Regulation of both apoptosis and cell survival by the v-Src oncoprotein.

scientific article published on August 2000

Regulation of both apoptosis and cell survival by the v-Src oncoprotein. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1048319575
P356DOI10.1038/SJ.CDD.4400700
P698PubMed publication ID10918442
P5875ResearchGate publication ID12402358

P50authorWilliam Charles EarnshawQ21004362
P2093author name stringD Johnson
K Samejima
M Frame
J Wyke
M Agochiya
P2860cites workMolecular characterization of mitochondrial apoptosis-inducing factorQ22001452
Mechanism of activation of protein kinase B by insulin and IGF-1Q24309528
A protein kinase involved in the regulation of inflammatory cytokine biosynthesisQ24311139
Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascadeQ24314554
Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein DaxxQ24315012
Daxx, a novel Fas-binding protein that activates JNK and apoptosisQ24316216
Selective interaction of JNK protein kinase isoforms with transcription factorsQ24317346
Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesisQ24559903
pp60c-src activation in human colon carcinomaQ24623701
Disruption of epithelial cell-matrix interactions induces apoptosisQ24673611
SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosisQ24682451
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machineryQ27860586
Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting [...]Q28280257
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complexQ28283294
ASK1 is essential for JNK/SAPK activation by TRAF2Q28285612
Regulation of cell death protease caspase-9 by phosphorylationQ28288607
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)Q28297419
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivoQ28609356
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosisQ29547567
Oncogenes and signal transductionQ29547804
Induction of apoptosis in fibroblasts by c-myc proteinQ29614346
Two CD95 (APO-1/Fas) signaling pathwaysQ29619631
Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.Q30452681
Mechanisms of apoptosis by c-MycQ33667315
Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas.Q33890659
Apoptotic cell death induced by c-myc is inhibited by bcl-2.Q34255589
Cooperative interaction between c-myc and bcl-2 proto-oncogenesQ34255596
Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteinsQ34471050
Activating SRC mutation in a subset of advanced human colon cancersQ34492512
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosisQ35885582
Mitogen-activated protein kinase kinase antagonized fas-associated death domain protein-mediated apoptosis by induced FLICE-inhibitory protein expressionQ36401247
Complementation of defective colony-stimulating factor 1 receptor signaling and mitogenesis by Raf and v-SrcQ39610851
The opposing roles of the Akt and c-Myc signalling pathways in survival from CD95-mediated apoptosisQ40982924
TRAIL/Apo2L activates c-Jun NH2-terminal kinase (JNK) via caspase-dependent and caspase-independent pathwaysQ40992331
Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signalsQ41050794
Protein kinase cascades activated by stress and inflammatory cytokinesQ41075765
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.Q41128352
A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA.Q41149112
Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosisQ41415956
Caspases and caspase inhibitorsQ41633125
Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.Q41714456
Mechanisms and consequences of activation of protein kinase B/AktQ41751003
Inhibition of human caspases by peptide-based and macromolecular inhibitorsQ42538024
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathwayQ42618265
The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motilityQ42635431
Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32.Q42981625
Anchorage and growth regulation in normal and virus-transformed cellsQ45810351
The selective isolation of temperature-sensitive mutants of Rous sarcoma virusQ45826938
The regulation of anoikis: MEKK-1 activation requires cleavage by caspasesQ46102806
Bcl-2 family proteinsQ46508339
Expression of the v-Src oncoprotein in fibroblasts disrupts normal regulation of the CDK inhibitor p27 and inhibits quiescence.Q53434589
c-myc gene activation as a permanent trait of RSV-infected quail cells.Q53481286
A method of isolating cells incapable of multiplication in suspension culture.Q53605568
Inhibition of Fas-induced apoptosis by Bcl-2.Q54114172
p19ARF links the tumour suppressor p53 to RasQ57562848
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2Q73386407
Traps to catch unwary oncogenesQ77401530
Stress signals for apoptosis: ceramide and c-Jun kinaseQ77900365
P433issue8
P304page(s)685-696
P577publication date2000-08-01
P1433published inCell Death & DifferentiationQ2943974
P1476titleRegulation of both apoptosis and cell survival by the v-Src oncoprotein
P478volume7

Reverse relations

cites work (P2860)
Q37169157A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes
Q26849503A critical evaluation of PI3K inhibition in Glioblastoma and Neuroblastoma therapy
Q34013783Adhesion-linked kinases in cancer; emphasis on src, focal adhesion kinase and PI 3-kinase
Q48832123Apoptosis induced by SRC-family tyrosine kinase inhibitors in cultured rat cortical cells.
Q30164299Blockade of v-Src-stimulated tumor formation by the Src homology 3 domain of Crk-associated substrate (Cas).
Q44214665Carbazolequinone induction of caspase-dependent cell death in Src-overexpressing cells
Q52541492Cleavage of focal adhesion kinase by different proteases during SRC-regulated transformation and apoptosis. Distinct roles for calpain and caspases.
Q37425090Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways
Q34088483Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1
Q40455966Deletions in the DNA-binding domain of the TP53 gene in v-src-transformed chicken cells.
Q41456604Differing Src signaling levels have distinct outcomes in Drosophila
Q30160161Distinct and opposite roles for SH2 and SH3 domains of v-src in embryo survival and hemangiosarcoma formation
Q44525192Distinct protease pathways control cell shape and apoptosis in v-src-transformed quail neuroretina cells
Q40750180Downregulating PKC delta provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression
Q44859699Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis
Q29615474Epidermal growth factor receptor mutations in lung cancer
Q38306649Expression of CCL9/MIP-1gamma is repressed by BCR/ABL and its restoration suppresses in vivo leukemogenesis of 32D-BCR/ABL cells
Q24315088Fhit is a physiological target of the protein kinase Src
Q40620317Inactivation of Src family kinases inhibits angiogenesis in vivo: implications for a mechanism involving organization of the actin cytoskeleton
Q37729153Involvement of Bcl-2, Src, and ERα in gossypol-mediated growth inhibition and apoptosis in human uterine leiomyoma and myometrial cells
Q36414488Mouse mammary tumor virus suppresses apoptosis of mammary epithelial cells through ITAM-mediated signaling.
Q39555554Pleiotropic action of AP-1 in v-Src-transformed cells
Q40709928Proapoptotic and redox state-related signaling of reactive oxygen species generated by transformed fibroblasts
Q35979002Proteinase-activated receptor 1 activation induces epithelial apoptosis and increases intestinal permeability
Q39415481Proteomics analysis of in vitro protein methylation during Src-induced transformation
Q38011985Regulation of pancreatic β-cell survival by nitric oxide: clinical relevance
Q38862860SRC inhibition represents a potential therapeutic strategy in liposarcoma
Q39961268SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling
Q50350473Src Acts as an Effector for Ku70-dependent Suppression of Apoptosis through Phosphorylation of Ku70 at Tyr-530.
Q39931885Src activity alters alpha3 integrin expression in colon tumor cells
Q33959239Src in cancer: deregulation and consequences for cell behaviour
Q37185828Src kinases in chondrosarcoma chemoresistance and migration: dasatinib sensitises to doxorubicin in TP53 mutant cells
Q58134094Src protein tyrosine kinases in stress responses
Q39386079Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik.
Q43713868Src tyrosine kinase is the trigger but not the mediator of ischemic preconditioning
Q33951212Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis
Q40775817The mechanism of cell cycle regulation by v-Src.
Q64235594Therapeutic Efficiency of an External Chinese Herbal Formula of Mammary Precancerous Lesions by BATMAN-TCM Online Bioinformatics Analysis Tool and Experimental Validation
Q37538535Understanding melanoma signaling networks as the basis for molecular targeted therapy
Q77649716p60(v-src) and serum control cell shape and apoptosis via distinct pathways in quail neuroretina cells
Q39540229v-Src generates a p53-independent apoptotic signal

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