Therapeutic use of a selective S1P1 receptor modulator ponesimod in autoimmune diabetes

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Therapeutic use of a selective S1P1 receptor modulator ponesimod in autoimmune diabetes is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...877296Y
P356DOI10.1371/JOURNAL.PONE.0077296
P932PMC publication ID3811978
P698PubMed publication ID24204793
P5875ResearchGate publication ID258350800

P50authorLucienne ChatenoudQ15440015
Jean-François BachQ16645214
Sylvaine YouQ56954682
Fabrice ValetteQ116996900
P2093author name stringBeat Steiner
Martine Clozel
Chantal Kuhn
Luca Piali
Virginia Sauvaget
P2860cites workChromogranin A is an autoantigen in type 1 diabetesQ24605199
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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonistsQ29618071
FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functionsQ33283482
Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organsQ33869799
Equivalent specificity of peripheral blood and islet-infiltrating CD8+ T lymphocytes in spontaneously diabetic HLA-A2 transgenic NOD mice.Q51707718
The selective sphingosine 1-phosphate receptor 1 agonist ponesimod protects against lymphocyte-mediated tissue inflammation.Q51769446
Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass.Q51778586
Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.Q53859655
Induction of allograft tolerance by monoclonal CD3 antibodies: a matter of timing.Q54297363
Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.Q55066037
FTY720 versus MMF with Cyclosporine in de novo Renal Transplantation: A 1-Year, Randomized Controlled Trial in Europe and AustralasiaQ63431636
CD3 antibody-induced dominant self tolerance in overtly diabetic NOD miceQ73128688
FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activationQ73423109
Effect of FTY720, a novel immunosuppressant, on adjuvant- and collagen-induced arthritis in ratsQ73480216
Immune therapy for type 1 diabetes mellitus-what is unique about anti-CD3 antibodies?Q34099969
Prime role for an insulin epitope in the development of type 1 diabetes in NOD miceQ34345367
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetesQ34428346
Oral fingolimod (FTY720) for relapsing multiple sclerosisQ34565985
Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.Q34569888
Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cellsQ34630923
CD3-specific antibodies: a portal to the treatment of autoimmunityQ34654024
A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responsesQ34778834
FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunityQ34786932
Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic miceQ34904815
Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.Q35191064
Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trialQ35321191
Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatmentQ35748567
Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropismQ36228105
Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transitQ36402627
Transforming growth factor-beta and T-cell-mediated immunoregulation in the control of autoimmune diabetesQ36563528
Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signalingQ36873593
Finding a way out: lymphocyte egress from lymphoid organsQ37008187
Suppressive functions of activated B cells in autoimmune diseases reveal the dual roles of Toll-like receptors in immunity.Q37700798
Immune regulatory function of B cells.Q37973774
2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.Q39707090
Pharmacokinetics and pharmacodynamics of ponesimod, a selective S1P1 receptor modulator, in the first-in-human studyQ42016913
The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphaticsQ42521813
Combined FTY720/cyclosporine A treatment promotes graft survival and lowers the peripheral lymphocyte count in DA to lewis heart and skin transplantation modelsQ43584351
Effects of FTY720 in MRL-lpr/lpr mice: therapeutic potential in systemic lupus erythematosus.Q43956895
Prevention of autoimmune diabetes by FTY720 in nonobese diabetic miceQ44260906
Multiple-dose FTY720: tolerability, pharmacokinetics, and lymphocyte responses in healthy subjectsQ44854831
Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice.Q44987202
Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreadingQ45760081
Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cellsQ45858705
Spreading of T-cell autoimmunity to cryptic determinants of an autoantigenQ46201877
Prevention and cure of autoimmune diabetes in nonobese diabetic mice by continuous administration of FTY720.Q46478164
Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetesQ46512140
Detection and characterization of T cells specific for BDC2.5 T cell-stimulating peptides.Q47564253
L-selectin(-/lo) and diabetogenic T cells are similarly distributed in prediabetic and diabetic nonobese diabetic mice.Q48032069
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)e77296
P577publication date2013-10-24
P1433published inPLOS OneQ564954
P1476titleTherapeutic use of a selective S1P1 receptor modulator ponesimod in autoimmune diabetes
P478volume8

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cites work (P2860)
Q38850104Clinical pharmacology, efficacy, and safety aspects of sphingosine-1-phosphate receptor modulators.
Q26771821Ponesimod, a selective S1P1 receptor modulator: a potential treatment for multiple sclerosis and other immune-mediated diseases
Q38794279Ponesimod, a selective sphingosine 1-phosphate (S1P1) receptor modulator for autoimmune diseases: review of clinical pharmacokinetics and drug disposition
Q37551932Sphingosine 1-Phosphate Receptor Modulators and Drug Discovery
Q38204270The organization of the sphingosine 1-phosphate signaling system
Q38830417Therapeutic anti-CD3 monoclonal antibodies: from bench to bedside