| scholarly article | Q13442814 |
| P2093 | author name string | Jianzhi Zhang | |
| Xionglei He | |||
| P2860 | cites work | Gene ontology: tool for the unification of biology | Q23781406 |
| Transcriptional regulatory code of a eukaryotic genome | Q27933887 | ||
| Altruism and social cheating in the social amoeba Dictyostelium discoideum | Q28141735 | ||
| Catalysis of S-nitrosothiols formation by serum albumin: the mechanism and implication in vascular control | Q28578257 | ||
| Lethality and centrality in protein networks | Q29547267 | ||
| Comparative assessment of large-scale data sets of protein-protein interactions | Q29547451 | ||
| Evidence for dynamically organized modularity in the yeast protein-protein interaction network | Q29614449 | ||
| Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways | Q30885679 | ||
| Why do hubs tend to be essential in protein networks? | Q33245657 | ||
| Pleiotropic models of quantitative variation | Q33956361 | ||
| The evolution of a pleiotropic fitness tradeoff in Pseudomonas fluorescens. | Q34331592 | ||
| From syndrome families to functional genomics | Q35813867 | ||
| A global view of pleiotropy and phenotypically derived gene function in yeast | Q40510242 | ||
| Highly expressed genes in yeast evolve slowly. | Q42541336 | ||
| Multifunctional genes | Q43147975 | ||
| Pleiotropy as a mechanism to stabilize cooperation | Q45095134 | ||
| A single determinant dominates the rate of yeast protein evolution | Q46525702 | ||
| Significant impact of protein dispensability on the instantaneous rate of protein evolution | Q46908778 | ||
| Seven types of pleiotropy. | Q52186240 | ||
| Pleiotropy and the preservation of perfection | Q52248147 | ||
| Two steps forward, one step back: the pleiotropic effects of favoured alleles. | Q55038485 | ||
| Protein networks, pleiotropy and the evolution of senescence. | Q55287052 | ||
| The Effect of Multifunctionality on the Rate of Evolution in Yeast | Q56930372 | ||
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | pleiotropy | Q1134884 |
| P1104 | number of pages | 7 | |
| P304 | page(s) | 1885-1891 | |
| P577 | publication date | 2006-05-15 | |
| P1433 | published in | Genetics | Q3100575 |
| P1476 | title | Toward a molecular understanding of pleiotropy | |
| P478 | volume | 173 |
| Q33633427 | Abundant indispensable redundancies in cellular metabolic networks |
| Q35542127 | Abundant pleiotropy in human complex diseases and traits. |
| Q36304182 | Adaptation of A-to-I RNA editing in Drosophila. |
| Q59328849 | Alleles of a gene differ in pleiotropy, often mediated through currency metabolite production, in E. coli and yeast metabolic simulations |
| Q33528269 | An integrative modular approach to systematically predict gene-phenotype associations |
| Q89637612 | Antagonistic pleiotropy conceals molecular adaptations in changing environments |
| Q28270717 | Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis |
| Q33356601 | Assessing duplication and loss of APETALA1/FRUITFULL homologs in Ranunculales |
| Q58802595 | Biased Inference of Selection Due to GC-Biased Gene Conversion and the Rate of Protein Evolution in Flycatchers When Accounting for It |
| Q34350835 | Canonical correlation analysis for gene-based pleiotropy discovery |
| Q85096472 | Characterization and precise mapping of a QTL increasing spike number with pleiotropic effects in wheat |
| Q30943423 | Chromatin regulation and gene centrality are essential for controlling fitness pleiotropy in yeast |
| Q38845311 | Comparative genomic analysis of novel Acinetobacter symbionts: A combined systems biology and genomics approach |
| Q37521835 | Complex Patterns of Association between Pleiotropy and Transcription Factor Evolution. |
| Q42385487 | Confounding by linkage disequilibrium |
| Q33842066 | Contrasting genetic paths to morphological and physiological evolution |
| Q55023679 | Correlates of evolutionary rates in the murine sperm proteome. |
| Q34417712 | Current advances in systems and integrative biology |
| Q28645761 | Determinants of the rate of protein sequence evolution |
| Q50764408 | Dictyostelium development shows a novel pattern of evolutionary conservation. |
| Q35871930 | Disentangling the multigenic and pleiotropic nature of molecular function |
| Q37685870 | Effects of different kinds of essentiality on sequence evolution of human testis proteins |
| Q42986908 | Elucidating the genotype-phenotype relationships and network perturbations of human shared and specific disease genes from an evolutionary perspective |
| Q41962122 | Evolution of UCP1 Transcriptional Regulatory Elements Across the Mammalian Phylogeny |
| Q82600043 | Evolution of adaptive phenotypic variation patterns by direct selection for evolvability |
| Q91627570 | Evolution of multifunctionality through a pleiotropic substitution in the innate immune protein S100A9 |
| Q35037992 | Evolution of pleiotropy: epistatic interaction pattern supports a mechanistic model underlying variation in genotype-phenotype map. |
| Q35740900 | Evolutionary Genomics of Genes Involved in Olfactory Behavior in the Drosophila melanogaster Species Group |
| Q42059556 | Evolutionary framework for protein sequence evolution and gene pleiotropy |
| Q35037568 | Evolutionary rate patterns of genes involved in the Drosophila Toll and Imd signaling pathway |
| Q36839033 | Exploring the genetic basis of chronic periodontitis: a genome-wide association study |
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| Q36439810 | Gene functional trade-offs and the evolution of pleiotropy. |
| Q30828640 | Gene pleiotropy constrains gene expression changes in fish adapted to different thermal conditions |
| Q33387068 | Genetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks |
| Q63683178 | Genetic overlap between birthweight and adult cardiometabolic diseases has implications for genomic medicine |
| Q64108527 | Genome analysis and pleiotropy assessment using causal networks with loss of function mutation and metabolomics |
| Q35799076 | Genome-Wide Detection and Analysis of Multifunctional Genes |
| Q36238787 | Genome-wide SNP discovery and QTL mapping for fruit quality traits in inbred backcross lines (IBLs) of solanum pimpinellifolium using genotyping by sequencing |
| Q64090101 | Genome-wide sexually antagonistic variants reveal long-standing constraints on sexual dimorphism in fruit flies |
| Q34140433 | Genomic patterns of pleiotropy and the evolution of complexity |
| Q35032288 | Going the distance for protein function prediction: a new distance metric for protein interaction networks |
| Q46042061 | Highly expressed genes evolve under strong epistasis from a proteome-wide scan in E. coli |
| Q35828145 | In search of the biological significance of modular structures in protein networks |
| Q46280561 | Linkage of A-to-I RNA editing in metazoans and the impact on genome evolution. |
| Q55116101 | Mapping biological process relationships and disease perturbations within a pathway network. |
| Q48164751 | Mapping genotype-phenotype associations of nsSNPs in coiled-coil oligomerization domains of the human proteome |
| Q90615329 | Mendel's laws, Mendelian randomization and causal inference in observational data: substantive and nomenclatural issues |
| Q27002487 | Mendelian randomization: genetic anchors for causal inference in epidemiological studies |
| Q57797074 | Metabolic determinants of enzyme evolution in a genome-scale bacterial metabolic network |
| Q36012810 | Molecular evolution of anthocyanin pigmentation genes following losses of flower color |
| Q42031438 | Molecular evolution, mutation size and gene pleiotropy: a geometric reexamination. |
| Q46821494 | Morphological integration and pleiotropy in the adaptive body shape of the snail-feeding carabid beetle Damaster blaptoides |
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| Q34529805 | Natural selection drives rapid evolution of mouse embryonic heart enhancers |
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| Q33484932 | Ontogeny and phylogeny: molecular signatures of selection, constraint, and temporal pleiotropy in the development of Drosophila |
| Q57147991 | Parallel evolution of gene expression between trophic specialists despite divergent genotypes and morphologies |
| Q34150453 | Phenomics: the next challenge |
| Q42071091 | Phylogenetic and physicochemical analyses enhance the classification of rare nonsynonymous single nucleotide variants in type 1 and 2 long-QT syndrome |
| Q34201078 | Phylomedicine: an evolutionary telescope to explore and diagnose the universe of disease mutations |
| Q33895021 | Pleiotropic mutations are subject to strong stabilizing selection |
| Q64982299 | Pleiotropy Modulates the Efficacy of Selection in Drosophila melanogaster. |
| Q90634750 | Pleiotropy facilitates local adaptation to distant optima in common ragweed (Ambrosia artemisiifolia) |
| Q43049008 | Pleiotropy of the de novo-originated gene MDF1. |
| Q40013436 | Positive Selection and Centrality in the Yeast and Fly Protein-Protein Interaction Networks |
| Q49822312 | Powerful and robust cross-phenotype association test for case-parent trios. |
| Q46805533 | Protein Moonlighting Revealed by Non-catalytic Phenotypes of Yeast Enzymes |
| Q92511133 | RNAi as a Tool to Study Virulence in the Pathogenic Yeast Candida glabrata |
| Q30838915 | Recombination rate and protein evolution in yeast |
| Q47363422 | Seed size is determined by the combinations of the genes controlling different seed characteristics in rice |
| Q99236135 | Speciation and the developmental alarm clock |
| Q27684658 | Structural Analysis and Mutant Growth Properties Reveal Distinctive Enzymatic and Cellular Roles for the Three Major L-Alanine Transaminases of Escherichia coli |
| Q38883822 | Structure of the Transcriptional Regulatory Network Correlates with Regulatory Divergence in Drosophila |
| Q42376635 | Synteny analysis of genes and distribution of loci controlling oil content and fatty acid profile based on QTL alignment map in Brassica napus |
| Q40950164 | Systematic Analyses and Prediction of Human Drug Side Effect Associated Proteins from the Perspective of Protein Evolution |
| Q36098282 | Systematic condition-dependent annotation of metabolic genes |
| Q24654990 | The developmentally active and stress-inducible noncoding hsromega gene is a novel regulator of apoptosis in Drosophila |
| Q42680491 | The genetics and development of mandibles and hypopharyngeal sclerite and cornua in larvae of Drosophila gaucha. |
| Q36442608 | The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast |
| Q33833630 | The impact of multifunctional genes on "guilt by association" analysis |
| Q37035424 | The loci of evolution: how predictable is genetic evolution? |
| Q37628813 | The nature and extent of mutational pleiotropy in gene expression of male Drosophila serrata. |
| Q37844408 | The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms. |
| Q42290316 | The relationship between selection, network connectivity, and regulatory variation within a population of Capsella grandiora |
| Q35185458 | The relationships among microRNA regulation, intrinsically disordered regions, and other indicators of protein evolutionary rate |
| Q38080742 | Three independent determinants of protein evolutionary rate |
| Q38298177 | Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant. |
| Q90170592 | Ultraviolet irradiation increases size of the first clutch but decreases longevity in a marine copepod |
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