Patterns of Epistasis between beneficial mutations in an antibiotic resistance gene

scientific article published on 15 May 2013

Patterns of Epistasis between beneficial mutations in an antibiotic resistance gene is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/MOLBEV/MST096
P932PMC publication ID3708503
P698PubMed publication ID23676768
P5875ResearchGate publication ID236911511

P2093author name stringMartijn F Schenk
Joachim Krug
J Arjan G M de Visser
Merijn L M Salverda
Ivan G Szendro
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Fitness as a function of beta-galactosidase activity in Escherichia coliQ70312405
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Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offsQ27639212
The genetic landscape of a cellQ28131628
Darwinian evolution can follow only very few mutational paths to fitter proteinsQ29616042
Positive epistasis drives the acquisition of multidrug resistanceQ33486486
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Initial mutations direct alternative pathways of protein evolutionQ33847781
Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscapeQ33892372
Epistasis in a model of molecular signal transductionQ33904013
Epistasis between beneficial mutations and the phenotype-to-fitness Map for a ssDNA virusQ33926816
Multidimensional epistasis and the disadvantage of sex.Q33947009
Do deleterious mutations act synergistically? Metabolic control theory provides a partial answerQ33960338
Evolutionary accessibility of mutational pathwaysQ34005257
Sequence space and the ongoing expansion of the protein universeQ34116384
Reciprocal sign epistasis is a necessary condition for multi-peaked fitness landscapes.Q34155513
Deleterious mutations and the evolution of sexual reproductionQ34164458
Perspective: Sign epistasis and genetic constraint on evolutionary trajectoriesQ34437784
Missense meanderings in sequence space: a biophysical view of protein evolutionQ34439602
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Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein.Q34584004
Predicting evolutionary potential: in vitro evolution accurately reproduces natural evolution of the tem beta-lactamaseQ34614621
Dependence of epistasis on environment and mutation severity as revealed by in silico mutagenesis of phage t7.Q34614741
The stability effects of protein mutations appear to be universally distributedQ34625806
Incipient speciation by divergent adaptation and antagonistic epistasis in yeastQ34632967
Epistasis correlates to genomic complexityQ35080659
Stickbreaking: a novel fitness landscape model that harbors epistasis and is consistent with commonly observed patterns of adaptive evolutionQ35748281
Predictability of evolution depends nonmonotonically on population sizeQ36535179
Epistasis between deleterious mutations and the evolution of recombinationQ36751300
Natural evolution of TEM-1 β-lactamase: experimental reconstruction and clinical relevanceQ37735903
Mutational effects and the evolution of new protein functions.Q37773157
The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms.Q37844408
Molecular mechanisms of epistasis within and between genesQ37891527
Diminishing returns epistasis among beneficial mutations decelerates adaptationQ39954065
Diminishing Returns From Beneficial Mutations and Pervasive Epistasis Shape the Fitness Landscape for Rifampicin Resistance in Pseudomonas aeruginosaQ41166962
Magnitude and sign epistasis among deleterious mutations in a positive-sense plant RNA virusQ41841604
Epistasis as the primary factor in molecular evolutionQ43975683
Negative epistasis between beneficial mutations in an evolving bacterial populationQ44010374
P433issue8
P921main subjectantibiotic resistanceQ380775
beneficial mutationQ111187232
P304page(s)1779-1787
P577publication date2013-05-15
P1433published inMolecular Biology and EvolutionQ1992656
P1476titlePatterns of Epistasis between beneficial mutations in an antibiotic resistance gene
P478volume30

Reverse relations

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