
| Q37973295 | Dysfunctional nucleus tractus solitarius: its crucial role in promoting neuropathogenetic cascade of Alzheimer's dementia--a novel hypothesis |
| Q43195508 | Effects of dietary extra-virgin olive oil on behaviour and brain biochemical parameters in ageing rats |
| Q36993185 | Enhanced apoptosis, oxidative stress and mitochondrial dysfunction in lymphocytes as potential biomarkers for Alzheimer's disease |
| Q34710871 | Evidence supporting a role for the calcium-sensing receptor in Alzheimer disease |
| Q40615439 | Gamma-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor-mediated signal transduction |
| Q26772294 | Getting to NO Alzheimer's Disease: Neuroprotection versus Neurotoxicity Mediated by Nitric Oxide |
| Q37176830 | HIV-1 Tat Regulates Occludin and Aβ Transfer Receptor Expression in Brain Endothelial Cells via Rho/ROCK Signaling Pathway |
| Q40436441 | Hypoxic augmentation of Ca2+ channel currents requires a functional electron transport chain |
| Q35783846 | Infectious agents and age-related neurodegenerative disorders |
| Q52917513 | Localization of 14-3-3δ/ξ on the neuronal cell surface. |
| Q36166123 | Mechanisms of the blood-brain barrier disruption in HIV-1 infection |
| Q24652987 | MicroRNA: Implications for Alzheimer Disease and other Human CNS Disorders |
| Q57729869 | Misoprostol decreases oxidative stress and liver injury in bacterial lipopolysaccharide-induced endotoxemia in mice |
| Q33563545 | Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis |
| Q37462244 | Molecular pathology of neuro-AIDS (CNS-HIV). |
| Q36302045 | Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases |
| Q34149384 | NMDA-mediated Ca(2+) influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer's disease mice |
| Q47566558 | Neural immunity: Friend or foe? |
| Q37190917 | Neuregulin-1 (Nrg1) signaling has a preventive role and is altered in the frontal cortex under the pathological conditions of Alzheimer's disease |
| Q35196248 | Neuronal and glial calcium signaling in Alzheimer's disease |
| Q37264028 | Neuronal injury in simian immunodeficiency virus and other animal models of neuroAIDS. |
| Q92641583 | Neuroprotective Effects of Ginseng Phytochemicals: Recent Perspectives |
| Q44804966 | Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells |
| Q37168959 | Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer's disease |
| Q48150702 | Neuroprotective effects of honokiol: from chemistry to medicine. |
| Q53073171 | Oil Palm Phenolics Inhibit the In Vitro Aggregation of β-Amyloid Peptide into Oligomeric Complexes. |
| Q38367422 | Oxidative Stress and Aberrant Cell Cycle in Alzheimer's Disease Lymphocytes: Diagnostic Prospects |
| Q41121746 | Oxidative damage in brain from human mutant APP/PS-1 double knock-in mice as a function of age. |
| Q53269766 | Oxidative imbalance and cathepsin D changes as peripheral blood biomarkers of Alzheimer disease: a pilot study. |
| Q30156903 | P2Y2 nucleotide receptor-mediated responses in brain cells |
| Q35600801 | Phospholipase A2 in the central nervous system: implications for neurodegenerative diseases |
| Q39638936 | Rosuvastatin and thapsigargin modulate γ-secretase gene expression and APP processing in a human neuroglioma model |
| Q37672845 | T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer's Disease: Potential Pools of New Biomarkers |
| Q37701322 | Targeting NADPH oxidase and phospholipases A2 in Alzheimer's disease |
| Q38094984 | The senescence hypothesis of disease progression in Alzheimer disease: an integrated matrix of disease pathways for FAD and SAD. |
| Q36678341 | Vitamin D-binding protein interacts with Aβ and suppresses Aβ-mediated pathology |
| Q39089001 | β-Amyloid-evoked apoptotic cell death is mediated through MKK6-p66shc pathway |
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