Autologous plasma activates Akt/protein kinase B and enhances basal survival and resistance to DNA damage-induced apoptosis in B-chronic lymphocytic leukaemia cells

scientific article

Autologous plasma activates Akt/protein kinase B and enhances basal survival and resistance to DNA damage-induced apoptosis in B-chronic lymphocytic leukaemia cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1046/J.1365-2141.2001.02978.X
P698PubMed publication ID11552986
P5875ResearchGate publication ID229525706

P2093author name stringD T Jones
A V Hoffbrand
J A Hartley
V J Spanswick
H G Prentice
M Wadhwa
A B Mehta
R Thorpe
C Lindsay
K Ganeshaguru
R G Wickremasinghe
P2860cites workAkt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factorQ22009126
The PI3K-PDK1 connection: more than just a road to PKBQ24531972
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machineryQ27860586
Interleukin-3-induced phosphorylation of BAD through the protein kinase AktQ28255373
Akt signaling: linking membrane events to life and death decisionsQ28302851
Caspases: enemies withinQ29547315
Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.Q34250223
Interferon gamma inhibits apoptotic cell death in B cell chronic lymphocytic leukemiaQ36361141
Cytokine receptor signallingQ40416594
Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expressionQ41808003
Development of immunoassays for human interleukin 3 and interleukin 4, some of which discriminate between different recombinant DNA-derived moleculesQ42808358
PIK3CA is implicated as an oncogene in ovarian cancer.Q46015944
Chemosensitivity testing of fresh leukaemia cells using the MTT colorimetric assay.Q54362264
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectchronic lymphocytic leukemiaQ1088156
lymphocyteQ715347
DNA damageQ5205747
leukemiaQ29496
P304page(s)608-615
P577publication date2001-09-01
P1433published inBritish Journal of HaematologyQ4970200
P1476titleAutologous plasma activates Akt/protein kinase B and enhances basal survival and resistance to DNA damage-induced apoptosis in B-chronic lymphocytic leukaemia cells
P478volume114

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cites work (P2860)
Q34653811A combination of cytokines rescues highly purified leukemic CLL B-cells from spontaneous apoptosis in vitro
Q45005116Bryostatin induces protein kinase C modulation, Mcl-1 up-regulation and phosphorylation of Bcl-2 resulting in cellular differentiation and resistance to drug-induced apoptosis in B-cell chronic lymphocytic leukemia cells
Q35930211CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death
Q49051354Deguelin inhibits expression of IkappaBalpha protein and induces apoptosis of B-CLL cells in vitro
Q39960462Dietary flavonoids inhibit the anticancer effects of the proteasome inhibitor bortezomib
Q36115671Genetics and molecular biology of chronic lymphocytic leukemia
Q40439092Good prognosis cytogenetics in B-cell chronic lymphocytic leukemia is associated in vitro with low susceptibility to apoptosis and enhanced immunogenicity
Q40615155Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias
Q35994836Microenvironmental interactions and survival of CLL B-cells
Q35847913Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha
Q41854903Proangiogenic stimulation of bone marrow endothelium engages mTOR and is inhibited by simultaneous blockade of mTOR and NF-kappaB.
Q35635542Protein kinases in the regulation of apoptosis in B-cell chronic lymphocytic leukemia
Q34764114Signal transducer and activator of transcription-3 induces microRNA-155 expression in chronic lymphocytic leukemia
Q36150234The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions.