Potentiation of 5-methoxy-N,N-dimethyltryptamine-induced hyperthermia by harmaline and the involvement of activation of 5-HT1A and 5-HT2A receptors

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Potentiation of 5-methoxy-N,N-dimethyltryptamine-induced hyperthermia by harmaline and the involvement of activation of 5-HT1A and 5-HT2A receptors is …
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scholarly articleQ13442814

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P356DOI10.1016/J.NEUROPHARM.2014.10.013
P932PMC publication ID4310233
P698PubMed publication ID25446678

P2093author name stringAi-Ming Yu
Hong-Wu Shen
Xi-Ling Jiang
P2860cites workDifferential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in miceQ24594834
Development of a LC-MS/MS method to analyze 5-methoxy-N,N-dimethyltryptamine and bufotenine, and application to pharmacokinetic studyQ24601816
Multiple receptors contribute to the behavioral effects of indoleamine hallucinogensQ24620764
Psychedelic 5-Methoxy-N,N-Dimethyltryptamine: Metabolism, Pharmacokinetics, Drug Interactions, and Pharmacological ActionsQ24633393
Animal models of the serotonin syndrome: a systematic reviewQ27010038
Identification of the substrate binding region of vesicular monoamine transporter-2 (VMAT-2) using iodoaminoflisopolol as a novel photoprobeQ27863370
WAY-100635 is a potent dopamine D4 receptor agonistQ28258364
Serotonin syndrome: recognition and treatmentQ44158916
Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine.Q44370451
Alpha-methyltryptamine revisited via easy Internet access.Q44459868
Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylaseQ44460548
Monoamine oxidase inhibitor poisoning resulting from Internet misinformation on illicit substancesQ44949973
New drugs of abuse update: Foxy MethoxyQ45081674
Dimethyltryptamine (DMT): prevalence, user characteristics and abuse liability in a large global sampleQ45383954
Bioanalytical and clinical evaluation of 103 suspected cases of intoxications with psychoactive plant materials.Q45935490
Pharmacological characterization of harmaline-induced tremor activity in mice.Q45982456
High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brainQ46629739
Foxy methoxy: a new drug of abuse.Q46856269
A fatal poisoning with 5-methoxy-N,N-diisopropyltryptamine, FoxyQ46889621
Adult siRNA-induced knockdown of mGlu7 receptors reduces anxiety in the mouseQ48027955
Tremorigenic effect and inhibition of tryptamine and serotonin receptor binding by beta-carbolinesQ48233472
Central serotonin level-dependent changes in body temperature following administration of tryptophan to pargyline- and harmaline-pretreated ratsQ48788728
On the role of brain 5-HT7 receptor in the mechanism of hypothermia: comparison with hypothermia mediated via 5-HT1A and 5-HT3 receptorQ48922479
Lu AF21934, a positive allosteric modulator of mGlu4 receptors, reduces the harmaline-induced hyperactivity but not tremor in rats.Q50247812
The Serotonin SyndromeQ55871784
The paradox of 5-methoxy-N,N-dimethyltryptamine: an indoleamine hallucinogen that induces stimulus control via 5-HT1A receptorsQ73363254
Evidence for functional interactions between 5-HT1A and 5-HT2A receptors in rat thermoregulatory mechanismsQ74467746
Modulation of phencyclidine-induced changes in locomotor activity and patterns in rats by serotoninQ74506058
Serotonin potentiates sympathetic responses evoked by spinal NMDAQ80264241
Cold-activated brown adipose tissue in healthy menQ29547382
Clinical toxicology of newer recreational drugsQ30407755
Enhanced effects of amphetamine but reduced effects of the hallucinogen, 5-MeO-DMT, on locomotor activity in 5-HT(1A) receptor knockout mice: implications for schizophreniaQ30445688
JL13 has clozapine-like actions on thermoregulatory cutaneous blood flow in rats: Involvement of serotonin 5-HT1A and 5-HT2A receptor mechanisms.Q33514157
Methodology for and the determination of the major constituents and metabolites of the Amazonian botanical medicine ayahuasca in human urine.Q33740814
Effects of monoamine oxidase inhibitor and cytochrome P450 2D6 status on 5-methoxy-N,N-dimethyltryptamine metabolism and pharmacokineticsQ33887065
Modification of the effects of 5-methoxy-N,N-dimethyltryptamine on exploratory behavior in rats by monoamine oxidase inhibitorsQ34087847
Pharmepéna-Psychonautics: Human intranasal, sublingual and oral pharmacology of 5-methoxy-N,N-dimethyl-tryptamineQ34112472
Schedules of controlled substances: placement of 5-methoxy-N,N-dimethyltryptamine into Schedule I of the Controlled Substances Act. Final ruleQ34155717
The effect of memantine in harmaline-induced tremor and neurodegeneration.Q34189781
High-affinity agonist binding is not sufficient for agonist efficacy at 5-hydroxytryptamine2A receptors: evidence in favor of a modified ternary complex modelQ34415673
A fatal intoxication following the ingestion of 5-methoxy-N,N-dimethyltryptamine in an ayahuasca preparationQ34476705
Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Evidence for opposing roles of 5-HT2 and 5-HT1A receptorsQ34562816
The roles of 5-HT1A and 5-HT2 receptors in the effects of 5-MeO-DMT on locomotor activity and prepulse inhibition in ratsQ34570539
Ability of ketanserin to block different receptors in human placental vessels.Q34659114
The natural hallucinogen 5-MeO-DMT, component of Ayahuasca, disrupts cortical function in rats: reversal by antipsychotic drugsQ34660497
Inhibition of monoamine oxidase A by beta-carboline derivativesQ34737351
Nonlinear pharmacokinetics of 5-methoxy-N,N-dimethyltryptamine in miceQ35079542
Stimulus control by 5-methoxy-N,N-dimethyltryptamine in wild-type and CYP2D6-humanized miceQ35085860
Clinical investigations of the therapeutic potential of ayahuasca: rationale and regulatory challengesQ35784312
Schedules of controlled substances: placement of alpha-methyltryptamine and 5-methoxy-N,N-diisopropyltryptamine into schedule I of the Controlled Substances Act. Final rule.Q35904580
The pathophysiology of serotonin toxicity in animals and humans: implications for diagnosis and treatmentQ36292734
Brown adipose tissue sympathetic nerve activity is potentiated by activation of 5-hydroxytryptamine (5-HT)1A/5-HT7 receptors in the rat spinal cordQ36569699
Pharmacokinetic interactions between monoamine oxidase A inhibitor harmaline and 5-methoxy-N,N-dimethyltryptamine, and the impact of CYP2D6 statusQ36776603
Central control of thermogenesis in mammalsQ36812556
Potential role of CYP2D6 in the central nervous systemQ37112464
Behavioral effects of α,α,β,β-tetradeutero-5-MeO-DMT in rats: comparison with 5-MeO-DMT administered in combination with a monoamine oxidase inhibitorQ37230473
Effects of CYP2D6 status on harmaline metabolism, pharmacokinetics and pharmacodynamics, and a pharmacogenetics-based pharmacokinetic modelQ37309305
Recognizing serotonin toxicity in the pediatric emergency departmentQ38032090
Overview of serotonin syndromeQ38059213
Brown adipose tissue in adult humans: a metabolic renaissanceQ38095425
Emerging psychoactive substance use among regular ecstasy users in AustraliaQ39668901
Prolonged delusional state triggered by repeated ingestion of aromatic liquid in a past 5-methoxy-N, N-diisopropyltryptamine abuserQ40138770
Activation but not blockade of GABAB receptors during early-life alters anxiety in adulthood in BALB/c miceQ40233997
On the mechanism of anti-hyperthermic effects of LY379268 and LY487379, group II mGlu receptors activators, in the stress-induced hyperthermia in singly housed miceQ40314677
The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse.Q40674439
PPI deficit induced by amphetamine is attenuated by the histamine H1 antagonist pyrilamine, but is exacerbated by the serotonin 5-HT2 antagonist ketanserinQ42919813
P407language of work or nameEnglishQ1860
P921main subjectN,N-dimethyl-5-methoxytryptamineQ570757
P1104number of pages10
P304page(s)342-351
P577publication date2015-02-01
P1433published inNeuropharmacologyQ15332439
P1476titlePotentiation of 5-methoxy-N,N-dimethyltryptamine-induced hyperthermia by harmaline and the involvement of activation of 5-HT1A and 5-HT2A receptors
P478volume89

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cites work (P2860)
Q38626654Behavioral Changes Over Time Following Ayahuasca Exposure in Zebrafish
Q37302207Development of a mechanism-based pharmacokinetic/pharmacodynamic model to characterize the thermoregulatory effects of serotonergic drugs in mice
Q58700862It's Tea Time: Interference of Ayahuasca Brew on Discriminative Learning in Zebrafish
Q36844764Modification of 5-methoxy-N,N-dimethyltryptamine-induced hyperactivity by monoamine oxidase A inhibitor harmaline in mice and the underlying serotonergic mechanisms
Q92120747N,N-dimethyltryptamine Prevents Renal Ischemia-Reperfusion Injury in a Rat Model

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