Direct inotropic effects of exogenous and endogenous urotensin-II: divergent actions in failing and nonfailing human myocardium

scientific article published on January 2009

Direct inotropic effects of exogenous and endogenous urotensin-II: divergent actions in failing and nonfailing human myocardium is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1161/CIRCHEARTFAILURE.107.748343
P932PMC publication ID2764958
P698PubMed publication ID19808314

P2093author name stringHajime Kubo
Kenneth B Margulies
Stephen A Douglas
Michael P Quaile
Carie L Kimbrough
P2860cites workHuman urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14Q22010575
Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failureQ28177421
Urotensin-II-mediated cardiomyocyte hypertrophy: effect of receptor antagonism and role of inflammatory mediatorsQ28566263
Differential effect of urotensin II on vascular tone in normal subjects and patients with chronic heart failureQ33199056
Hormones and hemodynamics in heart failureQ33713907
Pathophysiology of chronic heart failureQ34239875
Cardiostimulant effects of urotensin-II in human heart in vitroQ35043105
Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin IIQ35048941
The peptidic urotensin-II receptor ligand GSK248451 possesses less intrinsic activity than the low-efficacy partial agonists SB-710411 and urantide in native mammalian tissues and recombinant cell systemsQ35100902
Neurohormonal activation in congestive heart failure and the role of vasopressinQ36104992
Mechanisms of neurohormonal activation in chronic congestive heart failure: pathophysiology and therapeutic implicationsQ36133997
Effect of endothelins on the cardiovascular systemQ36576870
Differential vasoconstrictor activity of human urotensin-II in vascular tissue isolated from the rat, mouse, dog, pig, marmoset and cynomolgus monkeyQ42059806
Direct actions of urotensin II on the heart: implications for cardiac fibrosis and hypertrophyQ42169441
Sex-based differences in myocardial contractile reserveQ42502024
Patients with end-stage congestive heart failure treated with beta-adrenergic receptor antagonists have improved ventricular myocyte calcium regulatory protein abundanceQ43721249
Congestive heart failure and expression of myocardial urotensin II.Q44036542
Neurohormonal activation and the chronic heart failure syndrome in adults with congenital heart diseaseQ44047539
Effects of urotensin II on isolated rat hearts under normal perfusion and ischemia reperfusionQ44561032
Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heartQ45015009
Reduced sarcoplasmic reticulum Ca(2+) load mediates impaired contractile reserve in right ventricular pressure overloadQ46954786
Contribution of reverse-mode sodium-calcium exchange to contractions in failing human left ventricular myocytesQ48008656
Elevated plasma human urotensin-II-like immunoreactivity in ischemic cardiomyopathyQ48010955
The trabecula culture system: a novel technique to study contractile parameters over a multiday time period.Q48014051
Plasma urotensin in human systolic heart failureQ48434734
Urotensin-II blockade with SB-611812 attenuates cardiac dysfunction in a rat model of coronary artery ligation.Q53615834
Myocyte recovery after mechanical circulatory support in humans with end-stage heart failureQ74696316
Plasma urotensin II in heart failureQ74811631
Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardiumQ75301226
P433issue1
P304page(s)39-46
P577publication date2009-01-01
P1433published inCirculation: Heart FailureQ2865806
P1476titleDirect inotropic effects of exogenous and endogenous urotensin-II: divergent actions in failing and nonfailing human myocardium
P478volume2

Reverse relations

cites work (P2860)
Q577717631,3,4-Thiadiazol-2-amine Derivatives as Urotensin-II Receptor (UT) Antagonists
Q42070109A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart
Q46981255Contractile responses to rat urotensin II in resting and depolarized basilar arteries.
Q35680934Differential expression of PDE5 in failing and nonfailing human myocardium
Q34233981GSK1562590, a slowly dissociating urotensin-II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo
Q88287377The value of urotensin II in patients with left-sided rheumatic valvular regurgitation

Search more.