ZAP-70 promotes the infiltration of malignant B-lymphocytes into the bone marrow by enhancing signaling and migration after CXCR4 stimulation

scientific article

ZAP-70 promotes the infiltration of malignant B-lymphocytes into the bone marrow by enhancing signaling and migration after CXCR4 stimulation is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2013PLoSO...881221C
P356DOI10.1371/JOURNAL.PONE.0081221
P932PMC publication ID3849145
P698PubMed publication ID24312539
P5875ResearchGate publication ID259208980

P50authorCarlos PalacioQ83011236
Francesc BoschQ53260145
Marta CrespoQ42037673
Josep CastellviQ42648101
P2093author name stringPau Abrisqueta
Noelia Purroy
Cecilia Carpio
Eva Calpe
Júlia Carabia
P2860cites workAbdominal computed tomography predicts progression in patients with Rai stage 0 chronic lymphocytic leukemia.Q53495440
A novel role of the CX3CR1/CX3CL1 system in the cross-talk between chronic lymphocytic leukemia cells and tumor microenvironment.Q54592043
ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.Q55036524
CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potentialQ61640131
CXCR4 neutralization, a novel therapeutic approach for non-Hodgkin's lymphomaQ74198916
Signaling through ZAP-70 is required for CXCL12-mediated T-cell transendothelial migrationQ77975029
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3aQ80319155
ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL)Q81583965
Reproducible establishment of hemopoietic supportive stromal cell lines from murine bone marrowQ42816695
Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemiaQ43119715
Recruitment of PKC-betaII to lipid rafts mediates apoptosis-resistance in chronic lymphocytic leukemia expressing ZAP-70.Q43243964
Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemiaQ44189675
Down-regulation of CXCR4 and CD62L in chronic lymphocytic leukemia cells is triggered by B-cell receptor ligation and associated with progressive disease.Q44214843
Distinct role of ZAP-70 and Src homology 2 domain-containing leukocyte protein of 76 kDa in the prolonged activation of extracellular signal-regulated protein kinase by the stromal cell-derived factor-1 alpha/CXCL12 chemokineQ44484570
ZAP-70 expression is a prognostic factor in chronic lymphocytic leukemia.Q44605532
ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemiaQ44859885
ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemiaQ46112511
ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells.Q51119490
CD38 increases CXCL12-mediated signals and homing of chronic lymphocytic leukemia cells.Q53336736
BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgV H unmutated chronic lymphocytic leukemia (CLL) cells.Q53476669
ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chainQ24294340
Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemiaQ24599100
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)Q24677007
Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceuticalQ24681992
BCR ligation reprograms B cells for migration to the T zone and B-cell follicle sequentiallyQ28204940
In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cellsQ33830733
The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivoQ34029869
Expanded and highly active proliferation centers identify a histological subtype of chronic lymphocytic leukemia ("accelerated" chronic lymphocytic leukemia) with aggressive clinical behaviorQ34095636
The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemiaQ34249777
A combination of cytokines rescues highly purified leukemic CLL B-cells from spontaneous apoptosis in vitroQ34653811
Role of the microenvironment in chronic lymphocytic leukaemiaQ35583432
Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alphaQ35847913
B cell antigen receptor engagement inhibits stromal cell-derived factor (SDF)-1alpha chemotaxis and promotes protein kinase C (PKC)-induced internalization of CXCR4.Q36368196
ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemiaQ36478480
B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406.Q37028635
Gene expression profiling reveals differences in microenvironment interaction between patients with chronic lymphocytic leukemia expressing high versus low ZAP70 mRNAQ37207766
The microenvironment in mature B-cell malignancies: a target for new treatment strategiesQ37563816
Xenograft models of chronic lymphocytic leukemia: problems, pitfalls and future directionsQ38049970
ZAP-70 enhances migration of malignant B lymphocytes toward CCL21 by inducing CCR7 expression via IgM-ERK1/2 activationQ39485051
Effective therapy of human lymphoma xenografts with a novel recombinant ribonuclease/anti-CD74 humanized IgG4 antibody immunotoxinQ40383626
Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells.Q40420056
Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenibQ41763842
Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approachQ42191925
Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migrationQ42221150
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectB-cellQ188930
P304page(s)e81221
P577publication date2013-12-03
P1433published inPLOS OneQ564954
P1476titleZAP-70 promotes the infiltration of malignant B-lymphocytes into the bone marrow by enhancing signaling and migration after CXCR4 stimulation
P478volume8

Reverse relations

cites work (P2860)
Q35781372Co-culture of primary CLL cells with bone marrow mesenchymal cells, CD40 ligand and CpG ODN promotes proliferation of chemoresistant CLL cells phenotypically comparable to those proliferating in vivo
Q38237648Does B cell receptor signaling in chronic lymphocytic leukaemia cells differ from that in other B cell types?
Q42363684Microenvironment regulates the expression of miR-21 and tumor suppressor genes PTEN, PIAS3 and PDCD4 through ZAP-70 in chronic lymphocytic leukemia
Q40486626Syndecan-1 increases B-lymphoid cell extravasation in response to HIV-1 Tat via αvβ3/pp60src/pp125FAK pathway
Q47960121The role of G protein-coupled receptors in lymphoid malignancies
Q37618829The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system