review article | Q7318358 |
scholarly article | Q13442814 |
retracted paper | Q45182324 |
P50 | author | Kazuhiro Ito | Q87778476 |
Ian M. Adcock | Q38803002 | ||
Kian Fan Chung | Q43222898 | ||
P2093 | author name string | Gaetano Caramori | |
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An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment | Q81606189 | ||
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Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain | Q29620169 | ||
Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic leukemia cells activated via type I Fc epsilon receptors. | Q30176694 | ||
The potential role of PKC beta in diabetic retinopathy and macular edema | Q31123344 | ||
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome | Q33336718 | ||
The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus | Q33539989 | ||
Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease | Q33956768 | ||
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Update on glucocorticoid action and resistance | Q34171161 | ||
Cellular and structural bases of chronic obstructive pulmonary disease | Q34260279 | ||
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Protein kinase C inhibitors as novel anticancer drugs | Q34481881 | ||
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Emerging immune targets for the therapy of allergic asthma | Q34741560 | ||
NF-kappaB as a therapeutic target in cancer | Q34750172 | ||
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New concepts in chronic obstructive pulmonary disease | Q34930970 | ||
Effect of the p38 kinase inhibitor, SB 203580, on allergic airway inflammation in the rat. | Q35042718 | ||
A novel transcription factor inhibitor, SP100030, inhibits cytokine gene expression, but not airway eosinophilia or hyperresponsiveness in sensitized and allergen-exposed rat. | Q35043860 | ||
Allergen-induced inflammation and airway epithelial and smooth muscle cell proliferation: role of Jun N-terminal kinase | Q35045982 | ||
CGH2466, a combined adenosine receptor antagonist, p38 mitogen-activated protein kinase and phosphodiesterase type 4 inhibitor with potent in vitro and in vivo anti-inflammatory activities | Q35048762 | ||
A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity | Q35048852 | ||
Epidermal growth factor system regulates mucin production in airways | Q35065617 | ||
Tyrosine kinases as targets in cancer therapy - successes and failures | Q35095147 | ||
Targeting the JNK pathway for therapeutic benefit in CNS disease | Q35137435 | ||
Targeting JNK for therapeutic benefit: from junk to gold? | Q35158010 | ||
Targeting epidermal growth factor receptor--are we missing the mark? | Q35174501 | ||
Pharmacology of airway inflammation in asthma and COPD. | Q35183830 | ||
p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases | Q35209995 | ||
Corticosteroid-insensitive asthma: molecular mechanisms. | Q35216182 | ||
Tyrosine kinase inhibitors: a new approach for asthma | Q35692069 | ||
Protein kinase inhibitors: insights into drug design from structure. | Q35697409 | ||
PI 3-kinase inhibition: a therapeutic target for respiratory disease | Q35717638 | ||
The p38 MAP kinase pathway as a therapeutic target in inflammatory disease | Q35834912 | ||
Lung inflammation as a therapeutic target in cystic fibrosis. | Q35894285 | ||
The role of sphingosine and ceramide kinases in inflammatory responses | Q35976753 | ||
The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation | Q36107319 | ||
Respiratory syncytial virus pneumonia: mechanisms of inflammation and prolonged airway hyperresponsiveness | Q36111797 | ||
Strategies for the design of potent and selective kinase inhibitors. | Q36126762 | ||
Activation and localization of transcription factor, nuclear factor-kappaB, in asthma | Q38331366 | ||
Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia | Q38919861 | ||
BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo. | Q40448987 | ||
Enhancement of MEK/ERK signaling promotes glucocorticoid resistance in CD4+ T cells | Q40553683 | ||
Regulation of airway epithelial cell NF-kappa B-dependent gene expression by protein kinase C delta | Q40646086 | ||
A role for STAT5 in the pathogenesis of IL-2-induced glucocorticoid resistance | Q40691411 | ||
Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate | Q40721991 | ||
Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase | Q40857729 | ||
Involvement of the epidermal growth factor receptor in epithelial repair in asthma | Q40870399 | ||
p38 mitogen-activated protein kinase and c-jun-NH2-terminal kinase regulate RANTES production by influenza virus-infected human bronchial epithelial cells | Q40895310 | ||
Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis | Q40929895 | ||
The costs of asthma | Q41050636 | ||
The epithelium as a target of glucocorticoid action in the treatment of asthma | Q41075168 | ||
Developmental expression in the mouse nervous system of the p493F12 SAP kinase | Q41251934 | ||
Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells | Q41700451 | ||
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury | Q41982755 | ||
Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes. | Q42537136 | ||
Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils | Q42943439 | ||
p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma | Q43952642 | ||
Pyrazolo[3,4-d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck -- a selectivity insight | Q44011810 | ||
Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinase | Q44050002 | ||
BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice | Q44196757 | ||
Efficacy of imatinib mesylate in the treatment of idiopathic hypereosinophilic syndrome | Q44321379 | ||
Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice | Q44410698 | ||
The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents | Q44453360 | ||
A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts | Q44482174 | ||
Pyrrolopyrimidine c-Src inhibitors reduce growth, adhesion, motility and invasion of prostate cancer cells in vitro. | Q44558810 | ||
Distribution of therapeutic response in asthma control | Q44600710 | ||
AS602868, a pharmacological inhibitor of IKK2, reveals the apoptotic potential of TNF-alpha in Jurkat leukemic cells | Q44645811 | ||
Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokin | Q45021806 | ||
Treatment of cockroach allergen asthma model with imatinib attenuates airway responses | Q45063930 | ||
P433 | issue | 1-3 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | inflammation | Q101991 |
P304 | page(s) | 118-132 | |
P577 | publication date | 2006-02-08 | |
P1433 | published in | European Journal of Pharmacology | Q1376712 |
P1476 | title | Kinase inhibitors and airway inflammation | |
P478 | volume | 533 |
Q41287485 | A high-throughput chemical screen identifies novel inhibitors and enhancers of anti-inflammatory functions of the glucocorticoid receptor |
Q50627197 | Activation of MAPK participates in low shear stress-induced IL-8 gene expression in endothelial cells. |
Q41869210 | Activity of sputum p38 MAPK is correlated with airway inflammation and reduced FEV1 in COPD patients |
Q46213809 | Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease |
Q36724014 | Airway smooth muscle cell as therapeutic target of inflammation |
Q35600403 | Aldose reductase deficiency in mice protects from ragweed pollen extract (RWE)-induced allergic asthma |
Q37184811 | Altered phosphorylated signal transducer and activator of transcription profile of CD4+CD161+ T cells in asthma: modulation by allergic status and oral corticosteroids |
Q54620014 | Aminopyridinecarboxamide-based inhaled IKK-2 inhibitors for asthma and COPD: Structure-activity relationship. |
Q104993532 | Anti-inflammatory Activity |
Q33774669 | Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke. |
Q82041601 | Anti-inflammatory effects of LASSBio-998, a new drug candidate designed to be a p38 MAPK inhibitor, in an experimental model of acute lung inflammation |
Q34131740 | Atg7 deficiency impairs host defense against Klebsiella pneumoniae by impacting bacterial clearance, survival and inflammatory responses in mice |
Q61712331 | Attenuation of Ozone-Induced Airway Inflammation and Hyper-Responsiveness by c-Jun NH2 Terminal Kinase Inhibitor SP600125 |
Q37596127 | Basal p38 mitogen-activated protein kinase regulates unliganded glucocorticoid receptor function in airway smooth muscle cells. |
Q37411345 | Bronchial asthma, chronic obstructive pulmonary disease and NF-kappaB. |
Q37856648 | Chronic obstructive pulmonary disease and lung cancer: new molecular insights |
Q36443665 | Chronic obstructive pulmonary disease: an update of treatment related to frequently associated comorbidities |
Q39602460 | Cigarette smoke extract regulates cytosolic phospholipase A2 expression via NADPH oxidase/MAPKs/AP-1 and p300 in human tracheal smooth muscle cells |
Q30402152 | Comparative modeling: the state of the art and protein drug target structure prediction |
Q30393891 | Comprehensive Structural and Functional Characterization of the Human Kinome by Protein Structure Modeling and Ligand Virtual Screening |
Q37697884 | Corticosteroid insensitivity in severe asthma: significance, mechanisms and aetiology. |
Q39200193 | Cytokine profiles, signalling pathways and effects of fluticasone propionate in respiratory syncytial virus-infected human foetal lung fibroblasts |
Q48946969 | Development of a Method for Converting a TAK1 Type I Inhibitor into a Type II or c-Helix-Out Inhibitor by Structure-Based Drug Design (SBDD). |
Q91645802 | Differential expression of heat shock proteins and activation of mitogen-activated protein kinases in A549 alveolar epithelial cells exposed to cigarette smoke extract |
Q40026969 | Differential regulation of Moraxella catarrhalis-induced interleukin-8 response by protein kinase C isoforms. |
Q27721394 | Discovery of a potent and highly selective transforming growth factor β receptor-associated kinase 1 (TAK1) inhibitor by structure based drug design (SBDD) |
Q53439673 | Effect of imatinib on airway smooth muscle thickening in a murine model of chronic asthma. |
Q43258675 | Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma |
Q42964153 | Effects of budesonide on P38 MAPK activation, apoptosis and IL-8 secretion, induced by TNF-alpha and Haemophilus influenzae in human bronchial epithelial cells |
Q40147666 | Enhanced IL-1beta-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-kappaB signaling |
Q38033010 | Epigenetics in asthma and COPD. |
Q37852398 | Epigenetics of asthma |
Q37006440 | Equine recurrent airway obstruction and insect bite hypersensitivity: understanding the diseases and uncovering possible new therapeutic approaches |
Q33284018 | Evaluation of the utility of homology models in high throughput docking |
Q35099151 | GSTM1 modulation of IL-8 expression in human bronchial epithelial cells exposed to ozone |
Q83897571 | Gene expression profiling distinguishes radiation-induced fibrosing alveolitis from alveolitis in mice |
Q28761895 | Glucocorticoid insensitivity as a future target of therapy for chronic obstructive pulmonary disease |
Q36346434 | Glutathione-S-transferase M1 regulation of diesel exhaust particle-induced pro-inflammatory mediator expression in normal human bronchial epithelial cells |
Q45931397 | Homology modeling of human Fyn kinase structure: discovery of rosmarinic acid as a new Fyn kinase inhibitor and in silico study of its possible binding modes. |
Q58877117 | Increased activation of p38 MAPK in COPD |
Q46448195 | Inhibition by a selective IkappaB kinase-2 inhibitor of interleukin-1-induced collagen degradation by corneal fibroblasts in three-dimensional culture |
Q35903480 | Inhibition of p38 MAPK-dependent bronchial contraction after ozone by corticosteroids |
Q43290696 | Interference of alpha-alkyl-substituted pirinixic acid derivatives with neutrophil functions and signalling pathways |
Q35757161 | Intrapulmonary delivery of ricin at high dosage triggers a systemic inflammatory response and glomerular damage |
Q38817765 | Inundation of asthma target research: Untangling asthma riddles |
Q38882099 | Kinases as Novel Therapeutic Targets in Asthma and Chronic Obstructive Pulmonary Disease. |
Q47403914 | Lack of TAK1 in dendritic cells inhibits the contact hypersensitivity response induced by trichloroethylene in local lymph node assay |
Q33766033 | Lead Screening for Chronic Obstructive Pulmonary Disease of IKK2 Inhibited by Traditional Chinese Medicine |
Q23918409 | Lipopolysaccharide increases Na+, K+ -pump, but not ENaC, expression in guinea-pig airway epithelium |
Q83398595 | Macrolide antibiotics broadly and distinctively inhibit cytokine and chemokine production by COPD sputum cells in vitro |
Q37800575 | Mechanisms involved in lung cancer development in COPD. |
Q34331434 | Mechanistic links between COPD and lung cancer |
Q37235828 | Molecular mechanisms of corticosteroid resistance. |
Q51962478 | Monocyte chemoattractant protein-1 is a pathogenic component in a model for a hereditary peripheral neuropathy. |
Q47873103 | New approaches for identifying and testing potential new anti-asthma agents. |
Q80810673 | New drugs for asthma |
Q36485165 | New drugs targeting Th2 lymphocytes in asthma |
Q37274728 | New targets for drug development in asthma |
Q37765700 | New therapies for asthma: is there any progress? |
Q37532557 | New treatments for chronic obstructive pulmonary disease and viable formulation/device options for inhalation therapy |
Q33753476 | Nicotine enhances murine airway contractile responses to kinin receptor agonists via activation of JNK- and PDE4-related intracellular pathways. |
Q61712067 | Novel Anti-Inflammatory Treatments for Asthma and COPD |
Q40041782 | Novel anti-inflammatory treatments for asthma |
Q45991780 | Novel tight-binding inhibitory factor-kappaB kinase (IKK-2) inhibitors demonstrate target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation. |
Q37650688 | Opposing forces in asthma: regulation of signaling pathways by kinases and phosphatases |
Q37756117 | Overcoming reduced glucocorticoid sensitivity in airway disease: molecular mechanisms and therapeutic approaches. |
Q34159886 | Overlap Between Asthma and COPD: Where the Two Diseases Converge |
Q42726097 | Oxytocin inhibits NADPH oxidase and P38 MAPK in cisplatin-induced nephrotoxicity |
Q33873144 | Pathways analysis of molecular markers in chronic sinusitis with polyps |
Q39333160 | Porphyrins as new endogenous anti-inflammatory agents |
Q64008481 | Post-transcriptional regulators in inflammation: exploring new avenues in biological therapeutics |
Q39968952 | Proinflammatory effect of sodium 4-phenylbutyrate in deltaF508-cystic fibrosis transmembrane conductance regulator lung epithelial cells: involvement of extracellular signal-regulated protein kinase 1/2 and c-Jun-NH2-terminal kinase signaling |
Q37685168 | Regulation of allergy with RNA interference |
Q35029064 | Relationships between Cytokine Profiles and Signaling Pathways (IκB Kinase and p38 MAPK) in Parainfluenza Virus-Infected Lung Fibroblasts |
Q83617314 | Relevance of systems pharmacology in drug discovery |
Q39035070 | Roflumilast N-oxide prevents cytokine secretion induced by cigarette smoke combined with LPS through JAK/STAT and ERK1/2 inhibition in airway epithelial cells. |
Q37971131 | Severe asthma: advances in current management and future therapy |
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Q37140072 | Steroid resistance in asthma: mechanisms and treatment options |
Q39370971 | Synergism between interleukin (IL)-17 and Toll-like receptor 2 and 4 signals to induce IL-8 expression in cystic fibrosis airway epithelial cells. |
Q37132582 | Targeting airway inflammation in asthma: current and future therapies |
Q37955927 | Targeting airway smooth muscle in airways diseases: an old concept with new twists |
Q38026246 | Targeting of TAK1 in inflammatory disorders and cancer |
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Q34868949 | The C5a receptor on mast cells is critical for the autoimmune skin-blistering disease bullous pemphigoid |
Q51661762 | The NR3C1 Glucocorticoid Receptor Gene Polymorphisms May Modulate the TGF-beta mRNA Expression in Asthma Patients. |
Q37010493 | The mast cell and allergic diseases: role in pathogenesis and implications for therapy |
Q37966849 | The potential use of tyrosine kinase inhibitors in severe asthma |
Q43237599 | The role of protein tyrosine phosphatases in the regulation of allergic asthma: implication of TC-PTP and PTP-1B in the modulation of disease development |
Q38108873 | The therapeutic properties of Carapa guianensis. |
Q37362620 | Therapeutic perspectives in bronchial vascular remodeling in COPD. |
Q34571618 | Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease. |
Q61712269 | Transcription Factors |
Q37329286 | Transcriptional regulation of cytokine function in airway smooth muscle cells. |
Q37082594 | Treating COPD with PDE 4 inhibitors. |
Q27011823 | Treatment of allergic asthma: modulation of Th2 cells and their responses |
Q40588737 | Treatment with a p38 MAPK inhibitor attenuates cisplatin nephrotoxicity starting after the beginning of renal damage |
Q37061880 | Viral infection in asthma |
Q37988188 | p38 MAPK inhibitors, IKK2 inhibitors, and TNFα inhibitors in COPD. |
Q37886386 | p38 mitogen-activated protein kinase pathways in asthma and COPD. |
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