Optimality and evolutionary tuning of the expression level of a protein

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Optimality and evolutionary tuning of the expression level of a protein is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1007348192
P356DOI10.1038/NATURE03842
P698PubMed publication ID16049495
P5875ResearchGate publication ID7695245

P50authorUri AlonQ7900508
P2093author name stringErez Dekel
P2860cites workMathematical model of the lac operon: inducer exclusion, catabolite repression, and diauxic growth on glucose and lactose.Q52272848
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Population genetic variation in gene expression is associated with phenotypic variation in Saccharomyces cerevisiaeQ24791620
Analysis of optimality in natural and perturbed metabolic networksQ28213254
Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growthQ29397612
Network motifs: simple building blocks of complex networksQ29547340
From molecular to modular cell biologyQ29547493
Directed evolution of a genetic circuitQ30870894
High-throughput mutation detection underlying adaptive evolution of Escherichia coli-K12.Q31133406
Parallel changes in gene expression after 20,000 generations of evolution in EscherichiacoliQ34171913
Convergent evolution of gene circuitsQ34207780
Computation, prediction, and experimental tests of fitness for bacteriophage T7 mutants with permuted genomesQ36974531
The population genetics of Escherichia coliQ40080341
The protein burden of lac operon productsQ41563893
Biochemistry. How to make a superior cellQ43642011
The organization of metabolic reaction networks. III. Application for diauxic growth on glucose and lactoseQ43776901
Dynamics and bistability in a reduced model of the lac operon.Q44930453
P433issue7050
P407language of work or nameEnglishQ1860
P1104number of pages5
P304page(s)588-592
P577publication date2005-07-01
P1433published inNatureQ180445
P1476titleOptimality and evolutionary tuning of the expression level of a protein
P478volume436

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Q36850446The lag-phase during diauxic growth is a trade-off between fast adaptation and high growth rate
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Q33247453The life-cycle of operons
Q34247630The rate of the molecular clock and the cost of gratuitous protein synthesis
Q89876204The relation between crosstalk and gene regulation form revisited
Q28752207The relationship among gene expression, the evolution of gene dosage, and the rate of protein evolution
Q54310563The robustness and evolvability of transcription factor binding sites.
Q33868449The role of cellular objectives and selective pressures in metabolic pathway evolution.
Q42177302The shape-shifting quasispecies of RNA: one sequence, many functional folds
Q30582620The transcription factor titration effect dictates level of gene expression
Q97067846Time-resolved multi-omics analysis reveals the role of nutrient stress-induced resource reallocation for TAG accumulation in oleaginous fungus Mortierella alpina
Q92610747Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs
Q26998624Towards physiological complexity with in vitro single-molecule biophysics
Q36925231Transcriptional regulation constrains the organization of genes on eukaryotic chromosomes
Q28740288Transcriptional regulation is a major controller of cell cycle transition dynamics
Q37524872Transient protein-protein interactions perturb E. coli metabolome and cause gene dosage toxicity.
Q36021783Translation elicits a growth rate-dependent, genome-wide, differential protein production in Bacillus subtilis.
Q34678372Translational signatures and mRNA levels are highly correlated in human stably expressed genes
Q37203938Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation
Q51067465Tuning transcription of nutrient utilization genes to catabolic rate promotes growth in a gut bacterium.
Q37197219Underlying principles of natural selection in network evolution: systems biology approach.
Q34341551Understanding regulation of metabolism through feasibility analysis.
Q37787559Using Synthetic Biology to Understand the Evolution of Gene Expression
Q64988971Variable protein homeostasis in housekeeping and non-housekeeping pathways under mycotoxins stress.
Q35941090Varying environments can speed up evolution
Q33767436Visual account of protein investment in cellular functions
Q36249512Why are phenotypic mutation rates much higher than genotypic mutation rates?
Q92095155Yeasts collectively extend the limits of habitable temperatures by secreting glutathione

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