Pleiotropic scaling of gene effects and the 'cost of complexity'.

scientific article published in March 2008

Pleiotropic scaling of gene effects and the 'cost of complexity'. is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1044357623
P356DOI10.1038/NATURE06756
P698PubMed publication ID18368117
P5875ResearchGate publication ID5484625

P50authorJane P Kenney-HuntQ79750258
Mihaela PavličevQ79839599
James CheverudQ29922075
Gunter P WagnerQ57241866
P2093author name stringDavid Waxman
Joel R Peck
P2860cites workIs modularity necessary for evolvability? Remarks on the relationship between pleiotropy and evolvabilityQ73255917
Genetic architecture of adiposity in the cross of LG/J and SM/J inbred miceQ73441500
Mapping quantitative trait loci for murine growth: a closer look at genetic architectureQ73481624
Modularity and the cost of complexityQ79076931
A simple regression method for mapping quantitative trait loci in line crosses using flanking markersQ83828806
The Mouse Genome Database (MGD): from genes to mice--a community resource for mouse biologyQ24796985
The road to modularity.Q33305821
A general multivariate extension of Fisher's geometrical model and the distribution of mutation fitness effects across speciesQ33342879
The population genetic theory of hidden variation and genetic robustness.Q35990059
PERSPECTIVE: COMPLEX ADAPTATIONS AND THE EVOLUTION OF EVOLVABILITY.Q51606245
A simple correction for multiple comparisons in interval mapping genome scans.Q52052809
Pleiotropic effects on mandibular morphology I. Developmental morphological integration and differential dominance.Q52107509
Pleiotropy and the preservation of perfectionQ52248147
Perspective: Complex Adaptations and the Evolution of EvolvabilityQ56432056
The genetical theory of natural selectionQ61661297
ADAPTATION AND THE COST OF COMPLEXITYQ63918282
P433issue7186
P407language of work or nameEnglishQ1860
P921main subjectpleiotropyQ1134884
P304page(s)470-472
P577publication date2008-03-01
P1433published inNatureQ180445
P1476titlePleiotropic scaling of gene effects and the 'cost of complexity'
P478volume452

Reverse relations

cites work (P2860)
Q51714893A computational model of teeth and the developmental origins of morphological variation.
Q34082237A high frequency of beneficial mutations across multiple fitness components in Saccharomyces cerevisiae
Q37990117A model of developmental evolution: selection, pleiotropy and compensation.
Q111629295A note on gene pleiotropy estimation from phylogenetic analysis of protein sequences
Q30847585Aggressive behaviours, food deprivation and the foraging gene.
Q59328849Alleles of a gene differ in pleiotropy, often mediated through currency metabolite production, in E. coli and yeast metabolic simulations
Q90009982An atlas of evidence-based phenotypic associations across the mouse phenome
Q58741992Antagonistic pleiotropy for carbon use is rare in new mutations
Q51397216Bayesian mapping of multiple traits in maize: the importance of pleiotropic effects in studying the inheritance of quantitative traits.
Q81985351Biological theory: Postmodern evolution?
Q34350835Canonical correlation analysis for gene-based pleiotropy discovery
Q24600021Compensatory evolution and the origins of innovations
Q51349076Constraints on adaptation of Escherichia coli to mixed-resource environments increase over time.
Q53717083Diminishing-returns epistasis among random beneficial mutations in a multicellular fungus.
Q37337240Dissecting the pleiotropic consequences of a quantitative trait nucleotide
Q36130888Dissection of complex adult traits in a mouse synthetic population.
Q39748807Emergent adaptive behaviour of GRN-controlled simulated robots in a changing environment
Q51627623Enhancing effect of phenotype mutational robustness on adaptation in Escherichia coli.
Q38216619Epigenetic resolution of the 'curse of complexity' in adaptive evolution of complex traits
Q39246332Evolution of the Genotype-to-Phenotype Map and the Cost of Pleiotropy in Mammals
Q26751053Factors influencing the effect size distribution of adaptive substitutions
Q37358944Fine-mapping of obesity-related quantitative trait loci in an F9/10 advanced intercross line
Q34851593Fisher's geometric model with a moving optimum
Q34203627Fitness recovery and compensatory evolution in natural mutant lines of C. elegans
Q46741391Gene Conversion Facilitates Adaptive Evolution on Rugged Fitness Landscapes.
Q36439810Gene functional trade-offs and the evolution of pleiotropy.
Q42017279Genetic evaluation of eri silkworm Samia cynthia ricini: ISSR loci specific to high and low altitude regimes and quantitative attributes
Q33930782Genome factor and gene pleiotropy hypotheses in protein evolution
Q34140433Genomic patterns of pleiotropy and the evolution of complexity
Q38815938Genotypic Complexity of Fisher's Geometric Model
Q35878498Higher-order genetic and environmental structure of prevalent forms of child and adolescent psychopathology
Q42480395Humanized Foxp2 specifically affects cortico-basal ganglia circuits
Q59867557Impact of epistasis and pleiotropy on evolutionary adaptation
Q34436487Improved drug therapy: triangulating phenomics with genomics and metabolomics.
Q42056333Increase in quantitative variation after exposure to environmental stresses and/or introduction of a major mutation: G x E interaction and epistasis or canalization?
Q35551797Informed consent in genomics and genetic research
Q26830139Integrated phenotypes: understanding trait covariation in plants and animals
Q89431251Intermediate degrees of synergistic pleiotropy drive adaptive evolution in ecological time
Q48049403Intrinsic incompatibilities evolving as a by-product of divergent ecological selection: Considering them in empirical studies on divergence with gene flow
Q91575522Investigating the evolution and development of biological complexity under the framework of epigenetics
Q47229935Landscape of Pleiotropic Proteins Causing Human Disease: Structural and System Biology Insights
Q34314862Linear motif-mediated interactions have contributed to the evolution of modularity in complex protein interaction networks
Q41882961Mapping genetic variants underlying differences in the central nitrogen metabolism in fermenter yeasts
Q53412740Maternal vernalization and vernalization-pathway genes influence progeny seed germination.
Q27002487Mendelian randomization: genetic anchors for causal inference in epidemiological studies
Q83393973Modern lights
Q42031438Molecular evolution, mutation size and gene pleiotropy: a geometric reexamination.
Q46821494Morphological integration and pleiotropy in the adaptive body shape of the snail-feeding carabid beetle Damaster blaptoides
Q27348054Mosaic hoxb4a neuronal pleiotropism in zebrafish caudal hindbrain
Q98564761Natural variation at FLM splicing has pleiotropic effects modulating ecological strategies in Arabidopsis thaliana
Q91941936No Cost of Complexity in Bacteriophages Adapting to a Complex Environment
Q30493493Non-contact measurement of linear external dimensions of the mouse eye.
Q41904693On the pleiotropic structure of the genotype-phenotype map and the evolvability of complex organisms
Q34148932One Hundred Years of Pleiotropy: A Retrospective
Q49518041Pervasive Correlated Evolution in Gene Expression Shapes Cell and Tissue Type Transcriptomes.
Q50120268Pervasive, yet idiosyncratic, epistatic pleiotropy during adaptation in a behaviourally complex microbe
Q34150453Phenomics: the next challenge
Q59726405Pleiotropic effects of regulatory variation in tan result in correlation of two pigmentation traits in Drosophila melanogaster
Q33895021Pleiotropic mutations are subject to strong stabilizing selection
Q33389164Pleiotropic scaling and QTL data
Q64982299Pleiotropy Modulates the Efficacy of Selection in Drosophila melanogaster.
Q42544122Pleiotropy can be effectively estimated without counting phenotypes through the rank of a genotype-phenotype map.
Q90634750Pleiotropy facilitates local adaptation to distant optima in common ragweed (Ambrosia artemisiifolia)
Q50756042Pleiotropy in the wild: the dormancy gene DOG1 exerts cascading control on life cycles.
Q52745420Q(ST) < F(ST) As a signature of canalization.
Q37080868QTL clustering as a mechanism for rapid multi-trait evolution
Q88932496Robustness and evolvability of heterogeneous cell populations
Q42324334Selection Limits to Adaptive Walks on Correlated Landscapes
Q46466273Sex-specific repression of dachshund is required for Drosophila sex comb development
Q46249279Sympatric Speciation in the Genomic Era.
Q36429821Synergistic Pleiotropy Overrides the Costs of Complexity in Viral Adaptation
Q36155397The Genetic Architecture of Domestication in Animals
Q116202018The Tiger Rattlesnake genome reveals a complex genotype underlying a simple venom phenotype
Q38689208The Utility of Fisher's Geometric Model in Evolutionary Genetics
Q49557920The autonomous flowering-time pathway pleiotropically regulates seed germination in Arabidopsis thaliana
Q38273379The distribution of genetic variance across phenotypic space and the response to selection
Q28714473The effect of dietary adaption on cranial morphological integration in capuchins (order Primates, genus Cebus)
Q31040305The emergence of complexity and restricted pleiotropy in adapting networks
Q34768642The genesis of an exceptionally lethal venom in the timber rattlesnake (Crotalus horridus) revealed through comparative venom-gland transcriptomics
Q30276318The genetic architecture of local adaptation and reproductive isolation in sympatry within the Mimulus guttatus species complex
Q30275367The genetic architecture of novel trophic specialists: larger effect sizes are associated with exceptional oral jaw diversification in a pupfish adaptive radiation
Q33833630The impact of multifunctional genes on "guilt by association" analysis
Q34310887The many faces of pleiotropy
Q37628813The nature and extent of mutational pleiotropy in gene expression of male Drosophila serrata.
Q37844408The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms.
Q43102784The rate and effects of spontaneous mutation on fitness traits in the social amoeba, Dictyostelium discoideum
Q50476213The role of pleiotropy and linkage in genes affecting a sexual ornament and bone allocation in the chicken.
Q42701130The statistical mechanics of a polygenic character under stabilizing selection, mutation and drift
Q47430671The ubiquity of pleiotropy in human disease
Q39111011Trait Correlations in the Genomics Era.
Q89105578Transposable Element Exaptation into Regulatory Regions Is Rare, Influenced by Evolutionary Age, and Subject to Pleiotropic Constraints
Q46068445Understanding Evolutionary Impacts of Seasonality: An Introduction to the Symposium
Q33743116Understanding and using quantitative genetic variation
Q46529431Why ontogeny matters during adaptation: developmental niche construction and pleiotorpy across the life cycle in Arabidopsis thaliana

Search more.