A combination of cytokines rescues highly purified leukemic CLL B-cells from spontaneous apoptosis in vitro

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A combination of cytokines rescues highly purified leukemic CLL B-cells from spontaneous apoptosis in vitro is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...860370G
P356DOI10.1371/JOURNAL.PONE.0060370
P932PMC publication ID3608602
P698PubMed publication ID23555960
P5875ResearchGate publication ID236106817

P50authorGandhi DamajQ91137935
Jean-Pierre MarolleauQ54448958
P2093author name stringJean-Pierre Marolleau
Bruno Royer
Brigitte Gubler
Hussein Ghamlouch
Hakim Ouled-Haddou
P2860cites workInterleukin-15 promotes the growth of leukemic cells of patients with B-cell chronic lymphoproliferative disordersQ71010581
The antiapoptotic effects of blood constituents in patients with chronic lymphocytic leukemiaQ73267557
Higher levels of surface CD20 expression on circulating lymphocytes compared with bone marrow and lymph nodes in B-cell chronic lymphocytic leukemiaQ74505894
Non-malignant leukocytes delay spontaneous B-CLL cell apoptosisQ77378789
Interleukin-12 inhibits apoptosis in chronic lymphatic leukemia (CLL) B cellsQ78624059
CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironmentQ80837099
A proliferation-inducing ligand (APRIL) serum levels predict time to first treatment in patients affected by B-cell chronic lymphocytic leukemiaQ84148159
Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytesQ24319022
Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacityQ28268312
Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway.Q33193186
Different proliferative and survival capacity of CLL-cells in a newly established in vitro model for pseudofolliclesQ33385676
In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cellsQ33830733
Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells.Q34029409
A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the diseaseQ35029969
Identification of outcome-correlated cytokine clusters in chronic lymphocytic leukemiaQ35553576
Protein kinases in the regulation of apoptosis in B-cell chronic lymphocytic leukemiaQ35635542
Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alphaQ35847913
Microenvironmental interactions and survival of CLL B-cellsQ35994836
Bone biopsy derived marrow stromal elements rescue chronic lymphocytic leukemia B-cells from spontaneous and drug induced cell death and facilitates an "angiogenic switch".Q36825701
Cellular immune therapy for chronic lymphocytic leukemiaQ36885803
The normal counterpart to the chronic lymphocytic leukemia B cellQ36914060
Germinal centres: role in B-cell physiology and malignancyQ37039584
Microenvironmental influences in chronic lymphocytic leukaemia: the role of antigen stimulationQ37328562
Chemokines and chemokine receptors in chronic lymphocytic leukemia (CLL): From understanding the basics towards therapeutic targetingQ37795157
The role of IL-21 in hematological malignanciesQ37913683
Can ex vivo evaluation (testing) predict the sensitivity of CLL cells to therapy with purine analogs in conjunction with an alkylating agent? A comparison of in vivo and ex vivo responses to treatmentQ39442429
The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathwaysQ40067429
Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1.Q40710802
Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expressionQ41808003
Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy.Q42183094
Multiplex analysis of cytokines, chemokines, growth factors, MMP-9 and TIMP-1 produced by human bone marrow, adipose tissue, and placental mesenchymal stromal cellsQ42503938
Autologous plasma activates Akt/protein kinase B and enhances basal survival and resistance to DNA damage-induced apoptosis in B-chronic lymphocytic leukaemia cellsQ42509999
Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells.Q42519684
Antiapoptotic effect of interleukin-2 (IL-2) in B-CLL cells with low and high affinity IL-2 receptors.Q43026682
Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1.Q46044632
Baff serum level predicts time to first treatment in early chronic lymphocytic leukemia.Q51560137
Chronic lymphocytic leukemia cell CD38 expression and inducible nitric oxide synthase expression are associated with serum IL-4 levels.Q53665010
Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemiaQ58042064
Expression of Adhesion Molecules in B-cell Chronic Lymphocytic Leukaemia: an Analysis in Lymphoid Compartments - Peripheral Blood, Bone Marrow and Lymph NodeQ63634112
Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitroQ70902052
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
P304page(s)e60370
P577publication date2013-03-26
P1433published inPLOS OneQ564954
P1476titleA combination of cytokines rescues highly purified leukemic CLL B-cells from spontaneous apoptosis in vitro
P478volume8

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cites work (P2860)
Q55061968A novel ex vivo high-throughput assay reveals antiproliferative effects of idelalisib and ibrutinib in chronic lymphocytic leukemia.
Q33896639Antileukemic activity of sulforaphane in primary blasts from patients affected by myelo- and lympho-proliferative disorders and in hypoxic conditions
Q45833017B cell activation through CD40 and IL4R ligation modulates the response of chronic lymphocytic leukaemia cells to BAFF and APRIL.
Q38966197B cells and macrophages pursue a common path toward the development and progression of chronic lymphocytic leukemia
Q35054626Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton.
Q52579132Chronic Lymphocytic Leukemia B-Cell Normal Cellular Counterpart: Clues From a Functional Perspective.
Q89896570Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role
Q37417442Cytokine Contents in Chronic Lymphocytic Leukemia: Association with ZAP70 Expression
Q36759124Disruption of in vivo Chronic Lymphocytic Leukemia Tumor-Microenvironment Interactions by Ibrutinib--Findings from an Investigator-Initiated Phase II Study
Q38298483Factors involved in CLL pathogenesis and cell survival are disrupted by differentiation of CLL B-cells into antibody-secreting cells
Q42367941Macrophage-mediated chronic lymphocytic leukemia cell survival is independent of APRIL signaling
Q56514276Microenvironmental agonists generate phenotypic resistance to combined ibrutinib plus venetoclax in CLL and MCL
Q38984569Modeling the chronic lymphocytic leukemia microenvironment in vitro
Q34052050Phorbol myristate acetate, but not CD40L, induces the differentiation of CLL B cells into Ab-secreting cells
Q37362593STAT3 and NF-κB cooperatively control in vitro spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia.
Q35534809TACI expression and signaling in chronic lymphocytic leukemia
Q33760295TLR9 Ligand (CpG Oligodeoxynucleotide) Induces CLL B-Cells to Differentiate into CD20(+) Antibody-Secreting Cells
Q26798062Targeting chronic lymphocytic leukemia cells in the tumor microenviroment: A review of the in vitro and clinical trials to date
Q38895643The MEK1/2 inhibitor, MEKi-1, induces cell death in chronic lymphocytic leukemia cells under conditions that mimic the tumor microenvironment and is synergistic with fludarabine
Q35061209ZAP-70 promotes the infiltration of malignant B-lymphocytes into the bone marrow by enhancing signaling and migration after CXCR4 stimulation

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