Inhibition of phospholipid biosynthesis decreases the activity of the tombusvirus replicase and alters the subcellular localization of replication proteins

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Inhibition of phospholipid biosynthesis decreases the activity of the tombusvirus replicase and alters the subcellular localization of replication proteins is …
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scholarly articleQ13442814

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P356DOI10.1016/J.VIROL.2011.04.008
P932PMC publication ID3107895
P698PubMed publication ID21561636
P5875ResearchGate publication ID51116578

P2093author name stringPeter D Nagy
Monika Sharma
Zsuzsanna Sasvari
P2860cites workThree-dimensional analysis of a viral RNA replication complex reveals a virus-induced mini-organelleQ27334421
Host Factors in Positive-Strand RNA Virus Genome ReplicationQ27477670
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Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamilyQ27649764
The negative regulator Opi1 of phospholipid biosynthesis in yeast contacts the pleiotropic repressor Sin3 and the transcriptional activator Ino2.Q27929756
Import of proteins into mitochondria. Cytochrome b2 and cytochrome c peroxidase are located in the intermembrane space of yeast mitochondriaQ27935509
Viral reorganization of the secretory pathway generates distinct organelles for RNA replicationQ28283814
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Yeast genome-wide screen reveals dissimilar sets of host genes affecting replication of RNA virusesQ30851910
Genome-wide screen identifies host genes affecting viral RNA recombinationQ33219824
Screening of the yeast yTHC collection identifies essential host factors affecting tombusvirus RNA recombinationQ33231719
COPI activity coupled with fatty acid biosynthesis is required for viral replicationQ33260346
A key role for heat shock protein 70 in the localization and insertion of tombusvirus replication proteins to intracellular membranesQ33400948
A unique role for the host ESCRT proteins in replication of Tomato bushy stunt virusQ33521256
Complementary transcriptomic, lipidomic, and targeted functional genetic analyses in cultured Drosophila cells highlight the role of glycerophospholipid metabolism in Flock House virus RNA replicationQ33541729
Inhibition of sterol biosynthesis reduces tombusvirus replication in yeast and plantsQ33648937
Cpr1 cyclophilin and Ess1 parvulin prolyl isomerases interact with the tombusvirus replication protein and inhibit viral replication in yeast model hostQ33658068
A High‐Throughput Approach for Studying Virus Replication in YeastQ33739375
Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibitionQ33848936
Dengue virus-induced autophagy regulates lipid metabolismQ34024721
Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesisQ34182803
DNA-directed expression of an animal virus RNA for replication-dependent colony formation in Saccharomyces cerevisiaeQ34331492
Nodavirus-induced membrane rearrangement in replication complex assembly requires replicase protein a, RNA templates, and polymerase activityQ34416566
Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virusQ34791544
Advances in the molecular biology of tombusviruses: gene expression, genome replication, and recombinationQ35813294
Activation of cellular Arf GTPases by poliovirus protein 3CD correlates with virus replication.Q35948087
Involvement of cellular membrane traffic proteins in poliovirus replicationQ36716351
Cdc34p ubiquitin-conjugating enzyme is a component of the tombusvirus replicase complex and ubiquitinates p33 replication proteinQ36747704
In vitro assembly of the Tomato bushy stunt virus replicase requires the host Heat shock protein 70Q37018802
Membrane Synthesis, Specific Lipid Requirements, and Localized Lipid Composition Changes Associated with a Positive-Strand RNA Virus RNA Replication ProteinQ37060204
Modification of intracellular membrane structures for virus replicationQ37139313
Yeast as a model host to explore plant virus-host interactionsQ37142027
Regulation of phospholipid synthesis in yeastQ37310095
Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response.Q37425584
Coordination of lipid metabolism in membrane biogenesis.Q37540097
Flock house virus: a model system for understanding non-enveloped virus entry and membrane penetrationQ37734948
Cytoplasmic viral replication complexesQ37773687
Global Genomics and Proteomics Approaches to Identify Host Factors as Targets to Induce Resistance Against Tomato Bushy Stunt VirusQ37801998
The host Pex19p plays a role in peroxisomal localization of tombusvirus replication proteinsQ38288494
IN02, a positive regulator of lipid biosynthesis, is essential for the formation of inducible membranes in yeastQ38292669
Making of viral replication organelles by remodeling interior membranesQ38614268
Enhanced competitiveness of tomato bushy stunt virus defective interfering RNAs by segment duplication or nucleotide insertion.Q40041679
Cholesterol manipulation by West Nile virus perturbs the cellular immune responseQ40051201
Purification of the cucumber necrosis virus replicase from yeast cells: role of coexpressed viral RNA in stimulation of replicase activityQ40496402
Role of an internal and two 3'-terminal RNA elements in assembly of tombusvirus replicaseQ42582007
Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism.Q42924633
Identification of essential host factors affecting tombusvirus RNA replication based on the yeast Tet promoters Hughes CollectionQ43155068
Cytological analysis of Saccharomyces cerevisiae cells supporting cymbidium ringspot virus defective interfering RNA replication.Q45419794
Localization of the tomato bushy stunt virus replication protein p33 reveals a peroxisome-to-endoplasmic reticulum sorting pathwayQ45422568
Yeast as a model host to study replication and recombination of defective interfering RNA of Tomato bushy stunt virusQ45711001
A positive-strand RNA virus replication complex parallels form and function of retrovirus capsidsQ45733045
A 12-residue-long polyleucine tail is sufficient to anchor synaptobrevin to the endoplasmic reticulum membraneQ71081496
Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiaeQ77784495
Overproduction of the Opi1 repressor inhibits transcriptional activation of structural genes required for phospholipid biosynthesis in the yeast Saccharomyces cerevisiaeQ78004043
Exploiting alternative subcellular location for replication: tombusvirus replication switches to the endoplasmic reticulum in the absence of peroxisomesQ79755909
The role of the p33:p33/p92 interaction domain in RNA replication and intracellular localization of p33 and p92 proteins of Cucumber necrosis tombusvirusQ81814264
RNA chaperone activity of the tombusviral p33 replication protein facilitates initiation of RNA synthesis by the viral RdRp in vitroQ82428482
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)141-152
P577publication date2011-05-10
P1433published inVirologyQ7934867
P1476titleInhibition of phospholipid biosynthesis decreases the activity of the tombusvirus replicase and alters the subcellular localization of replication proteins
P478volume415

Reverse relations

cites work (P2860)
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Q27315960Viral Replication Protein Inhibits Cellular Cofilin Actin Depolymerization Factor to Regulate the Actin Network and Promote Viral Replicase Assembly
Q26998819Viruses and antiviral immunity in Drosophila

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