| scholarly article | Q13442814 |
| P50 | author | Daniel E. Dykhuizen | Q125800223 |
| P2093 | author name string | A M Dean | |
| D L Hartl | |||
| P2860 | cites work | The control of flux | Q28237216 |
| IN VIVO Function of Rare G6pd Variants from Natural Populations of DROSOPHILA MELANOGASTER. | Q33952168 | ||
| The molecular basis of dominance. | Q34283978 | ||
| ENZYME INDUCTION AS AN ALL-OR-NONE PHENOMENON | Q37617203 | ||
| The alcohol dehydrogenase polymorphism in populations of Drosophila melanogaster. I. Selection in different environments | Q39623347 | ||
| Inhibition of growth of Escherichia coli by lactose and other galactosides | Q41617211 | ||
| Quantification of the importance of individual steps in the control of aromatic amino acid metabolism | Q42503579 | ||
| Selective disadvantage of non-functional protein synthesis in Escherichia coli | Q44558505 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | flux | Q5463013 |
| P304 | page(s) | 25-31 | |
| P577 | publication date | 1987-01-01 | |
| P1433 | published in | Genetics | Q3100575 |
| P1476 | title | Metabolic flux and fitness | |
| P478 | volume | 115 |
| Q33319560 | "Ant" and "grasshopper" life-history strategies in Saccharomyces cerevisiae |
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| Q34130237 | Adaptive evolution of the lactose utilization network in experimentally evolved populations of Escherichia coli. |
| Q42876399 | Analysis of genetic systems using experimental evolution and whole-genome sequencing |
| Q36873739 | Bacteriophage adsorption rate and optimal lysis time |
| Q37173084 | Benefit of transferred mutations is better predicted by the fitness of recipients than by their ecological or genetic relatedness |
| Q36710493 | Biophysical principles predict fitness landscapes of drug resistance. |
| Q38997863 | Bridging the physical scales in evolutionary biology: from protein sequence space to fitness of organisms and populations |
| Q33955685 | Causes and consequences of variation in energy storage in Drosophila melanogaster |
| Q27316551 | Cellular Growth Arrest and Persistence from Enzyme Saturation |
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| Q28776650 | Comparative evolution: latent potentials for anagenetic advance |
| Q41478229 | Compensatory evolution for a gene deletion is not limited to its immediate functional network |
| Q90029099 | Comprehensive fitness maps of Hsp90 show widespread environmental dependence |
| Q37428442 | Contribution of selection for protein folding stability in shaping the patterns of polymorphisms in coding regions |
| Q36123436 | Control of gluconeogenic growth by pps and pck in Escherichia coli |
| Q39943390 | Control of glucose metabolism by enzyme IIGlc of the phosphoenolpyruvate-dependent phosphotransferase system in Escherichia coli |
| Q41807801 | Control of metabolic flux through the quinate pathway in Aspergillus nidulans |
| Q89287615 | Cover-Encodings of Fitness Landscapes |
| Q34589777 | Designing antibiotic cycling strategies by determining and understanding local adaptive landscapes |
| Q55283806 | Different adaptive strategies in E. coli populations evolving under macronutrient limitation and metal ion limitation. |
| Q37102641 | Direct evidence that genetic variation in glycerol-3-phosphate and malate dehydrogenase genes (Gpdh and Mdh1) affects adult ethanol tolerance in Drosophila melanogaster |
| Q33960338 | Do deleterious mutations act synergistically? Metabolic control theory provides a partial answer |
| Q60503746 | Effective models and the search for quantitative principles in microbial evolution |
| Q92002597 | Empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise |
| Q34615999 | Enzyme kinetics, substitutable resources and competition: from biochemistry to frequency-dependent selection in lac. |
| Q38740945 | Evolution of Resistance to Continuously Increasing Streptomycin Concentrations in Populations of Escherichia coli |
| Q34017244 | Evolution of a single gene highlights the complexity underlying molecular descriptions of fitness |
| Q24532228 | Evolution of bacterial transformation: is sex with dead cells ever better than no sex at all? |
| Q42021004 | Evolution of dominance in metabolic pathways. |
| Q24545715 | Evolution of specialists in an experimental microcosm |
| Q59357942 | Evolution on the Biophysical Fitness Landscape of an RNA Virus |
| Q83227653 | Evolutionary and functional insights into the mechanism underlying body-size-related adaptation of mammalian hemoglobin |
| Q30391409 | Evolutionary fates within a microbial population highlight an essential role for protein folding during natural selection |
| Q40743235 | Evolutionary genetics of the Drosophila alcohol dehydrogenase gene-enzyme system |
| Q41132191 | Evolutionary implications of Liebig's law of the minimum: Selection under low concentrations of two nonsubstitutable nutrients |
| Q27330287 | Evolutionary pressures on microbial metabolic strategies in the chemostat |
| Q40872434 | Excess capacity of H(+)-ATPase and inverse respiratory control in Escherichia coli |
| Q46298716 | Fitness Effects of Cis-Regulatory Variants in the Saccharomyces cerevisiae TDH3 Promoter |
| Q35541962 | Fitness landscapes: an alternative theory for the dominance of mutation |
| Q34608241 | Fluxes and metabolic pools as model traits for quantitative genetics. I. The L-shaped distribution of gene effects. |
| Q36439810 | Gene functional trade-offs and the evolution of pleiotropy. |
| Q41365996 | Gene network requirements for regulation of metabolic gene expression to a desired state |
| Q55031183 | Heterosis Is a Systemic Property Emerging From Non-linear Genotype-Phenotype Relationships: Evidence From in Vitro Genetics and Computer Simulations. |
| Q41077094 | How biochemical constraints of cellular growth shape evolutionary adaptations in metabolism. |
| Q34795559 | Latent effects of Hsp90 mutants revealed at reduced expression levels |
| Q36136977 | Linkage between Fitness of Yeast Cells and Adenylate Kinase Catalysis |
| Q54594121 | Low synonymous site variation at the lacY locus in Escherichia coli suggests the action of positive selection. |
| Q27331437 | Mapping the environmental fitness landscape of a synthetic gene circuit |
| Q35105723 | Mapping the fitness landscape of gene expression uncovers the cause of antagonism and sign epistasis between adaptive mutations. |
| Q35860764 | Metabolic control analysis: a survey of its theoretical and experimental development |
| Q38515559 | Metabolism at evolutionary optimal States. |
| Q40024277 | Microbial physiology and ecology of slow growth. |
| Q41914396 | Models of quantitative variation of flux in metabolic pathways |
| Q33958757 | Mutation-selection balance and metabolic control theory |
| Q39063396 | No Evidence That Protein Noise-Induced Epigenetic Epistasis Constrains Gene Expression Evolution |
| Q38457018 | Nonlinear fitness consequences of variation in expression level of a eukaryotic gene |
| Q33981298 | Nonlinear fitness landscape of a molecular pathway |
| Q33994101 | Optimality and evolution of transcriptionally regulated gene expression |
| Q34415262 | Optimality models in the age of experimental evolution and genomics |
| Q41875215 | Optimality principles in the regulation of metabolic networks |
| Q54150482 | Optimization of lag phase shapes the evolution of a bacterial enzyme. |
| Q92568694 | Patterns and Mechanisms of Diminishing Returns from Beneficial Mutations |
| Q41686698 | Predicting metabolic adaptation from networks of mutational paths |
| Q35814404 | Protein Homeostasis Imposes a Barrier on Functional Integration of Horizontally Transferred Genes in Bacteria |
| Q36078939 | Protein engineering reveals ancient adaptive replacements in isocitrate dehydrogenase |
| Q36532990 | Protein quality control acts on folding intermediates to shape the effects of mutations on organismal fitness |
| Q37029009 | Quantification of control of microbial metabolism by substrates and enzymes |
| Q38787151 | Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature |
| Q90244482 | Recent insights into the genotype-phenotype relationship from massively parallel genetic assays |
| Q38343258 | Selection and neutrality in lactose operons of Escherichia coli |
| Q34616928 | Sequence variation of alcohol dehydrogenase (Adh) paralogs in cactophilic Drosophila. |
| Q34388337 | Sex linkage, sex-specific selection, and the role of recombination in the evolution of sexually dimorphic gene expression |
| Q36504175 | Small changes in enzyme function can lead to surprisingly large fitness effects during adaptive evolution of antibiotic resistance |
| Q35882435 | Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations |
| Q33650982 | Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes |
| Q92089759 | Substrate inhibition imposes fitness penalty at high protein stability |
| Q34029750 | Temporal constraints on the incorporation of regulatory mutants in evolutionary pathways |
| Q42533037 | The effect of mobile element IS10 on experimental regulatory evolution in Escherichia coli |
| Q33688870 | The evolution of control and distribution of adaptive mutations in a metabolic pathway |
| Q28354231 | The functional impact of Pgm amino acid polymorphism on glycogen content in Drosophila melanogaster |
| Q33956782 | The inheritance of metabolic flux: expressions for the within-sibship mean and variance given the parental genotypes. |
| Q34604653 | The molecular basis of quantitative genetic variation in central and secondary metabolism in Arabidopsis. |
| Q33953520 | The relationship between dipeptidase activity variation and larval viability in Drosophila melanogaster |
| Q37310327 | Transcriptional regulation of metabolism associated with the increased desiccation resistance of the cactophilic Drosophila mojavensis |
| Q37524872 | Transient protein-protein interactions perturb E. coli metabolome and cause gene dosage toxicity. |
| Q33954298 | Variation among extracted lines of Drosophila melanogaster in triacylglycerol and carbohydrate storage |
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