| scholarly article | Q13442814 |
| P2093 | author name string | M J Weber | |
| A Klippel | |||
| G Kulik | |||
| P2860 | cites work | Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death | Q24336389 |
| DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product | Q24337388 | ||
| Apoptosis in the pathogenesis and treatment of disease | Q28235731 | ||
| FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex | Q28283294 | ||
| Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit | Q28508052 | ||
| PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo | Q28609356 | ||
| Apoptosis: molecular regulation of cell death | Q28611445 | ||
| Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis | Q29547567 | ||
| The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase | Q29618387 | ||
| Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction | Q29618388 | ||
| Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death | Q29620021 | ||
| SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat | Q29620254 | ||
| The Fas death factor | Q29620461 | ||
| The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death | Q29620519 | ||
| c phosphorylation and activation of the IGF-I receptor in src-transformed cells. | Q30463904 | ||
| Immune complex kinase assays for mitogen-activated protein kinase and MEK. | Q30467876 | ||
| A wortmannin-sensitive phosphatidylinositol 4-kinase that regulates hormone-sensitive pools of inositolphospholipids | Q34210092 | ||
| Cell death and control of cell survival in the oligodendrocyte lineage | Q34460930 | ||
| Insulin-like growth factor-I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro | Q34558274 | ||
| Signal transduction pathways to apoptosis | Q35632911 | ||
| Growth factors and cancer | Q36441643 | ||
| ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor | Q36653753 | ||
| Phosphatidylinositol kinase activity associates with viral p60src protein | Q36764186 | ||
| Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors | Q37549774 | ||
| The biochemistry of cell death by apoptosis | Q38008685 | ||
| Genetics of src: structure and functional organization of a protein tyrosine kinase | Q38211750 | ||
| Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways | Q38354870 | ||
| Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase | Q40018987 | ||
| A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain. | Q40020748 | ||
| Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. | Q40478337 | ||
| The insulin-like growth factor-I receptor. Structure, ligand-binding mechanism and signal transduction. | Q40600180 | ||
| Ionizing radiation-induced cell death | Q40635189 | ||
| Apoptosis in cancer therapy: crossing the threshold | Q40694262 | ||
| Phosphatidylinositol 3-kinase | Q40702617 | ||
| Cellular oncogenes and suppressor genes as prognostic markers in cancer | Q40723622 | ||
| Apoptosis. Its significance in cancer and cancer therapy | Q40739570 | ||
| c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. | Q40792572 | ||
| Mutational analysis of insulin receptor function: consensus and controversy | Q40824456 | ||
| The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling | Q40974450 | ||
| Structural and functional diversity of phosphoinositide 3-kinases. | Q40998279 | ||
| Insulin signal transduction and the IRS proteins | Q41048272 | ||
| Phosphoinositide kinases | Q41099687 | ||
| Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. | Q41218044 | ||
| Suppression of interleukin-1 beta-converting enzyme-mediated cell death by insulin-like growth factor | Q41224724 | ||
| Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases | Q41224926 | ||
| Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death | Q41228964 | ||
| Requirement for phosphatidylinositol 3'-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor. | Q41236069 | ||
| v-Abl-mediated apoptotic suppression is associated with SHC phosphorylation without concomitant mitogen-activated protein kinase activation. | Q41359429 | ||
| Ultraviolet B irradiation of human leukaemia HL-60 cells in vitro induces apoptosis | Q41690293 | ||
| Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating | Q41992885 | ||
| Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. | Q42555356 | ||
| Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate | Q42556020 | ||
| Growth factor-dependent survival of rodent fibroblasts requires phosphatidylinositol 3-kinase but is independent of pp70S6K activity. | Q42810929 | ||
| Wortmannin and its structural analogue demethoxyviridin inhibit stimulated phospholipase A2 activity in Swiss 3T3 cells. Wortmannin is not a specific inhibitor of phosphatidylinositol 3-kinase. | Q42823308 | ||
| The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo. | Q42827119 | ||
| Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase | Q42828607 | ||
| Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis. | Q42830680 | ||
| Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro | Q58327266 | ||
| Insulin-like growth factor-I inhibits apoptosis in IL-3-dependent hemopoietic cells | Q68196156 | ||
| Expression of insulin-like growth factor receptors I and II in normal human lung and in lung cancer | Q70469484 | ||
| Programmed cell death induced by ceramide | Q70619078 | ||
| Overexpression of the insulin-like growth factor-1 receptor and autocrine stimulation in human cervical cancer cells | Q71056263 | ||
| Activation of the CPP32 apoptotic protease by distinct signaling pathways with differential sensitivity to Bcl-xL | Q71144438 | ||
| Mitogen-activated protein kinase-independent pathways mediate the effects of nerve growth factor and cAMP on neuronal survival | Q71246241 | ||
| Apoptosis of human erythroid colony-forming cells is decreased by stem cell factor and insulin-like growth factor I as well as erythropoietin | Q72090100 | ||
| Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor | Q72121269 | ||
| The prognostic value of insulin-like growth factor-I in breast cancer patients. Results of a follow-up study on 126 patients | Q72520126 | ||
| Prognostic value of insulin-like growth factor-1 receptors in patients with colon/rectal cancer: correlation with plasma prolactin | Q72534393 | ||
| In vivo treatment with antibody against IGF-1 receptor suppresses growth of human rhabdomyosarcoma and down-regulates p34cdc2 | Q72710432 | ||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | preproinsulin | Q7240673 |
| P304 | page(s) | 1595-1606 | |
| P577 | publication date | 1997-03-01 | |
| P1433 | published in | Molecular and Cellular Biology | Q3319478 |
| P1476 | title | Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. | |
| P478 | volume | 17 |
| Q40468539 | 17-Allyamino-17-demethoxygeldanamycin and 17-NN-dimethyl ethylene diamine-geldanamycin have cytotoxic activity against multiple gynecologic cancer cell types. |
| Q32020545 | 3-Deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth |
| Q24336639 | 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase |
| Q29620730 | 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway |
| Q39915326 | A HIF-1alpha-dependent autocrine feedback loop promotes survival of serum-deprived prostate cancer cells |
| Q24603590 | A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans |
| Q35104763 | A decade of tyrosine kinases: from gene discovery to therapeutics |
| Q77899844 | A molecular blueprint for targeting cancer? |
| Q22253346 | A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis |
| Q36800387 | A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer |
| Q35043727 | A novel view on the mechanisms of action of insulin and other insulin superfamily peptides: involvement of adenylyl cyclase signaling system. |
| Q33944754 | A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus |
| Q45073541 | A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts |
| Q40364913 | A small molecule compound inhibits AKT pathway in ovarian cancer cell lines. |
| Q38218256 | AKT as a therapeutic target in multiple myeloma |
| Q37565415 | AKT-induced PKM2 phosphorylation signals for IGF-1-stimulated cancer cell growth |
| Q44007867 | AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival |
| Q34098413 | ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response |
| Q40758258 | Aberrant expression and activation of insulin-like growth factor-1 receptor (IGF-1R) are mediated by an induction of IGF-1R promoter activity and stabilization of IGF-1R mRNA and contributes to growth factor independence and increased survival of th |
| Q81305105 | Actinin-4 expression in ovarian cancer: a novel prognostic indicator independent of clinical stage and histological type |
| Q40399507 | Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells |
| Q36376143 | Activated Akt protects the lung from oxidant-induced injury and delays death of mice |
| Q42840914 | Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons |
| Q36226730 | Activation of AKT kinases in cancer: implications for therapeutic targeting |
| Q39737327 | Activation of PI 3-kinase/Akt/NF-kappaB and Stat3 signaling by avian reovirus S1133 in the early stages of infection results in an inflammatory response and delayed apoptosis |
| Q40364656 | Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions |
| Q39576120 | Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation |
| Q24530736 | Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha |
| Q55474277 | Activation of the IGF-IR system contributes to malignant growth of human and mouse medulloblastomas. |
| Q52176221 | Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex. |
| Q28185337 | Active stromelysin-3 (MMP-11) increases MCF-7 survival in three-dimensional Matrigel culture via activation of p42/p44 MAP-kinase |
| Q33542011 | Activity and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system |
| Q46890172 | Acute ethanol exposure inhibits insulin signaling in the liver |
| Q45127876 | Akt activation is necessary for growth factor-induced trafficking of functional K(Ca) channels in developing parasympathetic neurons |
| Q40816815 | Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology |
| Q40563758 | Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis |
| Q24795435 | Akt kinases in breast cancer and the results of adjuvant therapy |
| Q36760948 | Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner |
| Q42465729 | Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer |
| Q27860586 | Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery |
| Q33995467 | Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line |
| Q30453623 | Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I. |
| Q33959022 | Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria |
| Q42818650 | Akt1-mediated intracellular oxidation after UVB irradiation suppresses apoptotic cell death induced by cell detachment and serum starvation |
| Q40431966 | Akt1/PKB upregulation leads to vascular smooth muscle cell hypertrophy and polyploidization. |
| Q26991846 | Alcohol, insulin resistance and the liver-brain axis |
| Q31925986 | Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis |
| Q34020000 | Alzheimer's disease is type 3 diabetes-evidence reviewed |
| Q36730708 | An essential role of phosphatidylinositol 3-kinase in myogenic differentiation. |
| Q40846839 | Analysis of function and regulation of proteins that mediate signal transduction by use of lipid-modified plasma membrane-targeting sequences |
| Q43861826 | Anchorage-independent multi-cellular spheroids as an in vitro model of growth signaling in Ewing tumors |
| Q35074494 | Androgen-induced PSA expression requires not only activation of AR but also endogenous IGF-I or IGF-I/PI3K/Akt signaling in human prostate cancer epithelial cells |
| Q35571886 | Androgens and prostate cancer |
| Q52010509 | Anti-apoptotic effect of insulin-like growth factor (IGF)-I and its receptor in porcine preimplantation embryos derived from in vitro fertilization and somatic cell nuclear transfer. |
| Q74326180 | Anti-apoptotic signaling by a colony-stimulating factor-1 receptor/insulin receptor chimera with a juxtamembrane deletion |
| Q95717860 | Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways |
| Q42818086 | Anti-apoptotic signaling of the IGF-I receptor in fibroblasts following loss of matrix adhesion |
| Q40806178 | Anti-apoptotic signaling of the insulin-like growth factor-I receptor through mitochondrial translocation of c-Raf and Nedd4. |
| Q34490880 | Anti-myeloma activity of Akt inhibition is linked to the activation status of PI3K/Akt and MEK/ERK pathway. |
| Q42815008 | Antiapoptotic effects induced by different wavelengths of ultraviolet light |
| Q39381888 | Antitumor effects of novel shorter truncated insulin-like growth factor I receptors |
| Q40586198 | Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities. |
| Q37902996 | Apoptosis: why and how does it occur in biology? |
| Q48403241 | Asphyxial brain injury--the role of the IGF system |
| Q48792540 | Astrocyte-derived VEGF mediates survival and tube stabilization of hypoxic brain microvascular endothelial cells in vitro. |
| Q43046166 | Atrial natriuretic peptide inhibits angiotensin II-stimulated proliferation in fetal cardiomyocytes |
| Q39446559 | B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway |
| Q34990137 | BAD dephosphorylation and decreased expression of MCL-1 induce rapid apoptosis in prostate cancer cells |
| Q36580367 | Behavioral stress accelerates prostate cancer development in mice |
| Q39737833 | Beta cell expression of IGF-I leads to recovery from type 1 diabetes. |
| Q48034415 | Bidirectional regulation of p38 kinase and c-Jun N-terminal protein kinase by insulin-like growth factor-I. |
| Q36994879 | Bone marrow stromal cells protect oligodendrocytes from oxygen-glucose deprivation injury |
| Q33923323 | Brain ischemia and reperfusion: molecular mechanisms of neuronal injury |
| Q74339196 | Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3'-kinase/protein kinase B signaling |
| Q33940793 | CCL21/CCR7 promotes G2/M phase progression via the ERK pathway in human non-small cell lung cancer cells |
| Q73170407 | CD28 stimulates tyrosine phosphorylation, cellular redistribution and catalytic activity of the inositol lipid 5-phosphatase SHIP |
| Q106638260 | COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms |
| Q33968736 | CREB is one component of the binding complex of the Ces-2/E2A-HLF binding element and is an integral part of the interleukin-3 survival signal |
| Q28611335 | Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor |
| Q50248070 | Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and MEK-ERK pathways. |
| Q37393585 | Cardioprotective growth factors |
| Q44340556 | Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation |
| Q43786473 | Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithium |
| Q24656695 | Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells |
| Q39451271 | Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide |
| Q64377342 | Cell Cycle Progression and Activation of Akt Kinase Are Required for Insulin-Like Growth Factor I-Mediated Suppression of Apoptosis in Granulosa Cells |
| Q42834541 | Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes |
| Q33890748 | Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium |
| Q34548314 | Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases |
| Q42556634 | Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation |
| Q37328859 | Chorionic gonadotropin regulates prostaglandin E synthase via a phosphatidylinositol 3-kinase-extracellular regulatory kinase pathway in a human endometrial epithelial cell line: implications for endometrial responses for embryo implantation |
| Q33702529 | Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs |
| Q37360552 | Cigarette smoke, inflammation, and lung injury: a mechanistic perspective |
| Q40907975 | Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis |
| Q54100226 | Cleavage of zetaPKC but not lambda/iotaPKC by caspase-3 during UV-induced apoptosis. |
| Q48399935 | Co-ordinated and cellular specific induction of the components of the IGF/IGFBP axis in the rat brain following hypoxic-ischemic injury |
| Q41708790 | Co-receptor and accessory regulation of B-cell antigen receptor signal transduction. |
| Q40599210 | Coagulation factors VIIa and Xa inhibit apoptosis and anoikis |
| Q21245750 | Combined targeting of mTOR and c-MET signaling pathways for effective management of epithelioid sarcoma |
| Q40812342 | Comparison of anti-apoptotic signalling by the insulin receptor and IGF-I receptor in preadipocytes and adipocytes |
| Q40672605 | Conjugated linoleic acid inhibits cell proliferation and ErbB3 signaling in HT-29 human colon cell line |
| Q42064131 | Constitutive nuclear factor-kappaB activity is crucial for human retinoblastoma cell viability |
| Q43761459 | Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer |
| Q40279257 | Constitutively active alpha subunits of G(q/11) and G(12/13) families inhibit activation of the pro-survival Akt signaling cascade |
| Q40446897 | Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells. |
| Q53407295 | Cooperative transformation of 32D cells by the combined expression of IRS-1 and V-Ha-Ras. |
| Q37277344 | Critical prosurvival roles for C/EBP beta and insulin-like growth factor I in macrophage tumor cells |
| Q35209745 | Cutaneous photobiology. The melanocyte vs. the sun: who will win the final round? |
| Q40817514 | Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1. |
| Q40616177 | Cyclic phosphatidic acid elicits neurotrophin‐like actions in embryonic hippocampal neurons |
| Q57589068 | Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway |
| Q39702048 | Cyclooxygenase-2 inhibitor NS398 enhances radiosensitivity of radioresistant esophageal cancer cells by inhibiting AKT activation and inducing apoptosis |
| Q40950606 | Cytokine-induced apoptosis in epithelial HT-29 cells is independent of nitric oxide formation. Evidence for an interleukin-13-driven phosphatidylinositol 3-kinase-dependent survival mechanism |
| Q33863961 | Cytokines and their receptors in cardiovascular diseases--role of gp130 signalling pathway in cardiac myocyte growth and maintenance |
| Q34780162 | Cytostatic and cytotoxic effects of tyrphostin AG1296 on RMS cells |
| Q37217569 | DJ-1 Expression in Cervical Carcinoma and its Effects on Cell Viability and Apoptosis |
| Q46428443 | DNA damage uncouples the mitogenic response to IGF-I in MCF-7 malignant breast cancer cells by switching the roles of PI3 kinase and p21WAF1/Cip1. |
| Q40379454 | Decreased apoptosis in polyamine depleted IEC-6 cells depends on Akt-mediated NF-kappaB activation but not GSK3beta activity |
| Q44092522 | Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells |
| Q40722638 | Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin |
| Q34947603 | Differential signaling by adaptor molecules LRP1 and ShcA regulates adipogenesis by the insulin-like growth factor-1 receptor |
| Q35548912 | Dihydroaustrasulfone alcohol inhibits PDGF-induced proliferation and migration of human aortic smooth muscle cells through inhibition of the cell cycle |
| Q38103561 | Dissecting the PI3K Signaling Axis in Pediatric Solid Tumors: Novel Targets for Clinical Integration |
| Q40972597 | Dissociation between resistance to apoptosis and the transformed phenotype in IGF-I receptor signaling. |
| Q40593660 | Distinctive regulation and function of PI 3K/Akt and MAPKs in doxorubicin-induced apoptosis of human lung adenocarcinoma cells |
| Q83853850 | Diverse antiapoptotic signaling pathways activated by vasoactive intestinal polypeptide, epidermal growth factor, and phosphatidylinositol 3-kinase in prostate cancer cells converge on BAD |
| Q28360348 | Downregulation of Akt1 inhibits anchorage-independent cell growth and induces apoptosis in cancer cells |
| Q40709512 | Downregulation of PTEN/MMAC/TEP1 expression in human prostate cancer cell line DU145 by growth stimuli |
| Q48002873 | Downstream signalling events regulated by phosphatidylinositol 3-kinase activity |
| Q35932308 | Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway. |
| Q41561441 | Drug delivery approaches for breast cancer |
| Q33963275 | Dual control of muscle cell survival by distinct growth factor-regulated signaling pathways. |
| Q40855288 | Dual regulation of Akt/protein kinase B by heterotrimeric G protein subunits |
| Q39681753 | E5 protein of human papillomavirus type 16 protects human foreskin keratinocytes from UV B-irradiation-induced apoptosis |
| Q33248446 | Effect of blocking IGF-I receptor on growth of human hepatocellular carcinoma cells |
| Q42467687 | Effect of overexpression and nuclear translocation of constitutively active PKB-alpha on cellular survival and proliferation in HepG2 cells |
| Q33416685 | Effective prostate cancer chemopreventive intervention with green tea polyphenols in the TRAMP model depends on the stage of the disease |
| Q47340171 | Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft tissue sarcoma growth depend on tumor developmental stage. |
| Q77341888 | Effects of energy and purines in the diet on proliferation, differentiation, and apoptosis in the small intestine of the pig |
| Q33890758 | Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer |
| Q36614997 | Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer |
| Q44904081 | Endogenous IGF-I protects human intestinal smooth muscle cells from apoptosis by regulation of GSK-3 beta activity |
| Q39366985 | Endoplasmic reticulum stress modulates nicotine-induced extracellular matrix degradation in human periodontal ligament cells. |
| Q48543123 | Enhanced apoptosis in pilocytic astrocytoma: a comparative study of apoptosis and proliferation in astrocytic tumors. |
| Q40836382 | Enhanced cell killing by overexpression of dominant-negative phosphatidylinositol 3-kinase subunit, Deltap85, following genotoxic stresses |
| Q28377637 | Enhancement of susceptibility to diverse skin tumor promoters by activation of the insulin-like growth factor-1 receptor in the epidermis of transgenic mice |
| Q40887257 | Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway |
| Q36239648 | Epidermal growth factor inhibition in solid tumours |
| Q40949162 | Epidermal growth factor protects epithelial cells against Fas-induced apoptosis. Requirement for Akt activation |
| Q40254785 | Epidermal growth factor protects prostate cancer cells from apoptosis by inducing BAD phosphorylation via redundant signaling pathways |
| Q39752055 | Epidermal growth factor receptor signaling in nonsmall cell lung cancer |
| Q28141002 | Epidermal growth factor receptor tyrosine kinase as a target for anticancer therapy |
| Q44571675 | Epidermal growth factor receptor-dependent, NF-kappaB-independent activation of the phosphatidylinositol 3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytes |
| Q41089721 | Ethanol promotes cell death by inhibition of the insulin-like growth factor I receptor |
| Q52549848 | Evidence for differential ribonucleoprotein complex assembly in vitro on the 5'-untranslated region of the human IGF-IR transcript. |
| Q36611435 | Exploiting PI3K/mTOR signaling to accelerate epithelial wound healing |
| Q24676224 | Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival |
| Q30165455 | Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO). |
| Q40654612 | Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation |
| Q53605156 | Expression of insulin-like growth factor-1 receptor, p-AKT and p-ERK1/2 protein in extramammary Paget's disease. |
| Q43796925 | Expression of the oncogenic NPM-ALK chimeric protein in human lymphoid T-cells inhibits drug-induced, but not Fas-induced apoptosis. |
| Q40485173 | Externalization of host cell protein kinase C during enteropathogenic Escherichia coli infection |
| Q50475811 | Extracellular adenosine triphosphate protects oxidative stress-induced increase of p21(WAF1/Cip1) and p27(Kip1) expression in primary cultured renal proximal tubule cells: role of PI3K and Akt signaling. |
| Q36293373 | Extracellular matrix regulates apoptosis in mammary epithelium through a control on insulin signaling |
| Q24648522 | Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway |
| Q40957381 | FcgammaRIIb modulation of surface immunoglobulin-induced Akt activation in murine B cells |
| Q42504826 | Focal adhesion kinase mediates cell survival via NF-kappaB and ERK signaling pathways. |
| Q33647697 | Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions |
| Q26830002 | Functional roles and clinical values of insulin-like growth factor-binding protein-5 in different types of cancers |
| Q42812461 | Gas6-mediated survival in NIH3T3 cells activates stress signalling cascade and is independent of Ras. |
| Q44634369 | Gefitinib (ZD1839) in Previously Treated Advanced Non-Small-Cell Lung Cancer: Experience from a Single Institution |
| Q54633236 | Gene expression and localization of insulin-like growth factors and their receptors throughout amelogenesis in rat incisors. |
| Q35044581 | Gene expressions in Jurkat cells poisoned by a sulphur mustard vesicant and the induction of apoptosis |
| Q47070510 | Genetic analysis of protein kinase B (AKT) in Drosophila |
| Q36013284 | Genetic and epigenetic features in radiation sensitivity Part I: cell signalling in radiation response |
| Q35106501 | Genetic editing of dysfunctional myocardium |
| Q40782343 | Glial cell line-derived neurotrophic factor-stimulated phosphatidylinositol 3-kinase and Akt activities exert opposing effects on the ERK pathway: importance for the rescue of neuroectodermic cells |
| Q40126556 | Grb10 and active Raf-1 kinase promote Bad-dependent cell survival |
| Q24648537 | Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor |
| Q34318772 | Growth Hormone-Releaser Diet Attenuates Cognitive Dysfunction in Klotho Mutant Mice via Insulin-Like Growth Factor-1 Receptor Activation in a Genetic Aging Model |
| Q34079892 | Growth arrest and cell death in the breast tumor cell in response to ionizing radiation and chemotherapeutic agents which induce DNA damage. |
| Q80019111 | Growth factor attenuation of IFNgamma-mediated hepatocyte apoptosis requires p21waf-1 |
| Q37774602 | Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis. |
| Q38112030 | Growth factors and cytokines in acute lung injury |
| Q28276173 | Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein |
| Q34575948 | Growth hormone can act as a cytokine controlling survival and proliferation of immune cells: new insights into signaling pathways |
| Q35727465 | Growth inhibitory and chemo-sensitization effects of naringenin, a natural flavanone purified from Thymus vulgaris, on human breast and colorectal cancer |
| Q34500466 | HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45. |
| Q42032624 | HS-173, a novel PI3K inhibitor, attenuates the activation of hepatic stellate cells in liver fibrosis |
| Q37610451 | Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells |
| Q39610682 | Host cell death due to enteropathogenic Escherichia coli has features of apoptosis |
| Q34158953 | How do inhibitory phosphatases work? |
| Q33842473 | Human cytomegalovirus up-regulates the phosphatidylinositol 3-kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling |
| Q55475423 | Human malignant glioma therapy using anti-alpha(v)beta3 integrin agents. |
| Q35763217 | Human umbilical cord blood cells protect oligodendrocytes from brain ischemia through Akt signal transduction. |
| Q30876351 | Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway |
| Q43732934 | Hyperosmotic stress-induced apoptosis and tau phosphorylation in human neuroblastoma cells |
| Q44433179 | Hyperoxia induces retinal vascular endothelial cell apoptosis through formation of peroxynitrite |
| Q44522383 | IGF-1 inhibits the mitochondrial apoptosis program in mesangial cells exposed to high glucose |
| Q37036607 | IGF-1 protects intestinal epithelial cells from oxidative stress-induced apoptosis |
| Q48552439 | IGF-I and microglia/macrophage proliferation in the ischemic mouse brain. |
| Q44223760 | IGF-I elicits growth of human intestinal smooth muscle cells by activation of PI3K, PDK-1, and p70S6 kinase |
| Q73978686 | IGF-I receptor activation and BCL-2 overexpression prevent early apoptotic events in human neuroblastoma |
| Q37409955 | IGF-IR in neuroprotection and brain tumors |
| Q53878797 | IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes. |
| Q33918917 | Identification of an IGF-1R kinase regulatory phosphatase using the fission yeast Schizosaccharomyces pombe and a GFP tagged IGF-1R in mammalian cells. |
| Q60167271 | Iminosugar Analogues of Phosphatidyl Inositol as Potential Inhibitors of Protein Kinase B (Akt) |
| Q44391046 | Immunosuppressant FK506 affects multiple signaling pathways and modulates gene expression in astrocytes |
| Q47144111 | Impaired caudal fin-fold regeneration in zebrafish deficient for the tumor suppressor Pten. |
| Q37174066 | Improvement of cisplatin-related renal dysfunction by synthetic ghrelin: a prospective randomised phase II trial |
| Q33890192 | Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress |
| Q43596512 | Increased extracellular magnesium modulates proliferation in fetal neural cells in culture |
| Q35022890 | Inducible expression of keratinocyte growth factor (KGF) in mice inhibits lung epithelial cell death induced by hyperoxia |
| Q34137296 | Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1. |
| Q73171136 | Induction of tumor suppression and glandular differentiation of A549 lung carcinoma cells by dominant-negative IGF-I receptor |
| Q36696263 | Inhibition of AKT survival pathway by a small molecule inhibitor in human endometrial cancer cells |
| Q40287095 | Inhibition of Akt/PKB by a COX-2 inhibitor induces apoptosis in gastric cancer cells. |
| Q34152476 | Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines |
| Q40851731 | Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation |
| Q73786615 | Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice |
| Q39447094 | Inhibition of mitogen-activated kinase signaling sensitizes HeLa cells to Fas receptor-mediated apoptosis |
| Q34033114 | Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis |
| Q24548285 | Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest |
| Q77363665 | Inhibition of rat hepatocyte proliferation by transforming growth factor beta and glucagon is associated with inhibition of ERK2 and p70 S6 kinase |
| Q35204241 | Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress |
| Q34928606 | Inositol hexaphosphate inhibits growth and induces G1 arrest and apoptotic death of androgen-dependent human prostate carcinoma LNCaP cells |
| Q46128356 | Insulin activates the PI3K-Akt survival pathway in vulnerable neurons following global brain ischemia. |
| Q36081580 | Insulin and insulin-like growth factor resistance in alcoholic neurodegeneration |
| Q38875590 | Insulin protects H9c2 rat cardiomyoblast cells against hydrogen peroxide-induced injury through upregulation of microRNA-210. |
| Q28289288 | Insulin receptor substrate-1 as a signaling molecule for focal adhesion kinase pp125(FAK) and pp60(src) |
| Q40875121 | Insulin receptor substrate-1, p70S6K, and cell size in transformation and differentiation of hemopoietic cells |
| Q90479283 | Insulin-Like Growth Factor Binding Protein-5 in Physiology and Disease |
| Q64966018 | Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases. |
| Q94079090 | Insulin-Like Growth Factor-I Protects Axotomized Rat Retinal Ganglion Cells from Secondary Death via PI3-K-Dependent Akt Phosphorylation and Inhibition of Caspase-3 |
| Q40923622 | Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death--proliferative and anti-apoptotic effects |
| Q42829461 | Insulin-like growth factor 1 (IGF-1)-induced twist expression is involved in the anti-apoptotic effects of the IGF-1 receptor |
| Q39297908 | Insulin-like growth factor 1 mediates negative feedback to somatotroph GH expression via POU1F1/CREB binding protein interactions |
| Q33921296 | Insulin-like growth factor 2 expression modulates Taxol resistance and is a candidate biomarker for reduced disease-free survival in ovarian cancer. |
| Q40821287 | Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner. |
| Q40747113 | Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage |
| Q44557717 | Insulin-like growth factor I promotes maturation and inhibits apoptosis of immature cord blood monocyte-derived dendritic cells through MEK and PI 3-kinase pathways. |
| Q43882352 | Insulin-like growth factor I receptor is downregulated after alveolarization in an apoptotic fibroblast subset |
| Q42466887 | Insulin-like growth factor I-mediated activation of the transcription factor cAMP response element-binding protein in PC12 cells. Involvement of p38 mitogen-activated protein kinase-mediated pathway. |
| Q37773265 | Insulin-like growth factor receptor type I as a target for cancer therapy |
| Q33668776 | Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) in immunity and inflammation |
| Q42831003 | Insulin-like growth factor-1 receptor signaling in 3T3-L1 adipocyte differentiation requires lipid rafts but not caveolae |
| Q42830476 | Insulin-like growth factor-I (IGF-I) receptor activation rescues UV-damaged cells through a p38 signaling pathway. Potential role of the IGF-I receptor in DNA repair |
| Q44308224 | Insulin-like growth factor-I and the cytokines IL-3 and IL-4 promote survival of progenitor myeloid cells by different mechanisms |
| Q40379423 | Insulin-like growth factor-I induces the phosphorylation and nuclear exclusion of forkhead transcription factors in human neuroblastoma cells. |
| Q48974747 | Insulin-like growth factor-I overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally specific manner. |
| Q28296952 | Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology |
| Q42819294 | Insulin-like growth factor-I-dependent stimulation of nuclear phospholipase C-beta1 activity in Swiss 3T3 cells requires an intact cytoskeleton and is paralleled by increased phosphorylation of the phospholipase |
| Q36417183 | Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis |
| Q33966727 | Insulin-like growth factor-mediated muscle cell survival: central roles for Akt and cyclin-dependent kinase inhibitor p21 |
| Q47074406 | Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism |
| Q31943467 | Interaction of vitamin D analogs with signaling pathways leading to active cell death in breast cancer cells |
| Q36593239 | Interleukin 3-dependent survival by the Akt protein kinase |
| Q36582781 | Interventions for heart disease and their effects on Alzheimer's disease |
| Q40999183 | Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B. |
| Q40219918 | Ionizing radiation activates IGF-1R triggering a cytoprotective signaling by interfering with Ku-DNA binding and by modulating Ku86 expression via a p38 kinase-dependent mechanism |
| Q33826749 | Is CREB a key to neuronal survival? |
| Q59237520 | Isolation, biological activity and synthesis of the natural product ellipticine and related pyridocarbazoles |
| Q40519298 | Keratinocyte growth factor induces Akt kinase activity and inhibits Fas-mediated apoptosis in A549 lung epithelial cells |
| Q28119207 | Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation |
| Q51405942 | LPIN1 promotes epithelial cell transformation and mammary tumourigenesis via enhancing insulin receptor substrate 1 stability. |
| Q36961820 | Latent membrane protein 2A inhibits transforming growth factor-beta 1-induced apoptosis through the phosphatidylinositol 3-kinase/Akt pathway |
| Q80693835 | Leptin induces CD40 expression through the activation of Akt in murine dendritic cells |
| Q34078555 | Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways |
| Q40071517 | Leptin stimulates alpha1(I) collagen expression in human hepatic stellate cells via the phosphatidylinositol 3-kinase/Akt signalling pathway |
| Q41079207 | Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B. |
| Q59102227 | Linking extracellular survival signals and the apoptotic machinery |
| Q35047180 | Lipoapoptosis: its mechanism and its diseases |
| Q28140459 | Lipoarabinomannan from Mycobacterium tuberculosis promotes macrophage survival by phosphorylating Bad through a phosphatidylinositol 3-kinase/Akt pathway |
| Q33689399 | Long-term IGF-I exposure decreases autophagy and cell viability |
| Q34541960 | Lung cancer therapeutics that target signaling pathways: an update |
| Q40844684 | Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase |
| Q73616956 | MAP kinase pathway signalling is essential for extracellular matrix determined mammary epithelial cell survival |
| Q35131665 | MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells |
| Q39925975 | MR-1 modulates proliferation and migration of human hepatoma HepG2 cells through myosin light chains-2 (MLC2)/focal adhesion kinase (FAK)/Akt signaling pathway |
| Q39374509 | Mature breast adipocytes promote breast cancer cell motility |
| Q41732739 | Mechanism of activation and function of protein kinase B. |
| Q33958737 | Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase |
| Q33716190 | Mechanism of protein kinase B activation by insulin/insulin-like growth factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase--significance for diabetes and cancer |
| Q41751003 | Mechanisms and consequences of activation of protein kinase B/Akt |
| Q36072079 | Mechanisms of the development of androgen independence in prostate cancer |
| Q57146844 | Metabolomic serum profiling detects early-stage high-grade serous ovarian cancer in a mouse model |
| Q40806474 | Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation |
| Q28255046 | Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta |
| Q106536338 | Modulation of Host Cell Death by SARS Coronavirus Proteins |
| Q33771748 | Modulation of cellular apoptotic potential: contributions to oncogenesis |
| Q41722123 | Molecular and cellular mechanisms of T lymphocyte apoptosis |
| Q111347895 | Molecular cloning and characterization under different stress conditions of insulin-like peptide 2 gene (AccILP-2) from Apis cerana cerana |
| Q36849062 | Molecular mechanisms of hepatic fibrogenesis |
| Q78357688 | Molecular pathogenesis of human hepatocellular carcinoma |
| Q33959860 | Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis |
| Q36908289 | Myocardial AKT: the omnipresent nexus |
| Q37170896 | Myogenic signaling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt/protein kinase B. |
| Q28513537 | Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN |
| Q52177288 | Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells. |
| Q48144694 | Nerve growth factor-induced PKB/Akt activity is sustained by phosphoinositide 3-kinase dependent and independent signals in sympathetic neurons |
| Q41551583 | Neuronal NCX1 overexpression induces stroke resistance while knockout induces vulnerability via Akt |
| Q34652379 | Neuroprotection by curcumin in ischemic brain injury involves the Akt/Nrf2 pathway |
| Q24316173 | Neuroprotection of insulin against oxidative stress-induced apoptosis in cultured retinal neurons: involvement of phosphoinositide 3-kinase/Akt signal pathway |
| Q48204930 | Neuroprotective actions of peripherally administered insulin-like growth factor I in the injured olivo-cerebellar pathway. |
| Q43794811 | Neuroprotective effect of sodium orthovanadate on delayed neuronal death after transient forebrain ischemia in gerbil hippocampus |
| Q34975049 | New advances on structural and biological functions of ceramide in apoptotic/necrotic cell death and cancer |
| Q44760929 | New insulin-competent adenylate cyclase signaling system as putative mechanism of antiapoptotic effect of insulin and insulin-like growth factor I. |
| Q90133464 | Nimodipine-Dependent Protection of Schwann Cells, Astrocytes and Neuronal Cells from Osmotic, Oxidative and Heat Stress Is Associated with the Activation of AKT and CREB |
| Q44555527 | Nitric oxide prevents UV-induced phosphorylation of the p53 tumor-suppressor protein at serine 46: a possible role in inhibition of apoptosis |
| Q40377146 | Nordihydroguaiaretic acid (NDGA) inhibits the IGF-1 and c-erbB2/HER2/neu receptors and suppresses growth in breast cancer cells |
| Q35173073 | Novel approaches with targeted therapies in bladder cancer. Therapy of bladder cancer by blockade of the epidermal growth factor receptor family |
| Q34043331 | Novel strategies and therapeutics for the treatment of prostate carcinoma |
| Q52662023 | Obesity and Cancer: Existing and New Hypotheses for a Causal Connection. |
| Q40601308 | Opposite effects of Ha-Ras and Ki-Ras on radiation-induced apoptosis via differential activation of PI3K/Akt and Rac/p38 mitogen-activated protein kinase signaling pathways |
| Q39699666 | Opposite expression of securin and γ-H2AX regulates baicalein-induced cancer cell death |
| Q38865958 | Original Research: Polyphenols extracted from grape powder induce lipogenesis and glucose uptake during differentiation of murine preadipocytes |
| Q33406279 | Oscillations of the p53-Akt network: implications on cell survival and death |
| Q36197789 | Oxidative stress due to radiation in CD34(+) hematopoietic progenitor cells: protection by IGF-1 |
| Q35119337 | P2Y6 nucleotide receptor activates PKC to protect 1321N1 astrocytoma cells against tumor necrosis factor-induced apoptosis |
| Q40952577 | PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1. |
| Q37366558 | PDGF-mediated protection of SH-SY5Y cells against Tat toxin involves regulation of extracellular glutamate and intracellular calcium |
| Q41553975 | PDK1, one of the missing links in insulin signal transduction? |
| Q41944612 | PI3K Phosphorylation Is Linked to Improved Electrical Excitability in an In Vitro Engineered Heart Tissue Disease Model System |
| Q36453531 | PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo |
| Q54527804 | PI3K signalling: the path to discovery and understanding. |
| Q90379431 | PI3Kinase-p110δ Overexpression Impairs Dendritic Morphogenesis and Increases Dendritic Spine Density |
| Q46015944 | PIK3CA is implicated as an oncogene in ovarian cancer. |
| Q39401591 | PKCη is a negative regulator of AKT inhibiting the IGF-I induced proliferation. |
| Q24563328 | PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase |
| Q42830525 | PLAG proteins: how they influence apoptosis and cell proliferation |
| Q36268735 | PTEN and Akt expression during growth of human ovarian follicles |
| Q30434033 | PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity |
| Q40765673 | PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy |
| Q89495562 | PYP1-4 peptide from Pyropia yezoensis protects against acetaminophen-induced hepatotoxicity in HepG2 cells |
| Q38314425 | Personalized prostate cancer therapy based on systems analysis of the apoptosis regulatory network |
| Q44996584 | Phosphatidylinositol 3-kinase and Akt participate in the FSH-induced meiotic maturation of mouse oocytes |
| Q34462515 | Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. |
| Q40971137 | Phosphatidylinositol 3-kinase and protein kinase C are required for the inhibition of caspase activity by epidermal growth factor |
| Q40023501 | Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway. |
| Q48006829 | Phosphatidylinositol 3-kinase regulates bone morphogenetic protein-2 (BMP-2)-induced myocyte enhancer factor 2A-dependent transcription of BMP-2 gene in cardiomyocyte precursor cells. |
| Q34135631 | Phosphatidylinositol 3-kinases in tumor progression |
| Q39128526 | Phosphatidylinositol 3-kinases inhibitor LY294002 potentiates the cytotoxic effects of doxorubicin, vincristine, and etoposide in a panel of cancer cell lines. |
| Q40935748 | Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis |
| Q24321602 | Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120 |
| Q42991205 | Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling |
| Q39561256 | Phosphorylated insulin-like growth factor 1 receptor is implicated in resistance to the cytostatic effect of gefitinib in colorectal cancer cells |
| Q44062331 | Phosphorylation of Akt/PKB is required for suppression of cancer cell apoptosis and tumor progression in human colorectal carcinoma |
| Q40432782 | Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified. |
| Q49505214 | Physiologic Growth Hormone-Replacement Therapy and Craniopharyngioma Recurrence in Pediatric Patients: A Meta-Analysis. |
| Q24290484 | Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells |
| Q37275841 | Platelet-derived growth factor protects neurons against gp120-mediated toxicity |
| Q40022889 | Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade |
| Q40733083 | Predominant nuclear localization of mammalian target of rapamycin in normal and malignant cells in culture |
| Q39460149 | Prevention of ERK activation involves melatonin-induced G(1) and G(2) /M phase arrest in the human osteoblastic cell line hFOB 1.19. |
| Q43680908 | Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance |
| Q33858319 | Proinflammatory stem cell signaling in cardiac ischemia |
| Q40092905 | Protective effect of magnolol on TBHP-induced injury in H460 cells partially via a p53 dependent mechanism |
| Q42991716 | Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. |
| Q42828148 | Protein kinase B/AKT 1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation |
| Q46230285 | Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria |
| Q34155571 | Protein kinases as therapeutic targets |
| Q38362451 | Protein-tyrosine phosphatase PTPL1/FAP-1 triggers apoptosis in human breast cancer cells |
| Q74236515 | Putative role of the phosphatidylinositol 3-kinase-Akt signaling pathway in the survival of granulosa cells |
| Q33353741 | QTL region-specific microarrays reveal differential expression of positional candidate genes of signaling pathways associated with the liability for the inverted teat defect |
| Q28616251 | Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization |
| Q28568796 | RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation |
| Q28586410 | Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells |
| Q73443708 | Reactive astrocytes express cAMP-response-element-binding protein (CREB) binding protein (CBP) in the central nervous system of transgenic mice expressing a human Cu/Zn superoxide dismutase mutation |
| Q33299842 | Recombinant tissue factor pathway inhibitor induces apoptosis in cultured rat mesangial cells via its Kunitz-3 domain and C-terminal through inhibiting PI3-kinase/Akt pathway |
| Q51347935 | Reduced risk of apoptosis: mechanisms of stress responses. |
| Q33771763 | Regulated nuclear localization of stress-responsive factors: how the nuclear trafficking of protein kinases and transcription factors contributes to cell survival |
| Q40910700 | Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway |
| Q40764194 | Regulation of Drosophila tracheal system development by protein kinase B. |
| Q36060606 | Regulation of IGF-1 but not TGF-β1 by NGF in the smooth muscle of the inflamed urinary bladder |
| Q43768822 | Regulation of IRS-2 tyrosine phosphorylation in fasting and diabetes |
| Q40816834 | Regulation of Id2 gene expression by the insulin-like growth factor I receptor requires signaling by phosphatidylinositol 3-kinase. |
| Q40864831 | Regulation of both apoptosis and cell survival by the v-Src oncoprotein. |
| Q24291556 | Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A |
| Q36836773 | Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection. |
| Q33996549 | Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis |
| Q51101238 | Requirement of the caspase-3/CPP32 protease cascade for apoptotic death following cytokine deprivation in hematopoietic cells. |
| Q42506351 | Role of AKT kinase in sphingosine-induced apoptosis in human hepatoma cells |
| Q78054808 | Role of AKT1 in 17beta-estradiol- and insulin-like growth factor I (IGF-I)-dependent proliferation and prevention of apoptosis in MCF-7 breast carcinoma cells |
| Q36919677 | Role of Akt and c-Jun N-terminal kinase 2 in apoptosis induced by interleukin-4 deprivation |
| Q42452984 | Role of PTEN and Akt in the regulation of growth and apoptosis in human osteoblastic cells |
| Q73575616 | Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal |
| Q40884544 | Role of phosphatidylinositol 3-kinase and specific protein kinase B isoforms in the suppression of apoptosis mediated by the Abelson protein-tyrosine kinase |
| Q34103169 | Role of vasoactive factors in the pathogenesis of early changes in diabetic retinopathy |
| Q22253424 | Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells |
| Q28678652 | Roles of mitogen-activated protein kinase and phosphoinositide 3'-kinase in ErbB2/ErbB3 coreceptor-mediated heregulin signaling |
| Q40625071 | SH2-B Is a Positive Regulator of Nerve Growth Factor-mediated Activation of the Akt/Forkhead Pathway in PC12 Cells |
| Q39007397 | SUMOylation regulates AKT1 activity. |
| Q36455499 | Signal transduction cascades and hepatitis B and C related hepatocellular carcinoma |
| Q33860827 | Signal transduction in mammary tumorigenesis: a transgenic perspective |
| Q33683189 | Signal transduction pathways that regulate the fate of B lymphocytes. |
| Q33936999 | Signaling pathways mediating insulin-stimulated glucose transport |
| Q42948122 | Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation |
| Q24681382 | Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis |
| Q50350473 | Src Acts as an Effector for Ku70-dependent Suppression of Apoptosis through Phosphorylation of Ku70 at Tyr-530. |
| Q33959239 | Src in cancer: deregulation and consequences for cell behaviour |
| Q58134094 | Src protein tyrosine kinases in stress responses |
| Q46265301 | Stem cell factor induces ERM proteins phosphorylation through PI3K activation to mediate melanocyte proliferation and migration |
| Q40623756 | Supplementation-dependent differences in the rates of embryonic stem cell self-renewal, differentiation, and apoptosis |
| Q40624347 | Suppression of adriamycin-induced apoptosis by sustained activation of the phosphatidylinositol-3'-OH kinase-Akt pathway |
| Q31672728 | Suppression of apoptosis induced by growth factor withdrawal by an oncogenic form of c-Cbl |
| Q40929976 | Suppression of ultraviolet irradiation-induced apoptosis by overexpression of focal adhesion kinase in Madin-Darby canine kidney cells |
| Q35040157 | Surgical stress delays prostate involution in mice |
| Q30574736 | Survival and death signals can predict tumor response to therapy after oncogene inactivation |
| Q33911108 | Synergistic suppression of apoptosis in salivary acinar cells by IGF1 and EGF |
| Q40933956 | Synthetic peptide sequence from the C-terminus of the insulin-like growth factor-I receptor that induces apoptosis and inhibition of tumor growth |
| Q45216903 | Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells. Only phosphatidylinositol 3'-kinase is important |
| Q34307902 | TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival |
| Q40795252 | TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3'-kinase/protein kinase B signaling pathway |
| Q73886798 | TNF-alpha induces apoptosis in rat fetal brown adipocytes in primary culture |
| Q37420570 | Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor response |
| Q34722249 | Targeting anti-apoptotic genes upregulated by androgen withdrawal using antisense oligonucleotides to enhance androgen- and chemo-sensitivity in prostate cancer |
| Q24794247 | The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation |
| Q40805561 | The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity |
| Q33828931 | The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling |
| Q34825957 | The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network |
| Q40430306 | The antiapoptotic effect of fibroblast growth factor-2 is mediated through nuclear factor-kappaB activation induced via interaction between Akt and IkappaB kinase-beta in breast cancer cells. |
| Q33959407 | The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB |
| Q41039400 | The baculovirus anti-apoptotic p35 protein promotes transformation of mouse embryo fibroblasts |
| Q42050319 | The chitinase 3-like protein human cartilage glycoprotein 39 inhibits cellular responses to the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha |
| Q40521524 | The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway |
| Q73816403 | The cytokine hepatocyte growth factor/scatter factor inhibits apoptosis and enhances DNA repair by a common mechanism involving signaling through phosphatidyl inositol 3' kinase |
| Q37085226 | The differential effects of prostate stromal cells derived from different zones on prostate cancer epithelial cells under the action of sex hormones |
| Q77796080 | The discovery and validation of new drug targets in cancer |
| Q42797373 | The dynamics of protein kinase B regulation during B cell antigen receptor engagement |
| Q34323637 | The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis. |
| Q33716127 | The epidermal growth factor receptor and its inhibition in cancer therapy |
| Q28505609 | The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7 |
| Q41693148 | The insulin-like growth factor-I receptor and apoptosis. Implications for the aging progress |
| Q58130458 | The insulin-like growth factor-I receptor: Implications for the aging process |
| Q43583391 | The involvement of PI 3-K/Akt-dependent up-regulation of Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6. |
| Q33969029 | The multisubstrate adapter Gab1 regulates hepatocyte growth factor (scatter factor)-c-Met signaling for cell survival and DNA repair |
| Q38296022 | The osteopontin-CD44 survival signal involves activation of the phosphatidylinositol 3-kinase/Akt signaling pathway |
| Q24310123 | The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex |
| Q37454384 | The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications. |
| Q54090437 | The phosphoinositide 3-kinase/Akt pathway is activated by daunorubicin in human acute myeloid leukemia cell lines. |
| Q37724259 | The potential role of insulin-like growth factor receptor inhibitors in the treatment of advanced non-small cell lung cancer |
| Q24297392 | The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1 |
| Q28645742 | The protein kinase B/Akt signalling pathway in human malignancy |
| Q28589352 | The role of Asp-462 in regulating Akt activity |
| Q40900496 | The role of disulfide-linked dimerization in interleukin-3 receptor signaling and biological activity. |
| Q45242015 | The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation |
| Q40756384 | The role of phosphatidylinositol 3-kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation |
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