NEDD4L is downregulated in colorectal cancer and inhibits canonical WNT signaling

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NEDD4L is downregulated in colorectal cancer and inhibits canonical WNT signaling is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...881514T
P356DOI10.1371/JOURNAL.PONE.0081514
P932PMC publication ID3842946
P698PubMed publication ID24312311
P5875ResearchGate publication ID259208760

P2093author name stringXi Chen
Robert J Coffey
Jarred P Tanksley
P2860cites workNEDD4-1 is a proto-oncogenic ubiquitin ligase for PTENQ24292919
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signallingQ24310750
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APCQ24336321
The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.Q27863647
Lessons from hereditary colorectal cancerQ28131788
Modification of proteins by ubiquitin and ubiquitin-like proteinsQ28244250
Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancerQ28266601
Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arraysQ28566104
Physiological functions of the HECT family of ubiquitin ligasesQ29617293
Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signalingQ30945376
Transcription alterations of members of the ubiquitin-proteasome network in prostate carcinoma.Q33753890
WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradationQ34220865
Oncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomasQ34254614
Novel synergistic antitumor effects of rapamycin with bortezomib on hepatocellular carcinoma cells and orthotopic tumor modelQ34257851
Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk FactorsQ34624887
The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of GoosecoidQ34690036
A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent mannerQ34742525
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signalingQ35013177
Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer.Q36073367
HECT domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting dishevelled for proteasomal degradationQ36708554
Roles of TGFbeta in metastasisQ37339711
NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathwayQ39279494
Claudin-1 up-regulates the repressor ZEB-1 to inhibit E-cadherin expression in colon cancer cellsQ39482179
Genome profiling of pancreatic adenocarcinomaQ39574924
Phospho-Smad1 modulation by nedd4 E3 ligase in BMP/TGF-β signalingQ39594881
Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase the invasive activity of gallbladder cancerQ39637494
Amplification of 8q21 in breast cancer is independent of MYC and associated with poor patient outcomeQ39742324
NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptorQ40501781
Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.Q42100274
Down-regulation of Nedd4L is associated with the aggressive progression and worse prognosis of malignant gliomaQ43539447
Expression of NEDD4-1, a PTEN regulator, in gastric and colorectal carcinomasQ43861270
High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinomaQ44260403
Reduction of transforming growth factor-beta type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma.Q53302797
Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasiaQ82584279
Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patientQ84935997
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P4510describes a project that usesImageJQ1659584
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectcolorectal cancerQ188874
colorectal carcinomaQ25493920
P304page(s)e81514
P577publication date2013-11-28
P1433published inPLOS OneQ564954
P1476titleNEDD4L is downregulated in colorectal cancer and inhibits canonical WNT signaling
P478volume8