| P50 | author | Sarah Otto | Q7422662 |
| | Frédéric Guillaume | Q75233643 |
| P2093 | author name string | Frédéric Guillaume | |
| P2860 | cites work | The distribution of fitness effects of new mutations | Q22122013 |
| | Noise in gene expression: origins, consequences, and control | Q24537307 |
| | Preservation of duplicate genes by complementary, degenerative mutations | Q24548042 |
| | The role of population size, pleiotropy and fitness effects of mutations in the evolution of overlapping gene functions | Q24548107 |
| | Dissecting the regulatory circuitry of a eukaryotic genome | Q28131632 |
| | Stochastic gene expression in a single cell | Q28131784 |
| | Mechanisms of alternative pre-messenger RNA splicing | Q28131822 |
| | The evolutionary origin of complex features | Q28203090 |
| | The 'evolvability' of promiscuous protein functions | Q28295483 |
| | Pleiotropic scaling of gene effects and the 'cost of complexity'. | Q51691507 |
| | Seven types of pleiotropy. | Q52186240 |
| | Evolution of genetic redundancy. | Q52193461 |
| | Efficient attenuation of stochasticity in gene expression through post-transcriptional control. | Q52561212 |
| | Application of method of small parameters to multi-niche population genetic models. | Q52978465 |
| | THE POPULATION GENETICS OF ADAPTATION: THE DISTRIBUTION OF FACTORS FIXED DURING ADAPTIVE EVOLUTION. | Q53762739 |
| | The evolution of functionally novel proteins after gene duplication. | Q55065818 |
| | The Effect of Multifunctionality on the Rate of Evolution in Yeast | Q56930372 |
| | Live Where You Thrive: Joint Evolution of Habitat Choice and Local Adaptation Facilitates Specialization and Promotes Diversity | Q56996415 |
| | FISHER'S MODEL AND THE GENOMICS OF ADAPTATION: RESTRICTED PLEIOTROPY, HETEROGENOUS MUTATION, AND PARALLEL EVOLUTION | Q60312268 |
| | ADAPTATION AND THE COST OF COMPLEXITY | Q63918282 |
| | Is modularity necessary for evolvability? Remarks on the relationship between pleiotropy and evolvability | Q73255917 |
| | Modularity and the cost of complexity | Q79076931 |
| | A negative relationship between mutation pleiotropy and fitness effect in yeast | Q80416810 |
| | Complexity, pleiotropy, and the fitness effect of mutations | Q84283923 |
| | Regulation of noise in the expression of a single gene | Q29616626 |
| | Stochastic mechanisms in gene expression | Q29617407 |
| | The probability of duplicate gene preservation by subfunctionalization | Q29618530 |
| | The evolution of gene duplications: classifying and distinguishing between models | Q29619358 |
| | Evolution restricts the coexistence of specialists and generalists: the role of trade-off structure | Q33202553 |
| | Diversification and specialization of HIV protease function during in vitro evolution | Q33232096 |
| | The genetics of adaptive shape shift in stickleback: pleiotropy and effect size | Q33305668 |
| | Pervasive and persistent redundancy among duplicated genes in yeast | Q33349457 |
| | Metabolic flux and fitness | Q33952746 |
| | Enzyme promiscuity: a mechanistic and evolutionary perspective | Q34021669 |
| | Temporal constraints on the incorporation of regulatory mutants in evolutionary pathways | Q34029750 |
| | Maintenance of duplicate genes and their functional redundancy by reduced expression | Q34131177 |
| | Genomic patterns of pleiotropy and the evolution of complexity | Q34140433 |
| | High-dimensional and large-scale phenotyping of yeast mutants. | Q34230587 |
| | Perspective: Evolution and detection of genetic robustness | Q34271971 |
| | Optimality and evolutionary tuning of the expression level of a protein | Q34437723 |
| | Enzyme/crystallins: gene sharing as an evolutionary strategy | Q34499074 |
| | Rapid subfunctionalization accompanied by prolonged and substantial neofunctionalization in duplicate gene evolution | Q34570892 |
| | General models of multilocus evolution | Q34615594 |
| | Stochastic gene expression in fluctuating environments | Q34644561 |
| | Escape from adaptive conflict after duplication in an anthocyanin pathway gene | Q34791156 |
| | Distinguishing among evolutionary models for the maintenance of gene duplicates | Q34992045 |
| | Toward a molecular understanding of pleiotropy | Q35038443 |
| | Multiple routes to subfunctionalization and gene duplicate specialization | Q35748295 |
| | Evolution of functional specialization and division of labor | Q35751073 |
| | Macroevolutionary patterns of defense and pollination in Dalechampia vines: adaptation, exaptation, and evolutionary novelty | Q37416551 |
| | The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms. | Q37844408 |
| | Organ and cell type-specific complementary expression patterns and regulatory neofunctionalization between duplicated genes in Arabidopsis thaliana | Q39935489 |
| | A global view of pleiotropy and phenotypically derived gene function in yeast | Q40510242 |
| | Function of the Outer Membrane of Escherichia coli as a Permeability Barrier to Beta-Lactam Antibiotics | Q40816744 |
| | Selection to minimise noise in living systems and its implications for the evolution of gene expression | Q42231890 |
| | The evolution of epistasis and its links with genetic robustness, complexity and drift in a phenotypic model of adaptation | Q43138629 |
| | Heterogeneous patterns of gene-expression diversification in mammalian gene duplicates. | Q46159849 |
| | Stochastic switching as a survival strategy in fluctuating environments | Q46685546 |
| | QUANTITATIVE GENETIC ANALYSIS OF MULTIVARIATE EVOLUTION, APPLIED TO BRAIN:BODY SIZE ALLOMETRY. | Q47309479 |
| | Nemo: an evolutionary and population genetics programming framework. | Q48599388 |
| | Polymorphisms for genetic and ecological systems with weak coupling. | Q51227617 |
| | Individual-Level Bet Hedging in the Bacterium Sinorhizobium meliloti | Q51618847 |
| | Evolution of specialization in a spatially continuous environment. | Q51634637 |
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | pleiotropy | Q1134884 |
| P1104 | number of pages | 21 | |
| P304 | page(s) | 1389-1409 | |
| P577 | publication date | 2012-09-14 | |
| P1433 | published in | Genetics | Q3100575 |
| P1476 | title | Gene functional trade-offs and the evolution of pleiotropy | |
| P478 | volume | 192 | |