Kinase inhibitors and airway inflammation.

scientific article

Kinase inhibitors and airway inflammation. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814
retracted paperQ45182324

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P356DOI10.1016/J.EJPHAR.2005.12.054
P698PubMed publication ID16469308
P5875ResearchGate publication ID7305760

P50authorKazuhiro ItoQ87778476
Ian M. AdcockQ38803002
Kian Fan ChungQ43222898
P2093author name stringGaetano Caramori
P2860cites workThe protein kinase complement of the human genomeQ24324497
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c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritisQ28343409
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinaseQ28364720
MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesisQ28593865
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Missing pieces in the NF-kappaB puzzleQ29547864
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammationQ29614227
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinasesQ29614338
Potential role of c-Jun NH2-terminal kinase in allergic airway inflammation and remodelling: effects of SP600125.Q45207907
Altered protein tyrosine phosphorylation in asthmatic bronchial epitheliumQ46522256
Mitogen-activated protein kinase cascades as regulators of stress responsesQ46899777
SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lungQ46903300
Increased expression of nuclear factor-kappaB in bronchial biopsies from smokers and patients with COPD.Q51702183
Inhibition of p38 mitogen-activated protein kinase: dose-dependent suppression of leukocyte and endothelial response after endotoxin challenge in humans.Q51721285
The global burden of disease, 1990–2020Q53681952
In vivo resistance to corticosteroids in bronchial asthma is associated with enhanced phosyphorylation of JUN N-terminal kinase and failure of prednisolone to inhibit JUN N-terminal kinase phosphorylation.Q54079350
Expression and activation of protein kinase C-zeta in eosinophils after allergen challenge.Q54458959
Fos immunoreactivity assessment on human normal and pathological bronchial biopsies.Q54567044
Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice.Q54692531
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.Q55034563
Differential p38 mitogen-activated protein kinase target phosphorylation in responders and nonresponders to infliximabQ57244635
A 15-Year Follow-up Study of Ventilatory Function in Adults with AsthmaQ57956064
Defective T Cell Differentiation in the Absence of Jnk1Q58415329
Cellular protein kinase C activity in asthmaQ73227864
IKKβ Is Required for Peripheral B Cell Survival and ProliferationQ73299772
Vascular endothelial growth factor and the pathogenesis of emphysemaQ73315628
Superantigen-induced corticosteroid resistance of human T cells occurs through activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK-ERK) pathwayQ80985173
An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environmentQ81606189
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Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domainQ29620169
Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic leukemia cells activated via type I Fc epsilon receptors.Q30176694
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Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosomeQ33336718
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Asthma.Q34137112
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JAK-STAT signaling in asthmaQ34647024
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Effect of the p38 kinase inhibitor, SB 203580, on allergic airway inflammation in the rat.Q35042718
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CGH2466, a combined adenosine receptor antagonist, p38 mitogen-activated protein kinase and phosphodiesterase type 4 inhibitor with potent in vitro and in vivo anti-inflammatory activitiesQ35048762
A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activityQ35048852
Epidermal growth factor system regulates mucin production in airwaysQ35065617
Tyrosine kinases as targets in cancer therapy - successes and failuresQ35095147
Targeting the JNK pathway for therapeutic benefit in CNS diseaseQ35137435
Targeting JNK for therapeutic benefit: from junk to gold?Q35158010
Targeting epidermal growth factor receptor--are we missing the mark?Q35174501
Pharmacology of airway inflammation in asthma and COPD.Q35183830
p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseasesQ35209995
Corticosteroid-insensitive asthma: molecular mechanisms.Q35216182
Tyrosine kinase inhibitors: a new approach for asthmaQ35692069
Protein kinase inhibitors: insights into drug design from structure.Q35697409
PI 3-kinase inhibition: a therapeutic target for respiratory diseaseQ35717638
The p38 MAP kinase pathway as a therapeutic target in inflammatory diseaseQ35834912
Lung inflammation as a therapeutic target in cystic fibrosis.Q35894285
The role of sphingosine and ceramide kinases in inflammatory responsesQ35976753
The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validationQ36107319
Respiratory syncytial virus pneumonia: mechanisms of inflammation and prolonged airway hyperresponsivenessQ36111797
Strategies for the design of potent and selective kinase inhibitors.Q36126762
Activation and localization of transcription factor, nuclear factor-kappaB, in asthmaQ38331366
Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemiaQ38919861
BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo.Q40448987
Enhancement of MEK/ERK signaling promotes glucocorticoid resistance in CD4+ T cellsQ40553683
Regulation of airway epithelial cell NF-kappa B-dependent gene expression by protein kinase C deltaQ40646086
A role for STAT5 in the pathogenesis of IL-2-induced glucocorticoid resistanceQ40691411
Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidateQ40721991
Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinaseQ40857729
Involvement of the epidermal growth factor receptor in epithelial repair in asthmaQ40870399
p38 mitogen-activated protein kinase and c-jun-NH2-terminal kinase regulate RANTES production by influenza virus-infected human bronchial epithelial cellsQ40895310
Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxisQ40929895
The costs of asthmaQ41050636
The epithelium as a target of glucocorticoid action in the treatment of asthmaQ41075168
Developmental expression in the mouse nervous system of the p493F12 SAP kinaseQ41251934
Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cellsQ41700451
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injuryQ41982755
Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes.Q42537136
Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophilsQ42943439
p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthmaQ43952642
Pyrazolo[3,4-d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck -- a selectivity insightQ44011810
Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinaseQ44050002
BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in miceQ44196757
Efficacy of imatinib mesylate in the treatment of idiopathic hypereosinophilic syndromeQ44321379
Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD miceQ44410698
The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodentsQ44453360
A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblastsQ44482174
Pyrrolopyrimidine c-Src inhibitors reduce growth, adhesion, motility and invasion of prostate cancer cells in vitro.Q44558810
Distribution of therapeutic response in asthma controlQ44600710
AS602868, a pharmacological inhibitor of IKK2, reveals the apoptotic potential of TNF-alpha in Jurkat leukemic cellsQ44645811
Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokinQ45021806
Treatment of cockroach allergen asthma model with imatinib attenuates airway responsesQ45063930
P433issue1-3
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
P304page(s)118-132
P577publication date2006-02-08
P1433published inEuropean Journal of PharmacologyQ1376712
P1476titleKinase inhibitors and airway inflammation
P478volume533

Reverse relations

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