A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat.

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A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SJ.BJP.0704344
P932PMC publication ID1573037
P698PubMed publication ID11682451
P5875ResearchGate publication ID11671417

P2093author name stringK F Chung
T J Huang
I M Adcock
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Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysacchariQ42589688
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A novel inhibitor of nuclear factor-kappa B and activator protein-1 transcription factors in T cells suppresses host-versus-graft alloreactivity in vivoQ46788958
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Inflammation and the late phase reaction in asthma: the effect of polymorphonuclear leukocyte depletion on airways obstruction and bronchial hyperreactivity in an animal modelQ70026887
Neutrophil depletion inhibits airway hyperresponsiveness induced by ozone exposureQ70579218
Transcription factorsQ70974544
Depletion of CD8+ T cells enhances pulmonary inflammation but not airway responsiveness after antigen challenge in ratsQ71583440
Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosisQ71707597
Evaluation of airway hyperreactivity in interleukin-5 transgenic miceQ71719269
SP100030 is a novel T-cell-specific transcription factor inhibitor that possesses immunosuppressive activity in vivoQ71878966
Effects of an antibody to interleukin-5 in a monkey model of asthmaQ71954025
Effects of interleukin-5 inhibition on antigen-induced airway hyperresponsiveness and cell accumulation in guinea pigsQ72060132
Inhibitory effects of endogenous and exogenous interferon-gamma on bronchial hyperresponsiveness, allergic inflammation and T-helper 2 cytokines in Brown-Norway ratsQ73129015
Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitizationQ73263321
alpha4 integrin-dependent eotaxin induction of bronchial hyperresponsiveness and eosinophil migration in interleukin-5 transgenic miceQ77393419
Effect of CD8+ T-cell depletion on bronchial hyper-responsiveness and inflammation in sensitized and allergen-exposed Brown-Norway ratsQ77419265
Prevention of Th2-like cell responses by coadministration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia, and serum IgE levelsQ77484106
Inflammatory mediators of asthma: an updateQ77710217
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1029-1036
P577publication date2001-11-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleA novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat.
P478volume134

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cites work (P2860)
Q42108571A small molecule, orally active, alpha4beta1/alpha4beta7 dual antagonist reduces leukocyte infiltration and airway hyper-responsiveness in an experimental model of allergic asthma in Brown Norway rats.
Q34837225Airway smooth muscle: new targets for asthma pharmacotherapy
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Q47861309Upregulation of phosphodiesterase-4 in the lung of allergic rats

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