| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | Lin Chao | |
| Daniel M Weinreich | |||
| Richard A Watson | |||
| P433 | issue | 6 | |
| P1104 | number of pages | 10 | |
| P304 | page(s) | 1165-1174 | |
| P577 | publication date | 2005-06-01 | |
| P1433 | published in | Evolution | Q4038411 |
| P1476 | title | Perspective: Sign epistasis and genetic constraint on evolutionary trajectories | |
| P478 | volume | 59 |
| Q36182021 | A Mutational Hotspot and Strong Selection Contribute to the Order of Mutations Selected for during Escherichia coli Adaptation to the Gut |
| Q42551296 | A comprehensive biophysical description of pairwise epistasis throughout an entire protein domain |
| Q33501199 | A developmental systems perspective on epistasis: computational exploration of mutational interactions in model developmental regulatory networks |
| Q28754894 | A framework for evolutionary systems biology |
| Q54474794 | A thousand empirical adaptive landscapes and their navigability. |
| Q35764270 | A tortoise-hare pattern seen in adapting structured and unstructured populations suggests a rugged fitness landscape in bacteria |
| Q41960754 | A unified model for functional and statistical epistasis and its application in quantitative trait Loci analysis. |
| Q37175865 | Adaptation in protein fitness landscapes is facilitated by indirect paths |
| Q33806975 | Adaptation to fluctuating temperatures in an RNA virus is driven by the most stringent selective pressure |
| Q35844678 | Adaptations to fluctuating selection in Drosophila |
| Q64241424 | Adaptive Landscapes in the Age of Synthetic Biology |
| Q34312048 | Adaptive evolution: evaluating empirical support for theoretical predictions |
| Q28607496 | Adaptive evolutionary paths from UV reception to sensing violet light by epistatic interactions |
| Q47587442 | Additive Phenotypes Underlie Epistasis of Fitness Effects |
| Q35991505 | Amino acid coevolution induces an evolutionary Stokes shift. |
| Q64060985 | An experimental assay of the interactions of amino acids from orthologous sequences shaping a complex fitness landscape |
| Q21145321 | Are there laws of genome evolution? |
| Q53800410 | Ascochyta blight disease of pea (Pisum sativum L.): defence-related candidate genes associated with QTL regions and identification of epistatic QTL. |
| Q37304871 | Assessing constraints on the path of regulatory sequence evolution |
| Q57029681 | Automated Design of Efficient and Functionally Diverse Enzyme Repertoires |
| Q36217511 | Beyond the Hypercube: Evolutionary Accessibility of Fitness Landscapes with Realistic Mutational Networks |
| Q51681337 | Bistability in two-locus models with selection, mutation, and recombination. |
| Q89531833 | Bridging non-overlapping reads illuminates high-order epistasis between distal protein sites in a GPCR |
| Q86832377 | Bypass of genetic constraints during mutator evolution to antibiotic resistance |
| Q47313036 | Cancer Progression Models and Fitness Landscapes: a Many-to-Many Relationship |
| Q28727500 | Cancer in light of experimental evolution |
| Q33829798 | Causes of molecular convergence and parallelism in protein evolution |
| Q92994631 | Changes in gene expression predictably shift and switch genetic interactions |
| Q36455998 | Clusters of Multiple Mutations: Incidence and Molecular Mechanisms |
| Q30300777 | Coevolution with bacteriophages drives genome-wide host evolution and constrains the acquisition of abiotic-beneficial mutations. |
| Q33844420 | Colloquium papers: Adaptive landscapes and protein evolution |
| Q33299585 | Coloration and the genetics of adaptation |
| Q47383675 | Compensatory mutations and epistasis for protein function |
| Q37173365 | Complementation and epistasis in viral coinfection dynamics |
| Q92126113 | Computational Complexity as an Ultimate Constraint on Evolution |
| Q42204146 | Contribution of silent mutations to thermal adaptation of RNA bacteriophage Qβ |
| Q38048269 | Current applications of models of genetic effects with interactions across the genome |
| Q35002361 | Damage-induced localized hypermutability. |
| Q35994748 | Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes |
| Q42633184 | Detecting epistasis from an ensemble of adapting populations. |
| Q42041571 | Deterministic and stochastic regimes of asexual evolution on rugged fitness landscapes |
| Q41166962 | Diminishing Returns From Beneficial Mutations and Pervasive Epistasis Shape the Fitness Landscape for Rifampicin Resistance in Pseudomonas aeruginosa |
| Q37244268 | Directed enzyme evolution: climbing fitness peaks one amino acid at a time |
| Q34082254 | Directionality of epistasis in a murine intercross population |
| Q35542057 | Distinguishing driver and passenger mutations in an evolutionary history categorized by interference |
| Q35862886 | Distribution of mutational fitness effects and of epistasis in the 5' untranslated region of a plant RNA virus |
| Q40158695 | Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin |
| Q61444092 | Do replicates of independent guppy lineages evolve similarly in a predator-free laboratory environment? |
| Q40599352 | Effect of host species on the topography of fitness landscape for a plant RNA virus. |
| Q64053406 | Effects of a previously selected antibiotic resistance on mutations acquired during development of a second resistance in Escherichia coli |
| Q53144970 | Efficient escape from local optima in a highly rugged fitness landscape by evolving RNA virus populations. |
| Q38218962 | Empirical fitness landscapes and the predictability of evolution |
| Q36858572 | Energy-dependent fitness: a quantitative model for the evolution of yeast transcription factor binding sites |
| Q37412772 | Environment determines epistatic patterns for a ssDNA virus |
| Q55436455 | Environmental change exposes beneficial epistatic interactions in a catalytic RNA. |
| Q33590790 | Enzyme Efficiency but Not Thermostability Drives Cefotaxime Resistance Evolution in TEM-1 β-Lactamase |
| Q35537800 | Epistasis among adaptive mutations in deer mouse hemoglobin. |
| Q36231358 | Epistasis and Entropy |
| Q39162611 | Epistasis and the Evolution of Antimicrobial Resistance |
| Q35536368 | Epistasis as a determinant of the HIV-1 protease's robustness to mutation |
| Q43975683 | Epistasis as the primary factor in molecular evolution |
| Q37404250 | Epistasis between antibiotic resistance mutations drives the evolution of extensively drug-resistant tuberculosis. |
| Q33926816 | Epistasis between beneficial mutations and the phenotype-to-fitness Map for a ssDNA virus |
| Q55226387 | Epistasis can lead to fragmented neutral spaces and contingency in evolution. |
| Q28652130 | Epistasis constrains mutational pathways of hemoglobin adaptation in high-altitude pikas |
| Q22122008 | Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems |
| Q21090199 | Epistatic adaptive evolution of human color vision |
| Q35204952 | Epistatic selection between coding and regulatory variation in human evolution and disease |
| Q34804767 | Estimate of effective recombination rate and average selection coefficient for HIV in chronic infection |
| Q90064873 | Estimating the predictability of cancer evolution |
| Q89925925 | Evolution Rapidly Optimizes Stability and Aggregation in Lattice Proteins Despite Pervasive Landscape Valleys and Mazes |
| Q34549616 | Evolution at increased error rate leads to the coexistence of multiple adaptive pathways in an RNA virus. |
| Q34596522 | Evolution of Escherichia coli rifampicin resistance in an antibiotic-free environment during thermal stress |
| Q35844800 | Evolution of coadaptation in a subdivided population |
| Q51720274 | Evolution of genetic architecture under directional selection. |
| Q35037992 | Evolution of pleiotropy: epistatic interaction pattern supports a mechanistic model underlying variation in genotype-phenotype map. |
| Q92879130 | Evolutionary Dynamics in the RNA Bacteriophage Qβ Depends on the Pattern of Change in Selective Pressures |
| Q34005257 | Evolutionary accessibility of mutational pathways |
| Q89545822 | Evolutionary constraints in fitness landscapes |
| Q35259655 | Evolutionary constraints to viroid evolution |
| Q30396932 | Evolutionary ecology of virus emergence |
| Q30587544 | Evolutionary rescue from extinction is contingent on a lower rate of environmental change |
| Q35867457 | Evolvability of an Optimal Recombination Rate |
| Q41140967 | Expected Effect of Deleterious Mutations on Within-Host Adaptation of Pathogens |
| Q27011210 | Experimental approaches to evaluate the contributions of candidate protein-coding mutations to phenotypic evolution |
| Q44331574 | Experimental evolution of a green fluorescent protein composed of 19 unique amino acids without tryptophan. |
| Q33523627 | Experimental evolution with E. coli in diverse resource environments. I. Fluctuating environments promote divergence of replicate populations |
| Q34362047 | Experiments on the role of deleterious mutations as stepping stones in adaptive evolution |
| Q28476065 | Fast growth increases the selective advantage of a mutation arising recurrently during evolution under metal limitation |
| Q38414823 | Fighting microbial drug resistance: a primer on the role of evolutionary biology in public health |
| Q28681872 | Fine-scale signatures of molecular evolution reconcile models of indel-associated mutation |
| Q30671403 | Fisher's geometric model of adaptation meets the functional synthesis: data on pairwise epistasis for fitness yields insights into the shape and size of phenotype space |
| Q36365273 | Fitness Costs of Drug Resistance Mutations in Multidrug-Resistant Mycobacterium tuberculosis: A Household-Based Case-Control Study |
| Q26797312 | Fitness Landscapes of Functional RNAs |
| Q33853183 | Fitness epistasis and constraints on adaptation in a human immunodeficiency virus type 1 protein region |
| Q33732926 | Fitness flux and ubiquity of adaptive evolution |
| Q33261002 | From bad to good: Fitness reversals and the ascent of deleterious mutations |
| Q36586464 | Functional evolution of an anthocyanin pathway enzyme during a flower color transition |
| Q58541909 | Functional trade-offs and environmental variation shaped ancient trajectories in the evolution of dim-light vision |
| Q35579843 | Genetic architecture and functional characterization of genes underlying the rapid diversification of male external genitalia between Drosophila simulans and Drosophila mauritiana |
| Q43184230 | Genetic background affects epistatic interactions between two beneficial mutations |
| Q38639465 | Genetic variation in adaptability and pleiotropy in budding yeast |
| Q92450927 | Genetic variations on 31 and 450 residues of influenza A nucleoprotein affect viral replication and translation |
| Q35627463 | Genetically integrated traits and rugged adaptive landscapes in digital organisms |
| Q34029760 | Genic incompatibilities in two hybrid bacteriophages |
| Q51610625 | Genome structure and the benefit of sex |
| Q38815938 | Genotypic Complexity of Fisher's Geometric Model |
| Q28703571 | Genotypic but not phenotypic historical contingency revealed by viral experimental evolution |
| Q37031955 | Gradual neofunctionalization in the convergent evolution of trichomonad lactate and malate dehydrogenases |
| Q34611420 | High-resolution quantitative trait locus mapping reveals sign epistasis controlling ovariole number between two Drosophila species |
| Q44307374 | High-throughput identification of genetic interactions in HIV-1. |
| Q22066316 | Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli |
| Q59867557 | Impact of epistasis and pleiotropy on evolutionary adaptation |
| Q28486262 | In vitro HIV-1 evolution in response to triple reverse transcriptase inhibitors & in silico phenotypic analysis |
| Q34910341 | Incremental steps toward incompatibility revealed by Arabidopsis epistatic interactions modulating salicylic acid pathway activation. |
| Q33730568 | Inferring fitness landscapes by regression produces biased estimates of epistasis. |
| Q47102776 | Inferring genetic interactions from comparative fitness data. |
| Q33847781 | Initial mutations direct alternative pathways of protein evolution |
| Q53840555 | Insights into the evolutionary trajectories of fluoroquinolone resistance in Streptococcus pneumoniae. |
| Q34402716 | Integrating evolutionary and functional tests of adaptive hypotheses: a case study of altitudinal differentiation in hemoglobin function in an Andean Sparrow, Zonotrichia capensis |
| Q35620434 | Interactions among flower-size QTL of Mimulus guttatus are abundant but highly variable in nature |
| Q33601927 | Intricate environment-modulated genetic networks control isoflavone accumulation in soybean seeds |
| Q42706151 | Introduction to focus issue: genetic interactions |
| Q48062443 | Lack of Evidence for Sign Epistasis Between Beneficial Mutations in an RNA Bacteriophage |
| Q54246545 | Large-scale sequence analysis reveals novel human-adaptive markers in PB2 segment of seasonal influenza A viruses. |
| Q48297642 | Local Fitness Landscapes Predict Yeast Evolutionary Dynamics in Directionally Changing Environments |
| Q40567914 | Love the one you're with: replicate viral adaptations converge on the same phenotypic change |
| Q41841604 | Magnitude and sign epistasis among deleterious mutations in a positive-sense plant RNA virus |
| Q90117577 | Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape |
| Q64940140 | Mapping a Systematic Ribozyme Fitness Landscape Reveals a Frustrated Evolutionary Network for Self-Aminoacylating RNA. |
| Q35105723 | Mapping the fitness landscape of gene expression uncovers the cause of antagonism and sign epistasis between adaptive mutations. |
| Q34917091 | Mechanisms of protein sequence divergence and incompatibility |
| Q28757580 | Mechanistic approaches to the study of evolution: the functional synthesis |
| Q91891435 | Minimum epistasis interpolation for sequence-function relationships |
| Q33283066 | Mitotic recombination accelerates adaptation in the fungus Aspergillus nidulans |
| Q34244906 | Modelling the evolutionary dynamics of viruses within their hosts: a case study using high-throughput sequencing. |
| Q64232908 | Modular epistasis and the compensatory evolution of gene deletion mutants |
| Q28481297 | Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background |
| Q42919531 | Monotonicity is a key feature of genotype-phenotype maps |
| Q35207592 | Morphological evolution caused by many subtle-effect substitutions in regulatory DNA. |
| Q36779247 | Multidimensional adaptive evolution of a feed-forward network and the illusion of compensation |
| Q35260820 | Multidimensional epistasis and the transitory advantage of sex. |
| Q43245159 | Multiple Resistance at No Cost: Rifampicin and Streptomycin a Dangerous Liaison in the Spread of Antibiotic Resistance. |
| Q56985102 | Mutation and Epistasis in Influenza Virus Evolution |
| Q47613442 | Mutation-Driven Parallel Evolution during Viral Adaptation |
| Q34477455 | Mutational effects and population dynamics during viral adaptation challenge current models |
| Q56897124 | Mutational neighbourhood and mutation supply rate constrain adaptation in Pseudomonas aeruginosa |
| Q42686900 | Negative Epistasis and Evolvability in TEM-1 β-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder |
| Q46812108 | Negative Epistasis in Experimental RNA Fitness Landscapes. |
| Q44010374 | Negative epistasis between beneficial mutations in an evolving bacterial population |
| Q88454830 | Neutral Theory, Disease Mutations, and Personal Exomes |
| Q42219041 | Next generation genetics |
| Q91941936 | No Cost of Complexity in Bacteriophages Adapting to a Complex Environment |
| Q39063396 | No Evidence That Protein Noise-Induced Epigenetic Epistasis Constrains Gene Expression Evolution |
| Q37493368 | On the (un)predictability of a large intragenic fitness landscape |
| Q42024777 | On the evolution of epistasis III: the haploid case with mutation |
| Q51601956 | Origin of the fittest: link between emergent variation and evolutionary change as a critical question in evolutionary biology. |
| Q59049673 | Pairwise and higher-order genetic interactions during the evolution of a tRNA |
| Q45994253 | Parallel emergence of negative epistasis across experimental lineages. |
| Q36198245 | Parallel genetic changes and nonparallel gene-environment interactions characterize the evolution of drug resistance in yeast |
| Q41864870 | Patterns of Epistasis between beneficial mutations in an antibiotic resistance gene |
| Q92685171 | Pervasive Pairwise Intragenic Epistasis among Sequential Mutations in TEM-1 β-Lactamase |
| Q28476356 | Pervasive sign epistasis between conjugative plasmids and drug-resistance chromosomal mutations |
| Q41816651 | Phenotypic Consequences of a Spontaneous Loss of Heterozygosity in a Common Laboratory Strain of Candida albicans |
| Q21128784 | Phenotypic landscape inference reveals multiple evolutionary paths to C4 photosynthesis |
| Q33517082 | Phylogenetic analysis of population-based and deep sequencing data to identify coevolving sites in the nef gene of HIV-1. |
| Q46910878 | Polygenicity and Epistasis Underlie Fitness-Proximal Traits in the Caenorhabditis elegans Multiparental Experimental Evolution (CeMEE) Panel. |
| Q34200949 | Positive and purifying selection influence the evolution of doublesex in the Anastrepha fraterculus species group |
| Q33486486 | Positive epistasis drives the acquisition of multidrug resistance |
| Q41577456 | Positively selected amino acid replacements within the RuBisCO enzyme of oak trees are associated with ecological adaptations |
| Q36535179 | Predictability of evolution depends nonmonotonically on population size |
| Q21145317 | Predictability of evolutionary trajectories in fitness landscapes |
| Q35079781 | Properties of selected mutations and genotypic landscapes under Fisher's geometric model. |
| Q35556345 | Protein evolution. Pervasive degeneracy and epistasis in a protein-protein interface. |
| Q36525066 | Quantifying homologous replacement of loci between haloarchaeal species. |
| Q34082630 | Quantifying selection acting on a complex trait using allele frequency time series data. |
| Q35077513 | Quantifying the similarity of monotonic trajectories in rough and smooth fitness landscapes |
| Q41842018 | Random mutagenesis by error-prone pol plasmid replication in Escherichia coli |
| Q92624051 | Rank orders and signed interactions in evolutionary biology |
| Q42267948 | Rapid adaptive amplification of preexisting variation in an RNA virus |
| Q30555815 | Rate of adaptation in sexuals and asexuals: a solvable model of the Fisher-Muller effect |
| Q41911214 | Rates of fitness decline and rebound suggest pervasive epistasis |
| Q33892372 | Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape |
| Q41957848 | Recombinant inbred systems can advance research in behavioral ecology |
| Q52370978 | Recombination and peak jumping. |
| Q37446399 | Regulatory changes in two chemoreceptor genes contribute to a Caenorhabditis elegans QTL for foraging behavior. |
| Q86956375 | Repeatability of adaptation in experimental populations of different sizes |
| Q41905788 | Repeatability of evolution on epistatic landscapes |
| Q34039191 | Repeated elevational transitions in hemoglobin function during the evolution of Andean hummingbirds. |
| Q34504896 | Replaying the tape of life: quantification of the predictability of evolution |
| Q33507752 | Retracing evolution of red fluorescence in GFP-like proteins from Faviina corals |
| Q33956067 | Role of conservative mutations in protein multi-property adaptation |
| Q24635911 | Second-order selection for evolvability in a large Escherichia coli population |
| Q42324334 | Selection Limits to Adaptive Walks on Correlated Landscapes |
| Q92222637 | Selection for novel metabolic capabilities in Salmonella enterica |
| Q55455345 | Selection history and epistatic interactions impact dynamics of adaptation to novel environmental stresses. |
| Q34116384 | Sequence space and the ongoing expansion of the protein universe |
| Q38952339 | Sex in a test tube: testing the benefits of in vitro recombination |
| Q35035921 | Should evolutionary geneticists worry about higher-order epistasis? |
| Q28597478 | Should tissue structure suppress or amplify selection to minimize cancer risk? |
| Q37443790 | Spatially and temporally varying selection on intrapopulation quantitative trait loci for a life history trade-off in Mimulus guttatus |
| Q34451674 | Species-wide genetic incompatibility analysis identifies immune genes as hot spots of deleterious epistasis |
| Q42243500 | Speeding up Evolutionary Search by Small Fitness Fluctuations |
| Q33590863 | Stability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of Avian Hemoglobin |
| Q21128791 | Stability-mediated epistasis constrains the evolution of an influenza protein |
| Q28547894 | Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance |
| Q35065085 | Strain diversity, epistasis and the evolution of drug resistance in Mycobacterium tuberculosis |
| Q37346935 | Substrate ambiguous enzymes within the Escherichia coli proteome offer different evolutionary solutions to the same problem |
| Q40393216 | Survival probability of beneficial mutations in bacterial batch culture |
| Q41969617 | Symbiote transmission and maintenance of extra-genomic associations |
| Q36643918 | Synchronous waves of failed soft sweeps in the laboratory: remarkably rampant clonal interference of alleles at a single locus |
| Q37730909 | TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions |
| Q53085468 | Testing for Independence between Evolutionary Processes. |
| Q36060342 | The Context-Dependence of Mutations: A Linkage of Formalisms |
| Q55002438 | The Influence of Higher-Order Epistasis on Biological Fitness Landscape Topography. |
| Q28646039 | The Valley-of-Death: reciprocal sign epistasis constrains adaptive trajectories in a constant, nutrient limiting environment |
| Q26860873 | The causes of epistasis |
| Q35172659 | The changing geometry of a fitness landscape along an adaptive walk |
| Q39450951 | The competition between simple and complex evolutionary trajectories in asexual populations. |
| Q34399491 | The consistency of beneficial fitness effects of mutations across diverse genetic backgrounds |
| Q34893085 | The cost of antibiotic resistance depends on evolutionary history in Escherichia coli. |
| Q42145476 | The dynamics of adapting, unregulated populations and a modified fundamental theorem |
| Q34468851 | The effect of bacterial recombination on adaptation on fitness landscapes with limited peak accessibility |
| Q42533037 | The effect of mobile element IS10 on experimental regulatory evolution in Escherichia coli |
| Q46394732 | The effects of the genetic background on herbicide resistance fitness cost and its associated dominance in Arabidopsis thaliana |
| Q28070080 | The evolution of the placenta |
| Q39217959 | The frequency of fitness peak shifts is increased at expanding range margins due to mutation surfing |
| Q28649903 | The functional basis of adaptive evolution in chemostats |
| Q37353497 | The genetics of adaptation for eight microvirid bacteriophages |
| Q53743078 | The genomic basis of adaptation to the fitness cost of rifampicin resistance in Pseudomonas aeruginosa. |
| Q35231934 | The genomic landscape of compensatory evolution |
| Q88599476 | The geometry of partial fitness orders and an efficient method for detecting genetic interactions |
| Q36675409 | The heterogeneous evolution of multidrug-resistant Mycobacterium tuberculosis |
| Q33504886 | The impact of population size on the evolution of asexual microbes on smooth versus rugged fitness landscapes |
| Q34623901 | The overdue promise of short tandem repeat variation for heritability. |
| Q41872274 | The pace of evolution across fitness valleys |
| Q42427784 | The peaks and geometry of fitness landscapes |
| Q34214349 | The population genetics of X-autosome synthetic lethals and steriles |
| Q42778842 | The population genetics of mutations: good, bad and indifferent |
| Q34589995 | The rank ordering of genotypic fitness values predicts genetic constraint on natural selection on landscapes lacking sign epistasis |
| Q40546569 | The risk of low concentrations of antibiotics in agriculture for resistance in human health care |
| Q40587253 | The strength of genetic interactions scales weakly with mutational effects |
| Q35247990 | The time scale of evolutionary innovation |
| Q33307185 | Theme and variations in the evolutionary pathways to virulence of an RNA plant virus species |
| Q37073510 | Understanding quantitative genetics in the systems biology era. |
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| Q34190107 | Visualizing fitness landscapes |
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| Q26830367 | What can we learn from fitness landscapes? |
| Q53063745 | Why Rice yellow mottle virus, a rapidly evolving RNA plant virus, is not efficient at breaking rymv1-2 resistance. |
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| Q60930362 | Y-chromosomes can constrain adaptive evolution via epistatic interactions with other chromosomes |
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