Diminishing returns epistasis among beneficial mutations decelerates adaptation

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Diminishing returns epistasis among beneficial mutations decelerates adaptation is …
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scholarly articleQ13442814

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P356DOI10.1126/SCIENCE.1203799
P932PMC publication ID3244271
P698PubMed publication ID21636771
P5875ResearchGate publication ID51187209

P2093author name stringDaniel Segrè
Christopher J Marx
Hsin-Hung Chou
Hsuan-Chao Chiu
Nigel F Delaney
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Darwinian evolution can follow only very few mutational paths to fitter proteinsQ29616042
Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscapeQ33892372
Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humansQ34152058
Formaldehyde-detoxifying role of the tetrahydromethanopterin-linked pathway in Methylobacterium extorquens AM1.Q34231710
Optimality and evolutionary tuning of the expression level of a proteinQ34437723
The biochemical architecture of an ancient adaptive landscapeQ34461523
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Bacterial growth inhibition by overproduction of proteinQ36823896
The dynamics of adaptation on correlated fitness landscapesQ37399576
The contribution of epistasis to the architecture of fitness in an RNA virusQ37593251
Impact of individual mutations on increased fitness in adaptively evolved strains of Escherichia coliQ39765598
C1 transfer enzymes and coenzymes linking methylotrophic bacteria and methanogenic ArchaeaQ48036772
Modular epistasis in yeast metabolism.Q51982575
Distributions of epistasis in microbes fit predictions from a fitness landscape model.Q54444950
Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cellsQ58862259
P433issue6034
P407language of work or nameEnglishQ1860
P921main subjectbeneficial mutationQ111187232
P304page(s)1190-1192
P577publication date2011-06-01
P1433published inScienceQ192864
P1476titleDiminishing returns epistasis among beneficial mutations decelerates adaptation
P478volume332

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