Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature

scientific article published on 24 March 2016

Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/PRO.2928
P932PMC publication ID4918414
P698PubMed publication ID27010590

P2093author name stringDan S Tawfik
Daniel N A Bolon
Jeffrey I Boucher
P2860cites workEVOLUTION IN MENDELIAN POPULATIONSQ5418627
A Balance between Inhibitor Binding and Substrate Processing Confers Influenza Drug ResistanceQ38812500
Systems-level response to point mutations in a core metabolic enzyme modulates genotype-phenotype relationship.Q40170200
Learning the sequence determinants of alternative splicing from millions of random sequencesQ40398219
Systematic mutation of bacteriophage T4 lysozymeQ50183536
Widespread aneuploidy revealed by DNA microarray expression profiling.Q52923550
Gene Frequency in Small Populations of Mutant DrosophilaQ56029134
Complete mutagenesis of the HIV-1 proteaseQ59066144
Experimental illumination of a fitness landscapeQ22066261
Fitness and its role in evolutionary geneticsQ22122004
Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collectionQ22122301
The probability of fixation in populations of changing size.Q24533249
Detailed imaging and genetic analysis reveal a secondary BRAF(L505H) resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenibQ27853105
Pervasive Cryptic Epistasis in Molecular EvolutionQ28475868
Rapid bursts and slow declines: on the possible evolutionary trajectories of enzymesQ28607014
Viewing protein fitness landscapes through a next-gen lens.Q30367833
Selective pressure causes an RNA virus to trade reproductive fitness for increased structural and thermal stability of a viral enzymeQ30424370
The role of functional data in interpreting the effects of genetic variationQ31018970
A comprehensive, high-resolution map of a gene's fitness landscapeQ33654337
Metabolic flux and fitnessQ33952746
The molecular basis of dominance.Q34283978
Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeastQ34490441
Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein.Q34584004
Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domainQ34662736
Latent effects of Hsp90 mutants revealed at reduced expression levelsQ34795559
Novel multilocus measure of linkage disequilibrium to estimate past effective population size.Q34994163
Deep mutational scanning: a new style of protein scienceQ35541240
High-resolution sequence-function mapping of full-length proteinsQ35581370
Systematic Mapping of Protein Mutational Space by Prolonged Drift Reveals the Deleterious Effects of Seemingly Neutral MutationsQ35746027
Soluble oligomerization provides a beneficial fitness effect on destabilizing mutationsQ35882435
Drift-barrier hypothesis and mutation-rate evolution.Q36389558
Protein quality control acts on folding intermediates to shape the effects of mutations on organismal fitnessQ36532990
Analyses of the effects of all ubiquitin point mutants on yeast growth rateQ36736277
Amino acid sequence determinants of beta-lactamase structure and activityQ36799732
P433issue7
P304page(s)1219-1226
P577publication date2016-03-24
P1433published inProtein ScienceQ7251445
P1476titleQuantifying and understanding the fitness effects of protein mutations: Laboratory versus nature
P478volume25

Reverse relations

cites work (P2860)
Q41021919A statistical guide to the design of deep mutational scanning experiments
Q64241424Adaptive Landscapes in the Age of Synthetic Biology
Q97676621Altered expression of a quality control protease in E. coli reshapes the in vivo mutational landscape of a model enzyme
Q92767542Chance and pleiotropy dominate genetic diversity in complex bacterial environments
Q92994631Changes in gene expression predictably shift and switch genetic interactions
Q89661627Characterizing lineage-specific evolution and the processes driving genomic diversification in chordates
Q90029099Comprehensive fitness maps of Hsp90 show widespread environmental dependence
Q91703100Deep generative models of genetic variation capture the effects of mutations
Q39019516Deep sequencing methods for protein engineering and design.
Q30389475Detection and sequence/structure mapping of biophysical constraints to protein variation in saturated mutational libraries and protein sequence alignments with a dedicated server
Q30151151Determination of binding affinity upon mutation for type I dockerin-cohesin complexes from Clostridium thermocellum and Clostridium cellulolyticum using deep sequencing
Q55427705Differential strengths of molecular determinants guide environment specific mutational fates.
Q49586384Engineered control of enzyme structural dynamics and function
Q47238297Experimental determination and prediction of the fitness effects of random point mutations in the biosynthetic enzyme HisA.
Q46599055Frustration, function and folding
Q36226848Functional Segregation of Overlapping Genes in HIV.
Q92583041GEMME: a simple and fast global epistatic model predicting mutational effects
Q92342787Genotype network intersections promote evolutionary innovation
Q47247657Hierarchical design of artificial proteins and complexes toward synthetic structural biology
Q33698683Inference of Epistatic Effects Leading to Entrenchment and Drug Resistance in HIV-1 Protease.
Q64970399Insights into protein structure, stability and function from saturation mutagenesis.
Q39018179Mutation effects predicted from sequence co-variation
Q30395457Potts Hamiltonian models of protein co-variation, free energy landscapes, and evolutionary fitness.
Q91825640Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases
Q92445284Robust Prediction of Single and Multiple Point Protein Mutations Stability Changes
Q64780559The proteostasis network and its decline in ageing

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