Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin II

scientific article

Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin II is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SJ.BJP.0706217
P932PMC publication ID1576167
P698PubMed publication ID15821752
P5875ResearchGate publication ID7914554

P50authorFraser D RussellQ45015135
P2093author name stringPeter Molenaar
Joan Li
Jianchun Wang
P2860cites workTransient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathwaysQ24649132
Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failureQ28177421
A calcineurin-dependent transcriptional pathway for cardiac hypertrophyQ28269300
The Myristoylated Alanine‐Rich C‐Kinase Substrate (MARCKS) is Sequentially Phosphorylated by Conventional, Novel and Atypical Isotypes of Protein Kinase CQ28291411
Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophyQ28343890
Effects of ACE inhibition and angiotensin II type 1 receptor blockade on cardiac function and G proteins in rats with chronic heart failureQ28346745
Urotensin-II-mediated cardiomyocyte hypertrophy: effect of receptor antagonism and role of inflammatory mediatorsQ28566263
Differential activation of transcription factors induced by Ca2+ response amplitude and durationQ29619010
The human heart endothelin system: ET-1 synthesis, storage, release and effectQ34023346
Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programmeQ34246882
Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trialQ34246891
Cardiostimulant effects of urotensin-II in human heart in vitroQ35043105
AKAPs (A-kinase anchoring proteins) and molecules that compose their G-protein-coupled receptor signalling complexesQ35625359
Emerging roles of urotensin-II in cardiovascular disease.Q35909083
Determination of the specific substrate sequence motifs of protein kinase C isozymesQ36842048
Polar secretion of endothelin-1 by cultured endothelial cellsQ41129249
Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase beta (HPTP beta) using synthetic phosphopeptidesQ41868748
Direct actions of urotensin II on the heart: implications for cardiac fibrosis and hypertrophyQ42169441
Use of fluorinated tyrosine phosphates to probe the substrate specificity of the low molecular weight phosphatase activity of calcineurin.Q43689393
Angiotensin II induced cardiac hypertrophy in vivo is inhibited by cyclosporin A in adult ratsQ43840391
Congestive heart failure and expression of myocardial urotensin II.Q44036542
Beneficial neurohormonal profile of spironolactone in severe congestive heart failure: results from the RALES neurohormonal substudyQ44213168
(-)-CGP 12177 increases contractile force and hastens relaxation of human myocardial preparations through a propranolol-resistant state of the beta 1-adrenoceptorQ44343048
Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heartQ45015009
Increased regulatory activity of the calcineurin/NFAT pathway in human heart failureQ47973168
Phosphorylation of the calmodulin-dependent protein phosphatase by protein kinase C.Q48319626
Dose-Dependent Effects of the Renin Inhibitor Zankiren HCl After a Single Oral Dose in Mildly Sodium-Depleted Normotensive SubjectsQ56656065
Calcineurin and human heart failureQ56877814
Inhibition of myocardial endothelin pathway improves long-term survival in heart failureQ59063327
Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gαq/Gα11 in cardiomyocytesQ60687218
Revisiting calcineurin and human heart failureQ62397376
Plasma endothelin in chronic heart failureQ68054244
Inotropic effects of angiotensin II on human cardiac muscle in vitroQ68606390
Regulation of calcineurin by phosphorylation. Identification of the regulatory site phosphorylated by Ca2+/calmodulin-dependent protein kinase II and protein kinase CQ69355977
Dephosphorylation of protein kinase C substrates, neurogranin, neuromodulin, and MARCKS, by calcineurin and protein phosphatases 1 and 2AQ72565963
Both beta(2)- and beta(1)-adrenergic receptors mediate hastened relaxation and phosphorylation of phospholamban and troponin I in ventricular myocardium of Fallot infants, consistent with selective coupling of beta(2)-adrenergic receptors to G(s)-prQ73054101
Molecular heterogeneity of protein kinase C expression in human ventricleQ73131017
Congestive heart failure: fifty years of progressQ73194427
Contractile and arrhythmic effects of endothelin receptor agonists in human heart in vitro: blockade with SB 209670Q73289600
Calcineurin in human heart hypertrophyQ74098248
Activation of beta2-adrenergic receptors hastens relaxation and mediates phosphorylation of phospholamban, troponin I, and C-protein in ventricular myocardium from patients with terminal heart failureQ77781940
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)432-440
P577publication date2005-06-01
P1433published inBritish Journal of PharmacologyQ919631
P1476titleActivation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin II
P478volume145

Reverse relations

cites work (P2860)
Q61819782(-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through β2-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling
Q26748814Angiotensin II type 1 receptor antagonists in animal models of vascular, cardiac, metabolic and renal disease
Q37394539Direct inotropic effects of exogenous and endogenous urotensin-II: divergent actions in failing and nonfailing human myocardium
Q36916953Human heart beta-adrenoceptors: beta1-adrenoceptor diversification through 'affinity states' and polymorphism.
Q62026465Urotensin II acutely increases myocardial length and distensibility: potential implications for diastolic function and ventricular remodeling

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