A novel view on the mechanisms of action of insulin and other insulin superfamily peptides: involvement of adenylyl cyclase signaling system.

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A novel view on the mechanisms of action of insulin and other insulin superfamily peptides: involvement of adenylyl cyclase signaling system. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S1096-4959(02)00160-4
P698PubMed publication ID12524030

P50authorAlexander ShpakovQ59167040
P2093author name stringL A Kuznetsova
M N Pertseva
S A Plesneva
P2860cites workRole of cAMP-dependent pathway in eosinophil apoptosis and survivalQ74070672
A matter of life and cell deathQ77164675
On the mechanism of relaxin action: the involvement of adenylyl cyclase signalling systemQ77425672
Cell growth control by G protein-coupled receptors: from signal transduction to signal integrationQ77436385
The sevenfold way of PKC regulationQ77483361
Molecular basis of receptor/G-protein-coupling selectivityQ77795096
Inhibition of glucagon-stimulated adenyl cyclase by insulinQ77915667
Hormone action at the membrane level. I. Properties of adenyl cyclase in isolated plasma membranes of rat liverQ93809325
Tests for comparing related amino-acid sequences. Cytochrome c and cytochrome c551Q95394191
The free radical of the anaerobic ribonucleotide reductase from Escherichia coli is at glycine 681Q95819302
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155Q24532078
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegansQ24603590
Regions on adenylyl cyclase that are necessary for inhibition of activity by beta gamma and G(ialpha) subunits of heterotrimeric G proteinsQ27863656
Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activityQ28214197
Molecular diversity of adenylyl cyclases in human and rat myometrium. Correlation with global adenylyl cyclase activity during mid- and term pregnancyQ28255765
Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biologyQ28296952
Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transportQ28570514
Protein kinase C alters the responsiveness of adenylyl cyclases to G protein alpha and betagamma subunitsQ28572823
The Bcl-2 protein family: arbiters of cell survivalQ29618158
Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factorsQ30000921
Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.Q30452681
A region in the cytosolic domain of the epidermal growth factor receptor antithetically regulates the stimulatory and inhibitory guanine nucleotide-binding regulatory proteins of adenylyl cyclaseQ30453966
Programmed cell death: a missing link is foundQ31122193
Physiological regulation of G protein-linked signalingQ33744654
Signalling through the insulin receptorQ33860499
G proteins in signal transductionQ34152414
Insulin, glucagon and the receptor-mediated control of cyclic AMP concentrations in liver. Twenty-second Colworth medal lecture.Q34162132
Signalling by receptor tyrosine kinasesQ34306539
Heterotrimeric G proteins: organizers of transmembrane signalsQ34317073
Type-specific regulation of adenylyl cyclase by G protein beta gamma subunitsQ34993267
Roles of atypical protein kinase C in lysophosphatidic acid-induced type II adenylyl cyclase activation in RAW 264.7 macrophagesQ35041690
Structure and evolution of insulin and insulin-like growth factors in chordatesQ35222105
Structure and evolution of insulins: implications for receptor bindingQ35230812
Insulin receptor gene mutation: a molecular genetical and functional analysisQ35457145
Characterization of a putative molluscan insulin-related peptide receptorQ36681350
Evolutionary conservation of the insulin gene structure in invertebrates: cloning of the gene encoding molluscan insulin-related peptide III from Lymnaea stagnalisQ36755729
Gi-2 is at the centre of an active phosphorylation/dephosphorylation cycle in hepatocytes: the fine-tuning of stimulatory and inhibitory inputs into adenylate cyclase in normal and diabetic statesQ37335596
Cellular levels of feedback regulator of adenylate cyclase and the effect of epinephrine and insulinQ37462981
Analysis of stimulation-G protein subunit coupling by using active insulin-like growth factor II receptor peptideQ37592553
The cyclic AMP-mediated stimulation of cell proliferationQ38268154
Insulin and PIP3 activate PKC-zeta by mechanisms that are both dependent and independent of phosphorylation of activation loop (T410) and autophosphorylation (T560) sitesQ39423459
Multiple facets of the modulation of growth by cAMP.Q40372679
Signaling in new directionsQ40423247
Mammalian membrane-bound adenylyl cyclasesQ40565005
Does mitogen-activated-protein kinase have a role in insulin action? The cases for and againstQ40600008
Dissection of the protein phosphorylation cascades involved in insulin and growth factor actionQ40773667
The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potentialQ40788805
Mutations in G protein-linked receptors: novel insights on diseaseQ40795181
Specificity of receptor-G protein interactions: searching for the structure behind the signal.Q40816270
Relaxin binds to and elicits a response from cells of the human monocytic cell line, THP-1.Q41155312
Regulation of gene expression by insulinQ41169614
Signaling via the insulin-like growth factor-I receptor: does it differ from insulin receptor signaling?Q41194565
Effect of mutations at serines 1280-1283 on the mitogenic and transforming activities of the insulin-like growth factor I receptorQ41197904
Expression of type V adenylyl cyclase is required for epidermal growth factor-mediated stimulation of cAMP accumulationQ41270338
Structure and function of proteins in G-protein-coupled signal transferQ41291044
Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulinQ41302003
The adenylyl cyclases as integrators of transmembrane signal transductionQ41361889
Tailoring cAMP-signalling responses through isoform multiplicityQ41516369
Relaxin influences the growth of MCF-7 breast cancer cells. Mitogenic and antimitogenic action depends on peptide concentrationQ41612630
Models of insulin action on metabolic and growth response genesQ41640124
A Novel G Protein α Subunit Containing Atypical Guanine Nucleotide-binding Domains Is Differentially Expressed in a Molluscan Nervous SystemQ41680038
Towards understanding the role of insulin in the brain: lessons from insulin-related signaling systems in the invertebrate brain.Q41699800
Increase in cyclic AMP levels by relaxin in newborn rhesus monkey uterus cell cultureQ41732538
Interaction between cAMP-dependent and insulin-dependent signal pathways in tyrosine phosphorylation in primary cultures of rat hepatocytesQ42159721
Cyclic adenosine monophosphate-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytesQ42454944
Activation of cAMP signaling transiently inhibits apoptosis in vascular smooth muscle cells in a site upstream of caspase-3.Q42476386
Coupling of the insulin-like growth factor-I receptor tyrosine kinase to Gi2 in human intestinal smooth muscle: Gbetagamma -dependent mitogen-activated protein kinase activation and growthQ42497336
Protein kinase C zeta isoform is critical for mitogenic signal transductionQ42807317
Studies on the cell-cycle dependency of the actions of insulin-like growth factor-I in Balb/c 3T3 cellsQ42832401
An effect of insulin on adipose-tissue adenosine 3':5'-cyclic monophosphate phosphodiesteraseQ42926333
The insulin receptor tyrosyl kinase phosphorylates holomeric forms of the guanine nucleotide regulatory proteins Gi and Go.Q43408418
A dual role of protein kinase C in insulin signal transduction via adenylyl cyclase signaling system in muscle tissues of vertebrates and invertebratesQ43588653
The effects of the catecholamines, adrenergic blocking agents, prostaglandin E1, and insulin on cyclie AMP levels in the rat epididymal fat pad in vitroQ44490368
Type I cAMP-dependent protein kinase delays apoptosis in human neutrophils at a site upstream of caspase-3.Q45110248
The use of selective inhibitors and computer modelling to evaluate the role of specific high affinity cyclic AMP phosphodiesterases in the hormonal regulation of hepatocyte intracellular cyclic AMP concentrationsQ45278030
Human relaxin increases cyclic AMP levels in cultured anterior pituitary cellsQ46241365
Cloning and developmental regulation of a novel member of the insulin-like gene family in Caenorhabditis elegansQ46518743
Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.Q47072330
Origin of insulin receptor-like tyrosine kinases in marine spongesQ47907656
Regulation of type V adenylyl cyclase by PMA-sensitive and -insensitive protein kinase C isoenzymes in intact cellsQ48064743
Molecular cloning of G protein alpha subunits from the central nervous system of the mollusc Lymnaea stagnalisQ48143391
Effect of insulin on cerebral adenyl cyclase and phosphodiesteraseQ48678574
Distribution of adrenocorticotrophic hormone-stimulated adenylate cyclase in the adrenal cortexQ48678811
Insulin increases cyclic nucleotide content in human vascular smooth muscle cells: a mechanism potentially involved in insulin-induced modulation of vascular toneQ50759538
(Pro)insulin and insulin-like growth factor I complementary expression and roles in early development.Q52179554
Protein kinase A or C modulates the apoptosis induced by lectin II isolated from Korean mistletoe, Viscum album var. Coloratum, in the human leukemic HL-60 cells.Q53918062
Adenylate cyclase and insulin action. Effect of insulin, nonsuppressible insulin-like material, and diabetes on adenylate-cyclase activity in mouse liver.Q54091117
The Insulin Family: Evolution of Structure and Function in Vertebrates and InvertebratesQ56188611
Stimulation of an insulin receptor activates and down-regulates the Ca2+-independent protein kinase C, Apl II, through a Wortmannin-sensitive signaling pathway in AplysiaQ57043007
Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase PathwaysQ58197201
Beta-agonist-induced inhibitory-guanine-nucleotide-binding regulatory protein coupling to adenylate cyclase in mollusc Anodonta cygnea foot muscle sarcolemmaQ67507048
Cyclic AMP response to recombinant human relaxin by cultured human endometrial cells—A specific and high throughput in vitro bioassayQ67664850
Effect of various antilipolytic compounds on adenyl cyclase and phosphodiesterase activity in isolated fat cellsQ68630824
Modulation of adenylate cyclase activity in liver and fat cell membranes by insulinQ68636536
The involvement of cyclic AMP in the hormonal regulation of protein synthesis in rat adipocytesQ68639106
Antilipolytic action of insulin on fat cellsQ68646578
Involvement of the adenylyl cyclase signaling system in the action of insulin and mollusk insulin-like peptideQ70974654
Wortmannin-sensitive activation of p70s6k by endogenous and heterologously expressed Gi-coupled receptorsQ71058617
cAMP counter-regulates insulin-mediated protein phosphatase-2A inactivation in rat skeletal muscle cellsQ71825564
Type I insulin-like growth factor receptor activation regulates apoptotic proteinsQ71833567
On the tyrosine kinase mechanism of the novel effect of insulin and insulinlike growth factor I. Stimulation of the adenylyl cyclase system in muscle tissuesQ71850679
Cellular cyclic AMP levels modulate insulin sensitivity and responsiveness--evidence against a significant role of Gi in insulin signal transductionQ72547145
Regulation of cardiac adenylyl cyclase by epidermal growth factor (EGF). Role of EGF receptor protein tyrosine kinase activityQ72547305
GTP-binding protein-activator sequences in the insulin receptorQ72565330
Relaxin: structures, functions, promises, and nonevolutionQ72800420
TSH induces insulin receptors that mediate insulin costimulation of growth in normal human thyroid cellsQ73287089
P433issue1
P304page(s)11-36
P577publication date2003-01-01
P1433published inComparative Biochemistry and Physiology BQ5155618
P1476titleA novel view on the mechanisms of action of insulin and other insulin superfamily peptides: involvement of adenylyl cyclase signaling system
P478volume134

Reverse relations

cites work (P2860)
Q46547377A novel, adenylate cyclase, signaling mechanism of relaxin H2 action.
Q26781612Cardiac cAMP: production, hydrolysis, modulation and detection
Q37686388Cyclic AMP signaling in bivalve molluscs: an overview
Q43821228Etiology and pathophysiology of benign prostate hyperplasia
Q37229843Insulin: a novel agent in the pathogenesis of prostate cancer
Q36125547Involvement of adenylyl cyclase signaling mechanism in insulin and IGF-I coregulation of fundamental cell processes
Q44760929New insulin-competent adenylate cyclase signaling system as putative mechanism of antiapoptotic effect of insulin and insulin-like growth factor I.
Q83997329Peptide derivatives of the LGR7 relaxin receptor control the functional activity of relaxin-sensitive adenylate cyclase
Q46547387Relaxin adenylyl cyclase system of pregnant women with diabetes: functional defects in insulin and relaxin adenylyl cyclase signaling systems in myometrium of pregnant women with type 1 diabetes
Q45235176Role of phosphatidylinositol-3-kinase and protein kinase C zeta in the adenylate cyclase signal mechanism of action of relaxin in muscle tissues of rats and mollusks
Q37982071Signal protein-derived peptides as functional probes and regulators of intracellular signaling
Q37263640Signaling systems of lower eukaryotes and their evolution.
Q80975645Studies of the molecular mechanisms of action of relaxin on the adenylyl cyclase signaling system using synthetic peptides derived from the LGR7 relaxin receptor
Q53257114Taurine depresses cardiac contractility and enhances systemic heart glucose utilization in the cuttlefish, Sepia officinalis.
Q37603114The prokaryotic origin and evolution of eukaryotic chemosignaling systems

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